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Process analytical technology (PAT): field applications and current status in pharmaceutical industries (공정분석기술: 제약산업에서의 기술개발 사례 및 현황)

  • Woo, Young-Ah;Kim, Jong-Yun;Park, Yong Joon;Yeon, Jei-Won;Song, Kyuseok;Kim, Hyo-Jin
    • Analytical Science and Technology
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    • v.22 no.1
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    • pp.35-43
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    • 2009
  • The goal of PAT (Process Analytical Technology) is to build quality into products through better understanding and control of manufacturing processes, rather than merely testing the quality of the end product. Pharmaceutical manufacturers are trying to develop and implement new technologies in pharmaceutical production and quality control for real-time measurements of critical product and process parameters. Characterization of manufacturing process through experimental design, for evaluation of the effect of product and process variables, represents an integral part of the PAT framework. However, the publications regarding real PAT application to pharmaceutical process are very limited and the technologies are confidential as well. In this review, the case studies related to PAT are shown with real applications from a pharmaceutical company. Additionally, various applications of PAT on the developing stage are introduced with high analytical technologies for the improvement of quality control on manufacturing process.

Advantages and disadvantages of renewable energy-oil-environmental pollution-from the point of view of nanoscience

  • Shunzheng Jia;Xiuhong Niu;Fangting Jia;Tayebeh Mahmoudi
    • Advances in concrete construction
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    • v.16 no.1
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    • pp.69-78
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    • 2023
  • This investigation delves into the adverse repercussions stemming from the impact of arsenic on steel pipes concealed within soil designated for rice cultivation. Simultaneously, the study aims to ascertain effective techniques for detecting arsenic in the soil and to provide strategies for mitigating the corrosion of steel pipes. The realm of nanotechnology presents promising avenues for addressing the intricate intersection of renewable energy, oil, and environmental pollution from a novel perspective. Nanostructured materials, characterized by distinct chemical and physical attributes, unveil novel pathways for pioneering materials that exert a substantial impact across diverse realms of food production, storage, packaging, and quality control. Within the scope of the food industry, the scope of nanotechnology encompasses processes, storage methodologies, packaging paradigms, and safeguards to ensure the safety of consumables. Of particular note, silver nanoparticles, in addition to their commendable antibacterial efficacy, boast anti-fungal and anti-inflammatory prowess, environmental compatibility, minimal irritability and allergenicity, resilience to microbial antagonism, thermal stability, and robustness. Confronting the pressing issue of arsenic contamination within both environmental settings and the food supply is of paramount importance to preserve public health and ecological equilibrium. In response, this study introduces detection kits predicated upon silver nanoparticles, providing an expeditious and economically feasible avenue for identifying arsenic concentrations ranging from 0.5 to 3 ppm within rice. Subsequent quantification employs Hydride Atomic Absorption Spectroscopy (HG-AAS), which features a detection threshold of 0.05 ㎍/l. A salient advantage inherent in the HG-AAS methodology lies in its capacity to segregate analytes from the sample matrix, thereby significantly reducing instances of spectral interference. Importantly, the presence of arsenic in the soil beneath rice cultivation establishes a causative link to steel pipe corrosion, with potential consequences extending to food contamination-an intricate facet embedded within the broader tapestry of renewable energy, oil, and environmental pollution.

Influence analysis of Internet buzz to corporate performance : Individual stock price prediction using sentiment analysis of online news (온라인 언급이 기업 성과에 미치는 영향 분석 : 뉴스 감성분석을 통한 기업별 주가 예측)

