• Safety and Health at Work
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• v.10 no.3
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• pp.389-392
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• 2019

When conducting an exposure assessment, the primary goal of the industrial hygienist is to fully characterize the worker's exposure during a work shift to compare it with an occupational exposure limit. This applies regardless of the duration of the work activity as an activity that is relatively short in duration can still present exposure in excess of the occupational exposure limit even when normalized over an 8-hr shift. This goal, however, is often impeded by the specification of a minimum sample volume in the published sampling method, which may prevent the sample from being collected or submitted for analysis. Removing the specification of minimum sample volume (or adjusting it from a requirement to a recommendation), in contrast, allows for a broader assessment of jobs that consist of short-duration and high-exposure activities and also eliminates the unnecessary practice of running sampling pumps in clean air to collect a specified, minimum volume.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• v.61 no.12
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• pp.669-673
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• 2018

Background and Objectives Tinnitus, a common complaint of workers who are exposed to noise, can cause substantial negative effects on the quality of life of these workers. The aim of this study was to analyze the characteristics of tinnitus in patients with noise-induced hearing loss and the relationship between tinnitus and the duration of noise exposure. Subjects and Method Thirty-three patients with subjective tinnitus and noise-induced hearing loss were included in this study. Tinnitus questionnaire, Tinnitus Handicap Inventory (THI) and audiological examinations were investigated according to the duration of noise exposure. Results There was a significant correlation between the tinnitus loudness and the duration of noise exposure. Patients who had longer periods of noise exposure had a louder tinnitus and higher THI score. However, there is no significant correlation between the characteristics of tinnitus and aging process. Conclusion The duration of noise exposure influences the loudness and distress of tinnitus. An awareness of tinnitus should be considered as part of hearing conservation program.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.24 no.5
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• pp.319-325
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• 2012

A new formulae for the estimation of the exposure duration in the inter-tidal zone are developed. The exposure duration is one of the most important factors influencing the habitat distribution of the benthic organisms. The formulae can estimate the exposure duration only using the four major tidal harmonic constants available in almost coastal areas. It is easier than the existing method using the frequency analysis of the hourly tidal elevation data. The estimation results by using the formulae suggested in this study are compared with the value by using the observed tidal elevation data analysis in the west coast, Korea. The mean RMS (root-mean squared) errors ranged form 0.8 to 1.4%. It can be used to simply estimate the accurate exposure duration in the region not having the longterm hourly tidal elevation data.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.15 no.5 s.98
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• pp.550-557
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• 2005

Korean 'Law of Aviation' and 'Test Method of Measuring Noise and Vibration' designate to use WECPNL metric based on $L_{max}$ measurement for the accessment of aircraft noise in Korea. However, time duration of noise event can not be considered in $L_{max}$ metric in principle, compensation on the duration has been utilized. A study was done recently to evaluate appropriate duration compensation for the accessment of military aircraft noise under current metric of WECPNL and $L_{max}$. This study was carried out to evaluate what metric is the most appropriate to express aircraft noise including time duration of single noise event, computing and comparing noise exposure with 1 second noise measurement data of military aircraft in $L_{max}$, $L_{Aeq,\;T}$ and SEL. This study shows SEL is the most appropriate noise metric for the evaluation of noise exposure with time duration such as aircraft noise without compensation. It is suggested to use SEL noise metric instead of $L_{max}$ noise metric with duration compensation for the aircraft noise accessment either military aircraft or civilian aircraft.

• Clinical and Experimental Reproductive Medicine
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• v.39 no.1
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• pp.1-9
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• 2012

The safety of human exposure to an ever-increasing number and diversity of electromagnetic field (EMF) sources both at work and at home has become a public health issue. To date, many in vivo and in vitro studies have revealed that EMF exposure can alter cellular homeostasis, endocrine function, reproductive function, and fetal development in animal systems. Reproductive parameters reported to be altered by EMF exposure include male germ cell death, the estrous cycle, reproductive endocrine hormones, reproductive organ weights, sperm motility, early embryonic development, and pregnancy success. At the cellular level, an increase in free radicals and $[Ca^{2+}]i$ may mediate the effect of EMFs and lead to cell growth inhibition, protein misfolding, and DNA breaks. The effect of EMF exposure on reproductive function differs according to frequency and wave, strength (energy), and duration of exposure. In the present review, the effects of EMFs on reproductive function are summarized according to the types of EMF, wave type, strength, and duration of exposure at cellular and organism levels.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.11 no.1
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• pp.26-33
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• 2001

The goal of this study was to evaluate the relationship between ambient hexavalent chromium concentration and the concentration of the chromium in whole blood, plasma, erythrocytes, and its urinary excretion of male rats after inhalation exposure of sodium chromate during 1, 2, and 3 weeks. 1. Differences of mean chromium concentration in urine, whole blood, erythrocytes, and plasma of male rats exposed to sodium chromate by exposure level were statistically significance, respectively. 2. At low and high exposure groups, differences of mean chromium concentration in urine, whole blood, erythrocytes, and plasma of male rats by duration of inhalation exposure were statistically significance, respectively. 3. Ratio of whole blood chromium to plasma chromium increased with the increased duration of inhalation exposure of sodium chromate. 4. Ambient hexavalent chromium was positively and strongly correlated with in erythrocyte chromium, and also erythrocyte chromium was strongly correlated with in whole blood chromium. In conclusion, this study showed that chromium in erythrocyte increased with the increased exposure level and exposure duration, therefore this study suggests that chromium in erythrocytes is a good biological exposure index of the internal dose from exposure to soluble hexavalent chromium compound.

