• 동력기계공학회지
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• 제14권6호
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• pp.83-88
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• 2010

The wear behavior of epoxy matrix composites filled with nano sized silica particles is discussed in this paper. Especially, the variation of the coefficient of friction and the wear resistance according to the change of apply load and sliding velocity were investigated for these materials. Wear tests of pin-on-disc mode were carried out and the wear test results exhibited as following ; The epoxy matrix composites showed lower coefficient of friction compared to the neat epoxy through the whole sliding distance. As increasing the sliding velocity the epoxy matrix composites indicated lower coefficient of friction, whereas the neat epoxy showed higher coefficient of friction as increasing the sliding velocity. The specific friction work of both materials were increased with apply load. In case of the epoxy matrix composites, the running in periods of friction were reduced as increase in apply load. The epoxy matrix composites were improved the wear resistance by adding the nano silica particles remarkably. It is expected that the load carrying capacity of the epoxy matrix composites will be improved by increase of Pv factor.

• 한국지구과학회지
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• 제37권5호
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• pp.277-285
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• 2016

We introduce a depth scaling strategy to improve the accuracy of frequency-domain elastic full waveform inversion (FWI) using the new pseudo-Hessian matrix for seismic data without low-frequency components. The depth scaling strategy is based on the fact that the damping factor in the Levenberg-Marquardt method controls the energy concentration in the gradient. In other words, a large damping factor makes the Levenberg-Marquardt method similar to the steepest-descent method, by which shallow structures are mainly recovered. With a small damping factor, the Levenberg-Marquardt method becomes similar to the Gauss-Newton methods by which we can resolve deep structures as well as shallow structures. In our depth scaling strategy, a large damping factor is used in the early stage and then decreases automatically with the trend of error as the iteration goes on. With the depth scaling strategy, we can gradually move the parameter-searching region from shallow to deep parts. This flexible damping factor plays a role in retarding the model parameter update for shallow parts and mainly inverting deeper parts in the later stage of inversion. By doing so, we can improve deep parts in inversion results. The depth scaling strategy is applied to synthetic data without lowfrequency components for a modified version of the SEG/EAGE overthrust model. Numerical examples show that the flexible damping factor yields better results than the constant damping factor when reliable low-frequency components are missing.

• The Korean Journal of Physiology and Pharmacology
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• 제17권4호
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• pp.307-314
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• 2013

Connective tissue growth factor (CTGF) is a potent pro-fibrotic factor, which is implicated in fibrosis through extracellular matrix (ECM) induction in diabetic cardiovascular complications. It is an important downstream mediator in the fibrotic action of transforming growth factor ${\beta}$ ($TGF{\beta}$) and is potentially induced by hyperglycemia in human vascular smooth muscle cells (VSMCs). Therefore, the goal of this study is to identify the signaling pathways of CTGF effects on ECM accumulation and cell proliferation in VSMCs under hyperglycemia. We found that high glucose stimulated the levels of CTGF mRNA and protein and followed by VSMC proliferation and ECM components accumulation such as collagen type 1, collagen type 3 and fibronectin. By depleting endogenous CTGF we showed that CTGF is indispensable for the cell proliferation and ECM components accumulation in high glucose-stimulated VSMCs. In addition, pretreatment with the MEK1/2 specific inhibitors, PD98059 or U0126 potently inhibited the CTGF production and ECM components accumulation in high glucose-stimulated VSMCs. Furthermore, knockdown with ERK1/2 MAPK siRNA resulted in significantly down regulated of CTGF production, ECM components accumulation and cell proliferation in high glucose-stimulated VSMCs. Finally, ERK1/2 signaling regulated Egr-1 protein expression and treatment with recombinant CTGF reversed the Egr-1 expression in high glucose-induced VSMCs. It is conceivable that ERK1/2 MAPK signaling pathway plays an important role in regulating CTGF expression and suggests that blockade of CTGF through ERK1/2 MAPK signaling may be beneficial for therapeutic target of diabetic cardiovascular complication such as atherosclerosis.

