• Safety and Health at Work
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• v.15 no.1
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• pp.1-8
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• 2024

Background: The International Agency for Research on Cancer (IARC) Monograph conducted a systematic review of the relationship between asbestos and ovarian cancer. However, there may have been information bias due to the undue weight given to few articles. To address this limitation, the present study performed a meta-analysis integrating studies published both before and after the 2012 IARC Monograph on Asbestos, with the aim of investigating the association between asbestos exposure and ovarian cancer. Methods: A comprehensive search of major journal databases was conducted to identify studies examining the relationship between asbestos exposure and ovarian cancer, including those featured in the 2012 IARC Monograph on Asbestos. A meta-analysis on asbestos exposure and cancer risk was performed. Results: The meta-analysis of studies published after the 2012 IARC Monograph on Asbestos found a summary Standardized Mortality Ratio (SMR) of 2.04 (95% CI: 1.03-4.05; p = 0.0123; 5 studies), with a significant degree of heterogeneity among the studies (I² = 72.99%). The combined analysis of 15 studies before and after the 2012 IARC Monograph showed an overall summary SMR of 1.72 (95% CI: 1.43-2.06; p = 0.0349; 15 studies), with a moderate degree of heterogeneity (I² = 42.99%). Conclusion: This meta-analysis provides evidence of a significant association between asbestos exposure and ovarian cancer mortality. While the possibility of misdiagnosis in earlier studies cannot be completely ruled out, recent findings suggest a robust correlation between asbestos exposure and ovarian cancer. This highlights the importance of sustained efforts to minimize asbestos exposure and protect public health.

• The Journal of Engineering Geology
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• v.21 no.4
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• pp.393-402
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• 2011

Asbestos is a toxic material that can lead to lung cancer and other diseases. There is no information regarding areas in Korea that contain asbestos in nature; consequently we need to manage such areas with care. The purpose of this study was to construct a local graded map of asbestos exposure risk based on the natural occurrence of asbestos in rocks. We first developed a means of evaluating the asbestos exposure risk and produced thematic maps based on a field survey. In addition, we constructed a knowledge base for asbestos through analysis, representation and processes about asbestos data and prepare for the development of an evaluation model for asbestos exposure risk. The spatial analysis of asbestos exposure risk is based on a weighted-overlay analysis using expert opinion and the literature, and a fuzzy-overlay analysis using the uncertainty in the data. The map of asbestos exposure risk, compiled according to the weighted and fuzzy operations, is expected to be used to ensure safety and to reduce the risk of exposure to asbestos.

• Journal of the East Asian Society of Dietary Life
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• v.21 no.3
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• pp.451-462
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• 2011

The purpose of this study was to examine the level of concern and the level of knowledge of endocrine disruptors, and the level of dietary behaviors to decrease exposure to endocrine disruptors, to determine the factors affecting the level of knowledge and behaviors, and to assess the causal relationship between them. The data were collected from 579 adults in Seoul, Incheon, Daejeon, Daegu, Busan and Gwangju provinces. Frequencies, t tests, analysis of variance, Cronbach's alpha, Pearson's correlation coefficient analysis, multiple regression analyses, and path analysis were carried out by SPSS for Win V.18.0. The results of this study were as follows: The level of concern about endocrine disruptors was higher than the medium level. The respondents were most concerned about a container of cup ramen among products related to foods. The levels of both knowledge and behaviors in order to decrease exposure to endocrine disruptors in dietary life were not high. The factors affecting the level of knowledge of endocrine disruptors were educational level, attendance in education for endocrine disruptors, and concern about endocrine disruptors. On the other hand, sex, age, concern about endocrine disruptors, and the level of knowledge of endocrine disruptors affected the level of behaviors to decrease exposure toward endocrine disruptors. The results of the path analysis showed that educational level and education of endocrine disruptors had an indirect influence on the level of behaviors in order to decrease exposure to endocrine disruptors in dietary life. The concern about endocrine disruptors had both a direct and an indirect effect on the level of behaviors to decrease exposure to endocrine disruptors in dietary life. In addition, sex, age and the level of knowledge of endocrine disruptors directly affected the level of behaviors to decrease exposure to endocrine disruptors in dietary life.

