• Wind and Structures
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• v.13 no.6
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• pp.557-580
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• 2010

A new inflow turbulence generation method and a combined dynamic SGS model recently developed by the authors were applied to evaluate the wind effects on 508 m high Taipei 101 Tower. Unlike the majority of the past studies on large eddy simulation (LES) of wind effects on tall buildings, the present numerical simulations were conducted for the full-scale tall building with Reynolds number greater than $10^8$. The inflow turbulent flow field was generated based on the new method called discretizing and synthesizing of random flow generation technique (DSRFG) with a prominent feature that the generated wind velocity fluctuations satisfy any target spectrum and target profiles of turbulence intensity and turbulence integral length scale. The new dynamic SGS model takes both advantages of one-equation SGS model and a dynamic production term without test-filtering operation, which is particular suitable to relative coarse grid situations and high Reynolds number flows. The results of comparative investigations with and without generation of inflow turbulence show that: (1) proper simulation of an inflow turbulent field is essential in accurate evaluation of dynamic wind loads on a tall building and the prescribed inflow turbulence characteristics can be adequately imposed on the inflow boundary by the DSRFG method; (2) the DSRFG can generate a large number of random vortex-like patterns in oncoming flow, leading to good agreements of both mean and dynamic forces with wind tunnel test results; (3) The dynamic mechanism of the adopted SGS model behaves adequately in the present LES and its integration with the DSRFG technique can provide satisfactory predictions of the wind effects on the super-tall building.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.187-194
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• 2006

Recently satellite SAR techniques have become essential observation tools for various ocean phenomena such as wind, wave, and current. The CMOD4 and CMOD-IFR2 models are used to calculate the magnitude of wind at SAR resolution with no directional information. Combination of the wave-SAR spectrum analysis and the inter-look cross-spectra techniques provides amplitude and direction of the ocean wave over a square-km sized imagette, The Doppler shift measurement of SAR image yields surface speed of the ocean current along the rador looking direction, again at imagette resolution. In this paper we report the development of a SAR Ocean processor (SOP) incorporating all of these techniques. We have applied the SOP to several RADARSAT-1 images of the coast of Korean peninsula and compared the results with oceanographic data, which showed reliability of spaceborne SAR-based oceanographic research.

• Journal of Navigation and Port Research
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• v.31 no.1 s.117
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• pp.35-42
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• 2007

Recently satellite SAR techniques have become essential observation tools for various ocean phenomena such as wind, wave, and current. The CMOD4 and CMOD-IFR2 models are used to calculate the magnitude of wind at SAR resolution with no directional information. Combination of the wave-SAR spectrum analysis and the inter-look cross-spectra techniques provides amplitude and direction of the ocean wave over a square-km sized imagette, The Doppler shift measurement of SAR image yields surface speed of the ocean current along the radar looking direction, again at imagette resolution. In this paper we report the development of a SAR Ocean processor(SOP) incorporating all of these techniques. We have applied the SOP to several RADARSAT-1 images of the coast of Korean peninsula and compared the results with oceanographic data, which showed reliability of spaceborne SAR-based oceanographic research.

• Korean Journal of Oriental Medicine
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• v.15 no.3
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• pp.63-74
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• 2009

Background and Purpose : Oncheongeum(溫淸飮) composed of Samultang(四物湯) and Hwangryunhaedoktang(黃連解毒湯) was mainly used for healing metrorrhagia in the Qing dynasty of China. At present, Oncheongeum is used for treating a broad spectrum of diseases such as skin disease, stomatitis, behcets disease, diabetes mellitus and, especially in Japan, atopic dermatitis. To our knowledge, however, neither the precise constituents and their effects of Oncheongeum nor the criteria for the prescription of Oncheongeum were defined. To address this issue, we searched and performed analysis of Korean, Chinese and Japanese articles reporting the clinical and experimental studies of Oncheongeum. Methods : We searched articles in the national assembly library of Korea by using keyword 'Oncheongeum' korean. Similarly, we did chinese articles in the CNKI and japanese ones in the CiNii, respectively. Results : We found 13 korean articles about Oncheongeum in the national assembly library, 34 chinese articles in the CNKI, and 23 japanese in the CiNii. The papers were divided into clinical and experimental articles. The clinical articles were mainly published from China and Japan, and their subjects were predominantly on skin diseases. Conclusions : There were a lot of case reports about Oncheongeum used in the clinical studies. In order to better understand the effects of Oncheongeum, systematic review of the studies seems essential. The efficacy of Oncheongeum reported in the clinical studies should be supported by experimental data. Not much were clinical reports in Korea, although we are expecting more to come. It is possible to not only analyse but compare Oncheongeum with other prescriptions used for atopic dermatitis. More comprehensive and comparative analysis of three countries' prescriptions might provide a way of how to standardize prescriptions, which leads oriental medicine to an evidence based medicine.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.9
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• pp.4462-4466
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• 2013

