• Journal of the Korean Home Economics Association
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• v.25 no.3
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• pp.83-94
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• 1987

The floor plan of the folk houses in Korean-Middle area was "-" type, "ㄱ" type and "double " type. The common terms of lifespaces were Anbang(안방), Wootbang(웃방), Cunnunbang(건넌방), Taechung(대청), Maru(마루), Buoak(부엌), Chungji(정지), Sarangbang(사랑방), Bongdang(봉당). 1) Anbang was basically a master room and was a family room. The function of another presented in Anbang was a space of the dying hour, the mourning decorums, and the memorial services. 2) Wootbang, Cunnunbang was terms that coming from the space position. Such spaces were the private rooms of children. 3) Sarangbang was basically the space of a reception of guests. 4) Buoak, Chungji were cooking and working space. Primarily, Buoak was the terms meaned Bootumk(부뚜막) in Chosun dynasty. 5) Maru, Tachung were terms of presented from side of construction. Specially, it was the chief space in family in Summer. 6) Bongdang was a terms of space that mean working areas, entry hall etc.working areas, entry hall etc.

• BMB Reports
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• v.49 no.8
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• pp.424-430
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• 2016

Autophagy, an evolutionarily conserved cellular degradation pathway of the lysosome, is associated with many physiological and pathological processes. The hallmark of autophagy is the formation of the autophagosome that engulfs and degrades cytosolic components via its fusion with the lysosome, in either a selective or a non-selective manner. Autophagy is tightly regulated by proteins encoded by autophagy-related (atg) genes. Among these proteins, ATG8/LC3 is essential for autophagosome biogenesis/maturation and it also functions as an adaptor protein for selective autophagy. In mammalian cells, several homologs of yeast Atg8 such as MAP1LC3, GABARAP, and GABARAPL 1/2 have been identified. However, the biological relevance of this gene diversity in higher eukaryotes, and their specific roles, are largely unknown. In this review, we describe the mammalian ATG8/LC3 family and discuss recent advancements in understanding their roles in the autophagic process.

• Journal of Families and Better Life
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• v.16 no.2
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• pp.11-22
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• 1998

The purpose of this study is to contribute to the theoretical understanding of the nature of domestic labor in relation to the capitalist economic system. In this study I adopted the reproduction of labor for the analytical term. Also I owed theoretical basis to the political economy to analyze the relation between domestic labor and capitalist economy. The family is a very important place which functions to maintain and change both the present and future labor what is called the reproduction of labor power. It also has a close relationship with the total society. The reproduction of labor power is divided by 'gender division of labor' which allocates the responsibility to one gender(women) and exempts it to another gender(men). In conclusion the domestic labor is the very basis of capitalist economy and it is also the preliminary condition to its system. SO we can fully understand the capitalist economy with the 'visible' labor part and the 'invisible' domestic labor part inc usively. And we can also understand the interrelationship between family and labor market which constitutes one economic system and fuctions in it.

• BMB Reports
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• v.32 no.5
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• pp.419-428
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• 1999

Tumor necrosis factor (TNF) receptor members have unique structures composed of 2-4 cysteine - rich pseudorepeats in the extracellular domain. On ligation by trimeric ligand molecules, oligomerization of three receptor molecules occurs, which in turn activates the receptor and recruits intracellular signaling molecules to the cytoplasmic tail to initiate biological events. Recently, the numbers of tumor necrosis factor receptor and ligand family members have been rapidly expanding. Functional characterization of the new members has indicated redundant roles with other known members as well as provided insights into novel functions. In particular, identification of soluble decoy receptors which have the ability to bind multiple ligands highlights a complex control mechanism of immune responses by these molecules. Studies of the new members have also revealed that the TNF receptor and ligand family members play an important role in other than the immune system.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1719-1722
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• 2012

