• Animal cells and systems
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• v.3 no.4
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• pp.375-383
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• 1999

Gonadal development, gametogenesis, reproductive cycle, and first sexual maturity of Reishia clavigera were investigated monthly from July 1998 to June 1999 through cytological and histological observations. R. clavigera had separate sexes, and was an internal fertilizer. The ma1e penis was located near the two tentacles. The ovary and testis were composed of a great number of oogenic lobules and spermatogenic tubules, respectively. The size of ripe oocyte ranged from 130 to 140 ${\mu}$m in diameter. The peripheral cytoplasm of the germinal vesicle of the ripe oocyte in many cases were surrounded by smaller yolk granules, while the eccentric cytoplasm was occupied with larger ones. The reproductive cycle of R. clavigera could be classified into five successive stages: early active, late active, ripe, spawning, and recovery. Spawning of females occurred from early July to August when the seawater reached above 24.8$^{\circ}C$. Spawning of males occurred from early June to August in the water above 22.8$^{\circ}C$. Minimum size for sexual maturity of both sexes was above 10.0 mm in shell height. Each egg capsule was a cylinder or spindle in shape, 4-6 mm in length and 1-2 mm in width. Colors of newly spawned egg capsules showed yellowish white or pale yellow, while those with veliger larvae showed pale black, and released larvae or dead egg capsules showed black violet. The fecundity in an egg capsule ranged from 70 to 91 eggs (mean＝80.28 eggs).

• Animal cells and systems
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• v.16 no.6
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• pp.431-437
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• 2012

Calpains are a class of proteins that belong to the calcium-dependent, non-lysosomal cysteine proteases. There are three major types of calpains expressed in the skeletal muscle, namely, ${\mu}$-calpain, m-calpain, and calpain 3, which show proteolytic activities. Skeletal muscle fibers possess all three calpains, and they are $Ca^{2+}$-dependent proteases. The functional role of calpains was found to be associated with apoptosis and myogenesis. However, calpain 3 is likely to be involved in sarcomeric remodeling. A defect in the expression of calpain 3 leads to limb-girdle muscular dystrophy type 2A. Calpain 3 is found in skeletal muscle fibers at the N2A line of the large elastic protein, titin. A substantial proportion of calpain 3 is activated 24 h following a single bout of eccentric exercise. In vitro studies indicated that calpain 3 can be activated 2-4 fold higher than normal resting cytoplasmic [$Ca^{2+}$]. Characterization of the calpain system in the developing muscle is essential to explain which calpain isoforms are present and whether both ${\mu}$-calpain and m-calpain exist in differentiating myoblasts. Information from such studies is needed to clarify the role of the calpain system in skeletal muscle growth. It has been demonstrated that the activation of ubiquitous calpains and calpain 3 in skeletal muscle is very well regulated in the presence of huge and rapid changes in intracellular [$Ca^{2+}$].

• Earthquakes and Structures
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• v.7 no.1
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• pp.39-55
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• 2014

A modified procedure is presented for assessing the seismic response of elastic non-proportionate multistory buildings. This procedure retains the simplicity of the methodology presented by the author in earlier papers, but it presents higher accuracy in buildings composed by very dissimilar types of bents. As a result, not only frequencies and peak values of base resultant forces are determined with higher accuracy, but also the location of the first mode center of rigidity (m1-CR). The closeness of m1-CR with the axis passing through the centers of floor masses (mass axis) implies a reduced rotational response and it is demonstrated that in elastic systemsa practically translational response is obtained when this point lies on the mass axis.Besides, when common types of buildings are detailed as planar structures under a code load, this response is maintained in the inelastic phase of their response as a result of the almost concurrent yielding of all the resisting bents. This property of m1-CR can be used by the practicing engineer as a guideline to form a structural configuration which will sustain minimum rotational response, simply by allocating the resisting elements in such a way that this point lies close to the mass axis. Inelastic multistory building structures, detailed as above, may be regarded as torsionally balanced multistory systems and this is demonstrated in eight story buildings, composed by dissimilar bents, under the ground motions of Kobe 1995 (component KJM000) and Friuli 1976 (component Tolmezzo E-W).

