• Title/Summary/Keyword: effects analysis

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Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455)

  • Kim, Tae-Sung;Kim, Chang-Yeong;Lee, Hae-Kyung;Kang, Il-Hyun;Kim, Mi-Gyeong;Jung, Ki-Kyung;Kwon, Yong-Kwan;Nam, Hye-Seon;Hong, Soon-Keun;Kim, Hyung-Sik;Yoon, Hae-Jung;Rhee, Gyu-Seek
    • Toxicological Research
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    • v.27 no.3
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    • pp.181-184
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    • 2011
  • Screening of estrogenic activity on dichloro diphenyl trichloroethane (DDT), dichloro diphenyl dichloro ethylene (DDE), dieldrin, heptachlor, aldrin, chlordane, lindane, polybrominated diphenyl ethers (PBDE) and parabens was compared using Organization for Economic Cooperation and Development (OECD) test guideline 455 (TG455). The estrogenic activity of DDT was 58,000-fold ($PC_{50}$, $1.67{\times}10^{-6}$ M) less than $17{\beta}$-estradiol($E_2$) ($PC_{50}$, $2.88{\times}10^{-11}$ M) but DDE, dieldrin, heptachlor, aldrin, chlordane, lindane and PBDE did not show any estrogenic activity in this assay system. In the case of paraben compounds, the rank of relative transcriptional activation (logRTA) was butyl paraben -1.63752 ($PC_{50}$, $1.25{\times}10^{-7}$ M) > isobutyl paraben -2.34008 ($PC_{50}$, $6.3{\times}10^{-7}$ M) > ethyl paraben -2.64016 ($PC_{50}$, $1.26{\times}10^{-6}$ M) > isopropyl paraben -2.73993 ($PC_{50}$, $1.58{\times}10^{-6}$ M) > propyl paraben -2.84164 ($PC_{50}$, $2.0{\times}10^{-6}$ M). Our data suggest that OECD test guideline TG455 may be useful as a screening tool for potential endocrine disruptors.

A Simplified Method to Consider Forming Effects in a Car Crash Analysis (차량충돌해석 적용을 위한 간단화한 성형이력 고려 방법)

  • Huh, J.;Yoon, J.H.;Lim, J.H.;Park, S.H.;Huh, H.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2008.10a
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    • pp.259-262
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    • 2008
  • This paper introduces a simplified method to consider forming effects in a car crash analysis. Representative value was used to consider forming effects simply. Four representative values, which are the mean value of thicknesses and effective plastic strains at nodes, the median of thicknesses and effective plastic strains at nodes, were evaluated. A crash analysis of a front side member shows that analysis results from the suggested methods are similar to those from the conventional method to consider forming effects. Use of the mean effective plastic strain shows the best results. A car crash analysis for a ULSAB/AVC model under the condition of US SINCAP were carried out to demonstrate the validity of the suggested method. Analysis results show that the error of suggested method is less than 1.5%.

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Genetic Analysis of Major Characteristics in Flue-cured Tobacco (황색종 담배의 주요형질에 대한 유전분석)

  • 신승구;홍병희
    • Journal of the Korean Society of Tobacco Science
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    • v.13 no.2
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    • pp.59-65
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    • 1991
  • There was no a difference of genetic analysis among methods(means, joint scaling test, 3 Parameter model) . The magnitude of additive effects generally paralleled the magnitude of difference between parental means and appeared to be more independent from non-allelic interaction than did dominance effects, whereas the magnitude of dominance effects were inflated by non-allelic interaction. Additive effects were significant for all characteristics observed and it was a major effects in inheritance of number of leaves. Dominance effects were higher than additive effects for plant height, days to flower, flesh leaf weight per plant, curing rate, total alkaloid and total nitrogen.

