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http://dx.doi.org/10.3345/cep.2020.00864

Association between pesticide and polychlorinated biphenyl exposure during pregnancy and autism spectrum disorder among children: a meta-analysis  

Mehri, Fereshteh (Nutrition Health Research Center, Hamadan University of Medical Sciences)
Bashirian, Saeid (Social Determinants of Health Research Center, Hamadan University of Medical Sciences)
Khazaei, Salman (Department of Epidemiology, Hamadan University of Medical Sciences)
Jenabi, Ensiyeh (Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences)
Publication Information
Clinical and Experimental Pediatrics / v.64, no.6, 2021 , pp. 286-292 More about this Journal
Abstract
Background: The effect of exposure to environmental factors on autism spectrum disorders (ASD), especially during pregnancy, is unclear. Purpose: This meta-analysis investigated the association between exposure to pesticides and polychlorinated biphenyls (PCBs) during pregnancy and ASD risk among children. Methods: We searched Scopus, PubMed, Web of Science, and ProQuest for articles published through September 2019. Random-effects models were used to examine the association among studies using pooled odds ratios (ORs) and their 95% confidence intervals (CI). I2 tests were used to measure interstudy heterogeneity. Results: The pooled OR indicated a significant association between PCB and pesticide exposure during pregnancy and ASD risk among children (OR, 1.80; 95% CI, 1.26-2.34; and OR, 1.20; 95% CI, 1.02-1.39), respectively. Conclusion: Findings of the present study indicate that exposure to pesticides and PCBs during pregnancy may affect the risk of ASD among children.
Keywords
Autism spectrum disorders; Autism; Meta-analysis; Polychlorinated biphenyls; Pesticides;
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