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http://dx.doi.org/10.15269/JKSOEH.2022.32.3.253

A Study on the Selection of Candidates for Substances Subject to Permission Using Chemicals Ranking and Scoring (CRS)  

Kim, Hyo-dong (Department of Safety and Health Convergence Engineering, Soongsil University)
Park, Kyo-shik (Department of Safety and Health Convergence Engineering, Soongsil University)
Publication Information
Journal of Korean Society of Occupational and Environmental Hygiene / v.32, no.3, 2022 , pp. 253-267 More about this Journal
Abstract
Objectives: This study was performed to check whether the CRS (Chemical Ranking and Scoring) system is appropriate as a method to determine substances as candidates for substances subject to permission and to apply this system to the selection of candidates for substances subject to permission. Methods: A risk score was obtained by multiplying the hazard score and the exposure score and then ranking them. The hazard sub-indicators are carcinogenicity, germ cell mutagenicity, reproductive toxicity, specific target organ toxicity-repeated exposure, respiratory sensitization and endocrine disrupting chemicals. Exposure sub-indicators are persistence, bioaccumulation and emission volume. Sensitivity analysis was performed for missing values. Correlation analysis and multivariable linear regression analysis were performed among hazard, exposure and risk in order to confirm that CRS was an appropriate method. Results: As a result of the sensitivity analysis on missing values, it was confirmed that the effect on the risk ranking was not sensitive. Correlation and regression analysis confirmed that exposure had a greater effect on risk than hazard. Conclusions: The CRS system, which derives a risk score using a hazard and exposure score, is judged to be appropriate as a method for the selection of preliminary of candidates for substances subject to permission. Benzene, cadmium, nickel, and cobalt were selected as priority candidates for substances subject to permission.
Keywords
Candidates for substance subject to permission; chemical ranking and scoring; exposure; hazard; risk;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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1 National Institute of Chemical Safety (NICS) of South of Korea. Chemical Substance Information System. 2022a (Accessed March to August 2022) Available from: URL: https://icis.me.go.kr/main.do
2 Korea Occupational Safety Health Agency (KOSHA). Chemical information. 2022. (Accessed March to August 2022) Available from: URL: https://msds.kosha.or.kr/MSDSInfo/
3 Ministry of Environment (MoE) of South of Korea. Existing chemical substances that cause or are likely to cause cancer, mutation, or fertility abnormality, which must be registered by the year 21 (MoE No. 2018-232). 2018
4 Ministry of Environment (MoE) of South of Korea. Enforcement Decree of the Act on Registration, Evaluation, etc. of Chemicals (Presidential Decree No. 29413). 2021b
5 Ministry of Environment (MoE) of South of Korea. Draft Notice of Enactment of Regulations on Designation of Substance subject to permission etc. (Announcement No. 2022-91). 2022a
6 Ministry of Employment and Labor (MoEL) of South of Korea. Enforcement Rule of the Occupational Safety and Health Standards (Ordinance No. 362). 2022a
7 Ministry of Employment and Labor (MoEL) of South of Korea. Enforcement Decree of Occupational Safety and Health Standards (Presidential Decree No. 32873). 2022b
8 National Institute of Environmental Research (NIER) of South of Korea. Guidance on the assessment of degradability of chemicals (NIER-SP215-046). 2015
9 Cho TJ, Park JY. Recent trends and implications of chemical substance management in the EU. Korea Public Land Law Association Public Land Law Review 2019;87:641-671 (http://dx.doi.org/10.30933/KPLLR.2019.87.641.)   DOI
10 Baik NS, Chung JD, Park CH. Assessment of priority order using the chemical to cause to generate occupational diseases and classification by GHS. Journal of the Environmental Sciences 2010;19(6):715-735   DOI
11 ECHA. Candidate List of substances of very high concern for Authorisation. 2022a. (Accessed August 2022). Available from: URL: https://echa.europa.eu/candidatelist-table
12 ECHA. Authorisation List. 2022b. (Accessed August 2022). Available from: URL:https://echa.europa.eu/authorisation-list
13 ECHA, Substances restricted under REACH. 2022c. (Accessed September 2022). Available from: URL: https://echa.europa.eu/substances-restricted-under-reach
14 Han GM, Hong SH, Shim WJ, Ra KT, Kim KT et al. Assessment of persistent organic and heavy metal contamination in Busan coast: application of sediment quality index. Ocean and Polar Research 2016;38(3):171-184 (http://dx.doi.org/10.4217/OPR.2016.38.3.171)   DOI
15 ECHA. Registered substances. 2022d. (Accessed March to August 2022). Available from: URL: https://echa.europa.eu/information-on-chemicals/registered-substances
16 Industry Help Center. Collection of opinions on substance subject to permission. 2022. (Accessed July 2022). Available from: URL: https://www.chemnavi.or.kr/chemnavi/spopnn/selectOpnnList.do
17 National Institute of Environmental Research (NIER) of South of Korea. Regulations on classification and labeling of chemical substances (NIER No. 2021-104). 2021
18 Shin SM, A chemical risk ranking and scoring method for the selection of harmful substances to be specially controlled in occupational environments, Department of Health Science, master's thesis, Korea University Graduate School. 2014
19 National Institute of Chemical Safety (NICS) of South of Korea. 2020 Chemical Substance Emission Survey Results (National Statistical Approval No. 106013). 2022b
20 Ministry of Environment (MoE) of South of Korea. Regulations on the qualifying quantities of Toxic substances, Restricted substances, Prohibited substances and Substance subject to permission (MoE No. 2022-70). 2022c
21 KCMA, CSi. Preparation of measures to strengthen the designation and management of substance subject to intensive control (final report). Ministry of Environment (MoE) 2021
22 Ministry of Environment (MoE) of South of Korea. Act on Registration, Evaluation, Ect. of Chemicals (Act No. 18034). 2021a
23 Ministry of Environment (MoE) of South of Korea. Enforcement Rule of the Act on Registration, Evaluation, etc. of Chemicals (Ordinance No. 997). 2022b
24 Ministry of Environment (MoE) of South of Korea. Designation of Substance subject to intensive control (MoE No. 2022-79). 2022d
25 Ministry of Employment and Labor (MoEL) of South of Korea. Occupational Safety and Health Act (Act No. 18180). 2021