• Herbal Formula Science
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• v.25 no.4
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• pp.553-574
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• 2017

The purpose of this study is to find out effects of prescriptions according to the formula, manipulation of Rhei Rhizoma, configuration. The following results were reached through investigations on the prescriptions using Rhei Rhizoma as a main component. Objectives : Analysis of prescriptions According to the formula : Liquid Extract Prescriptions were used widely on three parts to treat fever and damp heat in the interior organs. Powder Prescriptions were taken with hot water, thin porridge, tea etc. to treat damp heat, congestion of phlegm, acute episodes. Liquid Mixed Pill treat congestion of QI, damp heat, phlegm. Honey Mixed Pill treat accumulated fever, distension, acute excessive fever. Paste Pill treat blood stagnation, excessive toxic-fever, epidemic diseases. External Application treat inflammation by injury, swelling due to severe fever by internal damage. Methods : Analysis of prescriptions According to the manipulation of Rhei Rhizoma : Prescriptions including Liquor processed Rhei Rhizoma treat excessive toxic-fever, congestion of phlegm, blocking orifices on the upper side. Steamed Rhei Rhizoma strengthen effects of making evacuate and cooling of heat. Processed Rhei Rhizoma with vinegar strengthen effects of removing blood stagnation by activating blood movement, releasing gathering. Results : Analysis of prescriptions According to the Composition of Rhei Rhizoma : 41% of the total prescriptions were on the area of less than 20%. In case of lower groups show increased frequency of combination with Pharbitidis Semen, Persicae Semen, Scutellariae Radix and manipulation of baking, steaming, roasting. In case of higher groups show increased frequency of treating excess syndrome, critical illness, acute severe illness, and using proccesed Rhei Rhizoma with vinegar. Treatment of damp heat on the liver and gallbladder, disorder of the spleen and stomach is done mostly by prescriptions on the area of less than 30%. Conclusions : Rhei Rhizoma-Coptidis Rhizoma pair treat damp heat, heat toxins in blood, and Constipation caused by excessive heat. Rhei Rhizoma-Glycyrrhizae Radix pair relieve effects of Rhei Rhizoma passing blocked feces, removing the poison, activating blood movement, releasing gathering with the effects of Glycyrrhizae Radix relaxing tension by harmonizing Middle. Rhei Rhizoma-Magnoliae Cortex pair are used to treat damp heat in middle area, excessive heat in the stomach and intestine. Rhei Rhizoma-Pharbitidis Semen pair act on both blood system and QI system treating edema, damp, stagnation, heat toxins, feces. Rhei Rhizoma-Persicae Semen pair treat blood stagnation with fever on blood system.

• Clinical and Experimental Pediatrics
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• v.53 no.5
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• pp.639-643
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• 2010

Purpose: Hand-foot-mouth disease (HFMD) is a common viral illness in children, which is usually mild and self-limiting. However, in recent epidemics of HFMD in Asia, enterovirus 71 (EV71) has been recognized as a causative agent with severe neurological symptoms with or without cardiopulmonary involvement. HFMD was epidemic in Korea in the spring of 2009. Severe cases with complications including death have been reported. The clinical characteristics in children with neurologic manifestations of EV71 were studied in Ewha Womans University Mokdong Hospital. Methods: Examinations for EV71 were performed from the stools, respiratory secretion or CSF of children who presented neurologic symptoms associated with HFMD by realtime PCR. Clinical and radiologic data of the patients were collected and analyzed. Results: EV71 was isolated from the stool of 16 patients but not from respiratory secretion or CSF. Among the 16 patients, meningitis (n=10) was the most common manifestation, followed by Guillain-Barre syndrome (n=3), meningoencephalitis (n=2), poliomyelitis-like paralytic disease (n=1), and myoclonus (n=1). Gene analysis showed that most of them were caused by EV71 subgenotype C4a, which was prevalent in China in 2008. Conclusion: Because EV71 causes severe complications and death in children, a surveillance system to predict upcoming outbreaks should be established and maintained and adequate public health measures are needed to control disease.

• Parasites, Hosts and Diseases
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• v.23 no.1
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• pp.33-40
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• 1985

Two cases of human Erhinostoma hortense infection and their probable infection source were identified by prasiqantel (Distocide) treatment of the patients and by examining two kinds of fresh water fish which were eaten raw by them. The result of the research can be summarized as follows: 1. The patients, each aged 31 and 30, were residing in the same house in Wonju City, Kangwon Province. The first case was hospitalized due to epidemic hemorrhagic fever (E.H. fever) and the second case was healthy but had slight degree of abdominal pain and diarrhea from time to time. In the stool examination, eggs of 5. hortense ($114.3{\times}71.0{\mu\textrm{m}}$) average from the first case and $119.1{\times}68.3{\mu\textrm{m}}$ average from the second) were found. By administering single dose of praziquantel (10~15mg/kg) and purgation with magnesium salt to them. sin adults of 5. hortense were collected from the diarrheal stools of the second case. 2. By examining 8:k Moroco oxycephalus and 20 Carassius carassius which were captured at the place where the two patients had captured and eaten the fresh water fish, the metacercariae of Echinostoma sp. were found from 3 (3.5%) M. oxycephalus. 3. After the experimental infection of 3 isolated metacercariae to one albino rat three adults of 5. hortense were recovered. By the present study, the two patients revealing the echinostomatid eggs in their stools were proven to be infected with 5. hortense and to be the second and third human cases of this luke infection in Korea. Mcroco oxycephalus harboured the metacercariae of E. hortense and appeared to be a new second intermediate host.

