• Journal of the Korean Home Economics Association
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• v.48 no.10
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• pp.133-141
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• 2010

The purpose of this study was to investigate the construct validity of the Penn Interactive Peer Play Scale on the parent version. The participants of this study were 231 children in the Seoul and Gyeonggi provincial areas. The instruments included the 32-item exploratory PIPPS (Choi & Shin, 2008), and the Preschool Behavior Questionnaire (PBQ; Park, 1992). The data were analyzed by descriptive statistics, factor analysis, Pearson's r and Cronbach ${\alpha}$. The results were as follows. First, the PIPPPS on the parent version was validated with supporting three factors: Play Disruption, Play Disconnection and Play Interaction with 30 items. The sub-factors of the PIPPS were related with those of the PBQ as criterion measurements. The reliability coefficients of the sub-factors of the PIPPS were ranged from .78 to .82.

• Journal of muscle and joint health
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• v.10 no.2
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• pp.119-130
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• 2003

Illness intrusiveness(illness induced lifestyle disruption) was investigated in 902 patients with arthritis and compared between rheumatoid arthritis(N=439) and osteoarthritis(N=463) patients. Arthritis patients were reported to perceive illness intrusiveness similar to patients with ESRD(end stage renal disease), bipolar disorder and peritoneal dialysis. Especially they were intrusive into health, work, and active recreation domains. And patients with rheumatoid arthritis were significantly more intrusive into activities, especially in diet, financial situation, family relations, other social relations, self-expression/self improvement, religious expression, and community and civic involvement. Differences in treatment regimens and age were hypothesized to account for these differences in illness intrusiveness.

• BMB Reports
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• v.35 no.3
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• pp.291-296
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• 2002

Thanatin, a 21-residue peptide, is an inducible insect peptide with a broad range of activity against bacteria and fungi. It has a C-terminal disulfide loop, like the frog skin secretion antimicrobial peptides of the brevinin family. In this study, we tried to find the effect of a number of amino acids between the disulfide bond. Thanatin showed stronger antibacterial activity to Gram negative bacteria than other mutants, except Th1; whereas, the mutant peptides with deletion had higher activity to Gram positive bacteria than thanatin. An increase in the number of amino acid(s) using the alanine residue decreased the antibacterial activity in all of the bacteria. Th1 with deletion of threonine at position 15 ($Thr^{15}$) showed similar antibacterial activity against Gram-negative bacteria, but had higher activity against the Gram positive bacteria. In order to study the structure-function relationship, we measured liposome disruption by the peptides and CD spectra of the peptides. Th1 also showed the highest liposome leaking activity and α-helical propensity in the sodium dodecyl sulfate solution, compared with other peptides. Liposome disruption activity was closely correlated with the anti-Gram positive bacterial activity. All of the peptides showed no hemolytic activity. Th1 was considered to be useful as an antimicrobial peptide with broad spectrum without toxicity.

• Journal of Families and Better Life
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• v.29 no.5
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• pp.121-140
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• 2011

The purpose of this study is to understand how the economic conditions and needs of single-parent families are different between single-mother and single-father families, and also how they are dependent on household composition. The data for this study were drawn from the 1st Korea Welfare Panel Study and analyzed by frequencies, means, ${\chi}^2$, t-test, F-test, and logistic regression with the STATA 9.1 program. The major findings are as follows: (1) Single-parent families are more likely to live in a three-generation household than married couple families. (2) The composition of a three-generation household of single-parent families is affected by sex, age, education, type of marital disruption, the type of employment of single parents and the age of the last-born child. (3) The income-to-needs ratio is not significantly different depending on the sex of the single parents and their household composition. However, material hardship is significantly low in three-generation household single-parent families. (4) There are differences between three-generation single-parent families and independent single-parent families in income sources: The ratio of public transfer to total incomes is higher in three-generation households than independent households, while the ratio of private transfer to total incomes is higher in independent households.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3131-3138
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• 2016

Several studies have addressed the possible role of hepatitis C virus genotype-4 (HCV GT4) in apoptosis. However, this still not fully understood. In the current study a re-constructed clone of E1/E2 polyprotein region of the HCV GT4 was transfected into the Huh7 cell line and a human apoptotic PCR array of 84 genes was used to investigate its possible significance for apoptosis. Out of the 84 genes, only 35 showed significant differential expression, 12 genes being up-regulated and 23 down-regulated. The highest-up regulated genes were APAF1 (apoptotic peptidase-activating factor 1), BID (BH3 interacting domain death agonist) and BCL 10 (B-cell CLL/lymphoma protein 10) with fold regulation of 33.2, 30.1 and 18.9, respectively. The most down-regulated were FAS (TNF receptor super family), TNFRSF10B (tumor necrosis factor receptor super-family member 10b) and FADD (FAS-associated death domain) with fold regulation of -30.2, -27.7 and -14.9, respectively. These results suggest that the E1/E2 proteins may be involved in HCV-induced pathogenesis by modulating apoptosis through the induction of the intrinsic apoptosis pathway and disruption of the BCL2 gene family.

