• Advances in pediatric surgery
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• 제3권2호
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• pp.98-107
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• 1997

To determine whether bile juice exclusion can prevent the mucosal damage, and Insulin-like growth factor-I can promote mucosal regeneration in ischemia-reperfusion injury of the bowel, 39 weanling rats with 10 cm of Thiry-Vella loop were studied. Animal groups were; Control, BL(common bile duct ligation), IGF{insulin-like growth factor-I(IGF-I) infusion} and IGF-BL(combined treatment). IGF-I(1.5 mg/kg/day) was continuously delivered through a subcutaneously implanted miniosmotic pump. After 15 minutes of superior mesenteric artery clamping, a tissue specimen(P) was taken after 30 minutes of reperfusion. Intestinal continuity was restored to allow oral feeding. A specimen of main tract(M) and another of the Thiry-Vella loop(T) were collected for histomorphometry after 48 hours of reperfusion and free feeding. Villus size ratio(VSR), crypt depth(CD), crypt-depth/villus-height ratio(CVR) and injury score(IS) were measured in 15 consecutive villi. The postoperative mortalities of bile duct ligation groups(BL and IGF-BL) were higher than those of other groups. In control group, VSR of M was lower(P<0.05) than P or T, but not in the other groups. VSR of M in control was lower than those in other groups. CD of T in control, IGF and IGF-BL group were higher than those of M. CD of M and T showed gradual increments from control, IGF and IGF-BL group, respectively. CVR of M and T in IGF group were higher than those in control. CVR in IGF-BL group, T was higher than M, and M was higher than P. About IS, M of BL($20.1{\pm}2.5$) and IGF-BL($20.9{\pm}3.3$) groups were significantly lower than that of control($32.4{\pm}2.5$). These results suggest that the exclusion of bile juice reduces the severity of the reperfusion injury of the mucosa, by inability to activate pancreatic enzymes and IGF-I stimulates mucosal regeneration in injured bowel, and the effect is potentiated by bile juice exclusion.

• 생명과학회지
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• 제25권5호
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• pp.601-606
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• 2015

허친슨(Hutchinson)은 동질성이 있고 잘 혼합된 환경에서는 경쟁배타의 원리가 작동하고 있어 많은 종이 공서할 수 없음에도 불구하고 여러 플랑크톤 군집에서 많은 종이 서식하고 있음을 주목하였다. 일부 자원만 공유하면 경쟁배타의 원리가 작용하여 일부 종만이 공존할 수 있다. 그럼에도 불구하고 많은 자연 집단에서 수많은 경쟁관계에 있는 종이 공존하는데 이를 플랑크톤 패러독스라 부른다. 본 연구에서 이 역설에 대한 수많은 견해 중 일부를 소개하였는데 Roy와 Chattopadhyay의 견해를 독성 생성 견해를 포함한 그들의 견해에 따라 기술되었다. 제시된 기작 중 물리적, 생물학적 환경에서 공간적, 시간적 이질성, 외부에서 부과되거나 자기-발생적 공간적 분리, 불완전한 수직 혼합층, 수평적 중간 규모의 소용돌이, 플랑크톤 간 자원경쟁에 의한 동요와 무질서, 자원경쟁에서 변동성 온도에서 안정된 공존과 상보적 역동성을 기술하였다. 본 연구를 통해 플랑크톤과 그 패러독스 연구를 수행하는데 정보가 제공되어 도움이 될 것이다.

• 한국노년학
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• 제37권4호
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• pp.835-852
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• 2017

본 연구의 목적은 최저생계비 이하 저소득 노인가구를 대상으로 공적 지원인 국민기초생활보장 수급에서의 배제가 물질적 결핍에 미치는 영향에 있어 사회적 지지가 조절효과를 갖는지 살펴보고자 하는 것이다. 이를 위하여 국가인권위원회가 2014년에 조사한 최저생계비 이하 저소득 가구 실태조사 자료를 사용하여 65세 이상 노인가구 255명의 응답자료를 분석하였다. 자료 분석은 STATA13 통계프로그램을 이용하여 기술통계분석, ANOVA, 상관분석 및 다중회귀분석 등을 실시하였다. 연구결과 전체 응답 노인의 물질적 결핍의 평균 수준은 1.45개로 가장 큰 어려움은 '난방' 및 '의료서비스 이용'에서의 어려움으로 나타났다. 회귀분석 결과, 기초생활보장 수급을 받다가 배제될 경우 수급을 받는 경우에 비해 물질적 결핍을 더 많이 경험하는 것으로 나타났으며, 이 경우 사회적 지지가 높으면 부적(-) 상호작용효과가 발생하여 수급배제가 물질적 결핍에 미치는 정적인(+)효과를 약화시키는 것으로 나타났다. 이와 같은 연구결과를 바탕으로 저소득 노인 가구의 물질적 결핍 수준을 낮출 수 있도록 실천적, 정책적 함의를 제시하였다.

