• Tuberculosis and Respiratory Diseases
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• v.54 no.4
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• pp.429-438
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• 2003

Background : The mortality from acute respiratory distress syndrome(ARDS) is >40-50%. Although some prospective trials have failed to demonstrate a survival benefit of steroids in the early stages of ARDS, there are some reports showing some success with steroids in the later stages. This study observed the changes in the physiologic parameters with time in late ARDS patients who were treated with steroids. Methods : The medical charts of 28 intensive care unit patients(male:female=24:4; mean age 64 years), who had been diagnosed with refractory late ARDS ($PaO_2/FIO_2$ <200) and were treated with corticosteroids from December 1999 to July 2002, were retrospectively reviewed. The patients were divided into two groups: the weaned group(n=14), which included the patients who had been successfully weaned from a ventilator after corticosteroid therapy, and the failed group(n=14), which included the patients who had failed weaning. The physiologic parameters included the $PaO_2/FIO_2$ ratio, the positive end-expiratory pressure(PEEP) level, the $PaCO_2$, compliance, the sequential organ failure assessment(SOFA) score, the acute physiologic and the chronic health evaluation(APACHE) II score, and the Murray Lung Injury Score(LIS) in the two groups were compared from the day of mechanical ventilation(Dmv) to 7 days after the corticosteroid therapy. Results : There was no significant difference in the clinical characteristics and the physiologic parameters between the two groups prior to the corticosteroid therapy except for the SOFA score at Dmv(weaned group : $6.6{\pm}2.5$ vs failed group : $8.8{\pm}2.9$, p=0.047). However, within 7 days after corticosteroid therapy, there was significant improvement in the $PaO_2/FIO_2$ ratio, the PEEP level, the $PaCO_2$, the SOFA score, the APACHE II score, and the LIS of the weaned group compared to the failed group. Conclusions : During corticosteroid therapy in late ARDS, the continuation of corticosteroid therapy should be determined carefully in patients who do not show improvement in their physiologic parameters by day 7.

• Journal of Korea Water Resources Association
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• v.53 no.9
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• pp.661-670
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• 2020

The water supply system has a wider installation range and various components of it than other infrastructure, making it difficult to secure stability against earthquakes. Therefore, it is necessary to develop methods for evaluating the seismic performance of water supply systems. Ground Motion Prediction Equation (GMPE) is used to evaluate the seismic performance (e.g, failure probability) for water supply facilities such as pump, water tank, and pipes. GMPE is calculated considering the independent variables such as the magnitude of the earthquake and the ground motion such as PGV (Peak Ground Velocity) and PGA (Peak Ground Acceleration). Since the large magnitude earthquake data has not accumulated much to date in Korea, this study tried to select a suitable GMPE for the domestic earthquake simulation by using the earthquake data measured in Korea. To this end, GMPE formula is calculated based on the existing domestic earthquake and presented the results. In the future, it is expected that the evaluation will be more appropriate if the determined GMPE is used when evaluating the seismic performance of domestic waterworks. Appropriate GMPE can be directly used to evaluate hydraulic seismic performance of water supply networks. In other words, it is possible to quantify the damage rate of a pipeline during an earthquake through linkage with the pipe failure probability model, and it is possible to derive more reasonable results when estimating the water outage or low-pressure area due to pipe damages. Finally, the quantifying result of the seismic performance can be used as a design criteria for preparing an optimal restoration plan and proactive seismic design of pipe networks to minimize the damage in the event of an earthquake.

• Journal of Korean Tunnelling and Underground Space Association
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• v.24 no.6
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• pp.451-464
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• 2022

The high-level nuclear waste repository is a deep geological disposal system exposed to complex environmental conditions such as high temperature, radiation, and ground-water due to handling spent nuclear fuel. Continuous exposure can lead to cracking and deterioration of the structure over time. On the other hand, the high-level nuclear waste repository requires an ultra-long life expectancy. Thus long-term structural health monitoring is essential. Various sensors such as an accelerometer, earth pressure gauge, and displacement meter can be used to monitor the health of a structure, and a piezoelectric sensor is generally used. Therefore, it is necessary to develop a highly durable sensor based on the durability assessment of the piezoelectric sensor. This study designed an accelerated life test for durability assessment and life prediction of the piezoelectric sensor. Based on the literature review, the number of accelerated stress levels for a single stress factor, and the number of samples for each level were selected. The failure mode and mechanism of the piezoelectric sensor that can occur in the environmental conditions of the high-level waste repository were analyzed. In addition, two methods were proposed to investigate the maximum harsh condition for the temperature stress factor. The reliable operating limit of the piezoelectric sensor was derived, and a reasonable accelerated stress level was set for the accelerated life test. The suggested methods contain economical and practical ideas and can be widely used in designing accelerated life tests of piezoelectric sensors.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.5A
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• pp.565-575
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• 2009

