• 한국경영과학회:학술대회논문집
• /
• 대한산업공학회/한국경영과학회 1990년도 춘계공동학술대회논문집; 한국과학기술원; 28 Apr. 1990
• /
• pp.299-311
• /
• 1990

A computer simulation model is proposed for selecting effective agrees paths and estimating the evacuation time in case of evacuating all the residents of a building to the safe area. The physical structure of a building is formulated into a network. The followings are considered in the model : the congestion effect to the velocity, the behavioral pattern of the evacuees, and the probabilistic nature of the evacuation process. Coded in SLAM II/PC, the simulation model can generate the output such as evacuation time(max, average), utilization of exits, utilization of passages, floor clearance times, and bottleneck information. The "rigorous" validation of the proposed model is not completed yet but remains to be a future research topic.rch topic.

• International Journal of Fluid Machinery and Systems
• /
• 제2권2호
• /
• pp.136-146
• /
• 2009

Small axial fans have become widely used as cooling devices in recent years. Because of their increasing importance, studies have been conducted on ways to improve the performance and reduce the noise of such fans. In this report, a small axial fan with a diameter of 85 mm (a type popularity used in personal computer or workstation) was selected for further examination. The influence on aerodynamic performance and noise of such frame design parameters as blade tip clearance results in a decrease of discrete frequency noise and an increase of broad-spectrum noise. As for the most suitable design refinement in terms of fan efficiency, we found that the treatment of outlet corner roundness and altering spoke skew to the direction counter to that of fan rotation was effective.

• 한국정밀공학회지
• /
• 제18권1호
• /
• pp.117-122
• /
• 2001

Many kinds of channels are used in industrial equipment and production machinery. Although mechanical saw has been used to cut many sorts of channels, there is cost rise problem because of low productivity. Shearing of channel has a special place because it helps to cut expected shape and size easily. A channel cutting die set which can be mounted and used on a hydraulic press is developed to improve the productivity of channel cutting process. Mode for the channel cutting is divided into single cut and double cut method. This study use double cut method, and the developed channel cutting die set is composed of upper and lower die set. Shearing time can be reduced from 40 minutes to 20 seconds using the developed channel cutting die set. The productivity of channel cutting process can be increased with shearing time reduction as well as cost reduction.

• Molecules and Cells
• /
• 제43권1호
• /
• pp.10-22
• /
• 2020

Mitochondria have several quality control mechanisms by which they maintain cellular homeostasis and ensure that the molecular machinery is protected from stress. Mitophagy, selective autophagy of mitochondria, promotes mitochondrial quality control by inducing clearance of damaged mitochondria via the autophagic machinery. Accumulating evidence suggests that mitophagy is modulated by various microbial components in an attempt to affect the innate immune response to infection. In addition, mitophagy plays a key role in the regulation of inflammatory signaling, and mitochondrial danger signals such as mitochondrial DNA translocated into the cytosol can lead to exaggerated inflammatory responses. In this review, we present current knowledge on the functional aspects of mitophagy and its crosstalk with innate immune signaling during infection. A deeper understanding of the role of mitophagy could facilitate the development of more effective therapeutic strategies against various infections.

• 한국임상약학회지
• /
• 제9권1호
• /
• pp.66-70
• /
• 1999

The effect of circadian rhythm on cyclosporine pharmacokinetics was studied in rabbits after oral administration of 10 mg/kg dose of cyclosporine at 10:00 a.m. and 10:00 p.m. The blood concentration data were subjected to simultaneous computer nonlinear least squares regression analysis using a 1-compartment pharmacokinetic model. The blood concentrations of cyclosporine at 10:00 a. m. were increased significantly during 2-6 hr compared to those at 10:00 p.m. The area under the blood concentration-time curve (AUC) and peak concentration $(C_{max})$ of cyclosporine at 10:00 a.m. were increased significantly compared to those at 10:00 p.m. The mean total body clearance (CL) of cyclosporine at 10:00 a.m. were decreased significantly compared to those at 10:00 p.m. It is reasonable to consider individual circadian rhythm for effective dosage regimen of cyclosporine in therapeutics.