  • Jeong, Ji Seon;Kim, Dong Sung;Kim, Jong Woo
    • Journal of Intelligence and Information Systems
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    • v.21 no.4
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    • pp.37-51
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    • 2015
  • Due to the development of internet technology and the rapid increase of internet data, various studies are actively conducted on how to use and analyze internet data for various purposes. In particular, in recent years, a number of studies have been performed on the applications of text mining techniques in order to overcome the limitations of the current application of structured data. Especially, there are various studies on sentimental analysis to score opinions based on the distribution of polarity such as positivity or negativity of vocabularies or sentences of the texts in documents. As a part of such studies, this study tries to predict ups and downs of stock prices of companies by performing sentimental analysis on news contexts of the particular companies in the Internet. A variety of news on companies is produced online by different economic agents, and it is diffused quickly and accessed easily in the Internet. So, based on inefficient market hypothesis, we can expect that news information of an individual company can be used to predict the fluctuations of stock prices of the company if we apply proper data analysis techniques. However, as the areas of corporate management activity are different, an analysis considering characteristics of each company is required in the analysis of text data based on machine-learning. In addition, since the news including positive or negative information on certain companies have various impacts on other companies or industry fields, an analysis for the prediction of the stock price of each company is necessary. Therefore, this study attempted to predict changes in the stock prices of the individual companies that applied a sentimental analysis of the online news data. Accordingly, this study chose top company in KOSPI 200 as the subjects of the analysis, and collected and analyzed online news data by each company produced for two years on a representative domestic search portal service, Naver. In addition, considering the differences in the meanings of vocabularies for each of the certain economic subjects, it aims to improve performance by building up a lexicon for each individual company and applying that to an analysis. As a result of the analysis, the accuracy of the prediction by each company are different, and the prediction accurate rate turned out to be 56% on average. Comparing the accuracy of the prediction of stock prices on industry sectors, 'energy/chemical', 'consumer goods for living' and 'consumer discretionary' showed a relatively higher accuracy of the prediction of stock prices than other industries, while it was found that the sectors such as 'information technology' and 'shipbuilding/transportation' industry had lower accuracy of prediction. The number of the representative companies in each industry collected was five each, so it is somewhat difficult to generalize, but it could be confirmed that there was a difference in the accuracy of the prediction of stock prices depending on industry sectors. In addition, at the individual company level, the companies such as 'Kangwon Land', 'KT & G' and 'SK Innovation' showed a relatively higher prediction accuracy as compared to other companies, while it showed that the companies such as 'Young Poong', 'LG', 'Samsung Life Insurance', and 'Doosan' had a low prediction accuracy of less than 50%. In this paper, we performed an analysis of the share price performance relative to the prediction of individual companies through the vocabulary of pre-built company to take advantage of the online news information. In this paper, we aim to improve performance of the stock prices prediction, applying online news information, through the stock price prediction of individual companies. Based on this, in the future, it will be possible to find ways to increase the stock price prediction accuracy by complementing the problem of unnecessary words that are added to the sentiment dictionary.

Experimental Study on the Combined Effect of Power and Heat according to the Ventilation of Back Side in Roof Integrated PV System (주택 지붕일체형 PV시스템 후면환기에 따른 발전성능 변화 실험연구)

  • Yoon, Jong-Ho;Han, Kyu-Bok;An, Young-Sub
    • Journal of the Korean Solar Energy Society
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    • v.27 no.3
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    • pp.169-174
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    • 2007
  • Building integrated photovoltaic(BIPV) system operates as a multi-functional building construction material. They not only produce electricity, but also are building integral components such as facade, roof, window and shading device. As PV modules function like building envelope in BIPV, combined thermal and PV performance should be simultaneously evaluated. This study is to establish basic Information for designing effective BIPV by discovering relations between temperature and generation capability through experiment when the PV module is used as roof material for houses. To do so, we established 3kW full scale mock-up model with real size house and attached an PV array by cutting in half. This is to assess temperature influence depending on whether there is a ventilation on the rear side of PV module or not.

Nuclear Safety Analysis with the Performance of NPPs (원전운전지표를 이용한 원전의 안전성 변화 분석)

  • Park, Wooyoung
    • Environmental and Resource Economics Review
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    • v.26 no.2
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    • pp.139-172
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    • 2017
  • Nuclear safety measures such as safety technology, culture, and regulation affects nuclear performances. This paper analyzes the change of nuclear performance by considering nuclear safety measures. Nuclear performance and technical data ranging 1970 to 2015 are collected from the Power Reactor Information System (PRIS) of IAEA. The result of panel regression analysis shows that overall engineering level, maintenance engineering and productivity decrease the forced loss rate (FLR). FLR structurally increase after Chernobyl accident in 1986 whereas after TMI and Fukushima accidents FLR didn't show any significant changes. The structural increase of FLR after Chernobyl are likely to result from the efforts of international communities for nuclear safety culture which makes nuclear operating company pay more opportunity cost to achieve nuclear safety.