In recent years, there have been numerous explosion-related accidents due to military and terrorist activities. Such incidents caused not only damages to structures but also human casualties, especially in urban areas. To protect structures and save human lives against explosion accidents, better understanding of the explosion effect on structures is needed. In an explosion, the blast load is applied to concrete structures as an impulsive load of extremely short duration with very high pressure and heat. Generally, concrete is known to have a relatively high blast resistance compared to other construction materials. However, normal strength concrete structures require higher strength to improve their resistance against impact and blast loads. Therefore, a new material with high-energy absorption capacity and high resistance to damage is needed for blast resistance design. Recently, Ultra High Strength Concrete(UHSC) and Reactive Powder Concrete(RPC) have been actively developed to significantly improve concrete strength. UHSC and RPC, can improve concrete strength, reduce member size and weight, and improve workability. High strength concrete are used to improve earthquake resistance and increase height and bridge span. Also, UHSC and RPC, can be implemented for blast resistance design of infrastructure susceptible to terror or impact such as 9.11 terror attack. Therefore, in this study, the blast tests are performed to investigate the behavior of UHSC and RPC slabs under blast loading. Blast wave characteristics including incident and reflected pressures as well as maximum and residual displacements and strains in steel and concrete surface are measured. Also, blast damages and failure modes were recorded for each specimen. From these tests, UHSC and RPC have shown to better blast explosions resistance compare to normal strength concrete.

• Tunnel and Underground Space
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• v.22 no.2
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• pp.77-85
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• 2012

In a material, micro-cracks can be progressively occurred, propagated and finally lead to failure when it is subjected to cyclic or periodic loading less than its ultimate strength. This phenomenon, fatigue, is usually considered in a metal, alloy and structures under repeated loading conditions. In underground structures, a static creep behavior rather than a dynamic fatigue behavior is mostly considered. However, when compressed air is stored in a rock cavern, an inner pressure is periodically changed due to repeated in- and-out process of compressed air. Therefore mechanical properties of surrounding rock mass and an inner lining system under cyclic loading/unloading conditions should be investigated. In this study, considering an underground lined rock cavern for compressed air energy storage (CAES), the mechanical properties of a lining system, that is, concrete lining and plug under periodic loading/unloading conditions were characterized through cyclic bending tests and shear tests. From these tests, the stability of the plug was evaluated and the S-N line of the concrete lining was obtained.

• Journal of the Korean Geosynthetics Society
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• v.18 no.4
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• pp.181-191
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• 2019

Most of the reservoirs in South Korea are fill dam, and overflow and piping phenomena have been detected as the main causes of failure of fill dam. In this study, an operating ◯◯ reservoir located in Gongju-si is modeled in centrifuge model test to study the behavior of reservoir during water level rise and overflow conditions. In order to simulate seepage and overflow in the real reservoir, the model was constructed in 1/50 scale, and deteriorated and reinforced conduits were installed. After modeling the reinforced and deteriorated conditions of the conduits, LVDTs, pore pressure gauges were installed and centrifuge model tests were carried out with water level rise and overflow conditions in order to analyze the reservoir behavior according to the reinforcement methods. The results of centrifuge model test in water level rise condition show that deteriorated conduit has adverse effects in the stability of the reservoir body, and the conduit which is reinforced by the inverse lining method has enhanced stability of the reservoir body. Moreover, installation of water spillway is seen to prevent the scour and erosion of the reservoir body. The study provides a basic data required for the reinforcement of conduit and water spillway in the reservoir.

• Journal of the Korean GEO-environmental Society
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• v.18 no.4
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• pp.31-40
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• 2017

In this study, a simple method to evaluate the seismic vulnerability of river levees was examined considering the structural characteristic of river levee, that is long, and the functional characteristic of river levee that performs temporary function against flood but is a permanent structure in the ordinary way. Considering the fact that one of the main failure modes of the levee during the earthquake are the settlement due to the strength reduction of the ground caused by the increase of the excess pore pressure in the levee body and foundation and the settlement due to liquefaction, the 2-dimensional section of the levee was regarded as the 1-dimensional section and the liquefaction potential index (LPI) for the regarded section was estimated. The estimated LPI was correlated with the seismic vulnerability of river levees. The relationship between the displacement of the levee crest caused by the earthquake and the seismic vulnerability of the levees was obtained from the results of previous researches and the correlation between the displacements of the levee crest computed by 2-dimensional dynamic coupled analyses and LPIs based on the results of 1-dimensional seismic response analyses was investigated. In connection with this correlation, as a result of examination of the correlation between LPI and the seismic vulnerability of the levee, it was concluded that the method for evaluation of the seismic vulnerability of the Korean river levee using LPI is applicable.

