• 제목/요약/키워드: effects analysis

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Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455)

  • Kim, Tae-Sung;Kim, Chang-Yeong;Lee, Hae-Kyung;Kang, Il-Hyun;Kim, Mi-Gyeong;Jung, Ki-Kyung;Kwon, Yong-Kwan;Nam, Hye-Seon;Hong, Soon-Keun;Kim, Hyung-Sik;Yoon, Hae-Jung;Rhee, Gyu-Seek
    • Toxicological Research
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    • 제27권3호
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    • pp.181-184
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    • 2011
  • Screening of estrogenic activity on dichloro diphenyl trichloroethane (DDT), dichloro diphenyl dichloro ethylene (DDE), dieldrin, heptachlor, aldrin, chlordane, lindane, polybrominated diphenyl ethers (PBDE) and parabens was compared using Organization for Economic Cooperation and Development (OECD) test guideline 455 (TG455). The estrogenic activity of DDT was 58,000-fold ($PC_{50}$, $1.67{\times}10^{-6}$ M) less than $17{\beta}$-estradiol($E_2$) ($PC_{50}$, $2.88{\times}10^{-11}$ M) but DDE, dieldrin, heptachlor, aldrin, chlordane, lindane and PBDE did not show any estrogenic activity in this assay system. In the case of paraben compounds, the rank of relative transcriptional activation (logRTA) was butyl paraben -1.63752 ($PC_{50}$, $1.25{\times}10^{-7}$ M) > isobutyl paraben -2.34008 ($PC_{50}$, $6.3{\times}10^{-7}$ M) > ethyl paraben -2.64016 ($PC_{50}$, $1.26{\times}10^{-6}$ M) > isopropyl paraben -2.73993 ($PC_{50}$, $1.58{\times}10^{-6}$ M) > propyl paraben -2.84164 ($PC_{50}$, $2.0{\times}10^{-6}$ M). Our data suggest that OECD test guideline TG455 may be useful as a screening tool for potential endocrine disruptors.

차량충돌해석 적용을 위한 간단화한 성형이력 고려 방법 (A Simplified Method to Consider Forming Effects in a Car Crash Analysis)

  • 허지향;윤종헌;임지호;박성호;허훈
    • 한국소성가공학회:학술대회논문집
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    • 한국소성가공학회 2008년도 추계학술대회 논문집
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    • pp.259-262
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    • 2008
  • This paper introduces a simplified method to consider forming effects in a car crash analysis. Representative value was used to consider forming effects simply. Four representative values, which are the mean value of thicknesses and effective plastic strains at nodes, the median of thicknesses and effective plastic strains at nodes, were evaluated. A crash analysis of a front side member shows that analysis results from the suggested methods are similar to those from the conventional method to consider forming effects. Use of the mean effective plastic strain shows the best results. A car crash analysis for a ULSAB/AVC model under the condition of US SINCAP were carried out to demonstrate the validity of the suggested method. Analysis results show that the error of suggested method is less than 1.5%.

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황색종 담배의 주요형질에 대한 유전분석 (Genetic Analysis of Major Characteristics in Flue-cured Tobacco)

  • 신승구;홍병희
    • 한국연초학회지
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    • 제13권2호
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    • pp.59-65
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    • 1991
  • There was no a difference of genetic analysis among methods(means, joint scaling test, 3 Parameter model) . The magnitude of additive effects generally paralleled the magnitude of difference between parental means and appeared to be more independent from non-allelic interaction than did dominance effects, whereas the magnitude of dominance effects were inflated by non-allelic interaction. Additive effects were significant for all characteristics observed and it was a major effects in inheritance of number of leaves. Dominance effects were higher than additive effects for plant height, days to flower, flesh leaf weight per plant, curing rate, total alkaloid and total nitrogen.