• 한국실내디자인학회논문집
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• 제23권2호
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• pp.90-98
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• 2014

This study has analyzed the meaning of observation time in the course of acquiring the information of subjects who observed the space of hall in subway stations to figure out the process of spatial information excluded and the features of intensive searching. The followings are the results from the analysis of searching process with the interpretation of the process for information acquirement through the interpretation of observation area and time. First, based on the general definition of observation time, the reason for analyzing the features of acquiring spatial information according to the subjects' observation time has been established. The feature of decreased analysis data reflected that of observation time in the process of perceiving and recognizing spatial information, which showed that the observation was focused on the enter of the space during the time spent in the process of observing the space and the spent time with considerable exclusion of bottom end (in particular, right bottom end). Second, while the subjects were observing the space of hall in subway stations, they focused on the top of the left center and the signs on the right exit the most, which was followed by the focus on the both side horizontally and the clock on the top. Third, the analysis of consecutive observation frequency enabled the comparison of the changes to the observation concentration by area. The difference of time by area produced the data with which the change to the contents of spatial searching in the process of searching space could be known. Fourth, as the observation frequency in the area of I changed [three times -> six times -> 9 times], the observation time included in the area increased, which showed the process for the change from perception to recognition of information with the concentration of attention through visual information. It makes it possible to understand that more time was spent on the information to be acquired with the exclusion of the unnecessary information around.

• 대한한방내과학회지
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• 제26권2호
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• pp.333-340
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• 2005

Background: Cancer reseach is done in earnest world-wide, because cancer is one of most threatening diseases to humans. Orostachyos Herba is a widely used herb that has long been in use in Korea as an anti-inflammatory and anti-cancer therapy. The purpose of this study is to verify any anti-cancer effects on stomach and liver cancer in vitro. Materials & Methods: AGS and KATO III stomach cancer cells and Hep3B and HepG2 liver cancer cells, all obtained from Korean Cell Line Bank, were used. The boiled extract of Orostachyos Herba(20 and 40 microliters) were injected into cultures and observed at 0 hours, and at 24-hour intervals up to 96 hours. The destruction of stomach and liver cancer cells was measured through Trypan blue exclusion testing. The suppression on viability of stomach and liver cancer cells was observed, and anti-cancer mechanisms was examined by analyzing the cell cycle. Results: In morphologic change, AGS, KATO III, HepG2 and Hep3B showed some of the withdrawn and floating appearance that is typical in cellular imparment. AGS, KATO III, HepG2 and Hep3B showed more destruction of stomach cancer cells in each test group than in the control group to a statistically significant degree. Analysis of the cell cycle after introduction of Orostachyos Herba showed very little inhibition of divisions of all cell lines. Conclusions: This experiment suggests that Orostachyos Herba has some anti-tumor effects on stomach and liver cancer cells. Progressive research on Orostachyos Herba and it's anti-tumor effects will be needed to determine its practicability as a cancer treatment.

• 대한원격탐사학회지
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• 제31권5호
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• pp.433-440
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• 2015

본 연구에서는 초분광영상을 이용한 표적탐지에 있어 배경 신호 특징에 포함되는 표적 신호가 탐지성능에 미치는 영향을 살펴보고, 분광각을 기준으로 표적과 유사한 분광반사 특성을 가지는 화소들을 배경 특징화 과정에서 제외함으로써 표적탐지 성능을 향상시킬 수 있는 방법을 제안하였다. 초분광 표적탐지를 위해 가장 흔히 이용되는 matched Filter와 adaptive cosine estimator 기법에 대해 실제 항공 초분광영상 자료와 여기에 인공표적을 삽입하여 생성한 모의 자료를 이용한 실험 결과, 배경 특징화를 위한 공분산행렬 계산 시 표적 스펙트럼과 유사도가 높은 표적 유사화소들을 제외함으로써 탐지 성능이 크게 향상될 수 있음이 확인되었다. 분광각외에 다양한 유사도 판정 기준들에 대한 적용성 연구와 함께, 제외되는 표적 유사화소들의 양이 최적으로 결정될 수 있는 방법에 대한 추가 연구가 이루어진다면 사용이 간편하고 성능이 우수한 초분광 표적탐지 기법으로 활용될 수 있을 것으로 기대된다.

