• Title/Summary/Keyword: early intervention

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Pharmacological Action of Radix Scutellariae on Nicotine-Induced Locomotor Activity and C-Fos Expression in Rats. (황금의 니코틴 약물투여에 의한 유전자 발현과 행동적 변동에 미치는 약리작용)

  • Lee Bom-Bi;Chae Youn-Byoung;Kwon Young-Kyu;Yang Chae-Ha;Kim Mi-Ryeo;Kim Kwang-Jung;Seo Yong-Min;Kim Jang-Hyun;Hahm Dae-Hyun;Lee Hye-Jung;Pyun Kwang-Ho;Shim In-Sop
    • The Journal of Korean Medicine
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    • v.26 no.3 s.63
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    • pp.1-12
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    • 2005
  • Objectives : Substantial evidence suggests that reinforcing effects of nicotine can be mediated by the mesolimbic dopaminergic system. It has been shown that repeated injections of nicotine produce an increase in locomotor activity and expression of the immediate-early gene, c-fos, in the dopaminergic target areas. Herbal medicine as a therapeutic intervention has been widely used for the treatment of mental dysfunction. Many studies have shown that Radix Scutellariae (RS) can affect the biochemical balance in the central nervous system. Tn order to investigate whether RS has an influence on nicotine-induced behavioral sensitization, we examined the effect of RS on nicotine-induced locomotor activity and c-fos expression in the striatum and nucleus accumbens utilizing the fos-tike immunohistochemistry (FLI). Methods : Male SD rats received RS (200mg/kg, i.p.) 30min before repeated daily injections of nicotine (0.4mg/kg, s.c.) for 7 days. This was followed by withdrawal for 3 days and one challenge for 1 day. Results : System challenge with nicotine produced a much larger increase in locomotor activity and accumbal FLI. Pretreatment with RS significantly inhibited nicotine-induced locomotor activity and FLI in the striatum and nucleus accumbens. Conclusions : These results demonstrate that reduction in locomotor activity by RS may be reflected by reduction of dopamine release and postsynaptic neuronal activity in the striatum and nucleus accumbens. Our results suggest that RS may have therapeutic effect on nicotine addiction.

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The Current Status and Implications of Disaster Management System and Psychological Support System in Disaster Response in Japan (일본의 재난관리체계 및 재난심리지원체계 고찰과 시사점)

  • Lee, Dong-Hun;Kim, Jiyoon;Kang, Hyun-Suk;Lee, Hye-Rim
    • The Journal of the Korea Contents Association
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    • v.16 no.7
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    • pp.73-90
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    • 2016
  • The purpose of this study is to contribute to developing psychological support system in disaster response of South Korea by examining that of Japan. Psychosocial support from the Red Cross with the psychiatric support by the DPAT from local government were achieved in the early stage of disaster psychology support system in Japan. In the long term intervention after disaster, psychiatric support from Kokoro-no care center has been established. In other words, not only traditional mental health approach but also disaster psychology support activities including psychosocial support are deployed. National Information Center of Disaster Mental Health, which is control tower of disaster psychology support, understand the disaster in the level of nationwide through collecting and analyzing the data related to disaster, and manage disaster psychological support activities. Disaster psychology support system in Japan modified problems immediately during large scale disaster that they are equipped with state of the current. Implications for disaster psychological support system and crisis counseling program in South Korea are discussed.

The Diagnosis and Treatment of Osteoporosis (골다공증의 진단과 치료)

