• Molecules and Cells
• /
• 제21권3호
• /
• pp.356-359
• /
• 2006

The transcription factor E2F1 coordinates cell cycle progression and induces apoptosis in response to DNA damage stress. Aside from DNA damage, the role of E2F1 in the endoplasmic reticulum (ER) stress signaling pathways is unclear. We found that $E2F1^{-/-}$ murine embryonic fibroblasts (MEFs) are resistant to apoptosis triggered by the ER stress inducer thapsigargin. In addition, E2F1 deficiency results in enhanced phosphorylation of eukaryotic translation initiation factor $2{\alpha}$ ($elF2{\alpha}$). These results therefore indicate that E2F1 deficiency increases phosphorylation of $elF2{\alpha}$ in response to ER stress triggered by thapsigargin, and suggest that the reduction in ER stress-induced apoptosis in E2F1-deficient cells is related to the high level of $elF2{\alpha}$ phosphorylation.

• 설비공학논문집
• /
• 제29권4호
• /
• pp.149-158
• /
• 2017

In general, the air-side j and f factors of evaporators or condensers are obtained through single-design tests performed under air-dry and wet-bulb temperatures. Considering that the indoor or outdoor air temperatures vary significantly during the operation of an air conditioner, it is necessary to confirm that the experimentally-obtained j and f factors are widely applicable under variable air conditions. In this study, a series of tests were conducted on a two-row slit-finned heat exchanger to confirm the applicability. The results showed that, for the dry-surface condition, the changes of the tube-side water temperature, water-flow rate, and air temperature had virtually no effect on the air-side j and f factors. For the wet condition, however, the f factor was significantly affected by these changes; contrarily, the j factor is relatively independent regarding this change. The formulation of the possible reasoning is in consideration of the condensation behavior underneath the tube. The wet-surface j and f factors are larger than those of the dry surface, with a larger amount for the f factor.

• Journal of applied mathematics & informatics
• /
• 제28권3_4호
• /
• pp.909-912
• /
• 2010

In this note we present a short proof of the following result by Zhou, Liu and Xu. Let G be a graph of order n, and let a and b be two integers with 1 $\leq$ a < b and b $\geq$ 3, and let g and f be two integer-valued functions defined on V(G) such that a $\leq$ g(x) < f(x) $\leq$ b for each $x\;{\in}\;V(G)$ and f(V(G)) - V(G) even. If $n\;{\geq}\;\frac{(a+b-1)^2+1}{a}$ and $\delta(G)\;{\geq}\;\frac{(b-1)n}{a+b-1}$,then G has a connected (g, f)-factor.

• Journal of the Korean Data and Information Science Society
• /
• 제19권4호
• /
• pp.1059-1071
• /
• 2008

In a balanced factorial design with a nested factor where crossed factors as well as a nested factor exist simultaneously, powers of the rank transformed FR statistic for testing the main, nested and interaction effects are superior to those of the parametric F statistic. In heavy tailed distributions such as exponential and double exponential distributions, powers of the FR statistic show much higher level than those of the F statistic. Further powers of the F and FR statistic for testing the main effect show the highest level in an absolute size as compared with powers of the F and FR statistic for testing the nested and interaction effects. However powers of the FR statistic for testing the nested and interaction effects rather than the main effect are greater in a relative size than powers of F statistic for the all population distributions.

• 대한수학회지
• /
• 제45권6호
• /
• pp.1613-1622
• /
• 2008

Let G be a graph with vertex set V(G) and edge set E(G), and let g, f be two nonnegative integer-valued functions defined on V(G) such that $g(x)\;{\leq}\;f(x)$ for every vertex x of V(G). We use $d_G(x)$ to denote the degree of a vertex x of G. A (g, f)-factor of G is a spanning subgraph F of G such that $g(x)\;{\leq}\;d_F(x)\;{\leq}\;f(x)$ for every vertex x of V(F). In particular, G is called a (g, f)-graph if G itself is a (g, f)-factor. A (g, f)-factorization of G is a partition of E(G) into edge-disjoint (g, f)-factors. Let F = {$F_1$, $F_2$, ..., $F_m$} be a factorization of G and H be a subgraph of G with mr edges. If $F_i$, $1\;{\leq}\;i\;{\leq}\;m$, has exactly r edges in common with H, we say that F is r-orthogonal to H. If for any partition {$A_1$, $A_2$, ..., $A_m$} of E(H) with $|A_i|=r$ there is a (g, f)-factorization F = {$F_1$, $F_2$, ..., $F_m$} of G such that $A_i\;{\subseteq}E(F_i)$, $1\;{\leq}\;i\;{\leq}\;m$, then we say that G has (g, f)-factorizations randomly r-orthogonal to H. In this paper it is proved that every (0, mf - (m - 1)r)-graph has (0, f)-factorizations randomly r-orthogonal to any given subgraph with mr edges if $f(x)\;{\geq}\;3r\;-\;1$ for any $x\;{\in}\;V(G)$.