• Reproductive and Developmental Biology
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• 제28권4호
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• pp.227-233
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• 2004

This study was conducted to investigate the effect of various addition and exclusion time of glucose (Control: no addition, A: 24～72 h, B: 24～48 h, C: 48～72 h, D: 0～72 h, E: 0～48 h, F: 0～24 h and 48～72 h, G: 0～24 h) on embryonic developmental capacity of 2-cell embryos in mice. Developed blastocysts were assessed for mean cell number by differential staining. The zona-intact blastocyst (ZiB) rates were higher (p<0.05) in group B than control. However, the zona-escape blastocyst (ZeB) rates were not significantly different in all groups. At 72 h, total blastocyst (ZiB + ZeB) formation rates were not significantly different in all groups. The mean cell number was not significantly different among all groups. The inner cell mass (ICM) cell number was higher (p<0.05) in group F than control, group A, B and G. The trophectoderm (TE) cell number was higher (p<0.05) in control than group A and D. The %ICM was higher (p<0.05) in group C, D and F than control. The ICM : TE ratio was not significantly different in all groups. Between control and glucose group, no significant difference was observed in the total blastocysts (ZiB + ZeB) formation rates. Also, no significant difference was observed in the mean cell number, ICM cell number and ICM : TE ratio. However the TE cell number was higher (p<0.05) in control than glucose group and %ICM was higher (p<0.05) in glucose group than control. In conclusion, glucose added in culture medium was not inhibitory on blastocyst formation but glucose added for 48 ～72 h in culture medium increases %ICM of blastocysts in mice.

• 대한통합의학회지
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• 제11권2호
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• pp.77-86
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• 2023

Purpose : This study systematically assessed 9 emotion-function programs for schizophrenic individuals that have been implemented over the past 10 years in Korea and abroad, with the objective of providing clinical grounds and data for further programs. Methods : This study identified 2,558 studies from among those registered in the RISS, KISS, EMbase, PubMed and Scopus databases from 2013 to September 2023, using 'schizophrenia' AND 'emotion' AND ('program' OR 'therapy') as keywords. Of the 2,558 studies retrieved from electronic databases, 602 duplicate papers were excluded. After this process, 1,915 papers that did not meet the study's inclusion and exclusion criteria were excluded based on their titles and abstracts. Following a review of the texts of the remaining 41 papers, nine papers were finally selected, excluding 32 papers according to the selection and exclusion criteria. Results : Programs for the emotional function of patients with schizophrenia have continued to be researched. The results of an evaluation on the quality of the selected literature confirmed that a majority of the reviewed items were "uncertain", confirming that there was a risk of bias. The interventions for emotions included art, cognitive-behavioral, and physical programs, of which art programs were frequently applied. Most of the interventions were implemented in hospitals. The dependent variables for evaluating emotions included emotional expression, depression, anxiety, and positive emotions, and among them, emotional expression was used most frequently. Accordingly, the Berkeley expressivity questionnaire was commonly used as an evaluation tool. Conclusion : This study is significant for intending to analyze domestic and overseas programs for the emotions of patients with schizophrenia, thereby proposing the direction for planning and applying interventions in clinical settings. In follow-up studies, it will be necessary to develop a protocol that confirms interventions according to the settings and patient characteristics of programs and expands the scope of literature reviews.