In optical system, the signal and additive noise for statistical properties of a variety of ways to evaluate the performance of the system is essential for the optimization. In this paper, performance analysis of spectrum-sliced optical system in the optical pre-amplifier in the receiver the received signal by including the error limits for the bit that is, the bit error rate (BER: Bit Error Rate) required to maintain the average optical power represents the number of photons per bit is included in this paper to digital form, noticeable signal the receiver to calculate the sensitivity of the method for the calculation was performed. The general strength of the transmission of the modulated signal and digital signal transmission was required for the comparison of optical power. As shown in Figure 3, the general strength of the digital signal transmission system for transmitting a modulated signal compared with the case is improved by at least 10dB.

• Nuclear Engineering and Technology
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• v.53 no.2
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• pp.626-636
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• 2021

Boron-neutron capture therapy (BNCT) is a cancer treatment method that exploits the high neutron reactivity of boron. Monitoring the prompt gamma rays (PGs) produced during neutron irradiation is essential for ensuring the accuracy and safety of BNCT. We investigate the imaging of PGs produced by the boron-neutron capture reaction through Monte Carlo simulations of a gamma camera with a SrI₂ scintillator and parallel-hole collimator. GAGG scintillator is also used for a comparison. The simulations allow the shapes of the energy spectra, which exhibit a peak at 478 keV, to be determined along with the PG images from a boron-water phantom. It is found that increasing the size of the water phantom results in a greater number of image counts and lower contrast. Additionally, a higher septal penetration ratio results in poorer image quality, and a SrI₂ scintillator results in higher image contrast. Thus, we can simulate the BNCT process and obtain an energy spectrum with a reasonable shape, as well as suitable PG images. Both GAGG and SrI₂ crystals are suitable for PG imaging during BNCT. However, for higher imaging quality, SrI₂ and a collimator with a lower septal penetration ratio should be utilized.

• Journal of the Earthquake Engineering Society of Korea
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• v.25 no.3
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• pp.111-119
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• 2021

A shear wall is a structural member designed to effectively resist in-plane lateral forces, such as strong winds and earthquakes. Due to its efficiency and stability, shear walls are often installed in residential buildings and essential facilities such as nuclear power plants. In this research, to predict the results of the shaking table test of the three-story shear wall RC structure hosted by the Korea Atomic Energy Research Institute, three types of numerical modeling techniques are proposed: Preliminary, Calibrated 1, and Calibrated 2 models, in order of improvement. For the proposed models, an earthquake of the 2016 Gyeongju, South Korea (peak ground acceleration of 0.28 g) and its amplified earthquake (peak ground acceleration of 0.50 g) are input. The response spectra of the measuring points are obtained by numerical analysis. Good agreement is observed in the comparisons between the experiment results and the simulation conducted on the finally adopted numerical model, Calibrated 2. In the process of improving the model, this paper investigates the influences of the mode shape, material properties, and boundary conditions on the structure's seismic behavior.

