• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.3A
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• pp.261-267
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• 2011

This study reveals the longitudinal vibration mechanism of tendon embedded in a prestressed concrete. The extensional and torsional displacements of the strand are coupled, and the applied prestress level of tendon affects not only axial rigidity but also torsional rigidity. Measuring the elastic wave velocity of tendon, the applied prestress level of tendon could be evaluated. This is because the elastic wave velocity is a function of extensional and torsional rigidity. Using the experimental results for the six prsteressed concrete beams with different prestress levels, the longitudinal vibration mechanism and the effect of prestress level have been examined. To estimate the system ridigities of tendon, a system identification algorithm has been newly developed. The estimated system rigidities have been compared with the available results of related previous study.

• Toxicological Research
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• v.34 no.4
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• pp.343-354
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• 2018

Aluminum oxide nanoparticles ($Al_2O_3$ NPs) are among the most widely used nanomaterials; however, relatively little information about their risk identification and assessment is available. In the present study, we aimed to investigate the potential toxicity of $Al_2O_3$ NPs following repeated inhalation exposure in male Sprague-Dawley rats. Rats were exposed to $Al_2O_3$ NPs for 28 days (5 days/week) at doses of 0, 0.2, 1, and $5mg/m^3$ using a nose-only inhalation system. During the experimental period, we evaluated the clinical signs, body weight change, hematological and serum biochemical parameters, necropsy findings, organ weight, and histopathology findings. Additionally, we analyzed the bronchoalveolar lavage fluid (BALF), including differential leukocyte counts, and aluminum contents in the major organs and blood. Aluminum contents were the highest in lung tissues and showed a dose-dependent relationship in the exposure group. Histopathology showed alveolar macrophage accumulation in the lungs of rats in the $5mg/m^3$ group during exposure and recovery. These changes tended to increase at the end of the recovery period. In the BALF analysis, total cell and neutrophil counts and lactate dehydrogenase, tumor necrosis factor-${\alpha}$, and interleukin-6 levels significantly increased in the 1 and $5mg/m^3$ groups during exposure. Under the present experimental conditions, we suggested that the no-observed-adverse-effect level of $Al_2O_3$ NPs in male rats was $1mg/m^3$, and the target organ was the lung.

• The Journal of Internal Korean Medicine
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• v.39 no.1
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• pp.44-68
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• 2018

Objective: This study aimed to investigate the trend in the research on breast cancer using traditional Korean medicine (TKM) and establish the direction for further study. Methods: Breast cancer studies using Korean medicine were searched using the Oriental Medicine Advanced Searching Integrated System (OASIS). The search term was 'breast' and there was no restriction in year. The searched studies were analyzed according to the type of research. Results: 1. 83 studies were searched. The types and numbers of study were as follows: 42 were in vitro studies, 5 were in vivo studies, 12 were studies for review, and 27 were clinical research including case reports. 2. Various cell lines such as MCF-7, MDA-MB-231, SKBR3, and MCF-10A were used for in vitro studies. The studies reported a decrease in cell viability, induction of apoptosis, and change of expression in cancer-related genes. In vivo studies also reported induction of apoptosis, and anti-proliferative activity of herbal medicine against the cancer cells. 3. Among the clinical research, 8 were cross-sectional studies, 3 were controlled-trial, and 15 were case reports. The baseline characteristics of breast cancer patients were analyzed in the cross-sectional studies. Interventions such as pharmacopuncture, herbal medicine, massage, Qi gong, acupuncture, electroacupuncture and moxibustion were used in clinical research. 4. Research on the review of breast cancer covered various subjects as follows: herbal medicine, acupuncture, pattern identification of breast cancer in traditional Korean medicine, analysis of previous experimental studies, and clinical trials. Conclusion: We have found the applicability of TKM for treatment of breast cancer through this review. It is necessary to conduct further studies, such as well-designed clinical trials based on the results from experimental research.

