• Korean Journal of Food Science and Technology
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• v.36 no.4
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• pp.677-682
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• 2004

Debates on safety of genetically modified (GM) crops have led to mandatory-labeling legislation of GM foods in many countries including Korea. Effects of heat, pressure, and acid treatments on degradation of DNAs or proteins in GM soybean at levels below detection limits of qualitative PCR and lateral flow strip test (LFST) methods were examined. Results showed that genomic DNAs and proteins were degraded into fragment sizes no longer possible for detection of inserted gene depending on thermal, or thermal and pressure treatment period. Detectaability of LFST for toasted meal increased in weakly treated soybean. DNA and protein detection methods were barely effective for detection of GM ingredient after $121^{\circ}C$ and 1.5 atmospheric treatment for 20 min. These results will be useful in determining GM labeling requirements of processed foods.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.2
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• pp.285-295
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• 2016

The post-evaluation system after construction projects can evaluate estimates of use demand, project cost, and project schedule estimated in the planning phase of construction projects in public sector. Thus, it was introduced in 2000 for the purpose of reduction in future errors during similar constructions by project orderer by referring the post-evaluation results. However, many barriers to the post-evaluation system after construction projects have been reported due to evaluation systems that lack objectivity and reliability and lack of main bodies that utilize the system. Thus, this study derived implications for improvements of the post-evaluation system in Korea by benchmarking building project evaluation system and management as well as utilization systems of developed nations. Then this study conducted a survey with experts who have experienced activities in the post-evaluation committee and members of post-evaluation for public project owners. Therefore it identified the need of installation of specialized post-evaluation institutions as well as functions and work tasks to be taken by specialized institutions. Based on the analysis results, this paper provided revision drafts of related legislations and guidelines to be effective in post-evaluation. Through the study results, many trial and errors can be reduced in similar projects in the future by performing in-depth analysis on large-scale construction projects and repeatedly applied building project practices can be improved to raise technical competitiveness if the specialized institution is installed.

• Journal of Ginseng Research
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• v.48 no.3
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• pp.298-309
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• 2024

Background: 20(S)-ginsenoside Rh2(GRh2), an effective natural histone deacetylase inhibitor, can inhibit acute myeloid leukemia (AML) cell proliferation. Lactate regulated histone lactylation, which has different temporal dynamics from acetylation. However, whether the high level of lactylation modification that we first detected in acute promyelocytic leukemia (APL) is associated with all-trans retinoic acid (ATRA) resistance has not been reported. Furthermore, Whether GRh2 can regulate lactylation modification in ATRA-resistant APL remains unknown. Methods: Lactylation and METTL3 expression levels in ATRA-sensitive and ATRA-resistant APL cells were detected by Western blot analysis, qRT-PCR and CO-IP. Flow cytometry (FCM) and APL xenograft mouse models were used to determine the effect of METTL3 and GRh2 on ATRA-resistance. Results: Histone lactylation and METTL3 expression levels were considerably upregulated in ATRA-resistant APL cells. METTL3 was regulated by histone lactylation and direct lactylation modification. Overexpression of METTL3 promoted ATRA-resistance. GRh2 ameliorated ATRA-resistance by downregulated lactylation level and directly inhibiting METTL3. Conclusions: This study suggests that lactylation-modified METTL3 could provide a promising strategy for ameliorating ATRA-resistance in APL, and GRh2 could act as a potential lactylation-modified METTL3 inhibitor to ameliorate ATRA-resistance in APL.

• Journal of Radiation Protection and Research
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• v.39 no.4
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• pp.159-167
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• 2014

In Korea, July 2012, the law as called 'Act on Safety Control of Radioactive Rays Around Living Environment' was implemented to control the consumer product containing Naturally Occurring Radioactive Material (NORM), but, there are no appropriate database and effective dose calculation system. The aim of this study was to develop evaluation technique of the exposure dose with the use of the consumer products containing NORM and to understand the characteristics of the exposed dose according to the radiation type and energy. For the evaluate of exposure dose, the ICRP reference phantom was simulated by the MCNPX code based on Monte Carlo method, and the minimum, medium, maximum energy of alphas, betas, gammas from the representative NORM of Uranium decay series were used as the source term in the simulation. The annual effective doses were calculated by the exposure scenario of the consumer product usage time and position. Short range of the alpha and beta rays are mostly delivered the dose to the skin. On the other hand, the gamma rays mostly delivered the similar dose to all of the organs. The results of the annual effective dose with $1Bq{\cdot}g^{-1}$ radioactive stone-bed and 10% radioactive concentration were employed with the usage time of 7 hours 50 minute per day, the maximum annual effective dose of alphas, betas, gammas were calculated 0.0222, 0.0836, $0.0101mSv{\cdot}y^{-1}$, respectively.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2C
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• pp.83-94
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• 2008

In this study an effective stress analysis was performed to evaluate liquefaction potential and ground settlement for reclaimed sites. The effective stress model can simulate the stiffness degradation due to excess pore pressure and resulting ground deformation. It is applicable to a wide range of strain. An equivalent linear analysis suitable for low strain levels was also carried out to compare the effective stress analysis. Shear stress ratio calculated from an equivalent linear analysis was used to determine SPT blow count to prevent liquefaction. Depending on the magnitude of potential earthquake and fine contents, the SPT blow count was converted into an equivalent cone tip resistance. It was compared with the measured cone tip resistance. The measured elastic shear wave velocity and cone tip resistance from two reclaimed sites in Incheon were used to perform liquefaction analyses. Two liquefaction evaluation methods showed similar liquefaction potential which was evaluated continuously. The predicted excess pore pressure ratio of upper 20 m was between 40% and 70%. The calculated post-shaking settlement caused by excess pore pressure dissipation was less than 10 cm.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.5A
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• pp.443-462
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• 2010