• Journal of fish pathology
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• v.5 no.1
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• pp.37-48
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• 1992

Antibiotics are chemical substances produced by various species of microorganisms that suppress the growth of other microorganisms or may destroy them. Among the more than 4000 antibiotics that has been identified, about 20s are using as the therapy of infectious fish diseases. There are several methods used to classify and group antibiotics, and the most common classification has been based on chemical structure and proposed mechanism of action. The effect of antibiotics may be determined by the kind of fish pathogens and by the external environment surrounded the infected fish. It implies that the kind of antibiotics and its application method should be decided after the determination of the reasons of fish disease. The uncontrolled usages of antibiotics may induce the selection of resistant mutants appeared spontaneously and present in any group of bacteria. The epidemic spread of such antibiotic resistant strains of fish pathogenic bacteria already has been reported in various districts of japan. Importantly, transferable drug resistant(R) plasmids were detected in strains of most of fish pathogens. Based on those reports, the antimicrobial resistance appears to be a rapidly emerging problem in the fish industry on the country. The expanding literatures on the pharmacokinetics, clinical trials, withdrawal periods and efficacy of environmental effect for the commonly using antibiotics have met the needs of data for the practical application of antibiotics. However, the most important thing for the treatment of fish diseases would be the communication and exchanging of information between the site of aquaculture and the diagnostic laboratory.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.31 no.4
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• pp.440-446
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• 1986

The physiological reaction of two soybean (Glycine max (L.) Merrill) cultivars tolerant and susceptible to rust (Phakopsora pachyrhizi Syd.) was studied at the AVRDC in Taiwan, ROC. The rust epidemic on the susceptible cultivar began earlier and progressed more rapidly than on the tolerant cultivar. The defoliation by rust infection increased rapidly after the latter half of pod filling. The reduction of LA! by rust in the susceptible cultivar occurred earlier than in the tolerant cultivar. The differences in the chlorophyll content between the rust-free and rust-infected plants was 2.04% in the tolerant, and 16.43% in the susceptible cultivar. The shoot dry weight increased at each growth stage in the fungicide protected plots, but decreased in the non-fungicide protected plots after the R6 growth stage onward and the tendency to decrease was more severe in the susceptible than in the tolerant cultivar. The pod and seed dry weight of the suscep-tible cultivar in the fungicide-protected plot increased dramatically from the R6 growth stage, but in the non-fungicide plot, there was almost no increase in pod and seed dry weight from R6 growth stage, due to rust. The number of empty pods and imperfect grains were increased by rust infection, but the protein content was not afftected. There were reductions of oil content, seed length, seed width, seed thickness, pod thickness, number of pods and seeds, 100 seed weight, and yield due to rust infection. The yield losses by rust infection were 22.3%in the tolerant and 68.7% in the susceptible cultivar.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.1
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• pp.29-36
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• 2018

Dimorphic fungi are characterized by the production of mycelia in the environment or when incubated at lower temperatures ($25{\sim}30^{\circ}C$) on media. The conversion to yeast occurs when invading a human body or when incubated at elevated temperatures ($35{\sim}37^{\circ}C$). Dimorphic fungi cause systemic infection and occur only in endemic regions; they can cause deep mycosis, which invades tissues and organs. Imported thermally dimorphic fungal pathogen has five genera, such as Coccidioides immitis, Histoplasma capsulatum, Blastomyces dermatitidis, Talaromyces (Penicillium) marneffei, and Paracoccidioides brasiliensis. Thus far, 30 cases of dimorphic fungi have been reported in Korea, including C. immitis in 18, H. capsulatum in 5, B. dermatitidis in 3, and T. marneffei in 4 cases. Three 3 cases of C. immitis, 2 cases of H. capsulatum, 1 case of B. dermatitidis, and 1 case of Talaromyces (Penicillium) marneffei were reported in Korea, even though no experience of an epidemic was present. None the dimorphic fungi except for Sporothrix schenkii (Dimorphic fungi) occur in Korea but are caused by endemic fungi that can be found only in specific regions and limited areas of foreign countries. Considering the trends of migratory locals and the increasing number of immigrants living in and returning home, the incidence of imported infections is expected to increase.