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The Effects of Self-Efficacy on Adolescents' School Adjustment : The Mediating Effects of Depression and Aggression (청소년의 자기효능감이 학교생활적응에 미치는 영향 : 우울과 공격성의 매개효과)

  • Kim, Soyoun;Chun, JongSerl
    • Korean Journal of Child Studies
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    • v.36 no.4
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    • pp.193-208
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    • 2015
  • The aims of this study were to investigate the effects of self-efficacy on adolescents' school adjustments and to identify mediating effects of depression and aggression. To this end, we conducted descriptive analysis, correlation analysis, and path analysis, using data from the 2008 Korean Youth Panel Survey undertaken by the National Youth Policy Institute. Our analysis shows that self-efficacy has positive effects on adolescents' school adjustments, while both depression and aggression have negative effects on adolescents' school adjustments. Moreover, both depression and aggression have a mediating effect when it comes to self-efficacy and school adjustments. These results imply that schools should consider developing a service delivery system by providing students with professional services that enhance self-efficacy. Moreover, such services will be more effective when they are combined with a program that reduces students' depression and aggression.

An Analysis on the economic and technological effects of Smart UAV Development Project (스마트무인기 기술개발의 경제적·기술적 파급효과 분석)

  • Park, Sang-Bum
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.7
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    • pp.2991-2995
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    • 2011
  • The Smart UAV is one of the 21st Century Frontier R&D Programs funded by the Ministry of Knowledge Economy. This paper is to analyze the economic and technological effects of the Smart UAV project. Interindustry Analysis (Input-Output Analysis) is used, Overall, the total amount of economic effects is almost 13,000 billion won.

The effects of sociocultural influences of appearance on body dissatisfaction and appearance enhancement behavior of female college students (외모에 대한 사회문화적 영향이 여대생의 신체불만족과 외모향상추구행동에 미치는 영향)

  • Park, Eun-Jeong;Chung, Myung-Sun
    • The Research Journal of the Costume Culture
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    • v.21 no.3
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    • pp.361-375
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    • 2013
  • This study investigates the effects of sociocultural influences of appearance(parental influence, media influence, peer influence) on body dissatisfaction and appearance enhancement behaviors(clothing selection, skin care, make-up, hair care, weight management). For data collection, a questionnaire was administrated to 562 female college students in Gwangju, Chonnam area and Chonbuk area, Korea, from May 23 to June 10, 2011. To analysis the data, descriptive statistical analysis, factor analysis, regression analysis, and path analysis were conducted. The results were as follows. First, the overall effects of sociocultural influences of appearance on body enhancement behavior turned out to have positive effects. Second, overall sociocultural influences of appearance had positive effects on body dissatisfaction. Third, the overall effects of body dissatisfaction on appearance enhancement behavior did not appear to be statistically significant. Forth, the effects that sociocultural influences of appearance on appearance enhancement behavior mediated body dissatisfaction appeared to be insignificant.

Analysis of Field Test Data using Robust Linear Mixed-Effects Model (로버스트 선형혼합모형을 이용한 필드시험 데이터 분석)

  • Hong, Eun Hee;Lee, Youngjo;Ok, You Jin;Na, Myung Hwan;Noh, Maengseok;Ha, Il Do
    • The Korean Journal of Applied Statistics
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    • v.28 no.2
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    • pp.361-369
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    • 2015
  • A general linear mixed-effects model is often used to analyze repeated measurement experiment data of a continuous response variable. However, a general linear mixed-effects model can give improper analysis results when simultaneously detecting heteroscedasticity and the non-normality of population distribution. To achieve a more robust estimation, we used a heavy-tailed linear mixed-effects model for a more exact and reliable analysis conclusion than a general linear mixed-effects model. We also provide reliability analysis results for further research.

An Analysis of Economic Effects on the Investment of Measurement Standards by Cost Function (비용함수에 의한 측정표준투자의 경제적 효과 분석)

  • 남경희;이병민;김동진
    • Journal of Korea Technology Innovation Society
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    • v.4 no.2
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    • pp.172-181
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    • 2001
  • This is a paper to understand the economic effects of the measurement standards by translog cost function. The data, as of the end of 1998, are from a survey of 514 firms in Korean industry. The analysis is compared to that of 1992 data analysis to check the trend. There are a little differences on the estimated coefficients, but there is no basic difference on trend of economic effects. The Investment on measurement standards have been contributed positively on the major managerial indicators such as productivity, profit, and so on.

