Journal of Preventive Medicine and Public Health
- Volume 27 Issue 1 Serial No. 45
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- Pages.84-106
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- 1994
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- 1975-8375(pISSN)
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- 2233-4521(eISSN)
Effects of Hyperoxia on 8-Hydroxydeoxyguanosine Formation in Carbon Monoxide Exposed Rats
일산화탄소 중독시 고압산소투여가 8-hydroxydeoxyguanosine 생성에 미치는 영향
- Kim, Heon (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
- Cho, Soo-Hun (Department of Preventive Medicine, Seoul National University College of Medicine) ;
- Chung, Myung-Hee (Department Pharmacology, Seoul National University College of Medicine)
- Published : 1994.03.01
Abstract
Hyperbaric oxygen (HBO) therapy for carbon monoxide (CO) poisoning eventually inducing the hypoxia-reoxygenation condition, may produce oxygen free radicals, which forms 8-hydroxydeoxyguanosine (8-OH-dG) by attacking C-8 position of deoxyguanosine (dG) in DNA. Effects of oxygen partial pressure or duration of HBO therapy with or without CO poisoning on the tissue 8-OH-dG formation were investigated. Male Sprague-Dawley rats were grouped and exposed to air (control group), 4000 ppm of CO for 10 to 30 minutes (CO only group), air for 30 minutes after 30 minute exposure to 4000 ppm of CO(CO-air exposure group), HBO after 30 minute exposure to 4000 ppm of CO(CO-HBO group), or HBO therapy fo.