• Journal of Food Hygiene and Safety
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• v.18 no.2
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• pp.61-66
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• 2003

This study was conducted to produce the egg yolk Imunoglobulin (IgY) on Vibrio parahaemolyticus from immunized hen with lipopolysaccharide (LPS). Vibrio parahaemolyticus is considered as a potentially pathogenic bacteria, the causative agents of the gastroenteritis. According as the LPS antigens were injected into laying hens in order to produce antibodies against Vibrio parahaemolyticus in egg yolk. After chickens were immunized four times in 2 weeks interval and three times booster in 2 weeks interval, the profile of antibody Production was examined by ELISA. The Production of antibody in egg yolk was started in 1 week after the first immunization, reached peak in 7 weeks and maintained until 13 weeks later. The antibody titre in serum showed similar tendency as IgY. No significant difference in antibody titre when the titre compared to water diluted IgY and commercial IgY kit. Purified IgY reacted with only Vibrio parahaemolyticus, but other Vibrio species and food-borne pathogenic bacteria. In conclusion, we showed that it is possible to obtain a high antibody titre in chicken with quite low amounts of LPS antigen. These results suggested that egg yolk antibodies could be a good source for production of specific antibodies to pathogenic bacteria inducing epidemic gastroenteritis.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.34 no.3
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• pp.231-242
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• 2016

As of late, air quality information has been actively gathered and investigated in order to find possible environmental risk factors that may affect the onset of cardiovascular disease. Nevertheless, existing studies are limited in the detailed analysis because they take advantage of the air quality information of the macro statistics divided into administrative districts. This paper proposes the construction of distance-based air quality dataset using a domestic hospital’s geographical location information as a reliable data gathering step for a more detailed analysis of environmental risk factors. For the construction of the dataset, air quality information was obtained by utilizing the geographical location of a hospital—in which a patient with cardiovascular disease had been admitted—and then matching the hospital with a meteorological and air pollution station in its vicinity. An air quality acquisition system based on GMap.net was devised for the purpose of data gathering and visualization. The reliability of the experiment was confirmed by evaluating the matching rate and error of air quality values between the acquired dataset with existing area-based air quality datasets from matched distances. Therefore, this dataset, which considers geographical information, can be utilized in multidisciplinary research for the discovery of environmental risk factors that can affect not only cardiovascular diseases but also potentially other epidemic diseases.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.2
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• pp.85-93
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• 2020

Despite the development of modern medical sciences, the outbreak and spread of infections continue to threaten populations, and the spread of infections among populations is caused by social contacts. There have only been a few studies on social contacts in the Republic of Korea (hereafter Korea). This study identified the types of social contacts in other countries through a systemic literature review and this helped provide basic data for Korea. Twelve studies were finally selected and then published from 2000 to December 2017. The most common study method was a retrospective contact diary (7cases, 58.3%), and random sampling (9cases, 75%). The number of contacts was 4.9-17.7/day, there were more frequent contacts during the weekdays than on weekends, and the most contacted people were those people that met daily. Physical contact was frequent at home. The highest frequency of contacts was between people 5-19 years old. In case of an epidemic, the spread of infection by this age group could be a concern. Assortative mixing was high in the 5-20 years old group, suggesting that this age group may be more likely to spread infection by contact within the same age group. Therefore, a national-wide survey on social contacts will be needed to predict the spread of infections, and to develop infection prevention based on a domestic basis in Korea.

• Herbal Formula Science
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• v.18 no.1
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• pp.23-42
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• 2010

This report describes 90 prescriptions related to the use of Platycodi Radix main blended from Dongeuibogam. The following conclusions were reached through investigations on the prescriptions that use Platycodi Radix as a key component. Prescriptions that Platycodi Radix was taken as a monarch drug are utilized for 30 therapeutic purposes, for example, cough disease, throat disease, abscess and pus, and wind disease. In particular, 12.1% of prescriptions appear in the chapter of cough, and 9.9% of those appear in the chapter of throat, and each 8.8% of those appear in the chapter of abscess and of wind disease. Prescriptions that utilize Platycodi Radix as the main ingredient are used in the treatment of cough disease, throat disease and abscess, and they are also used for treating 74 different types of disease. The prescriptions are compounded with Platycodi Radix as a monarch drug are related to exogenous agents such as wind-cold pathogen, wind-heat pathogen, epidemic diseases, and endogenous agents such as seven emotions, and non-endo-exopathogenic factors like excessive labor, deficiency of Qi and blood, phlegm-mass, phlegm-fire, ect. The dosage of Platycodi Radix is 2pun(about 0.75g) to 1nyang(about 37.5g), however 1don (about 3.75g) has been taken the most for clinical application. We can find out that according to herbs or prescriptions blended with it self, Platycodi Radix makes a variety of functions to penetrate lung stagnancy and remove phlegm, relieve throat pain and get rid of pus, and regulate Qi flow. And Gamgiltang is the most useful base prescription which used the Platycodi Radix as the main component.