• 생명과학회지
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• 제16권7호
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• pp.1207-1213
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• 2006

Tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$는 염증성 골질환에서의 골조직의 손실과 밀접한 관련이 있다. 본 연구에서는 인체 골수 유래 중간엽 줄기세포의 골세포로의 분화과정에 대한 $TNF-{\alpha}$의 영향을 조사하였다. $TNF-{\alpha}$는 골수 유래 중간엽 줄기세포의 골세포로의 분화를 나타내는 표시인 세포외 무기질 축적과 alkaline phosphatase의 발현의 증가를 일으켰으며 2ng/ml의 농도에서 최대의 증가를 나타내었다. $TNF-{\alpha}$에 의한 골세포로의 분화는 $NF_kB$의 저해제에 의해서는 영향받지 않았으나 JNK 특이 저해제인 SP600125에 의해 완벽하게 억제되었다. 이는 $TNF-{\alpha}$에 의한 골수 유래 중간엽 줄기세포의 골세포로의 분화과정에 JNK가 중요한 역할을 한다는 것을 제시한다.

• Journal of Power Electronics
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• 제17권4호
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• pp.1048-1057
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• 2017

An indirect matrix converter (IMC) is a modern power generation system that enables a direct ac/ac conversion without the need for any bulky and limited lifetime electrolytic capacitor. This system also allows four-quadrant operation, generation of sinusoidal output voltage waveforms with variable frequency and amplitude, and control of input power factor. This study proposes a pulse-width modulation-based sliding-mode controller to achieve unity input-power factor operation of the IMC independently of the active power exchanged with the grid, as well as a fast dynamic response. The designed equivalent control law determines, at each sampling period, the appropriate q-axis component of the modulated input current to be injected into the grid through the LC input filter. An integral term of the error is included in the expression of the sliding surface to increase the accuracy of the control method. A double space vector modulation method is used to synthesize the direction of the space vector of the input currents as required by the sliding-mode controller and the space vectors of the target output voltages. Simulation and experimental results are provided to show the effectiveness and evaluate the performance of the proposed control method.

• BMB Reports
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• 제52권6호
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• pp.373-378
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• 2019

The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis (OA). We investigated whether NOD2 was involved in 29-kDa FN-f-induced pro-catabolic gene expression in human chondrocytes. The expression of mRNA and protein was measured using quantitative real-time polymerase chain reaction (qrt-PCR) and Western blot analysis. Small interfering RNAs were used for knockdown of NOD2 and toll-like receptor 2 (TLR-2). An immunoprecipitation assay was performed to examine protein interactions. The NOD2 levels in human OA cartilage were much higher than in normal cartilage. NOD1 and NOD2 expression, as well as pro-inflammatory cytokines, including interleukin-1beta (IL-$1{\beta}$) and tumor necrosis factor-alpha (TNF-${\alpha}$), were upregulated by 29-kDa FN-f in human chondrocytes. NOD2 silencing showed that NOD2 was involved in the 29-kDa FN-f-induced expression of TLR-2. Expressions of IL-6, IL-8, matrix metalloproteinase (MMP)-1, -3, and -13 were also suppressed by TLR-2 knockdown. Furthermore, NOD2 and TLR-2 knockdown data demonstrated that both NOD2 and TLR-2 modulated the expressions of their adaptors, receptorinteracting protein 2 (RIP2) and myeloid differentiation 88, in 29-kDa FN-f-treated chondrocytes. 29-kDa FN-f enhanced the interaction of NOD2, RIP2 and transforming growth factor beta-activated kinase 1 (TAK1), an indispensable signaling intermediate in the TLR-2 signaling pathway, and activated nuclear factor-${\kappa}B$ (NF-${\kappa}B$), subsequently leading to increased expressions of pro-inflammatory cytokines and cartilage-degrading enzymes. These results demonstrate that 29-kDa FN-f modulated pro-catabolic responses via cross-regulation of NOD2 and TLR-2 signaling pathways.