• Journal of Medicine and Life Science
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• v.17 no.3
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• pp.65-73
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• 2020

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a single-gene disease of the cerebral small blood vessels caused by mutations in the NOTCH3 gene on chromosome 19. Although CADASIL was known as a rare disease, recent research has suggested that the NOTCH variants could be found frequently even in the general population. The main clinical features included recurrent stroke, migraine, psychiatric symptoms, and progressive cognitive decline. On brain magnetic resonance imaging, patients with CADASIL showed multifocal white matter hyperintensity lesions, lacunar infarcts, microbleeds, and brain atrophy. Among them, lacunar infarcts and brain atrophy are important in predicting the clinical outcomes of patients with CADASIL. In the Jeju National University Hospital, we have diagnosed 213 CADASIL patients from 2004 to 2020. Most NOTCH3 mutations were located in exon 11 (94.4%), and p.Arg544Cys was the most common mutation. The mean age at diagnosis was 61.0±12.8 years. The most common presenting symptoms were ischemic stroke (24.4%), followed by cognitive impairment(15.0%), headache (8.9%), and dizziness(8.0%). Although the exact prevalence of CADASIL in Jeju is still unknown, the disease prevalence could be as high as 1% of the population considering the prevalence reported in Taiwan. Therefore, it is necessary to discover efficient biomarkers and genetic tests that can accurately screen and diagnose patients suspected of having CADASIL in this region. Ultimately, it is urgent to explore the exact pathogenesis of the disease to identify leading substances of treatment potential, and for this, multi-disciplinary research through active support from the Jeju provincial government as well as the national government is essential.

• Journal of mucopolysaccharidosis and rare diseases
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• v.5 no.1
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• pp.17-21
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• 2021

Hunter syndrome or mucopolysaccharidosis type II (MPS-II) (OMIM 309900) is a rare lysosomal storage disorder caused by deficiency in the activity of the enzyme iduronate-2-sulfatase. This enzyme is responsible for the catabolism of the following two different glycosaminoglycans (GAGs): dermatan sulfate and heparan sulfate. The lysosomal accumulation of these GAG molecules results in cell, tissue, and organ dysfunction. Patients can be broadly classified as having one of the following two forms of MPS II: a severe form and an attenuated form. In the severe form of the disease, signs and symptoms (including neurological impairment) develop in early childhood, whereas in the attenuated form, signs and symptoms develop in adolescence or early adulthood, and patients do not experience significant cognitive impairment. The involvement of the skeletal-muscle system is because of essential accumulated GAGs in joints and connective tissue. MPS II has many clinical features and includes two recognized clinical entities (mild and severe) that represent two ends of a wide spectrum of clinical severities. However, enzyme replacement therapy is likely to have only a limited impact on bone and joint disease based on the results of MPS II studies. The aim of this study was to review the involvement of joints in MPS II.

• Korean Journal of Remote Sensing
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• v.38 no.1
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• pp.83-101
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• 2022

Accurate atmospheric correction is essential for the analysis of land surface and environmental monitoring. Aerosol optical depth (AOD) information is particularly important in atmospheric correction because the radiation attenuation by Mie scattering makes the differences between the radiation calculated at the satellite sensor and the radiation measured at the land surface. Thus, it is necessary to use high-quality AOD data for an appropriate atmospheric correction of high-resolution satellite images. In this study, we examined the Second Simulation of a Satellite Signal in the Solar Spectrum (6S)-based atmospheric correction results for the Sentinel-2 images in South Korea using raster AOD (MODIS) and single-point AOD (AERONET). The 6S result was overall agreed with the Sentinel-2 level 2 data. Moreover, using raster AOD showed better performance than using single-point AOD. The atmospheric correction using the single-point AOD yielded some inappropriate values for forest and water pixels, where as the atmospheric correction using raster AOD produced stable and natural patterns in accordance with the land cover map. Also, the Sentinel-2 normalized difference vegetation index (NDVI) after the 6S correction had similar patterns to the up scaled drone NDVI, although Sentinel-2 NDVI had relatively low values. Also, the spatial distribution of both images seemed very similar for growing and harvest seasons. Future work will be necessary to make efforts for the gap-filling of AOD data and an accurate bi-directional reflectance distribution function (BRDF) model for high-resolution atmospheric correction. These methods can help improve the land surface monitoring using the future Compact Advanced Satellite 500 in South Korea.