  • Moon, Jun-Sung;Won, Kyu-Chang
    • Journal of Yeungnam Medical Science
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    • v.25 no.1
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    • pp.19-30
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    • 2008
  • Osteoporosis, a disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and fracture risk, is a major public health problem. The diagnostic methods for osteoporosis include simple radiography, bone scan, DXA (Dual energy X-ray Absortiometry) and biochemical markers of bone turnover. Optimal treatment and prevention of osteoporosis require modification of risk factors, particularly smoking cessation, adequate physical activity, and attention to diet, in addition to pharmacologic intervention. The estrogens and raloxifene both prevent bone loss in postmenopausal women, and the estrogens probably also decrease the risk of first fracture. There is good evidence that raloxifene prevents further fractures in postmenopausal women who already have had fractures and some evidence that estrogen does as well. Bisphosphonate prevents bone loss and reduces fractures in healthy and osteoporotic postmenopausal women and in osteoporotic men as well. Risedronate is more potent and has fewer side effects than alendronate and reduces the incidence of fractures in osteoporotic women. Calcitonin increases bone mineral density in early postmenopausal women and men with idiopathic osteoporosis, and also reduces the risk of new fractures in osteoporotic women. All of the agents discussed above prevent bone resorption, whereas teriparatide and strontium increase bone formation and are effective in the treatment of osteoporotic women and men. New avenues for targeting osteoporosis will emerge as our knowledge of the regulatory mechanisms of bone remodeling increases, although issues of tissue specificity may remain to be addressed.

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Minimal Invasive Plate Osteosynthesis in Proximal Humerus Fractures (상완골 근위부 골절에서의 최소 침습적 금속판 술식)

  • Shin, Sang-Jin;Do, Nam-Hun;Song, Mi-Hyun;Sohn, Hoon-Sang
    • Clinics in Shoulder and Elbow
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    • v.13 no.2
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    • pp.202-208
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    • 2010
  • Purpose: In this study we introduced minimal invasive plate osteosynthesis (MIPO) and analyzed clinical outcomes to determine the effectiveness of this intervention in proximal humerus fractures. Materials and Methods: We studied 27 patients including 16 cases with a 2-part fracture, 10 cases with a 3-part fracture, and 1 case with a 4-part fracture. Clinical outcomes were evaluated using UCLA score, KSS score and recovery of range of motion. Time to union and humerus neck-shaft angle change were estimated by radiologic assessment. The average follow up period was 19 months. Results: UCLA scores were "excellent" for 15 patients, "good" for 12 patients. The mean KSS score was 91.4 at final follow-up. The average shoulder range of motion was $167.2^{\circ}$ in forward elevation. Bone union occurred by 14.1 weeks postoperatively. Humerus neck-shaft angle recovery was "excellent" in 24 patients and "moderate" in 3 patients. There were no complications such as axillary nerve paralysis, deep infection, or subacromial impingement of the plate. Conclusion: MIPO for proximal humerus fractures is an effective procedure if performed with sufficient understanding of the anatomical structures. MIPO leads to minimized dissection of soft tissue, low complication rates and early recovery of range of motion.

The New International Division of Labor:Re-evaluation (신국제노동분업의 재평가)

  • 고태경
    • Journal of the Korean Regional Science Association
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    • v.11 no.1
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    • pp.79-91
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    • 1995
  • As an exit to solve the economic depression of the development countries in the early twentieth century, the 'old international division of labor' developed. The economic crisis(i.e., under-consumption crisis) was due to the absence of the mode of regulation compatible with the extensive regime of accumulation(i.e., "Fordist" regime). The crisis was solved by the state intervention through the creation on institutions in order to increase the level of consumption. Until the late 1960s when "high Fordism" reached(i.e., a harmonious relation between the monopoly mode of regulation and the intensive accumulation of capital), the developed core countries enjoyed a remarkable economic growth. The external market was not a necessity for the economic growth because there were increases in labor productivity and proportional increases in real wages and thus increases in consumption level. In the 1970s, however, the core faced with economic crisis again. Due to the breakdown of the postwar "Fordist" regime of capital accumulation and the post 1973 world depression, the core needed the Third World as a solution for their internal and international economic crisis. Thus the 'new international division of labor'(NIDL) arose. The "Fordist" method of production(i.e., the divisions of production process) led to the territorial division of labor and to the detailed division of labor. The aim of the NIDL is to exploit reserve armies of labor on a world scale and thus to reduce production costs. According to the NIDL model, the Third World countries have been developing by the core countries' investment on mainly labor-intensive industries and thus have been playing an important role in the global economy. And the NIDL theorists argue that multinational corporations have increasingly invested in the Third World nations and contributed to the economic growth in those regions. Tables presented in the paper show that the global trend since the 1970s does not follow the argument exactly as the NIDL theorists predicted. On the contrary, the core countries focus on developing technology, adopting the automation of production process, and trading within the core countries rather than on investing in the periopheral countries. The continuing investment of multinational corporations into the periphery is not because of cheap labor force but because of the market potentials in the regions. Majority of corporations of the core tries to reduce production costs by investing in technological development more intensively and also by changing regional strategies (i.E., investment from metropolitan areas to medium - or small - size cities, focusing on agglomeration economy, boosting regional diversification, etc.) within their own countries. The main purpose of the paper is to review and to criticize the NIDL theory based on some empirical data.IDL theory based on some empirical data.