• Journal of the Korean Geosynthetics Society
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• v.14 no.3
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• pp.31-42
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• 2015

The Reinforced subgrade for railroad (RSR) was constructed for one way railway line with the dimension of 5 m high, 6 m wide and 20 m long to evaluate its performance under train design load. The RSR has characteristics of short length (0.3-0.4 H) of reinforcement and rigid wall, 30 and 40 cm vertical spacing of reinforcement installation. To enhance economics and constructability, three kinds of connections (welding, hinge & bolt, bold wire) were also designed to realize the integration between rigid wall and reinforced subgrade. Two times of static loading tests were done on the full size railroad subgrade. The maximum applied pressure was 0.98 MPa (the maximum test load 5.88 MN), which corresponds to 19.6 times of the design load for railroad subgrade, 50 kPa. The performance on the RSR was evaluated with the safety on the failure, subgrade bearing capacity and settlement, horizontal displacement of wall, and reinforcement strain. Based on the full scale test, we confirmed that the RSR with the conditions of 0.35 H (35% of height) short reinforcement length, hinge & bolt type connection for integration between rigid wall and reinforced subgrade, and 40cm vertical spacing of reinforcement installment shows good performance under train design load.

• Journal of Chest Surgery
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• v.29 no.8
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• pp.807-815
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• 1996

The protective effect of'ischemic preconditioning'on ischemid-reperfusion injury of heart has been reported in various animal species. but without known mechAnism in detail, In An attempt to investigate the cardioprotective mechanism of ischemic preconditioning, we examined the effects of nitric oxide(UO) synthesis in preconditioned heart of rat The isolated hearts perfused by Langendorfr's method were ex- posed to 30min global ischemia followed by 30min reperfusion with oxygenated Krebs-Henseleit(K-H) sol- ution. Ischemic preconditioning was performed with three episodes of Sm n ischemia and Smin repeyfusion before the induction of prolong ischemia(30min)-reperfusion(30min). Ischemic preconditioning prevented the depression of cardiac function(left ventricular pressure .K heart rate) observed in the ischemia- reperfusion hearts and reduced the release of lactate dehydrogenase during the reperfusion period. On electromicroscopic pictures, myocardial ultrastructures wore relatively well preserved in isthemic preconditioned hearts. N6_nitro-L-arginine methyl ester(L-NAME) an inhibitor of L-arginine citric oxide pathway, was infused at a rate O.Smllmin In a dose of 10mg kg-1 before the initial ischemic preconditioning. neither the protection of cardiac function nor the reduction of LDH releAse in ischemic preconditioning hearts was altered in the presence of added L-NAME On ultrastructural finding, the preservation of morphology in ischemic preconditioning heart was not change by the pretreatment of L-UAME. The failure of the WO synthesis inhibitor to reduce t e effect of ischemic preconditioning may be related to be species specific in that NO may allot be the trigger for ischemic preconditioning in rats.

• Journal of Chest Surgery
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• v.31 no.10
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• pp.1004-1008
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• 1998

We report a case of heart-lung transplantation in a 32 year-old female with Eisenmenger syndrome secondary to patent ductus arteriosus. She has been suffered from congestive heart failure since June 1996 and repeatedly treated at Intensive Care Unit with intravenous inotropic support since July 1997. Preoperative echocardiography showed a patent ductus arteriosus with right to left shunt, severe regurgitation of tricuspid valve and estimated right ventricular systolic pressure of 100mmHg. The brain-dead donor was an 18 year-old male with head trauma from traffic accident 3 days ago. Heart-lung block procurement was performed at another general hospital and was transported to the Seoul National University Hospital by ambulance. Total ischemic time of the transplanted heart and lung were 249 minutes and 270 minutes, respectively. The immunosuppressive therapy was commenced preoperatively with cyclosporine and azathioprine. Corticosteroid was not used until postoperative 3 weeks in order to avoid infection and delayed healing at the tracheal anastomotic site. The patient was discharged at 31st postoperative day, and has been regularly followed up at outpatient clinic without specific complication. The follow-up bronchoscopy, performed 2 weeks and 4 months after surgery, revealed no evidence of cellular rejection.