• Journal of the Korean Society of Safety
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• v.37 no.4
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• pp.101-112
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• 2022

Expanding urbanization practices result in high numbers of buildings being developed in city centers. This high building concentration leads to an increased fire risk, resulting in higher casualty rates and increased economic damages compared to fires in the past. The purpose of this study was to analyze the structural behavior of fire-damaged reinforced concrete buildings using analytical methods and to suggest methods of improving fire resistance in the event of a fire. Damage levels were measured using commercial software to apply the finite element method, ABAQUS, and MIDAS GEN to the dataset. Load-deflection curves were calculated using the effective area and moment of inertia of the fire-damaged columns provided by ABAQUS. The results of this analysis indicate that fire-damaged beams with experience greater deflection from indoor fires than they will from outdoor fires. Fires that occurred on the middle floors were more dangerous than those occurring on higher floors, and eccentrically loaded columns experienced more damage than axially loaded columns. The results indicate that these methods accurately predict structural behaviors of fire damaged concrete columns by considering fire exposure area and eccentric loading.

• Smart Structures and Systems
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• v.28 no.6
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• pp.827-838
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• 2021

The dynamic displacement is considered to be an important indicator of structural safety, and becomes an indispensable part of Structural Health Monitoring (SHM) system for high-speed railway bridges. This paper proposes an indirect strain based dynamic displacement reconstruction methodology for high-speed railway box girders. For the typical box girders under eccentric train load, the plane section assumption and elementary beam theory is no longer applicable due to the bend-torsion coupling effects. The monitored strain was decoupled into bend and torsion induced strain, pre-trained multi-output support vector regression (M-SVR) model was employed for such decoupling process considering the sensor layout cost and reconstruction accuracy. The decoupled strained based displacement could be reconstructed respectively using box girder plate element analysis and mode superposition principle. For the transformation modal matrix has a significant impact on the reconstructed displacement accuracy, the modal order would be optimized using particle swarm algorithm (PSO), aiming to minimize the ill conditioned degree of transformation modal matrix and the displacement reconstruction error. Numerical simulation and dynamic load testing results show that the reconstructed displacement was in good agreement with the simulated or measured results, which verifies the validity and accuracy of the algorithm proposed in this paper.

• Steel and Composite Structures
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• v.43 no.4
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• pp.483-500
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• 2022

Cold-formed steel wall panels sheathed with gypsum plasterboard have shown superior thermal and structural performance in fire. Recent damage caused by fire events in Australia has increased the need for accurate fire resistance ratings of wall systems used in low- and mid-rise construction. Past fire research has mostly focused on light gauge steel framed (LSF) walls under uniform axial compression and LSF floors under pure bending. However, in reality, LSF wall studs may be subject to both compression and bending actions due to eccentric loading at the wall to-roof or wall-to-floor connections. In order to investigate the fire resistance of LSF walls under the effects of these loading eccentricities, four full-scale standard fire tests were conducted on 3 m × 3 m LSF wall specimens lined with two 16 mm gypsum plasterboards under different combinations of axial compression and lateral load ratios. The findings show that the loading eccentricity can adversely affect the fire resistance level of the LSF wall depending on the magnitude of the eccentricity, the resultant compressive stresses in the hot and cold flanges of the wall studs caused by combined loading and the temperatures of the hot and cold flanges of the studs. Structural fire designers should consider the effects of loading eccentricity in the design of LSF walls to eliminate their potential failures in fire.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.7
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• pp.693-700
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• 2015

To estimate the fatigue crack propagation behavior of compact tension shear (CTS) specimen under mixed-mode loads, crack path prediction theories and Tanaka's equation were applied. The stress intensity factor at a newly created crack tip was calculated using a finite element method via ANSYS, and the crack path and crack increment were then obtained from the crack path prediction theories, Tanaka's equation, and the Paris' equation, which were preprogrammed in Microsoft Excel. A new method called the finite element crack tip updating method (FECTUM) was developed. In this method, the finite element method and Microsoft Excel are used to calculate the stress intensity factors and the crack path, respectively, at the crack tip per each crack increment. The developed FECTUM was applied to simulate the fatigue crack propagation of a single-edge notched bending (SENB) specimen under eccentric three-point bending loads. The results showed that the number of cycles to failure of the specimen obtained experimentally and numerically were in good agreement within an error range of less than 3%.