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PRE-ORTHODONTIC TREATMENT WITH MYOFUNCTIONAL APPLIANCE (근기능장치를 이용한 교정 전 치료)

  • Kim, Min-Soo;Yoo, Seung-Hoon;Kim, Jong-Soo
    • Journal of the korean academy of Pediatric Dentistry
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    • v.32 no.4
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    • pp.620-627
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    • 2005
  • The purposes of early orthodontic intervention are to correct obvious problems, to intercept developing problems and prevent them from becoming worse. Myofunctional influence on facial growth and the dentition change in muscle function and initiate morphologic variation in the normal configuration of the teeth and enhance an already existing malocclusion. Myofunctional therapy has been advocated since 1960's as the treatment for tongue thrust and other oral habits. Pre-orthodontic $TRAINER^{(R)}$ is introduced as functional device usable in children of mixed dentition to correct functional problems concerning soft tissue, tooth and skeleton. The most common cases to treat with Pre-orthodontic $TRAINER^{(R)}$ are lower anterior crowding, anterior open bite, Class II malocclusion and deep bite. Also, it can be used as correction of oral habits. Patients in this cases visited Department of Pediatric Dentistry, School of dentistry, Dankook University for orthodontic treatment. Pre-orthodontic treatment with Pre-orthodontic $TRAINER^{(R)}$ was carried out for correction of the oral habits.

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Examining Children's Peer - relationship Strategies of Free Play in a Child-care Center (어린이집의 자유놀이에서 놀이 틀 유지와 변화를 위한 유아의 또래관계 전략들)

  • Jeon, Ga Il;Yi, Soon Hyung
    • Korean Journal of Childcare and Education
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    • v.9 no.5
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    • pp.407-436
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    • 2013
  • This study, based on understanding the play features of the participants, explores early children's peer-relation strategies of maintaining and altering play frame and understanding the meaning of the strategies. Free play of 5-year-old children's was observed. The child-care center was visited 1 or 2 days a week, from March to October, 2012. The data collected were based from field notes, interviews with participants, their workbooks and more. The participants used strategies such as 'refusing', 'incapacitating', 'interpreting in a way to sympathize', and 'changing the rules of play' to maintain the play, whilst 'tell-on', 'being on the same side', 'accepting 3rd party' features were used to alter play frame. Participants using these various play-frame strategies experienced life implications of 'dialectic of exclusion and selection' and 'quiver of boundary'. This study, specifying efforts of the children to maintain and alter the play frame, will provide an understanding of perception of "social exclusion" to children, which has been viewed negatively in the past. It will also benefit on-site teachers in helping them understand peer-relationship within children and provide a more in-depth intervention for peer-relationship issues.

Maternal Age and Infant Mortality in Korea (산모 연령과 영아 사망과의 관련성 연구)

