• Bulletin of the Korean Chemical Society
• /
• 제32권9호
• /
• pp.3382-3388
• /
• 2011

Reaction of barbituric acid (BA), 1,3-dimethyl barbituric acid (DMBA) and 2-thiobarbituric acid (TBA) with cyanogen bromide and aldehydes in the presence of L-(+)-tartaric acid afforded a new route for the synthesis of stable heterocyclic 5-aryl-1H,1'H-spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]2,2',4,4',6'(3H,3'H,5H)-pentaones which is a dimeric form of barbiturate (uracil and thiouracil derivative). In the reaction of 1,3-diethyl thiobarbituric acid (DETBA) the Knoevenagel condensation and then Michael adducts were obtained under the same condition. Structure elucidation is carried out by $^1H$ NMR, $^{13}C$ NMR, FT-IR and Mass analyses. Mechanism of the formation is discussed.

• 대한화학회지
• /
• 제54권3호
• /
• pp.287-290
• /
• 2010

Peracetylated lactosyl carbamides와 N-phenyl-S-chloro isothiocarbamoyl chloride를 고리화 반응을 시켜서 peracetylated N-Lactosyl-1,2,4-thiadiazolidin-3-one hydrochlorides를 합성하였으며, 얻어진 화합물을 이용하여 bacteria S. aureus, E. coli, P. Vulgaris, P. Aeruginosa and fungi A. Niger, Penicillium 항균 활성을 연구하였다.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1989년도 추계학술대회 논문집 학회본부
• /
• pp.142-144
• /
• 1989

Triggering characteristics of a trigatron spark gap have been studied by measuring self-emission UV light. By combining the measurement of the UV light with that of the trigger gap voltage and the lain discharge current, we distinguished clearly the differences between the trigatron operations in which the lain discharge occurs after the trigger discharge in the case of sale polarity between the trigger pin and the lain electrode at the opposite side, and the lain gap breakdown takes place before the formation of the trigger spark in the case of different polarity. We show the observation of UV radiation with the other electromagnetic measurements is a simple and reliable scheme to investigate the triggering properties of the trigatron spark gaps.

• Tuberculosis and Respiratory Diseases
• /
• 제38권3호
• /
• pp.228-235
• /
• 1991

Pulmonary surfactant is a lipoprotein complex composed primarily of phospholipid and lungspecific apoproteins that reduces surface tension in the alveolus and maintains alveolar stability at low lung volume. Three families of lung-specific apoproteins have been described: SP-A, a glycoprotein with a reduced molecular weight of 28~36 KDa. SP-B a hydrophobic protein with a nonreduced molecular weight of 18 KDa, and SP-C a hydrophobic protein with a non-reduced molecular weight of 5~8 KDa. Surfactant proteins have important roles in regulating surfactant metabolism as well as in determining its physical properties. The synthesis of the active surfactant peptides appears to be modulated by system with considerable complexity, including numerous levels of regulation such as cell-specific, hormonal and developmental controls. Endotoxin appears to alter surfactant protein mRNAs differentially. It is hoped that the elucidation of the factors controlling the synthesis and metabolism of the surfactant proteins will aid in understanding the pathogenesis of hyaline membrane disease and offer new avenues for the therapy and diagnosis of ther pulmonary disorders as well.

• BMB Reports
• /
• 제41권1호
• /
• pp.1-10
• /
• 2008

Surgery, Chung-Ang Unviersity College of Medicine, Yong-San Hospital, Seoul, Korea Apoptosis is considered to be a programmed and controlled mode of cell death, whereas necrosis has long been described as uncontrolled and accidental cell death resulting from extremely harsh conditions. In the following review, we will discuss the features and physiological meanings as well as recent advances in the elucidation of the signaling pathways of both apoptotic cell death and programmed necrotic cell death.

• Molecules and Cells
• /
• 제25권2호
• /
• pp.279-288
• /
• 2008

The analysis of microarray data is essential for large amounts of gene expression data. In this review we focus on clustering techniques. The biological rationale for this approach is the fact that many co-expressed genes are co-regulated, and identifying co-expressed genes could aid in functional annotation of novel genes, de novo identification of transcription factor binding sites and elucidation of complex biological pathways. Co-expressed genes are usually identified in microarray experiments by clustering techniques. There are many such methods, and the results obtained even for the same datasets may vary considerably depending on the algorithms and metrics for dissimilarity measures used, as well as on user-selectable parameters such as desired number of clusters and initial values. Therefore, biologists who want to interpret microarray data should be aware of the weakness and strengths of the clustering methods used. In this review, we survey the basic principles of clustering of DNA microarray data from crisp clustering algorithms such as hierarchical clustering, K-means and self-organizing maps, to complex clustering algorithms like fuzzy clustering.

• 대한기계학회논문집
• /
• 제19권3호
• /
• pp.763-770
• /
• 1995

Gas flow characteristics within the cylinder is important factors in impoving lean combustion stability. This paper shows the effects of various flow fields generated by a swirl control valve(SCV) on combustion process in a 4-valve spark ignition engine. An impulse swirl/tumble meter was used to elucidation the steady-state flow characteristics, and a rotating grating type LDV was developed to measure the mean velocity and tunbulence intensity in relation to the crank angle. These methodologies were applied to clarify the correlation between gas flow characteristics and combustion stability at a lean air fuel ratio. An analysis of the correlation revealed the gas flow conditions required to optimize a lean-burn system.

• 생약학회지
• /
• 제23권1호
• /
• pp.14-19
• /
• 1992

A mixture of acylglucosyl sterols together with ${\beta}-sitosterol$, ${\beta}-sitosterol\;3{\beta}-O-glucoside$ and fatty acids was isolated from the roots of Caragana chamlagu as their acetate forms and the structure elucidated by chemical and spectroscopic means. The major acylglucosyl sterol was ${\beta}-sitosteryl\;3-O-[6'-O-oleoyl]-{\beta}-D-glucopyranoside$ while the minor components were $6'-O-palmitoyl-\;and\;6'-O-stearoyl-{\beta}-D-glucosyl$ sitosterol congeners. The isolation and structure elucidation of these acylglucosyl sterols are reported for the first time from the genus Caragana.

• Bulletin of the Korean Chemical Society
• /
• 제32권2호
• /
• pp.687-692
• /
• 2011

$^1H$ and $^{13}C$ NMR spectra of series of (E)-1-aryl-(2- and 3-thienyl)-2-propenones, that are aldol condensation products between 2- and 3-thiophenecarbaldehydes and m- and p-substituted acetophenones, were examined to make complete assignments of the chemical shifts. Long range couplings, $^4J$ and $^5J$, are observed in the $^1H-^1H$ COSY of both 2- and 3-thienyl compounds, which makes the elucidation of the conformation in solution possible. In contrast, the 2-furyl analogue shows the long range coupling phenomena, but the 3-furyl and phenyl analogues do not show similar phenomena.

• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2006년도 한국약용작물학회 공동춘계학술발표회
• /
• pp.470-471
• /
• 2006