• 생물정신의학
• /
• 제4권2호
• /
• pp.251-258
• /
• 1997

The dysfunction of either or both noradrenaline and serotonin system are important in the pathophysiology of depression. Previous reports have suggested that there may be an important interaction between these two systems. Recently, some investigators have suggested that the combination of tricyclic antidepressants(TCAs) and selective serotonin reuptake inhibitors(SSRIs) would produce a rapid synergistic effect on down-regulation of either or both of these two systems and that this combination may produce a more rapid and absolute antidepressant effect. We compared the treatment efficacy, treatment associated side effects, treatment satisfaction, and the quality of life between the combination therapy of dothiepin-sertraline as well as the therapy of dothiepin alone in the treatment of major depressive disorder and dysthymic disorder. In our study, the combination therapy of dothiepin and sertraline produced a more rapid and absolute antidepressant effect than dothiepin alone. And the patients with combination therapy experienced relatively high treatment satisfaction than the patients with dothiepin therapy. The patients' quality of life improved more rapidly in the combination therapy, especially, in the health perception, social behavior, and life satisfaction, than dothiepin alone. These results support the hypothesis that the combination of TCA and SSRI may produce a rapid synergistic effect on either or both norepinephrine and serotonin system, and more rapid antidepressant effect and high treatment satisfaction.

• 한국환경보건학회지
• /
• 제27권4호
• /
• pp.93-98
• /
• 2001

Wastewaters produced in textile industrial processes contain dyes which are not easily amenable to biological treatment. The object of this study is to determine the post-treatment system of biological process for the textile wastewater by comparing three different types of chemical process, which were 1) post-treatment by ozone or UV, 2) post-treatment by coagulation,3) post-treatment by ozone or UV followed by coagulation. In an application ozone or UV as a post-treatment, color was generally decreased with time, however, SCOD removal effect was not that good. When coagulation was used as point-treatment process, the effluent quality was satisfying. Therefore, the application of coagulation process as a post-treatment of biological process would be more desirable than that as a ozone or UV.

• Biomolecules & Therapeutics
• /
• 제19권1호
• /
• pp.84-89
• /
• 2011

The present study was undertaken to determine whether combined treatment with prokinetic trimebutine and mosapride has a synergic effect on gastrointestinal motility and visceral pain associated with gastrointestinal dysfunction. To develop effective gastroprokinetic agents with greater potencies than trimebutine or mosapride for the treatment of gastrointestinal tract disease, a mixture of trimebutine and mosapride was designed and prepared. In the present study, treatment with trimebutine alone showed a dose-dependent effect on propelling movements of normal small and large intestine in mice, whereas mosapride effected only small intestine motility. Co-administration of trimebutine with mosapride, a well-established prokinetic drug, produced a synergistic influence on normal small intestine motility, but demonstrated an unclear effect on large intestine motility, with a slight tendency to reduce the propelling time. In a stress model, the small and large intestine motilities were significantly decreased. The reduction of intestine motility was restored to a normal level and the restoring effect was more pronounced in the combined treatment with trimebutine plus mosapride than treatment with trimebutine or mosapride alone. Furthermore, treatment with trimebutine plus mosapride significantly decreased acute visceral pain which was not controlled by trimebutine or mosapride alone. These data suggest that combination therapy with trimebutine plus mosapride has a synergic effect on small and large intestine motility and visceral pain control in gastrointestinal disorders.

• 한국의학물리학회지:의학물리
• /
• 제33권4호
• /
• pp.101-107
• /
• 2022

Purpose: Radiotherapy after bladder filling protocol (BFP) is known to enhance treatment quality and reduce side effects in prostate cancer, a common male solid cancer globally. However, due to the need to hold back urine during treatment, patients frequently complain of discomfort, and treatment is frequently suspended when patients urinate during treatment and urine penetrates the treatment device, causing malfunction. Therefore, the effect of minimizing treatment time when partial-arc volumetric modulated arc therapy (VMAT) was used instead of full-arc was assessed in this study. Methods: A total of 70 plans were created in 10 patients using 7 different arc sizes, and the treatment time for each plan was calculated. Results: Reduced arc size by half resulted in a 54.4% decrease in mean treatment duration, with a proportional tendency observed. Furthermore, the effect of VMAT arc size reduction on target dose homogeneity was significantly limited, and the effect on surrounding organs at risk (OAR) was negligible. It should be noted, however, that when the arc size decreases by >40%, the dose increases in the area without OAR around the target. Conclusions: The results of this study demonstrated that partial-arc VMAT for enhancing treatment convenience and efficacy of prostate cancer patients undergoing BFP can achieve a considerable reduction in treatment time while preserving treatment quality, and it is expected to be useful for partial-arc VMAT plan design and implementation in practice.

• 동의생리병리학회지
• /
• 제20권3호
• /
• pp.596-602
• /
• 2006

This study evaluated neuroprotective effect of Sunghyangjungki-San (SHS) on the focal cerebral ischemia. The rats were induced infarct in cerebral cortex and caudoputamen by using temporal occlussion of the middle cerebral artery (MCAO), then water extract of SHS was treated for MCAO rats. Neuroprotective effect was evaluated by neurological score, infarct sizes and total volume, positive neurons against Bax, Caspase-3, HSP-72, and $HIF-1{\alpha}$ in infarct area with immunohistochemistry. The results obtained were as follows: Treatment of SHS improved neurological score of MCAO rats, but there was not a statistical significance. Treatment of SHS reduced significantly infarct sizes in the brain sections of MCAO rats. Treatment of SHS reduced significantly total volume of infarct of MCAO rats. Treatment of SHS reduced significantly Bax positive neurons in penumbra of cerebral cortex of MCAO rats. Treatment of SHS reduced significantly Caspase-3 positive neurons in caudoputamen and penumbra of cerebral cortex of MCAO rats. Treatment of SHS reduced significantly HSP-72 positive neurons in penumbra of cerebral cortex of MCAO rats. Treatment of SHS reduced significantly $IF-1{\alpha}$ positive neurons in penumbra of cerebral cortex of MCAO rats.

