• 대한화장품학회지
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• 제24권3호
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• pp.116-122
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• 1998

It is well known that all-trans-retinol is not only very unstable in heat, light, air, and water, but also skin-irritant despite a good anti-wrinkle effect. Therefore, it is very difficult to stabilize retinol and make the safe retinol containing cosmetics by using a certain concentration of retinol with real effect. In order to dissolve these problems and apply retinol for skin care cream, firstly retinol is to be encapsulated in the vesicle called Liposphere (pseudo-liposome) which is made by homogenizing under high pressure the mixtures of lecithin, retinol, caprylic/capric triglyceride, and hydroalcoholic solution ; and then this retinol containing Liposphere is to be intercalated in lamellar liquid crystal layer which is prepared by emulsifying in an optimal ratio the mixtures composed of non-ionic emulsifier (cetearyl glucoside, sorbitan stearate & sucrose cocoate etc), cetearyl alcohol, stearic acid, cholesterol, and ceramide. In addition, the stability of the retinol containing oil in water cream by adding the polymeric emulsifier such as acrylate /C10-30 alkyl alkylate crosspolymer is to be ensured even at 55 C. Retinol containing oil in water cream prepared through above procedure could be very stable at 45 C for at least 50 days. The structure identification of lamellar liquid crystal was determined using polarized light microscope and electron microscope Conclusively, we could make the very stable retinol containing oil in water cream by triple procedure, that is, encapsulation of retinol in Liposphere, intercalation of retinol in lamellar liquid crystal layer, and assurance of the high temperature stability of cream even at 55 C.

• 대한화장품학회지
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• 제39권2호
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• pp.89-96
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• 2013

본 연구에서는 폴리에틸렌아디페이트와 폴리메틸메타크릴레이트로 구성된 고분자 마이크로입자에 닥나무 뿌리 추출물을 함유시켜 닥나무 뿌리 추출물의 안정도와 상용성을 성공적으로 향상시켰다. 마이크로입자를 구성하는 고분자의 비율에 따라 마이크로입자에 함유된 닥나무 뿌리 추출물의 장기안정도에 미치는 영향을 평가하였다. 폴리에틸렌아디페이트 마이크로입자의 물리적 강도를 높여주기 위하여 폴리메틸메타크릴레이트를 도입하였으며, 이는 마이크로입자에 안정화시킨 닥나무 뿌리 추출물의 안정도에는 큰 영향이 없었다. 광학현미경, 편광현미경, 주사전자현미경을 이용하여 고분자 마이크로입자의 물리적 안정도를 관찰하였고, in vitro 실험을 통하여 고분자 마이크로입자로 안정화된 닥나무 뿌리 추출물의 미백 효과도 잘 유지되고 있음을 확인하였다.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.294-302
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• 2003

Unstable cosmetic active ingredients could be degraded rapidly by chemical and photochemical process. Particularly, some of active ingredients like retinol are known to cause skin irritation when applied on the skin excessively. Therefore, it has become a very important issue to encapsulate cosmetic actives for the stabilization and skin protection. This study was performed in order to prepare a chitosan microcapsule containing liposoluble cosmetic actives and to investigate the stabilization effect of actives when chitosan microcapsule was applied in cosmetic formulation. Chitosan, deacetylated form of chitin, has been of interest in the industrial applications due to its biocompatibility, biodegradability, non-toxicity, antimicrobial activity and also used as a wall material of capsule. Retinol was used as a core material and was stabilized by a wall of chitosan and antioxidants. The chitosan microcapsule containing retinol(CMR) was prepared by using coacervation method and W$_1$/O/W$_2$ emulsification techniques. The CMR has 0.5~10.0 ${\mu}{\textrm}{m}$ size distribution and a long-term stability of more than an year inside the cosmetic formulation(O/W). Remaining retinol percentages at 45$^{\circ}C$ after 8 weeks in the CMR dispersion were 15.6%(pH 4.0), 59.8%(pH 6.0) and 65.0%(pH 6.0 with antioxidant) respectively. Retinol stability when added CMR inside a ONV emulsion was better than that of ONV emulsion added non-capsulated retinol. As a result, remaining retinol at 45$^{\circ}C$ after 8 weeks in O/W emulsion added non-capsulated retinol and O/W emulsion containing CMR was 12.7%, 70.5% respectively. It appeared that chitosan treated microcapsule may be used for a potential encapsulation method of unstable active ingredients.