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청소년의 자기효능감이 학교생활적응에 미치는 영향 : 우울과 공격성의 매개효과 (The Effects of Self-Efficacy on Adolescents' School Adjustment : The Mediating Effects of Depression and Aggression)

  • 김소연;전종설
    • 아동학회지
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    • 제36권4호
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    • pp.193-208
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    • 2015
  • The aims of this study were to investigate the effects of self-efficacy on adolescents' school adjustments and to identify mediating effects of depression and aggression. To this end, we conducted descriptive analysis, correlation analysis, and path analysis, using data from the 2008 Korean Youth Panel Survey undertaken by the National Youth Policy Institute. Our analysis shows that self-efficacy has positive effects on adolescents' school adjustments, while both depression and aggression have negative effects on adolescents' school adjustments. Moreover, both depression and aggression have a mediating effect when it comes to self-efficacy and school adjustments. These results imply that schools should consider developing a service delivery system by providing students with professional services that enhance self-efficacy. Moreover, such services will be more effective when they are combined with a program that reduces students' depression and aggression.

스마트무인기 기술개발의 경제적·기술적 파급효과 분석 (An Analysis on the economic and technological effects of Smart UAV Development Project)

  • 박상범
    • 한국산학기술학회논문지
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    • 제12권7호
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    • pp.2991-2995
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    • 2011
  • 본 연구의 목적은 스마트무인기 기술개발의 경제적효과를 측정하고자 하는데 있다. 기술개발의 경제적효과는 투입산물의 파급효과는 물론 기술개발에서 오는 파급효과 측정 또한 매우 중요하다. 본 연구에서는 투입산출법에 의한 효과분석을 하였으며 전체적으로 약13조원의 효과가 있는 것으로 나타나고 있다.

외모에 대한 사회문화적 영향이 여대생의 신체불만족과 외모향상추구행동에 미치는 영향 (The effects of sociocultural influences of appearance on body dissatisfaction and appearance enhancement behavior of female college students)

  • 박은정;정명선
    • 복식문화연구
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    • 제21권3호
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    • pp.361-375
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    • 2013
  • This study investigates the effects of sociocultural influences of appearance(parental influence, media influence, peer influence) on body dissatisfaction and appearance enhancement behaviors(clothing selection, skin care, make-up, hair care, weight management). For data collection, a questionnaire was administrated to 562 female college students in Gwangju, Chonnam area and Chonbuk area, Korea, from May 23 to June 10, 2011. To analysis the data, descriptive statistical analysis, factor analysis, regression analysis, and path analysis were conducted. The results were as follows. First, the overall effects of sociocultural influences of appearance on body enhancement behavior turned out to have positive effects. Second, overall sociocultural influences of appearance had positive effects on body dissatisfaction. Third, the overall effects of body dissatisfaction on appearance enhancement behavior did not appear to be statistically significant. Forth, the effects that sociocultural influences of appearance on appearance enhancement behavior mediated body dissatisfaction appeared to be insignificant.

로버스트 선형혼합모형을 이용한 필드시험 데이터 분석 (Analysis of Field Test Data using Robust Linear Mixed-Effects Model)

  • 홍은희;이영조;옥유진;나명환;노맹석;하일도
    • 응용통계연구
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    • 제28권2호
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    • pp.361-369
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    • 2015
  • 연속측도의 반응변수가 반복측정된 실험 자료의 분석을 위해 흔히 선형혼합모형이 사용된다. 그러나, 잔차의 분포가 이분산성이거나 비정규성을 가질 때 표준적인 선형혼합모형은 적절하지 않은 결과를 가져온다. 잔차의 분포가 두터운 꼬리를 가진 비정규분포를 보이는 타이어 필드시험 데이터를 로버스트 선형혼합모형에 적합시킴으로써 보다 더 정확하고 신뢰할 수 있는 분석결과를 얻을 수 있다. 추가적으로 신뢰성 분석 결과를 제시한다.