• Journal of Environmental Health Sciences
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• v.43 no.2
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• pp.157-166
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• 2017

Objectives: Exposure to hazardous air pollutants could be affected by sociodemographic factors such as age, gender and more. Information on time spent in microenvironments has a critical role in exposure assessment. The purpose of this study was to analyze the exposure pathways which influence personal exposure through time-activity patterns and sociodemographic factors. Methods: A total of 379 subjects were collected from the second term of the Korean National Environmental Health Survey. A questionnaire survey in relation to sociodemographic factors and a time-activity diary were carried out for personal exposure to toluene. Focusing on personal exposure to toluene, factors affecting personal exposure were analyzed using multiple regression analysis. Results: Participants spent their time in an indoor house for $16.8{\pm}4.0hr$, workplace or school $2.3{\pm}3.5hr$, and other indoor $2.1{\pm}2.2hr$. Sociodemographic factors were significantly different among each personal exposure and microenvironment. Time of staying at an office turned out to be a main factor from point of exposure in exposure pathway using multiple regression analysis. As a result, this means that exposure may be different according to the time of staying in each microenvironment. Conclusions: Personal exposure to air pollutants might be decided by time-activity pattern indicating when, where, and which activities people pursue, as well as individual sociodemographic factors.

• Progress in Medical Physics
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• v.9 no.4
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• pp.217-225
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• 1998

In this paper, the analysis of the relation between noise induced hearing loss and noise exposure is described for the A-weighted noise levels and exposure duration. The hearing loss and sensitivity threshold shift is investigated by changing the various parameters such as the effects of aging and noise exposure. Total hearing loss is proportional to a function of exposure level based upon the integral of pressure with time. If the noise exposure term is large so that the presbycusis may be neglected, the hearing loss due to aging and noise exposure becomes the noise induced hearing loss. It is shown that exposure to excessive noise can cause temporary loss of hearing that may become permanent if the exposure is prolonged or intense. An audiogram taken from a person suffering from noise induced hearing loss will usually show the greatest loss of hearing sensitivity in the 4kHz region, which is typically the region most sensitive to damage resulting from many types of industrial noise.

• Journal of Preventive Medicine and Public Health
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• v.46 no.5
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• pp.213-225
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• 2013

Objectives: The aim of this study was to evaluate the association between Agent Orange exposure and self-reported diseases in Korean Vietnam veterans. Methods: A postal survey of 114 562 Vietnam veterans was conducted. The perceived exposure to Agent Orange was assessed by a 6-item questionnaire. Two proximity-based Agent Orange exposure indices were constructed using division/brigade-level and battalion/ company-level unit information. Adjusted odds ratios (ORs) for age and other confounders were calculated using a logistic regression model. Results: The prevalence of all self-reported diseases showed monotonically increasing trends as the levels of perceived self-reported exposure increased. The ORs for colon cancer (OR, 1.13), leukemia (OR, 1.56), hypertension (OR, 1.03), peripheral vasculopathy (OR, 1.07), enterocolitis (OR, 1.07), peripheral neuropathy (OR, 1.07), multiple nerve palsy (OR, 1.14), multiple sclerosis (OR, 1.24), skin diseases (OR, 1.05), psychotic diseases (OR, 1.07) and lipidemia (OR, 1.05) were significantly elevated for the high exposure group in the division/brigade-level proximity-based exposure analysis, compared to the low exposure group. The ORs for cerebral infarction (OR, 1.08), chronic bronchitis (OR, 1.05), multiple nerve palsy (OR, 1.07), multiple sclerosis (OR, 1.16), skin diseases (OR, 1.05), and lipidemia (OR, 1.05) were significantly elevated for the high exposure group in the battalion/company-level analysis. Conclusions: Korean Vietnam veterans with high exposure to Agent Orange experienced a higher prevalence of several self-reported chronic diseases compared to those with low exposure by proximity-based exposure assessment. The strong positive associations between perceived self-reported exposure and all self-reported diseases should be evaluated with discretion because the likelihood of reporting diseases was directly related to the perceived intensity of Agent Orange exposure.