• Journal of Animal Science and Technology
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• 제65권5호
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• pp.895-911
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• 2023

Processed meat products play a vital role in our daily dietary intake due to their rich protein content and the inherent convenience they offer. However, they often contain synthetic additives and ingredients that may pose health risks when taken excessively. This review explores strategies to improve meat product quality, focusing on three key approaches: substituting synthetic additives, reducing the ingredients potentially harmful when overconsumed like salt and animal fat, and boosting nutritional value. To replace synthetic additives, natural sources like celery and beet powders, as well as atmospheric cold plasma treatment, have been considered. However, for phosphates, the use of organic alternatives is limited due to the low phosphate content in natural substances. Thus, dietary fiber has been used to replicate phosphate functions by enhancing water retention and emulsion stability in meat products. Reducing the excessive salt and animal fat has garnered attention. Plant polysaccharides interact with water, fat, and proteins, improving gel formation and water retention, and enabling the development of low-salt and low-fat products. Replacing saturated fats with vegetable oils is also an option, but it requires techniques like Pickering emulsion or encapsulation to maintain product quality. These strategies aim to reduce or replace synthetic additives and ingredients that can potentially harm health. Dietary fiber offers numerous health benefits, including gut health improvement, calorie reduction, and blood glucose and lipid level regulation. Natural plant extracts not only enhance oxidative stability but also reduce potential carcinogens as antioxidants. Controlling protein and lipid bioavailability is also considered, especially for specific consumer groups like infants, the elderly, and individuals engaged in physical training with dietary management. Future research should explore the full potential of dietary fiber, encompassing synthetic additive substitution, salt and animal fat reduction, and nutritional enhancement. Additionally, optimal sources and dosages of polysaccharides should be determined, considering their distinct properties in interactions with water, proteins, and fats. This holistic approach holds promise for improving meat product quality with minimal processing.

• 공업화학
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• 제35권2호
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• pp.128-133
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• 2024

안티솔벤트를 이용한 결정화는 밀도 높고 균일한 페로브스카이트 필름을 얻는 효과적인 접근 방법이나, 일반적으로 사용되는 chlorobenzene (CB)과 같은 안티솔벤트는 독성을 가지며, 공기 중에서 페로브스카이트 결정화의 제어가 용이하지 않다. 본 연구에서는 공기 중 공정에 적합하며 친환경적인 안티솔벤트인 isopropyl acetate (IA)를 사용하여 페로브스카이트 태양전지를 제작하고자 하며 사이아노기, 카보닐기 및 벤젠 고리와 같은 작용기를 포함한 ethyl-4-cyanocinnamate (E4CN)을 안티솔벤트에 첨가제로 사용함으로서 성능 및 안정성을 개선하고자 한다. E4CN과 페로브스카이트 결함과의 상호작용으로 페로브스카이트 필름에 존재하는 un-coordinated Pb²⁺ 및 I₂ 결함을 제어할 수 있으며 이로 인한 재조합의 억제와 전하추출의 개선을 관찰할 수 있다. 그 결과 E4CN을 사용한 페로브스카이트 소자는 기준 소자 대비 개선된 18.89%의 최대 전력 변환 효율을 보여준다. 더불어, 기준 소자의 경우, 소자효율이 시간에 따라 급격히 감소하여 200 시간 후 효율값이 0%까지 저하되지만 E4CN이 도입된 소자의 경우, 300 시간 후 초기 광전변환효율의 60%를 유지하는 개선된 안정성을 보여준다.