• Korean Journal of Child Education & Care
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• v.18 no.1
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• pp.77-102
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• 2018

The objectives of this study were to analyze the longitudinal mediation effects of maternal parenting stress and psychosocial development of infant on the influence of paternal involvement during infancy to children's peer interactions. For these objectives, latent growth modeling was used and adapted to the data taken from the Panel Study on Korean Children(PSKC), Wave I (0-year olds) to Wave III (2-year olds) and Wave V(4-year olds) to Wave VII(6-year olds). During a total of six years, 1,018 parent responded. The major results of this study were as follows. First, maternal parenting stress(initial status) had a significant mediating effect on the influence of paternal involvement(initial status) to children's play interaction(initial status). Second, maternal parenting stress(initial status/change rate) had a longitudinal mediating eff ect on the influence of paternal involvements(initial status/change rate) to children's play disruption-disconnection interactions(initial status/change rate). Third, psychosocial development of infants(initial status/change rate) had a longitudinal mediating effect on the influence of paternal involvement(initial status/change rate) to children's play interactions(initial status/change rate). Fourth, psychosocial development of infant(initial status) had a significant mediating effect on the influence of paternal involvement(initial status) to children's play disruption-disconnection interactions(initial status). The implications of the findings of the current study and suggestions for future research were also discussed.

• Korean Journal of Social Welfare
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• v.52
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• pp.201-221
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• 2003

This paper aims to examine whether there are significant differences in various aspects of a household's arrangements by type of employment of married woman; 1) the extent of the division of labor, 2) the authority of decision making, and 3) financial and expenditure responsibilities. It also investigates the determinants of gender equality in the family. Based on data collected in the fall of 2002 from a representative sample of the Korean population, this study finds that nonstandard employment of married woman including temporary work and daily basis work does not contribute to gender equality within the household, although most of nonstandard employees are full-time workers. However, standard employment of married woman contribute to gender equality in the family. The results of this study show that husbands whose wives are standard-employed are more likely to take part in housework chores that are female-dominated, and standardly employed wives are more likely than non-standardly employed or housewives to take part in the household's financial and expenditure responsibilities. Standardly employed wives also have more power in decision making process within households. On the contrary, non-standardly employed wives gain no advantage over housewives within their families, due to lack of bargaining resources that enable them to affect the household's arrangements. Thus, they have confronted additional burdens, which stem from carrying the dual role of doing house work as well as paid work. Such increasing work-family conflict may bring about disruption of family. Therefore, this study maintains that it is high time that government-level efforts should be made in order to improve the status of irregularly employed wives in the workplace.

• The Journal of the Korea Contents Association
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• v.13 no.3
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• pp.152-161
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• 2013

This study attempted to test the causal effect of structural characteristics of metropolitan neighborhoods on crime, based on the ecological model of crime explanation. To this end, a Negative Binomial Regression analysis was performed for Seoul's 424 Dong Districts. Results showed that the incidence of homicide increases as much as the scales of economic disadvantage, family disruption, and commercial land use go worse. It suggested that family integrity is one of the most strong and consistent factors that could deter crime in neighborhood's contexts. Economic disadvantage and commercial land use were also critical targets as crime-generating factors. Reasoning with the results of past studies implied that neighborhood-specific approaches need to be developed for effective crime prevention. Although a few limitations could raise a caveat against such interpretation of the results, the value of this research would not be simply denied as the first attempt to utilize all Dong districts of Seoul. It is expected that this study contributes to activating Dong level research and developing effective crime control policy.

• Human Ecology Research
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• v.54 no.3
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• pp.321-332
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• 2016

This study clarified the maintenance of relationship between children and teachers based on longitudinal data and explored the latent classes. It clarified the latent classes connection with the children's peer play interaction. The subjects of this study were 194 children (aged 3) who attended 11 different kindergartens and daycare centers. We collected data three times (once every 6 months) until they reached age 4. The results of this study were: first, closeness, conflict, and dependence of child-teacher relationship that showed a continuous short-term connection. Second, we classified the child-teacher relationship into three groups according to longitudinal data. Those groups were, 'low level maintenance group' which had the lowest conflict and dependence compared to the highest closeness with teacher, 'middle level maintenance group' which had the teacher relationship in the middle level of the sub element area, and 'high level maintenance group' which showed high conflict and dependence compared to low closeness with the teacher. Third, the group which maintains a longitudinal high conflict.dependence showed more interruption and disruption behavior than the group which maintained a low conflict and dependence. In conclusion, the child-teacher relationship seemed to be the steady characteristic because it showed the early formation of a stable relationship. It was possible to predict the child's peer interaction through an early child-teacher relationship. Teachers need to be educated by the kindergarten and daily care center because the early formation of a child-teacher relationship can be the foundation of child's later peer and teacher relationships.

• Biomedical Science Letters
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• v.17 no.3
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• pp.177-184
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• 2011

Potassium cyanate (KOCN) is an inorganic compound and induces the carbamylation of proteins with cytotoxic effects on human cells. Although there is a potential cytotoxic molecule, the role of KOCN on the apoptosis of cancer cell is not well understood. The present study investigated the effects of KOCN on the human colorectal cancer cell line, HCT 116 cells. To understand the anti-cancer effect of KOCN on HCT 116 cells, we examined alteration of apoptosis, the intracellular $Ca^{2+}$ concentration, the intracellular signaling pathway and generation of reactive oxygen species (ROS) in these cells treated with KOCN. The apoptosis of HCT 116 cells was induced by KOCN in a dose-dependent manner at 24 hours and 48 hours, respectively. The apoptosis was processed via the cleavage of poly ADP-ribose polymerase (PARP) and activation of caspase 3 in HCT 116 cells. KOCN induced the elevation of intracellular $Ca^{2+}$ concentration and changed the expressions of Bcl-2 family proteins. The pro-apoptotic Bax was continuously up-regulated, and the anti-apoptotic Bcl-2 was down-regulated by KOCN. KOCN also induced the hyperpolarization of mitochondria and the generation of ROS in HCT 116 cells. Taken together, these results indicate that KOCN induces the apoptosis of HCT 116 cells by disruption of $Ca^{2+}$ homeostasis and via mitochondrial pathway. This study provides the compound that may be used as a potent agent for the treatment of colorectal cancer.