  • Hong, Jae-Seok
    • Journal of Digital Convergence
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    • v.14 no.9
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    • pp.379-387
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    • 2016
  • The purpose of this study was to examine the relationship between maternal age and infant mortality in Korea(n=617,867). Data of Korean vital statistics linked National Infant Mortality Survey conducted on births in 1999 were used in this study. The odds ratios (ORs) of infant death by maternal age were estimated with the multiple logistic regression model, adjusting for gender, plurality, birth order, low birth weight, and congenital malformation. After adjusting for the relevant variables, the odds of infant death in the group of maternal age with less than 20 years(Odds ratio [OR], 5.29, 95% confidence interval [CI], 3.51-7.98), 20-24 years(OR, 1.44, 95% CI, 1.23-1.69), 35-39 years(OR, 1.28, 95% CI, 1.11-1.46), and more than 40 years(OR, 1.94, 95% CI, 1.53-2.45) was higher than that of reference group(25-29 years). In conclusion, the higher infant mortality in the group of maternal age with less than 25 years and more than 35 years in Korea appears to be due to higher proportion of low birth weight and pre-term birth. Prenatal care intervention programs which tackle biological factors for advanced maternal age and address socio-economic problems and social stigma for early maternal age should be devised.

Characteristics of Vegetation Structure in Chamaecyparis Obtusa Stands (편백림의 식생구조 특성 분석)

  • Park, Seok-Gon;Kang, Hyun-Mi
    • Korean Journal of Environment and Ecology
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    • v.29 no.6
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    • pp.907-916
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    • 2015
  • The purpose of this study was to identify characteristics of vegetation structure, vegetation succession, and species diversity of artificially planted Chamaecyparis obtusa (CO) stands. The study was carried out by performing vegetation survey for eight CO stands located in Jeollanam-do Province, Korea. Analysis on vegetation classification and ordinations of the stands was conducted using the data from the vegetation survey, and as a result, the stands were classified into five types of communities. Community I showed a considerably lower index of species diversity when compared to other communities because the canopy of the dominant CO was so highly dense that the low-height vegetation was not able to develop or the low-height vegetation almost disappeared due to elimination of weed trees. Meanwhile, the Community II - IV had relatively higher indices of species diversity because various native tree species mixed with the low-height vegetation and competed with each other in the understory and shrub layers to some degree of stability or in their early stage of vegetation development. Community V, lastly, showed higher use intensity as a recreational forest, thus developing simpler vegetation structure on account of artificial intervention. There was positive correlation between photosynthetically active radiation entering the forest floor, number of observed species and index of species diversity. Such characteristics of vegetation structure in CO stands are closely associated with forest management and prescription for planting reforestation, thinning, and brush cutting in the past. There was a slight difference in vegetation structure and species diversity by communities, based on rotation time of the vegetational succession, process of disturbance frequency and disturbance, development, and maturity by planting CO stands. However, when compared to natural forests, the CO stands showed simpler vegetation structure. Because artificial forests are vulnerable in ecosystem service with lower species diversity, a drive for ecological management is needed for such forests to change into healthy ecosystems that can display functions of public benefit.

A Comparative Study of Influencing Factors on Elder Abuse of Public Assistance Recipient Elderlies and Community Elderlies (국민기초생활보장 노인과 일반노인의 노인학대 관련요인 비교연구)

  • Park, Mi-Eun
    • Korean Journal of Social Welfare
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    • v.56 no.2
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    • pp.93-119
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    • 2004
  • This article investigates 230 public assistance recipient elderlies and 354 community elderlies in order to find out the current status and influencing factors on elder abuse. It surveyed at Gwangju metropolitan city. The result from the research were 1) the degree of elder abuse is generally low, and the primary type of abuse is psychological abuse and neglect. The victims of abuse experienced psychological pain rather than physical pain. 2) the abuser are mainly in early forties, and very unstable economically. 3) based on personal characteristics of the recipient and non-recipient elderlies, there are significant differences between respondents' sex, age, education level, income, ADL, IADL, chronic disease, depression, social support, and number of friends. 4) the factors affecting elder abuse of public assistance recipient elderlies are depression, alcohol, social support(elderly-related factors), alcohol, childhood abuse(abuser- related factors), and emotional relationship, number of family members(family- related factors). And, the factors affecting elder abuse of community elderlies are childhood abuse, social support(elderly-related), relationship with victims(abuser -related), and emotional relationship(family-related). Finally, the research recommends that differential intervention strategies are needed in order to prevent elder abuse of the public assistance recipient elderlies and the community elderlies.

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