• Structural Engineering and Mechanics
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• v.51 no.3
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• pp.447-470
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• 2014

Numerical simulation of the non-linear behavior of (RC) structural walls subjected to severe earthquake ground motions requires a reliable modeling approach that includes important material characteristics and behavioral response features. The objective of this paper is to optimize a simplified method for the assessment of the seismic response and damage development analyses of an RC structural wall building using macro-element model. The first stage of this study investigates effectiveness and ability of the macro-element model in predicting the flexural nonlinear response of the specimen based on previous experimental test results conducted in UCLA. The sensitivity of the predicted wall responses to changes in model parameters is also assessed. The macro-element model is next used to examine the dynamic behavior of the structural wall building-all the way from elastic behavior to global instability, by applying an approximate Incremental Dynamic Analysis (IDA), based on Uncoupled Modal Response History Analysis (UMRHA), setting up nonlinear single degree of freedom systems. Finally, the identification of the global stiffness decrease as a function of a damage variable is carried out by means of this simplified methodology. Responses are compared at various locations on the structural wall by conducting static and dynamic pushover analyses for accurate estimation of seismic performance of the structure using macro-element model. Results obtained with the numerical model for rectangular wall cross sections compare favorably with experimental responses for flexural capacity, stiffness, and deformability. Overall, the model is qualified for safety assessment and design of earthquake resistant structures with structural walls.

• Smart Structures and Systems
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• v.16 no.3
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• pp.415-433
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• 2015

Tendon failures in bonded post-tensioned bridges over the last two decades have motivated ongoing investigations on various aspects of unbonded tendons and their monitoring methods. Recent research shows that change of strain distribution in anchor heads can be useful in detecting wire breakage in unbonded construction. Based on this strain variation, this paper develops a damage detection model that enables an automated tendon monitoring system to identify and locate wire breaks. The first part of this paper presents an experimental program conducted to study the strain variation in anchor heads by generating wire breaks using a mechanical device. The program comprised three sets of tests with fully populated 19-strand anchor head and evaluated the levels of strain variation with number of wire breaks in different strands. The sensitivity of strain variation with wire breaks in circumferential and radial directions of anchor head in addition to the axial direction (parallel to the strand) were investigated and the measured axial strains were found to be the most sensitive. The second part of the paper focuses on formulating the wire breakage detection framework. A finite element model of the anchorage assembly was created to demonstrate the algorithm as well as to investigate the asymmetric strain distribution observed in experimental results. In addition, as almost inevitably encountered during tendon stressing, the effects of differential wedge seating on the proposed model have been analyzed. A sensitivity analysis has been performed at the end to assess the robustness of the model with random measurement errors.

• Journal of the Korea institute for structural maintenance and inspection
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• v.13 no.5 s.57
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• pp.121-132
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• 2009

This paper introduces an experimental verification and a field application of the proposed technique using the combination of FEM and HGA about the loss prestressing force of an exteranl tendon by above same authors. The vibration tests have been conducted by using a laboratory models and the externally prestressed tendon at the field and the natural frequencies are extracted from the vibration tests. The proposed technique based on the extracted natural frequencies is applied. It is seen that the errors in the tension and lost prestressing force by proposed technique are about 4% from a laboratory model test. For the model verification at field, exact modeling has beem made with Rayleigh damping. It is seen that the error in the tension by proposed technique is less than 1% and the estimated lost prestressing force converges less than the exact value.

• Korean Journal of Veterinary Research
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• v.54 no.4
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• pp.209-218
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• 2014

Experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis (MS), reflects pathophysiologic steps in MS such as the influence of T cells and antibodies reactive to the myelin sheath, and the cytotoxic effect of cytokines. Galectin-9 (Gal-9) is a member of animal lectins that plays an essential role in various biological functions. The expression of Gal-9 is significantly enhanced in MS lesions; however, its role in autoimmune disease has not been fully elucidated. To identify the role of Gal-9 in EAE, we measured changes in mRNA and protein expression of Gal-9 as EAE progressed. Expression increased with disease progression, with a sharp rise occurring at its peak. Gal-9 immunoreactivity was mainly expressed in astrocytes and microglia of the central nervous system (CNS) and macrophages of spleen. Flow cytometric analysis revealed that $Gal-9^+CD11b^+$ cells were dramatically increased in the spleen at the peak of disease. Increased expression of tumor necrosis factor (TNF)-R1 and p-Jun N-terminal kinase (JNK) was observed in the CNS of EAE mice, suggesting that TNF-R1 and p-JNK might be key regulators contributing to the expression of Gal-9 during EAE. These results suggest that identification of the relationship between Gal-9 and EAE progression is critical for better understanding Gal-9 biology in autoimmune disease.

