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http://dx.doi.org/10.14348/molcells.2019.0291

The Roles of RUNX Family Proteins in Development of Immune Cells  

Seo, Wooseok (Department of Immunology, Nagoya University Graduate School of Medicine)
Taniuchi, Ichiro (Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences)
Publication Information
Molecules and Cells / v.43, no.2, 2020 , pp. 107-113 More about this Journal
Abstract
The Runt-related transcription factors (RUNX) transcription factors have been known for their critical roles in numerous developmental processes and diseases such as autoimmune disorders and cancer. Especially, RUNX proteins are best known for their roles in hematopoiesis, particularly during the development of T cells. As scientists discover more types of new immune cells, the functional diversity of RUNX proteins also has been increased over time. Furthermore, recent research has revealed complicated transcriptional networks involving RUNX proteins by the current technical advances. Databases established by next generation sequencing data analysis has identified ever increasing numbers of potential targets for RUNX proteins and other transcription factors. Here, we summarize diverse functions of RUNX proteins mainly on lymphoid lineage cells by incorporating recent discoveries.
Keywords
development; immune cells; Runx family; transcription factors;
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