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A Meta-Analytic Path Analysis on the Outcome Variables of Nursing Unit Managers' Transformational Leadership: Systemic Review and Meta-Analysis (간호단위 관리자의 변혁적 리더십 결과변인에 관한 메타경로분석)

  • Kim, Sunmi;Jeong, Seok Hee
    • Journal of Korean Academy of Nursing
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    • v.50 no.6
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    • pp.757-777
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    • 2020
  • Purpose: The purpose of this study was to identify the outcome variables of nursing unit managers' transformational leadership and to test a hypothetical model using meta-analytic path analysis. Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. Data analysis, conducted using R version 3.6.2 software, included 49 studies for the meta-analysis and 119 studies for meta-analytic path analysis. Results: In the meta-analysis, four out of 32 outcome variables were selected. These four variables were empowerment, nursing performance, job satisfaction, and organizational commitment, which showed larger effect sizes than the median and more than five k. The hypothetical model for the meta-analytic path analysis was established by using these four variables and transformational leadership. A total of 22 hypothetical paths including nine direct effects and 13 indirect effects were set and tested. The meta-analytic path analysis showed that transformational leadership had direct effects on the four variables. Finally, eight direct effects, 12 indirect effects, and six mediating effects were statistically significant, and the hypothetical model was verified. Conclusion: Nursing unit managers can use the transformational leadership to improve empowerment, nursing performance, job satisfaction, and organizational commitment of nurses. This study empirically showed the importance of transformational leadership of nursing managers. This finding will be used as evidence to develop strategies for enhancing transformational leadership, empowerment, nursing performance, job satisfaction, and organizational commitment in nursing science and practice.

Meta-analysis of Associations between ATM Asp1853Asn and TP53 Arg72Pro Polymorphisms and Adverse Effects of Cancer Radiotherapy

  • Su, Meng;Yin, Zhi-Hua;Wu, Wei;Li, Xue-Lian;Zhou, Bao-Sen
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.24
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    • pp.10675-10681
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    • 2015
  • Background: The ataxia telangiectasia mutated (ATM) protein and p53 play key roles in sensing and repairing radiation-induced DNA double strand breaks (DSBs). Accumulating epidemiological evidence indicates that functional genetic variants in ATM and TP53 genes may have an impact on the risk of radiotherapy-induced side effects. Here we performed a meta-analysis to investigate the potential interaction between ATM Asp1853Asn and TP53 polymorphisms and risk of radiotherapy-induced adverse effects quantitatively. Materials and Methods: Relevant articles were retrieved from PubMed, ISI Web of Science and the China National Knowledge Infrastructure (CNKI) databases. Eligible studies were selected according to specific inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled to estimate the association between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and risk of radiotherapy adverse effects. All analyses were performed using the Stata software. Results: A total of twenty articles were included in the present analysis. In the overall analysis, no significant associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and the risk of radiotherapy adverse effects were found. We conducted subgroup analysis stratified by type of cancer, region and time of appearance of side effects subsequently. No significant association between ATM Asp1853Asn and risk of radiotherapy adverse effects was found in any subgroup analysis. For TP53 Arg72Pro, variant C allele was associated with decreased radiotherapy adverse effects risk among Asian cancer patients in the stratified analysis by region (OR=0.71, 95%CI: 0.54-0.93, p=0.012). No significant results were found in the subgroup analysis of tumor type and time of appearance of side effects. Conclusions: The TP53 Arg72Pro C allele might be a protective factor of radiotherapy-induced adverse effects among cancer patients from Asia. Further studies that take into consideration treatment-related factors and patient lifestyle including environmental exposures are warranted.