• 동력기계공학회지
• /
• 제21권5호
• /
• pp.13-19
• /
• 2017

The effect of heat treatment temperature (HTT) on the mechanical properties of polyacrylonitrile (PAN)-based carbon fiber had been investigated. The heat treatment on the carbon fiber was conducted under high vacuum atmosphere of $10^{-6}mmHg$, and the range of temperature of $1,000^{\circ}C$ to $2,000^{\circ}C$. As a results, The tensile strength of carbon fiber and carbon fiber composites showed increasing tendency with the rise of heat treatment temperature. And, the shape parameter of Weibull distribution for the strength of carbon single fiber showed an increasing trend until $1,800^{\circ}C$. But the shape parameter of Weibull distribution for the strength of carbon fiber composites showed no clear tendency with the rise of heat treatment temperature. The cause of reinforcement effect of the carbon fiber by the heat treatment was regarded as the carbonization of carbon single fiber.

• 열처리공학회지
• /
• 제6권4호
• /
• pp.185-193
• /
• 1993

The effect and Condition of heat treatment on the tensile strength of welded joint was investigated in 300 grade 18% Ni-Co-Mo-Ti maraging steel sheets welded with electron beam. A good tensile strength of welded joint was obtained by following heat treatment cycle ; At $1100^{\circ}C$ the specimen was high temperature solution treated for 1 hour and then it was repeated solution treated at $900^{\circ}C$, $820^{\circ}C$ for 1 hour respectively to recrystallize the coarsened ${\gamma}$ grain. These heat treatment cycle was completed by an final aging heat treatment at $480^{\circ}C$ for 4 hour. Moreover, dissolution of dendrite, a significant decrease in seregation of Mo, Ti in weld metal were observed and also the coarsened ${\gamma}$ grain formed at $1100^{\circ}C$, $1200^{\circ}C$ changed to fine grain due to the effect of recrystallization.

• 한국재료학회지
• /
• 제26권5호
• /
• pp.287-291
• /
• 2016

The effect of heat treatment on the microstructure and mechanical properties of cast Ti-6%Al-4%V alloy was investigated. Heat treatment of cast Ti-6Al-4V alloy was conducted by solution treatment at $950^{\circ}C$ for 30 min; this was followed by water quenching and then aging at $550^{\circ}C$ for 1 to 1440 min. The highest hardness of the heat-treated specimens was obtained by solution treatment and subsequent aging for 5 min due to precipitates of fine ${\alpha}$ that formed from retained ${\beta}$ phase. The tensile strength of this alloy increased without dramatic decrease of the ductility due to microstructural refinement resulting from the decomposition of ${\alpha}^{\prime}$ martensite into fine ${\alpha}$ and ${\beta}$ phases, and also due to the fine ${\alpha}$ phase formed from the retained ${\beta}$ phase by aging treatment for 5 min. In addition, this strengthening might be caused by the transformation induced plasticity (TRIP) effect, which is a strain-induced martensite transformation from the retained ${\beta}$ phase during deformation, and which occurs even after aging treatment at $550^{\circ}C$ for 5 min.

• 대한한방소아과학회지
• /
• 제25권3호
• /
• pp.12-26
• /
• 2011

Objectives: The purpose of this study is to investigate the effect of traditional Korean medical treatment; acupuncture and herb therapy in pediatric allergic rhinitis patients. Methods: This study population was 69 pediatric allergic rhinitis patients who had been treated in ${\bigcirc\bigcirc}$ hospital. All the patients were asked to answer the questionnaires that consist of 10 questions about symptoms of allergic rhinitis. Results: 1. The total scores from the same questionnaire about allergic rhinitis symptoms were significantly improved after the treatment compared to the scores before the treatment(p<0.01). 2. The Nasal symptom, especially, nasal obstruction rhinorrhea had significantly improved in all groups of patients(p<0.01). 3. The effect of the treatment was better with spending more time with acupuncture. Conclusions: Traditional Korean medical treatment is relatively effective in treating pediatric allergic rhinitis.

• 대한약침학회지
• /
• 제9권1호
• /
• pp.95-101
• /
• 2006

Objectives : This study was to investigate the effect of National Health Services for obesity patients by oriental medical treatment. Methods : We analyzed 46 obesity patient joined to Oriental Treatment for Obesity in Sunchang Medical Center with BCA(bocy component analysis), after we had treated them with our obesity program. We analyzed changes of BCA during before and after treatment, and analyzed items in BCA are weight(kg), amount of muscle(kg), amount of body fat(kg), body fat rate(%) and BMI(body mass index). Results : 1. Weight, amount of muscle, amount of body fat, body fat rate and BMI were decreased in after treatment, but they didn't have statistical significance. 2. This studies suggest oriental treatment for obesity may be an effective overweigh group(BMI $25{\sim}30$), because it had statistical significance(P<0.05). 3. It appears that oriental treatment for obesity have an effect in National Health Services