The Wiskott-Aldrich Syndrome Protein family Verprolin - homologous proteins (WAVEs), encoded by a metastasis promoter gene, play considerable roles in adhesion of immune cells, cell proliferation, migration and destruction of foreign agents by reactive oxygen species. These diverse functions have lead to the hypothesis that WAVE proteins have multi-functional roles in regulating cancer invasiveness, metastasis, development of tumor vasculature and angiogenesis. Differentials in expression of WAVE proteins are associated with a number of neoplasms include colorectal cancer, hepatocellular cancer, lung squamous cell carcinoma, human breast adenocarcinoma and prostate cancer. In this review we attempt to unify our knowledge regarding WAVE proteins, focusing on their potentials as diagnostic markers and molecular targets for cancer therapy.

• BMB Reports
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• v.41 no.5
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• pp.353-357
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• 2008

LRR family proteins play important roles in a variety of physiological processes. To facilitate their production and crystallization, we have invented a novel method termed "Hybrid LRR Technique". Using this technique, the first crystal structures of three TLR family proteins could be determined. In this review, design principles and application of the technique to protein crystallization will be summarized. For crystallization of TLRs, hagfish VLR receptors were chosen as the fusion partners and the TLR and the VLR fragments were fused at the conserved LxxLxLxxN motif to minimize local structural incompatibility. TLR-VLR hybridization did not disturb structures and functions of the target TLR proteins. The Hybrid LRR Technique is a general technique that can be applied to structural studies of other LRR proteins. It may also have broader application in biochemical and medical application of LRR proteins by modifying them without compromising their structural integrity.

• Molecules and Cells
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• v.28 no.4
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• pp.315-320
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• 2009

The RAS family of oncoproteins has been studied extensively for almost three decades. While we know that activation of RAS represents a key feature of malignant transformation for many cancers, we are only now beginning to understand the complex underpinnings of RAS biology. Here, we will discuss emerging cancer genome sequencing data in the context of what is currently known about RAS function. Taken together, retrospective studies of primary human tissues and prospective studies of experimental models support the notion that the variable mutation frequencies exhibited by the RAS oncogenes reflect unique functions of the RAS oncoproteins.

• Communications for Statistical Applications and Methods
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• v.31 no.4
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• pp.427-440
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• 2024

The problem addressed is that of sequentially estimating the difference between the means of two populations with respect to the squared error loss, where each population distribution is a member of the one-parameter exponential family. A Bayesian approach is adopted in which the population means are estimated by the posterior means at each stage of the sampling process and the prior distributions are not specified but have twice continuously differentiable density functions. The main result determines an asymptotic second-order lower bound, as t → ∞, for the Bayes risk of a sequential procedure that takes M observations from the first population and t - M from the second population, where M is determined according to a sequential design, and t denotes the total number of observations sampled from both populations.

• Journal of the Korean Mathematical Society
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• v.52 no.1
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• pp.23-41
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• 2015

We present a semilocal convergence analysis of a third order method for approximating a locally unique solution of an equation in a Banach space setting. Recently, this method was studied by Chun, Stanica and Neta. These authors extended earlier results by Kou, Li and others. Our convergence analysis extends the applicability of these methods under less computational cost and weaker convergence criteria. Numerical examples are also presented to show that the earlier results cannot apply to solve these equations.

• Molecules and Cells
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• v.43 no.2
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• pp.107-113
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• 2020

The Runt-related transcription factors (RUNX) transcription factors have been known for their critical roles in numerous developmental processes and diseases such as autoimmune disorders and cancer. Especially, RUNX proteins are best known for their roles in hematopoiesis, particularly during the development of T cells. As scientists discover more types of new immune cells, the functional diversity of RUNX proteins also has been increased over time. Furthermore, recent research has revealed complicated transcriptional networks involving RUNX proteins by the current technical advances. Databases established by next generation sequencing data analysis has identified ever increasing numbers of potential targets for RUNX proteins and other transcription factors. Here, we summarize diverse functions of RUNX proteins mainly on lymphoid lineage cells by incorporating recent discoveries.