• 한국수산과학회지
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• 제35권3호
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• pp.231-236
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• 2002

국내산 송이의 특징인 송이 향을 효과적으로 보존할 수 있는 방법을 개발하기 위하여 알긴산으로 송이 향의 주된 성분인 1-oc-ten-3-ol을 캡슐화 공정과 송이 향의 잔존량에 영향을 미치는 요인을 조사한 결과는 다음과 같다. 분무건조를 위한 alginates의 점도는 350cp 이하가 되어야 하므로, alginates 용액의 점도를 낮추기 위하여 첨가한 citric acid 량이 증가할수록 점도는 낮아졌으며, 또한 $0.1\%의 농도에서 150cp 이하의 점도를 나타내었다. 1-octen-3-ol과 유화제를 첨가하여 에멀젼시킨 alginates 용액의 점도는 에멀젼시키기 전의 점도보다 높았지만 150cp 이하를 나타내 분무 건조 공정에는 영향이 없었다. alginates 용액의 점도가 낮을수록 용액의 EAI는 증가하였으나 ESI는 감소하였고 캡슐의 1-octen-3-of의 잔존량이 감소하였다. alginates 용액의 점도를 낮추는 공정에서 citric acid 첨가 후 가열시간이 길어질수록 점도는 급격히 감소하였고 에멀전 전후의 점도는 큰 차이 없었다 생송이를 알긴 산용액으로 캡슐화할 때 첨가되는 대두유의 량이 많을수록 1-oc-ten-3-ol의 잔존량이 많았다. 생송이를 alginates용액으로 캡슐화한 후 진공동결건조한 캡슐이 풍건한 것보다 1-octen-3-ol의 잔존량이 많았다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9249-9258
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• 2014

Background: The encapsulation of curcumin (Cur) in polylactic-co-glycolic acid (PLGA) nanoparticles (Cur-NPs) was designed to improve its solubility and stability. Conjugation of the Cur-NPs with anti-P-glycoprotein (P-gp) antibody (Cur-NPs-APgp) may increase their targeting to P-gp, which is highly expressed in multidrugresistance (MDR) cancer cells. This study determined whether Cur-NPs-APgp could overcome MDR in a human cervical cancer model (KB-V1 cells) in vitro and in vivo. Materials and Methods: First, we determined the MDR-reversing property of Cur in P-gp-overexpressing KB-V1 cells in vitro and in vivo. Cur-NPs and Cur-NPs-APgp, in the range 150-180 nm, were constructed and subjected to an in vivo pharmacokinetic study compared with Cur. The in vitro and in vivo MDR-reversing properties of Cur-NPs and Cur-NPs-APgp were then investigated. Moreover, the stability of the NPs was determined in various solutions. Results: The combined treatment of paclitaxel (PTX) with Cur dramatically decreased cell viability and tumor growth compared to PTX treatment alone. After intravenous injection, Cur-NPs-APgp and Cur-NPs could be detected in the serum up to 60 and 120 min later, respectively, whereas Cur was not detected after 30 min. Pretreatment with Cur-NPs-APgp, but not with NPs or Cur-NPs, could enhance PTX sensitivity both in vitro and in vivo. The constructed NPs remained a consistent size, proving their stability in various solutions. Conclusions: Our functional Cur-NPs-APgp may be a suitable candidate for application in a drug delivery system for overcoming drug resistance. The further development of Cur-NPs-APgp may be beneficial to cancer patients by leading to its use as either as a MDR modulator or as an anticancer drug.