• The Journal of Engineering Geology
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• v.23 no.2
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• pp.127-136
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• 2013

We analyzed the patent trends for whole drilling bits to reveal the main R&D directions, focusing on patents applied for and registered in Korea, the USA, Japan, and Europe. The technology was classified into two groups as a primary classification step (reaming systems and fixed systems), and into seven groups as a secondary classification step (sliding, odex, horizontal pivot, vertical pivot, concentric, eccentric, and etc.). A total of 33,614 patents were retrieved and 870 patents were selected for final effective analysis by data deduplication and filtering. A portfolio analysis using the correlation between the number of patents and the applicants for each patents revealed a sliding system as the key technology with greatest growth potential. From an analysis of the barriers to patents being granted, we emphasize the need to avoid similar topics existing patents or patent applications and to develop differential technology.

• Smart Structures and Systems
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• v.26 no.3
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• pp.373-390
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• 2020

Hybrid simulation (HS) is a versatile tool for structural performance evaluation under dynamic loads. Although real structural responses are often multiple-directional owing to an eccentric mass/stiffness of the structure and/or excitations not along structural major axes, few HS in this field takes into account structural responses in multiple directions. Multi-directional loading is more challenging than uni-directional loading as there is a nonlinear transformation between actuator and specimen coordinate systems, increasing the difficulty of suppressing loading error. Moreover, redundant actuators may exist in multi-directional hybrid simulations of large-scale structures, which requires the loading strategy to contain ineffective loading of multiple actuators. To address these issues, lately a new strategy was conceived for accurate reproduction of desired displacements in bi-directional hybrid simulations (BHS), which is characterized in two features, i.e., iterative displacement command updating based on the Jacobian matrix considering nonlinear geometric relationships, and force-based control for compensating ineffective forces of redundant actuators. This paper performs performance validation and application of this new mixed loading strategy. In particular, virtual BHS considering linear and nonlinear specimen models, and the diversity of actuator properties were carried out. A validation test was implemented with a steel frame specimen. A real application of this strategy to BHS on a full-scale 2-story frame specimen was performed. Studies showed that this strategy exhibited excellent tracking performance for the measured displacements of the control point and remarkable compensation for ineffective forces of the redundant actuator. This strategy was demonstrated to be capable of accurately and effectively reproducing the desired displacements in large-scale BHS.

• Earthquakes and Structures
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• v.8 no.2
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• pp.305-377
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• 2015

The problem of earthquake induced torsion in buildings is quite old and although it has received a lot of attention in the past several decades, it is still open. This is evident not only from the variability of the pertinent provisions in various modern codes but also from conflicting results debated in the literature. Most of the conducted research on this problem has been based on very simplified, highly idealized models of eccentric one-story systems, with single or double eccentricity and with load bearing elements of the shear beam type, sized only for earthquake action. Initially, elastic models were used but were gradually replaced by inelastic models, since building response under design level earthquakes is expected to be inelastic. Code provisions till today have been based mostly on results from one-story inelastic models or on results from elastic multistory idealizations. In the past decade, however, more accurate multi story inelastic building response has been studied using the well-known and far more accurate plastic hinge model for flexural members. On the basis of such research some interesting conclusions have been drawn, revising older views about the inelastic response of buildings based on one-story simplified model results. The present paper traces these developments and presents new findings that can explain long lasting controversies in this area and at the same time may raise questions about the adequacy of code provisions based on results from questionable models. To organize this review better it was necessary to group the various publications into a number of subtopics and within each subtopic to separate them into smaller groups according to the basic assumptions and/or limitations used. Capacity assessment of irregular buildings and new technologies to control torsional motion have also been included.