• Design & Manufacturing
• /
• 제15권1호
• /
• pp.41-47
• /
• 2021

The Fine Blanking process is an effective precision shearing process that can obtain a smooth cutting surface and high product precision through a single blanking process. It is widely used in various manufacturing fields. However, shearing through this fine blanking process is only intended to minimize burrs, die rolls and fracture surfaces and does not completely remove them. Therefore, it is necessary to study the minimization of burrs, die rolls and fracture surfaces in the fine blanking process. In this study, a study was conducted on the relationship between the fracture surface and process conditions that occurred during product production using the fine blanking process. For this purpose, the shape of the V-ring indenter, the distance to the punch, and the pressure force, clearance, shear rate, and physical properties of the material were selected as process and design variables, and the relationship with the fracture surface according to each process and design condition was tested. It was analyzed through the Experimental Design Method.

• 무역학회지
• /
• 제45권2호
• /
• pp.17-29
• /
• 2020

This study analyzed that the effects of AEO MRA benefit on decreasing of trade cost and the strategies for expanding of trade. It uses the system GMM for effective solutions of endogenous matter with lagged dependent variable. In terms of the result of analysis, AEO MRA has a positive effect on decreasing of trade cost, especially this study proved the result of previous study AEO MRA expanded the trade through improving the time required for customs clearance and deregulation of non-tariff barriers. In conclusion, this study proposes the policy fo AEO MRA by analyzing the trade cost of AEO MRA by using the system GMM.

• Journal of Electrical Engineering and Technology
• /
• 제12권1호
• /
• pp.39-44
• /
• 2017

This paper proposes a novel approach to determine symmetrical components of power system by applying method of least squares in time domain. For the modern power system stability, clearance of faults on high voltage transmission lines in zero response time is crucial and important. Symmetrical components have a great attention since last century. They have been found an effective tool for the analysis of symmetrical and unsymmetrical faults in power system. Moreover, magnitude of symmetrical components are also used as a caution about faults in system. With rapid changes in technology, Microprocessor assumed to be fastest machine of the modern era. Hence microprocessor based techniques were developed and implemented for last few decades. The proposed technique apply least square method in the computation of symmetrical components which is suitable as an application in microprocessor based monitoring and controlling power system in order to avoid cascading failures. Simulation of proposed model is carried out in MATLAB/SIMULINK and all results exploit the validity of model.

• 대한조선학회논문집
• /
• 제46권5호
• /
• pp.460-470
• /
• 2009

In recent practice a half round prismatic bar has fillet welded or formed through foundry work along the centerline on rear concave surface of the horn to mitigate gap flow between fixed and movable part of the rudder system. When the gap clearance has been blocked with this practice, numerical simulations indicate that the practices are not only effective in reducing the gap flow but also in mitigating the cavitation. The blocking effects are remarkably improved when a pair of blocking bar is bisymmetrically attached with respect to centerline on the opposite convex surface of the movable part. The blocking bar could be placed on the exposed surface under maximum rudder angle. This implies that the blocking bar could be easily adopted not only in a design stage but also in a maintenance stage for mitigating rudder cavitation. In addition, the numerical simulations imply that more improvements could be anticipated through the selection of section shape of prismatic bar for gap flow blocking.

• 한국해양공학회지
• /
• 제23권3호
• /
• pp.30-34
• /
• 2009

Oil hydraulic piston pumps are being extensively used in the world, because of simple design, light weight and effective cost etc. An oil hydraulic pump is likely to have serious problems of high leakage, friction and low energy efficiency according to large time use. In the oil hydraulic piston pumps the clearance between the valve block and piston plays an important role for volumetric and overall efficiency. In this paper, the wear property of the SACM645 material used the hydraulic piston pump has been work out by experimentation with variable heat treatment. To investigate the effect according to the piston surface condition, seven different types specimen were prepared. From the wear test results, induction hardening and nitration were definitely superior to the others. On the whole, nitration was estimated for high strength material to wear resistance.