• The KIPS Transactions:PartB
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• v.17B no.1
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• pp.47-54
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• 2010

Old archived film shows two major defects: line scratch and blobs. In this paper, we present a design and implementation of an automatic video restoration system for line scratches observed in archived film. We use autoregressive (AR) image model because we can make stochastic and specifically autoregressive image generation process with our PAST-PRESENT model and Sampling Pattern. We designed locality maximizing scanning pattern, which can generate nearly stationary time-like series of pixels, which is a strong requirement for a stochastic series to be autoregressive. The sampled pixel series undergoes filtering and model fitting using Durbin-Levinson algorithm before interpolation process. We designed three-stage film restoration system, which includes (1) film acquisition from VHS tapes, (2) simple line scratch detection and restoration, and (3) manual blob identification and sophisticated inpainting scheme. We implemented film acquisition and simple inpainting scheme on Texas Instruments DSP board TMS320DM642 EVM, and implemented our AR inpainting scheme on PC for sophisticated restoration. We experimented our scheme with two old Korean films: "Viva Freedom" and "Robot Tae-Kwon-V", and the experimental results show that our scheme improves Bertalmio's scheme for subjective quality (MOS), objective quality (PSNR), and especially restoration ratio (RR), which reflects how much similar to the manual inpainting results.

• Clinical and Experimental Pediatrics
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• v.64 no.10
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• pp.504-510
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• 2021

Population screening of newborns is an extremely important and informative diagnostic approach that allows early identification of babies who are predisposed to the development of a number of serious diseases. Some of these diseases are known and have effective treatment methods. Neonatal screening enables the early diagnosis and subsequent timely initiation of therapy. This helps to prevent serious complications and reduce the percentage of disability and deaths among newborns and young children. Primary immunodeficiency diseases and primary immunodeficiency syndrome (PIDS) are a heterogeneous group of diseases and conditions based on impaired immune system function associated with developmental defects and characterized by various combinations of recurrent infections, development of autoimmune and lymphoproliferative syndromes (genetic defects in apoptosis, gene mutation Fas receptor or ligand), granulomatous process, and malignant neoplasms. Most of these diseases manifest in infancy and lead to serious illness, disability, and high mortality rates. Until recently, it was impossible to identify children with PIDS before the onset of the first clinical symptoms, which are usually accompanied by complications in the form of severe coinfections of a viral-bacterial-fungal etiology. Modern advances in medical laboratory technology have allowed the identification of children with severe PIDS, manifested by T- and/or B-cell lymphopenia and other disorders of the immune system. This review discusses the main existing strategies and directions used in PIDS screening programs for newborns, including approaches to screening based on excision of T-cell receptors and kappa-recombination excision circles, as well as the potential role and place of next-generation sequencing technology to increase the diagnostic accuracy of these diseases.

• Economic and Environmental Geology
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• v.52 no.4
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• pp.313-322
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• 2019

SAR (Synthetic Aperture Radar) remote sensing data is a very useful tool for near-real-time identification of landslide affected areas that can occur over a large area due to heavy rains or typhoons. This study aims to develop an effective algorithm for automatically delineating landslide areas from the polarimetric SAR data acquired after the landslide event. To detect landslides from SAR observations, reduction of the speckle effects in the estimation of polarimetric SAR parameters and the orthorectification of geometric distortions on sloping terrain are essential processing steps. Based on the experimental analysis, it was found that the IDAN filter can provide a better estimation of the polarimetric parameters. In addition, it was appropriate to apply orthorectification process after estimating polarimetric parameters in the slant range domain. Furthermore, it was found that the polarimetric entropy is the most appropriate parameters among various polarimetric parameters. Based on those analyses, we proposed an automatic landslide detection algorithm using the histogram thresholding of the polarimetric parameters with the aid of terrain slope information. The landslide detection algorithm was applied to the ALOS-2 PALSAR-2 data which observed landslide areas in Japan triggered by Typhoon in September 2011. Experimental results showed that the landslide areas were successfully identified by using the proposed algorithm with a detection rate of about 82% and a false alarm rate of about 3%.