The strut-tie model approach has proven to be effective in the ultimate analysis and design of structural concrete with disturbed regions. For the reliable analysis and design by the approach, however, the effective strength of concrete struts must be determined accurately. In this study, the validity of the effective strength of concrete struts, presented by the several design codes and many researchers including the author, was examined through the ultimate strength analysis of 24 reinforced concrete panels, 275 reinforced concrete deep beams, and 218 reinforced concrete corbels by using the conventional linear strut-tie model approach of current codes. The present study shows that the author's approach, resulting in an accurate and consistent evaluation of the ultimate strength of the panels, deep beams, and corbels, may reflect rationally the effects of primary variables including the types of strut-tie model and structural concrete, the conditions of load and geometry, and the strength of concrete in the strut-tie model analysis and design of structural concrete.

• Journal of Korea Technology Innovation Society
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• v.12 no.4
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• pp.819-839
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• 2009

Proposed increases to the government's R&D budget should be discussed based on merits of meeting efficiency and effectiveness criteria. The evaluation of the national R&D budget and related programs are performed in two areas: a system of R&D budget coordination and allocation, and a system of R&D program performance. This paper mainly focuses on the operational areas of R&D budget evaluation system with a focus on their impact to efficiency and effectiveness. The core view point for a R&D budget evaluation system involves two directions: Firstly, to detail the relationships between the later stage (ex. post) activities such as, program survey, analysis, and program performance evaluation, with the budget evaluation. Secondly, to critically oversee all R&D coordination procedures with a different perspective. Budgeting is generally known as a serial process of policy making, planning and executing. It is highly desirable for the budget to be allocated to, and spent by, specific programs as planned, and that each plan be aligned with a specific policy. As such, a strong relevance between the program structure and budget code system is integral to successful execution. It should be performed using a decision making system which closely examines the link between policy and budget. It is also recommended that systematic relationships be maintained among budget coordination and allocation, performance evaluations of policy and program levels, and program survey and analysis system, and that their operational schedule should be reviewed comprehensively as a one integrated system. The National Science and Technology Council is expected to play a major and practical role as the center of policy planning and should be supported by the objective and unbiased system which covers overall process from policy making to program evaluation. Finally, increased utilization of contents, timely program survey and analysis, and accurate of activity scheduling of budget coordination and allocation, and diligent program performance evaluation all contribute towards a more efficient and effective overall evaluation system.

• Journal of Korean Library and Information Science Society
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• v.50 no.1
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• pp.293-312
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• 2019

The purpose of this study is to find ways to improve the evaluation system of school library operation whose participation rate is getting lower. We conducted analyzing the current status of operating evaluation of school libraries through literature search. In doing so, questionnaire method was conducted to inquire the recognition of the 205 staff members of school libraries. The outcome of the survey shows that the participation rate of operating evaluation of school libraries decreased from 22.2% in 2009 to 7.2% in 2017. The validity of the quantitative evaluation method was significantly low at 2.84 and the validity of the qualitative evaluation method was 2.97. The average score of the validity index for 'Establishing the annual operation plan' was the highest at 3.90, and that of 'Community service' was the lowest at 2.27. The biggest reason for not participating in the evaluation was due to the staff's high workload. There is a need to seek ways to improve the evaluation index and ways to participate since the result shows very low awareness of the school library evaluation. Through this study, it is expected that the school library evaluation will become the foundation for effective revitalization of school library operation.

• Journal of Advanced Navigation Technology
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• v.22 no.6
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• pp.566-576
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• 2018

The C-ITS requires the lane level positioning of the vehicle in the land transportation environment, and it is most effective to utilize the GNSS. In the precision positioning system based on satellite navigation, the evaluation of dynamic environment of lane level positioning performance should be accompanied and the evaluation system configuration should be preceded. In this paper, we selected performance indicators, assessment equipment, and reliability of reference equipment for evaluation of precision positioning user systems based on the GNSS. The performance evaluation system described above is applied to a real system, and the performance evaluation tool developed for the evaluation system is described. The numerical performance evaluation was carried out based on the data collected by carrying out the actual testbed driving. The performance evaluation by the actual driving trajectory and driving image comparison was performed to derive and analyse the evaluation results of the vehicle lane level positioning user system.

• Corrosion Science and Technology
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• v.4 no.3
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• pp.114-119
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• 2005

Since the degradation caused by corrosion is restricted to the surface of materials, conventional ultrasonic nondestructive evaluation methods based on ultrasonic bulk waves are not applicable to characterization of the corrosion degradation. To take care of this difficulty, a new nondestructive evaluation method that uses ultrasonic backward radiation has been proposed recently. This paper explores the potential of this newly developed method for nondestructive characterization and in-situ monitoring of corrosion degradation. Specifically, backward radiated ultrasounds from aged thermo-mechanically controlled process (TMCP) steel specimens by corrosion fatigue were measured and their characteristics were correlated to those of the aged specimens. The excellent correlation observed in the present study demonstrates the high potential of the backward radiated ultrasound as an effective tool for nondestructive characterization of corrosion degradation. In addition, the potential of the backward radiated ultrasound to in-situ monitoring of corrosion degradation is under current investigation.