• Environmental Analysis Health and Toxicology
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• v.17 no.4
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• pp.273-284
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• 2002

At present, the health risks associated with the natural radionuclides of ground water have become a concern as potential social problems. However, there are no regulatory actions or control strategies for such risks. Therefore, we have investigated and discussed the risks and associated management strategies for radionuclides in other countries. US EPA has proposed MCL (300 pCi/L) and AMCL (4,000 pCi/L) for radon, and 30 ppb for uranium, 15 pCi/L for gross-alpha and 5 pCi/L for radium as final MCLs. Also, Canada, WHO and European countries have their inherent management levels. Finally, we suggested several criteria for setting guidelines in our countries including exposure related criteria such as geological distribution, occurrence, exposure probability distribution, exposure population and multimedia exposure assessment, acceptable risk, and cost -benefit analysis. The national-scale exposure and risk assessment, and economic analysis should be conducted for producing and aggregating the representative information on these criteria.

• Clinical and Experimental Pediatrics
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• v.64 no.6
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• pp.286-292
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• 2021

Background: The effect of exposure to environmental factors on autism spectrum disorders (ASD), especially during pregnancy, is unclear. Purpose: This meta-analysis investigated the association between exposure to pesticides and polychlorinated biphenyls (PCBs) during pregnancy and ASD risk among children. Methods: We searched Scopus, PubMed, Web of Science, and ProQuest for articles published through September 2019. Random-effects models were used to examine the association among studies using pooled odds ratios (ORs) and their 95% confidence intervals (CI). I2 tests were used to measure interstudy heterogeneity. Results: The pooled OR indicated a significant association between PCB and pesticide exposure during pregnancy and ASD risk among children (OR, 1.80; 95% CI, 1.26-2.34; and OR, 1.20; 95% CI, 1.02-1.39), respectively. Conclusion: Findings of the present study indicate that exposure to pesticides and PCBs during pregnancy may affect the risk of ASD among children.

• Journal of Radiation Industry
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• v.18 no.2
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• pp.141-145
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• 2024

In Publication No. 66 of the International Commission on Radiological Protection, an activity median aerodynamic diameter (AMAD) of 5 ㎛ is considered in internal exposure dose assessment owing to inhalation of radionuclides in a workplace. However, analysis of aerosols generated during dismantling experiments, such as in the oxy-cutting of a reactor vessel conducted in Korea, revealed that the radioactive aerosols have AMAD ranging from 0.024 to 0.064 ㎛. Such extremely fine aerosols can induce internal exposure if inhaled. In particular, alpha radionuclides in aerosols can lead to significantly higher levels of radiation exposure than beta and gamma radionuclides, thus highlighting the need to establish appropriate internal exposure radiation protection programs and monitoring systems that specifically address alpha radionuclides when decommissioning nuclear power plants in Korea.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.32 no.3
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• pp.253-267
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• 2022

Objectives: This study was performed to check whether the CRS (Chemical Ranking and Scoring) system is appropriate as a method to determine substances as candidates for substances subject to permission and to apply this system to the selection of candidates for substances subject to permission. Methods: A risk score was obtained by multiplying the hazard score and the exposure score and then ranking them. The hazard sub-indicators are carcinogenicity, germ cell mutagenicity, reproductive toxicity, specific target organ toxicity-repeated exposure, respiratory sensitization and endocrine disrupting chemicals. Exposure sub-indicators are persistence, bioaccumulation and emission volume. Sensitivity analysis was performed for missing values. Correlation analysis and multivariable linear regression analysis were performed among hazard, exposure and risk in order to confirm that CRS was an appropriate method. Results: As a result of the sensitivity analysis on missing values, it was confirmed that the effect on the risk ranking was not sensitive. Correlation and regression analysis confirmed that exposure had a greater effect on risk than hazard. Conclusions: The CRS system, which derives a risk score using a hazard and exposure score, is judged to be appropriate as a method for the selection of preliminary of candidates for substances subject to permission. Benzene, cadmium, nickel, and cobalt were selected as priority candidates for substances subject to permission.