• 대한의생명과학회지
• /
• 제2권2호
• /
• pp.231-240
• /
• 1996

인체 혈액 응고 9인자는 간에서 생성되며 461개의 아미노산으로 구성된 당 단백질이다. 따라서 인체 혈액 응고 9인자 cDNA를 찾기 위해 태아의 간(fetal liver) cDNA library를 PCR(Polymerase Chain reaction) 방법으로 screening하였으며, 그 결과 ATG개시 코돈으로부터 TAA종료 코돈까지 포함하는 1.4 kb의 9인자 cDNA를 찾았다. 또한 클론된 9인자 cDNA를 박테리아에서 발현시키기 위해 박테리아 발현 벡터인 pGEX-2T 플라스미드에 클로닝하므로써 pGEX-F9 플라스미드를 제조하였다. pGEX-F9로 형질전환된 E. coli에서 PGEX-F9의 발현을 유도하면 73 kDa 크기의 GST-factor9 융합 단백질이 다량생성되며 , 이 단백질이 혈액 응고 9인자 단백질을 함유하는 융합 단잭질임을 혈액 응고 9인자 항체를 이용한 Western blot으로 입증하였다. E. coli에서 발현된 GST-factor 9 융합 단백질은 전체 단백질의 약 20%를 차지하며 GST agarose bead를 이용한 one step purificarion 방법을 통해 GST-factor9 융합 단백질을 쉽게 분리 할 수 있다.

• 한국복합재료학회:학술대회논문집
• /
• 한국복합재료학회 2003년도 춘계학술발표대회 논문집
• /
• pp.113-116
• /
• 2003

The investigation of delamination growth behavior in hybrid composite material such as FRMLs should be considered delamination growth rate, dA_D/da$ using the delamination shape factor, $f_S$ instead of traditional fracture mechanics parameters. The main objective of this study is to evaluate the relationship between delamination element (i. e. delamination width, b, delamination contour, c, delamination shape factor, $f_S$ and delamination growth rate, dA_D/da$) and delamination growth in FRMLs under cyclic bending moment. The delamination shape formed along the fatigue crack between aluminum layer and glass fiber/epoxy layer are measured by scanning method. The details of study are as follow : ⅰ) Relationship between crack length, a and delamination width, b. ⅱ) Variation of delamination growth rate, dA_D/da$ was attendant on delamination shape factors, $f_{S1}$, $f_{S2}$, $f_{S3}$. The test result indicated the delamination growth behavior depends in delamination element such as delamination width, b, delamination shape factors, $f_{S1}$, $f_{S2}$, $f_{S3}$.

• 한국수학교육학회지시리즈D:수학교육연구
• /
• 제13권1호
• /
• pp.49-61
• /
• 2009

In this paper some attempts have been made: (a) To identify all the elementary minor concepts of the Highest Common Factor (H.C.F.) and the Lowest Common Multiple (L.C.M.), and (b) To find the sequential order of these elementary concepts. Total 385 elementary minor concepts have been identified and sequenced.

• 한국전기전자재료학회논문지
• /
• 제16권5호
• /
• pp.397-403
• /
• 2003

Microwave dielectric properties of (1-x)ZnW $O_4$-xTi $O_2$ ceramic systems were investigated with calcination temperatures and Ti $O_2$ contents. The ZnW $O_4$ ceramic could be suitably sintered at 1075$^{\circ}C$ and showed the dielectric constant of 13.6, quality factor(Q$\times$ $f_{O}$value) of 22,000 and temperature coefficient of resonant frequency($\tau$$_{f}$) of -65$\pm$2ppm/$^{\circ}C$. Increasing the amount of Ti $O_2$ in the range of 0.25 to 0.45 mol, the dielectric constant and $\tau$$_{f}$ increased due to the role of Ti $O_2$ but the quality factor decreased due to the increase of phase boundaries. The 0.7ZnW $O_4$-0.3Ti $O_2$ ceramic showed the dielectric constant of 19.8, qualify factor(Q$\times$ $f_{0}$) of 20,000 and $\tau$$_{f}$ of -3$\pm$1ppm/$^{\circ}C$.>.EX>.>.>.

• Journal of Pharmaceutical Investigation
• /
• 제33권3호
• /
• pp.245-253
• /
• 2003

Dissolution profile comparsions can be done by virtue of the similarity factor $(f_2)$. It is a logarithmic reciprocal square root transformation of the sum of squared error of % dissolution differences between two profiles at several time points. It gives information on the degree of similarity between the two profiles: An $f_2$ value between 50 and 100 suggests the similarity/equivalence of the two dissolution curves being compared. The objective of this report was to provide a careful examination on the $f_2$ metrics in detail. It was shown that $f_2$ values exceeded 50, when relative differences in % dissolved between two products were less than 15% at all time points. The similarity factor value was also found to be greater than 50, in cases when absolute % dissolution differences were below 10% at all time points. Interestingly, the $f_2$ value was changed by the number of the time points selected for calculation. In particular, $f_2$ tended to have higher values, when the $f_2$ metrics used a large number of time points in which % dissolved reached plateau. Finally, since the similarity factor was a sample statistics, it was impossible to infer type I/II errors and sampling error. Despite certain limitations inherited in the $f_2$ metrics, it was easy and convenient to evaluate how similar the two dissolution profiles were.