• Journal of Life Science
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• v.25 no.2
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• pp.151-157
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• 2015

Zebrafish (Danio rerio) has been more widely used to study pharmacology. Oxytectracycline (OTC) is a broad-spectrum antibiotic and works by interfering with the ability to produce essential proteins of bacteria. The aim of this study was to identify the effects of exposure to OTC on behavioral changes or endocrine response in zebrafish. The behavioral effects of exposure to OTC (50, 100 or 200 mg/l) were characterized in several novelty-based paradigms such as the novel tank or open field test in zebrafish. Moreover, to investigate effects of exposure to OTC on endocrine response, we measured whole-body cortisol level using cortisol ELISA kit. As results of novel tank test, duration in top and immobile duration were significantly increased by the exposure to OTC in a concentration-dependent manner (p<0.05). In addition, moving distance, highly mobile, velocity and zone transition were significantly decreased by the exposure to OTC in a concentration-dependent manner (p<0.05). As results of open field test, the exposure to OTC increased immobile duration significantly (p<0.05). However, moving distance, mobile duration and velocity were significantly decreased by the exposure to OTC in a concentration-dependent manner (p<0.05). Besides, the exposure to OTC elevated whole-body cortisol levels in zebrafish. These results suggest that the exposure to OTC may induce chemical stress in zebrafish.

• Journal of Environmental Science International
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• v.1 no.1
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• pp.47-51
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• 1992

Volatile organic rompounds(VOCs) present in the VOCs-contaminated water are released to air while showering and their air concentrations depend on the shower parameters, resulting in the variation of the VOCs breath concentration. The present study evaluated the key shower parameters(water temperature and inhalation duration) that affect the inhalation exposure to air chloroform while showering, by determining chloroform breath concentration. The chloroform breath concentrations increased with water temperature and inhalation duration increase. The two inhalation exposure conditions which resulted in the greatest chloroform breath contentration difference were a 5 min-inhalation exposure with warm water and a 15 min-inhalation exposure with hot water. The chloroform breath concentration was almost three times higher after later exposure. The mathematical model analyzing the relationship between two key shower parameters and breath concentration normalized to water concentration fits quite Ivell with the experimental data at a probability of p : 0.0001.

• Journal of Preventive Medicine and Public Health
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• v.27 no.1 s.45
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• pp.84-106
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• 1994

Hyperbaric oxygen (HBO) therapy for carbon monoxide (CO) poisoning eventually inducing the hypoxia-reoxygenation condition, may produce oxygen free radicals, which forms 8-hydroxydeoxyguanosine (8-OH-dG) by attacking C-8 position of deoxyguanosine (dG) in DNA. Effects of oxygen partial pressure or duration of HBO therapy with or without CO poisoning on the tissue 8-OH-dG formation were investigated. Male Sprague-Dawley rats were grouped and exposed to air (control group), 4000 ppm of CO for 10 to 30 minutes (CO only group), air for 30 minutes after 30 minute exposure to 4000 ppm of CO(CO-air exposure group), HBO after 30 minute exposure to 4000 ppm of CO(CO-HBO group), or HBO therapy fo. $10{\sim}120$ minutes(HBO only group). The 8-OH-4G concentrations in the brain and the lung tissues were measured with high performance liquid chromatography and electrochemical detector (ECD). Average concentrations of the 8-OH-dG of each group were statistically compared. In the brain tissues, 8-OH-dG concentrations of the CO only group, the CO-air exposure group, and the CO-HBO group did not significantly differ from those of the control group. Similar insignificance was also found between the CO-HBO group and the HBO only groups. No appreciable dose-response relationship was observed between the 8-OH-dG concentration and the oxygen partial pressure or the duration of HBO. However, the 8-OH-dG concentrations of the 30 minute CO only group were higher than those of the CO-air exposure group (p-value<0.05). In the lung tissues, there were no significant differences between the 8-OH-dG concentrations of the control group and those of the CO only group, the CO-air exposure group, and the CO-HBO group. However, mean 8-OH-dG concentration of the CO-air exposure group was significantly higher than that of the CO only group under the same CO exposure condition(p-value<0.05). With the duration of CO exposure, the 8-OH-dG concentrations of the lung tissues decreased significantly (p-value<0.05). The concentrations of 8-OH-dG in the lung tissues proportionally increased with the duration of HBO, but no such relation was observed with the oxygen partial pressure. These results suggest that the brain may be more resistant to oxygen free radicals as compared with the lungs, and that oxygen toxicity following HBO may be affected by factors other than oxygen free radicals.

• Reproductive and Developmental Biology
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• v.35 no.3
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• pp.257-263
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• 2011

In general, the blood cell culture is a common method for animal chromosome preparation. However, every animal and its cells have unique physiological characteristics and functions. Hence, it is very difficult to find the suitable method of chromosome preparation using animal lymphocyte culture. This study was carried out to fine the suitable method of chromosome preparation using lymphocytes cultures in mammalians and aves including cattle, rat, mouse and chicken. To seek the optimal method of lymphocyte culture in each animal, $2^3$ factorial experiment was designed. The design evaluated three main effects in culture duration, kinds of mitogen supplements and colcemid exposure time with two levels within each effect. The mitotic index and the score of chromosome morphology were analyzed. In results, the suitable methods of lymphocyte culture for chromosome preparation were 72 hours culture, pokeweed mitogen(PWM) supplement and 90 minutes of colcemid exposure in cattle, 72 hours culture, PWM supplement and 50 minutes of colcemid exposure in chicken, 96 hours culture, concanavalin A supplement and 90 minutes of colcemid exposure in rat, and 72 hours culture, PWM supplement and 50 minutes of colcemid exposure in mouse, respectively. In conclusion, kinds of mitogen, culture duration and colcemid exposure time significantly affected the mitotic index and chromosome morphology, in animal lymphocyte culture. The interaction effects between/among treatment factors were also statistically significant.