• 한국식품과학회지
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• 제44권5호
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• pp.577-582
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• 2012

쌀 전분의 아밀로오스 함량차이에 따른 옥테닐호박산(OSAn) 변성전분의 제조 특성 및 이화학적 특성을 검토하였다. 아밀로오스의 함량은 Jinsumi가 15.42%, Milyang 261은 34.21%였으며 전분 추출 후의 Jinsumi가 20.31%, Milyang 261은 39.32%였다. 치환도 및 반응효율은 Milyang 261이 각각 0.0137, 89.89%였으며 Jinsumi는 0.0144, 95.92%로 Jinsumi가 Milyang 261보다 높았다. 점도는 Jinsumi와 Milyang 261이 각각 30.1 cP 및 7.8 cP이었으며 옥테닐호박산을 이용한 변성전분의 경우 240.5 cP 및 162.6cP으로 상승하였다. 변성전분의 유화안정성은 두 품종 모두 대체적으로 안정하였으며 특히 Jinsumi는 높은 유화안정성을 보였으며, 변성전분을 부형제로 이용하여 미세캡슐화한 후의 코팅효율은 Jinsumi가 65.70-73.54%, Milyang 261이 29.45-36.98%로 나타나 분무건조를 통한 미세캡슐 효율은 Jinsumi가 높았다. 이러한 결과를 볼 때 분무건조를 통한 미세캡슐화의 피복물질 소재로서 변성을 통한 쌀 전분이 이용가치가 있을 것으로 사료되며 특히 Jinsumi가 Milyang 261에 비하여 높은 활용도를 가질 것이라 판단된다.

• 폴리머
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• 제31권1호
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• pp.20-24
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• 2007

제조과정에서 단백질 약물의 생물학적 활성의 보존은 약물의 성공적인 전달에 있어 여전히 중요한 과제이다. 이중에멀션 유기용매 증발법을 사용하여 나노입자를 제조하였고, 입자의 형태, 크기, 함입률 그리고 방출속도와 방출되는 효소의 활성을 살펴보았다. 입자의 크기는 고분자인 락타이드 글리콜라이드 공중합체의 농도가 증가할수록 커졌으며, 유화제의 농도에는 큰 차이가 없었으나, 4% PVA의 사용에서 가장 좁은 입자분포를 얻을 수 있었다. 최적의 조건에서 72.6%의 단백질 함입률과 $198.3{\pm}13.8 nm$ 크기의 나노입자를 얻었다. 입자로부터 효소의 방출은 첫 방출시기에 매우 빠르게 일어났으며 12일 내에 83%가 방출되었다. 이에 따른 방출되는 효소의 활성은 6일째까지 증가되었다.

• Biomaterials and Biomechanics in Bioengineering
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• 제3권3호
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• pp.129-140
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• 2016

This article reports the development of biodegradable photoluminescent polymer (BPLP)-based nanoparticles (NPs) incorporating either magnetic nanoparticles (BPLP-MNPs) or gadopentate dimeglumine (BPLP-Gd NPs), for cancer diagnosis and treatment. The aim of the study is to compare these nanoparticles in terms of their surface properties, fluorescence intensities, MR imaging capabilities, and in vitro characteristics to choose the most promising dual-imaging nanoprobe. Results indicate that BPLP-MNPs and BPLP-Gd NPs had a size of $195{\pm}43nm$ and $161{\pm}55nm$, respectively and showed good stability in DI water and 10% serum for 5 days. BPLP-Gd NPs showed similar fluorescence as the original BPLP materials under UV light, whereas BPLP-MNPs showed comparatively less fluorescence. VSM and MRI confirmed that the NPs retained their magnetic properties following encapsulation within BPLP. Further, in vitro studies using HPV-7 immortalized prostate epithelial cells and human dermal fibroblasts (HDFs) showed > 70% cell viability up to $100{\mu}g/ml$ NP concentration. Dose-dependent uptake of both types of NPs by PC3 and LNCaP prostate cancer cells was also observed. Thus, our results indicate that BPLP-Gd NPs would be more appropriate for use as a dual-imaging probe as the contrast agent does not mask the fluorescence of the polymer. Future studies would involve in vivo imaging following administration of BPLP-Gd NPs for biomedical applications including cancer detection.