• 철학연구
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• 제145권
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• pp.271-296
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• 2018

이 글은 한국사회의 보수 집권 세력이 오랫동안 작동시켜 온, 동시에 그 정치 공학적 실효성이 여전히 발현되고 있는 이념적 정치적 낙인찍기의 횡행(橫行)과 그 효과에 기초한 적대적 배제 정치의 활성화 실태가 지닌 본질적인 난점과 그 부당성을 비판적으로 규명해 보는데 주안점을 두고 있다. 그로부터 이 글은 다음과 같은 몇 가지 '잠정적' 결론을 이끌어냈다. 우선, 해방 이후 한국사회를 장악, 지배해 온 소위 '보수 집권 세력'은 본질상 외세 의존적 반민족적인 동시에 반민주 반민중적인 '친일 독재 (잔존 및 추종) 세력'이라는 사실이다. 둘째, 친일 독재 집단으로서의 보수 집권 세력은, 자신의 본질적 한계와 실체를 은폐하고 지배계급으로서의 지위와 기득권을 항시적으로 보전하기 위한 통치 기법의 하나로, 자신을 향한 비판적 저항 세력을 반국가적 비국민으로 규정하여 그들에 대한 정치적 탄압과 배제가 불가피하고 정당한 것인 양, 구성원들로 하여금 오인케 만드는 낙인효과 및 그에 기초한 적대적 배제의 정치(술)을 구사해 왔다. 셋째, 독재 정권 등에 맞서 비판적 거부 투쟁을 전개한 민주(화) 세력에 대해 '종북좌파' 등으로 규정지어 정치적으로 매도하는 행태는, 정치 공학적으로 기획 연출된 '근거 없는' 낙인찍기의 전형적 사례이다. 동시에 그에 따른 현실적 효과를 이용해 민주(화) 세력을 한국사회에서 영구히 배제 추방하고, 통치권과 기득권을 지속적으로 장악, 향유하겠다는 것이 보수 집권세력이 구사한 적대적 배제 정치의 최종적 지향점이다. 넷째, 친일 독재 세력이라는 규정은 사실상 보수 집권 세력의 '본질적 실체'를 가리키는 바, 보수 지배층에 씌어진 '친일 독재 세력'이라는 낙인은 '결코' 정치 공학적 차원에서 치밀하게 기획된 '근거 없는' 낙인찍기에 해당되지 않음이 확인되었다. 더불어 그것을 통한 정치 사회적 효과를 이용해 모종의 정당화될 수 없는 불순한 정략적 의도를 관철 지으려는 적대적 배제정치의 조작적 수법과도 연관성이 없음이 밝혀졌다. 끝으로, 일부 호남 출신 지식인 및 정치인들이 주축이 되어 제기한 '영남 패권주의' 담론, 특히 노무현 정권과 친노(친문)을 '은폐된 투항적 영남패권주의' 세력의 하나로 규정지으려는 시도는, 사실상 노무현 및 친노(친문)에 대한 자신들이 지닌 '정서적 거부감'을 무리하게 논리적으로 체계화하려는 기획의 '불완전한' 산물로서, '근거 없는' 낙인찍기 행태이자 그를 통해 모종의 정치적 이해관계를 관철하려는, 규범적으로 정당화되기 어려운 정치적 배제술의 하나임이 확인되었다. 이후의 작업에서는, 특정 정략적 목적을 위해 치밀하게 기획되고 조작된, 정치 윤리적 차원에서 결코 용납될 수 없는 낙인찍기의 효과와 그에 터한 적대적 배제의 통치술이 이 사회에서 종식될 수 있는 구체적인 '실천 방안'을 모색해 보는데 매진할 것이다.

• 동의생리병리학회지
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• 제23권1호
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• pp.199-205
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• 2009

It is unclear whether Fructus ligustri Lucidi (FLL) extract anti-proliferative effect in human glioma cells. The present study was therefore undertaken to examine the effect of FLL on cell viability and to determine the underlying mechanism in A172 human glioma cells. Cell viability and cell death were estimated by MTT assay and trypan blue exclusion assay, respectively. Apoptosis was measured by Annexin-V binding assay and cell cycle analysis. Activation of kinases and caspase-3 was estimated by Western blot analysis. FLL resulted in apoptotic cell death in a dose- and time-dependent manner. FLL-induced cell death was not associated with reactive oxygen species generation. Western blot analysis showed that FLL treatment caused down-regulation of PI3K/Akt pathway, but not ERK. The PI3K/Akt inhibitor LY984002 sensitized the FLL-induced cell death and overexpression of Akt prevented the cell death. FLL induced caspase-3 activation and the FLL-induced cell death was prevented by caspase inhibitors. These findings indicate that FLL results in a caspase-dependent cell death through a P13K/Akt pathway in human glioma cells. These data suggest that FLL may serve as a potential therapeutic agent for malignant human gliomas.