• 대한전기학회논문지:전력기술부문A
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• 제52권7호
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• pp.429-436
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• 2003

This paper presents a new approach for evaluating the transmission marginal loss factors (MLFs) considering the reactive power. Generally, MLFs are represented as the sensitivity of transmission losses, which is computed from the change of the generation at reference bus by the change of the load at the arbitrary bus-i. The conventional evaluation method for MLFs uses the only H matrix, which is a part of jacobian matrix. Therefore, the MLFs computed by the existing method, don't consider the effect of the reactive power, although the transmission losses are a function of the reactive power as well as the active power. To compensate the limits of the existing method for evaluating MLFs, the power factor at the bus-i is introduced for reflecting the effect of the reactive power in the evaluation method of the MLFs. Also, MLFs calculated by the developed method are applied to energy spot markets to reflect the impacts of reactive power. This method is tested with the sample system with 5-bus, and analyzed how much MLFs have an effect on the bidding/offer price, market clearing price(MCP), and settlement in the competitive energy spot market. This paper compared the results of MLFs calculated by the existing and proposed method for the IEEE 14-bus system, and the KEPCO system.

• Structural Engineering and Mechanics
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• 제4권2호
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• pp.139-148
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• 1996

Vector algorithms and the relative importance of the four basic modules (computation of element stiffness matrices, assembly of the global stiffness matrix, solution of the system of linear simultaneous equations, and calculation of stresses and strains) of a finite element computer program for inelastic analysis of reinforced concrete shells are presented. Performance of the vector program is compared with a scalar program. For a cooling tower problem, the speedup factor from the scalar to the vector program is 34 for the element stiffness matrices calculation, 25.3 for the assembly of global stiffness matrix, 27.5 for the equation solver, and 37.8 for stresses, strains and nodal forces computations on a Gray Y-MP. The overall speedup factor is 30.9. When the equation solver alone is vectorized, which is computationally the most intensive part of a finite element program, a speedup factor of only 1.9 is achieved. When the rest of the program is also vectorized, a large additional speedup factor of 15.9 is attained. Therefore, it is very important that all the modules in a nonlinear program are vectorized to gain the full potential of the supercomputers. The vector finite element computer program for inelastic analysis of RC shells with layered elements developed in the present study enabled us to perform mesh convergence studies. The vector program can be used for studying the ultimate behavior of RC shells and used as a design tool.

• 한국환경과학회지
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• 제18권2호
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• pp.169-176
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• 2009

The present study observed temperature in order to identify factors affecting temperature by zoning and to measure the intensity of their impact on temperature. The empirical results of analyzing observed data are as follows. In order to make up for multicollinearity, a problem in multiple regression analysis, and to give more specific explanations, this study conducted factor analysis and obtained desirable data with adequacy and statistical significance. In the correlation matrix, factors decreasing temperature were planted areas, water surfaces and grasslands, and those increasing temperature were bare grounds, paved areas, and building area. According to land cover patterns, commercial areas had the highest temperature lowering effect. Through the rotated component matrix, we found that factors are grouped into those decreasing temperature, those increasing temperature, and those with low significance in increasing or decreasing temperature. In order to solve the problem of multicollinearity in multiple regression analysis, we performed factor analysis between the land use patterns and temperature and confirmed the usability of factor analysis as a new analysis method in urban heat island.

• 전자공학회논문지 IE
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• 제48권3호
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• pp.10-15
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• 2011

파워를 이용하는 음향 변환자를 설계할 경우 전기적 신호의 에너지가 가급적 많이 음향 에너지로 바뀌어서 전달되도록 하여야 한다. 이를 위해서는 방사임피던스를 포함한 초음파 변환자의 임피던스와 파워 앰프의 출력 임피던스 간에 정합이 필요하다. 특히 구동부의 출력 임피던스 값이 매우 작은 경우 센서의 역률 개선이 꼭 필요하다. 본 논문에서는 광대역 수중 음향 발신기의 역률 개선을 위해서 ABCD 전송 행렬을 사용한 정합 기법을 제안한다.