Output characteristics and measurement of the gain coefficient of a pulsed Nd:YAG laser (펄스형 Nd:YAG 레이저의 출력특성과 이득계수 측정)

  • 박대윤
    • Korean Journal of Optics and Photonics
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    • v.10 no.1
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    • pp.53-57
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    • 1999
  • We established the laser oscillator using Nd:YAG crystal grown at Ssang Yong company in Korea and investigated the characteristics of oscillation, Q-switching and wave front of output beam. We measured the single pass gain by controlling the threshold input energy with two output couplers of different output reflectances. Moreover, we compared the gain measured by different output couplers with the gain directly measured by the laser amplifier. The peak power of Q-switching, the pulse width, and the single pass gain coefficient at the threshold energy were 1.5 MW, 30ns, and 0.0958 cm-$^1$ respectively and they were compared with those of the commercial Nd:YAG crystal. Our crystal was proved to be as good as the commercial crystal.

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CFD Analysis on a Tall Building Augmented Wind Turbine (풍력발전기가 설치된 고층빌딩에 대한 전산유체역학적 고찰)

  • Jeon, Wan-Ho;Yoon, Seong-Wook;Kim, Wook;Cho, Jang-Hyung
    • Journal of Environmental Science International
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    • v.18 no.8
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    • pp.919-926
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    • 2009
  • Renewable energy or green energy is a hot issue in theses days. Since wind resource can be endlessly supplied by nature, researchers and common people are interested in study how to use that resource at home or company. Especially, many architects have tried to integrate wind power generator for a part of building. So in this paper, three buildings installed wind power turbine are targed to CFD analysis and these buildings are Bahrain trade center, Discovery tower, and Pearl river tower. Bahrain trade center is the first building installed real wind turbine, Discovery tower is constructing at Texas, and Pearl river tower is designed and proved by china researchers. These buildings have very different type of wind power turbine and each turbine has different conditions f3r best power generation. Therefor this paper will focus on characteristic shape of buildings, wind power turbine type, and expected purpose of construction. Moreover, CFD analysis will show wind flow pattern and wind speed while wind is passing through wind turbine of three tall buildings. CFD analysis for three buildings make comparison the wind flow patterns with experimental result.

The Optimal Operation Pattern and Heat Pricing Scheme for District Heating CHP System (지역난방용 열병합발전시스템의 최적운전패턴과 적정 열요금구조)

  • 권영한;김창수;진병문;김진오
    • Journal of Energy Engineering
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    • v.5 no.2
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    • pp.183-192
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    • 1996
  • This paper presents a numerical model of the optimal operation pattern of the CHP system built for duel-purpose of power generation and district heat production. The model can be differently formulated in accordance with the view of planner: society, electric utility or district-heating company. Here, the operation pattern of the system components and the effect of heat price are of major interest in the study. From the case study, it was found that the optimal use of auxiliary heating equipment is very important to achieve the minimum societal cost. And, the multi-step heat pricing scheme is desirable to induce the voluntary behavior of both companies towards the societal optimal pattern.

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A Study on Exhaust Gas Recirculation of Homogeneous Charge Compression Ignition Engine (균질혼합압축점화기관의 배기가스재순환 특성에 관한 연구)

  • Han, Sung-Bin;Kim, Sung-Mo
    • Journal of Energy Engineering
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    • v.18 no.3
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    • pp.163-168
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    • 2009
  • This paper describes the homogeneous charge compression ignition (HCCI) engine for a new concept. HCCI engines are being considered as a future alternative for diesel and gasoline engines. HCCI engines have the potential for high indicated thermal efficiency under part load and very low NOx emissions. The objective of this paper is to clear the effects of exhaust gas recirculation (EGR) rate on the HCCI. For this purpose, a 4-cylinder, compression ignition engine was converted into a HCCI engine This work has been run with propane and butane fuels at a constant speed.

A Study on Cyclic Variation by Idling in Gasoline Vehicle (가솔린자동차의 무부하 운전에서 사이클변동에 관한 연구)

  • Han, Sung-Bin;Kim, Sung-Mo
    • Journal of Energy Engineering
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    • v.18 no.3
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    • pp.156-162
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    • 2009
  • Cylinder-pressure based combustion analysis provides a mechanism through which a combustion researcher can understand the combustion process. This paper was to identify the most significant sources of cycle-to-cycle combustion variability in a spark ignition engine at idle. To analyse the cyclic variation in the test engine, the burn parameters are determined on a cycle-to-cycle basis through analysis of the engine pressure data. The burn rate analysis program was used in the analysis of the data. Burn parameters were used to determine the variations in the input parameter-i.e., fuel, air, residual mass, and so on.