비용함수에 의한 측정표준투자의 경제적 효과 분석 (An Analysis of Economic Effects on the Investment of Measurement Standards by Cost Function)

  • 남경희;이병민;김동진
    • 기술혁신학회지
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    • 제4권2호
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    • pp.172-181
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    • 2001
  • This is a paper to understand the economic effects of the measurement standards by translog cost function. The data, as of the end of 1998, are from a survey of 514 firms in Korean industry. The analysis is compared to that of 1992 data analysis to check the trend. There are a little differences on the estimated coefficients, but there is no basic difference on trend of economic effects. The Investment on measurement standards have been contributed positively on the major managerial indicators such as productivity, profit, and so on.

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간호단위 관리자의 변혁적 리더십 결과변인에 관한 메타경로분석 (A Meta-Analytic Path Analysis on the Outcome Variables of Nursing Unit Managers' Transformational Leadership: Systemic Review and Meta-Analysis)

  • 김선미;정석희
    • 대한간호학회지
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    • 제50권6호
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    • pp.757-777
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    • 2020
  • Purpose: The purpose of this study was to identify the outcome variables of nursing unit managers' transformational leadership and to test a hypothetical model using meta-analytic path analysis. Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. Data analysis, conducted using R version 3.6.2 software, included 49 studies for the meta-analysis and 119 studies for meta-analytic path analysis. Results: In the meta-analysis, four out of 32 outcome variables were selected. These four variables were empowerment, nursing performance, job satisfaction, and organizational commitment, which showed larger effect sizes than the median and more than five k. The hypothetical model for the meta-analytic path analysis was established by using these four variables and transformational leadership. A total of 22 hypothetical paths including nine direct effects and 13 indirect effects were set and tested. The meta-analytic path analysis showed that transformational leadership had direct effects on the four variables. Finally, eight direct effects, 12 indirect effects, and six mediating effects were statistically significant, and the hypothetical model was verified. Conclusion: Nursing unit managers can use the transformational leadership to improve empowerment, nursing performance, job satisfaction, and organizational commitment of nurses. This study empirically showed the importance of transformational leadership of nursing managers. This finding will be used as evidence to develop strategies for enhancing transformational leadership, empowerment, nursing performance, job satisfaction, and organizational commitment in nursing science and practice.

Meta-analysis of Associations between ATM Asp1853Asn and TP53 Arg72Pro Polymorphisms and Adverse Effects of Cancer Radiotherapy

  • Su, Meng;Yin, Zhi-Hua;Wu, Wei;Li, Xue-Lian;Zhou, Bao-Sen
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권24호
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    • pp.10675-10681
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    • 2015
  • Background: The ataxia telangiectasia mutated (ATM) protein and p53 play key roles in sensing and repairing radiation-induced DNA double strand breaks (DSBs). Accumulating epidemiological evidence indicates that functional genetic variants in ATM and TP53 genes may have an impact on the risk of radiotherapy-induced side effects. Here we performed a meta-analysis to investigate the potential interaction between ATM Asp1853Asn and TP53 polymorphisms and risk of radiotherapy-induced adverse effects quantitatively. Materials and Methods: Relevant articles were retrieved from PubMed, ISI Web of Science and the China National Knowledge Infrastructure (CNKI) databases. Eligible studies were selected according to specific inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled to estimate the association between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and risk of radiotherapy adverse effects. All analyses were performed using the Stata software. Results: A total of twenty articles were included in the present analysis. In the overall analysis, no significant associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and the risk of radiotherapy adverse effects were found. We conducted subgroup analysis stratified by type of cancer, region and time of appearance of side effects subsequently. No significant association between ATM Asp1853Asn and risk of radiotherapy adverse effects was found in any subgroup analysis. For TP53 Arg72Pro, variant C allele was associated with decreased radiotherapy adverse effects risk among Asian cancer patients in the stratified analysis by region (OR=0.71, 95%CI: 0.54-0.93, p=0.012). No significant results were found in the subgroup analysis of tumor type and time of appearance of side effects. Conclusions: The TP53 Arg72Pro C allele might be a protective factor of radiotherapy-induced adverse effects among cancer patients from Asia. Further studies that take into consideration treatment-related factors and patient lifestyle including environmental exposures are warranted.