• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.26 no.3
• /
• pp.146-155
• /
• 2023

Purpose: The starting time for probiotic supplementation in preterm infants after birth varies widely. This study aimed to investigate the optimal time for initiating probiotics to reduce adverse outcomes in preterm or very low birth weight (VLBW) infants. Methods: Medical records of preterm infants born at a gestational age (GA) of <32 weeks or VLBW infants in 2011-2020 were reviewed respectively. The infants who received Saccharomyces boulardii probiotics within 7 days of birth were grouped into an early introduction (EI) group, and those who received supplemented probiotics after 7 days of birth were part of the late introduction (LI) group. Clinical characteristics were compared between the two groups and analyzed statistically. Results: A total of 370 infants were included. The mean GA (29.1 weeks vs. 31.2 weeks, p<0.001) and birth weight (1,235.9 g vs. 1491.4 g, p<0.001) were lower in the LI group (n=223) than in the EI group. The multivariate analysis indicated that factors affecting the LI of probiotics were GA at birth (odds ratio [OR], 1.52; p<0.001) and the enteral nutrition start day (OR, 1.47; p<0.001). The late probiotic introduction was associated with a risk of late-onset sepsis (OR, 2.85; p=0.020), delayed full enteral nutrition (OR, 5.44; p<0.001), and extrauterine growth restriction (OR, 1.67; p=0.033) on multivariate analyses after adjusting for GA. Conclusion: Early supplementation of probiotics within a week after birth may reduce adverse outcomes among preterm or VLBW infants.

• Neonatal Medicine
• /
• v.16 no.2
• /
• pp.110-120
• /
• 2009

Mimicking fetal nutrition is the goal of early paretneral nutrition (PN) in very low birth weight infants, however the limited metabolic capacity of immature organs raises concern about the toxicity of metabolites to the developing brain. Starting parenteral amino acids from the first day of life, with a rate of 1.0 to 1.5 g/kg/day, is generally recommended to prevent endogenous protein breakdown by maintaining a positive nitrogen balance. A greater of amino acid infusion rate in the range of the fetal transfer rate (3.5-4.0 g/kg/day) is well tolerated during the early days after birth in VLBWI, however the influence on growth and long-term neurodevelopmental outcome remains unknown. Limited data are available from controlled trials regarding the effects of early supplementation with lipid emulsions on neonatal morbidity. Considering the role of long-chain polyunsaturated fatty acids in the neurodevelopment, the choice of an optimal lipid emulsion should be based on the quality as well as the quantity of the lipid contents. Little is known about the clinical benefit of higher rates of glucose infusion by permitting high serum glucose level or co-administration with insulin.

• Korean Journal of Community Nutrition
• /
• v.1 no.1
• /
• pp.47-60
• /
• 1996

This study was carried out to investigate growth performance, energy and protein metabolism of breast and formula fed infants from birth to 3 months postpartum. There were four groups : breast fed(BF) and three formula fed groups(FFM, FFN and FFP). There was no significant difference in the height of infants according to feeding method and formula brands. However, mean weight of FFM was significantly higher than that of FFP and BF at 1 and 3 months postpartum, respectively. Mean head circumference of FFN was lowest among groups. The average intake of breast milk was $781.4{\;}{pm}{\;}119.3m{\ell}/day$ and that of formula was $848.6{\;}{pm}{\;}118.5m{\ell}/day$. Mean apparent digestible energy intakes of formula-fed infants and breast-fed infants during 3months were 568.9 $\pm$146.9 kca1/day and 657.9$\pm$212.8 kca1/day, respectively. The average protein intake of brest-fed and formula-fed infants were 8.3$\pm$1.6g/day and 14.1$\pm$14.1 g/day, respectively. The protein intakes of formula-fed infants were significantly higher than those of breast-fed infants at 1, 2, 3 months. The apparent protein digestibility of breast-fed infants was singnificantly higher compared to formula fed infant. These data suggest that RDA for infants be established and breast feeding be encouraged.

• Clinical and Experimental Pediatrics
• /
• v.65 no.1
• /
• pp.1-9
• /
• 2022

With advancements in neonatal care and nutrition, the postnatal growth of preterm infants has improved; however, it remains an issue. Accurate assessments of growth using a standardized reference are needed to interpret the intrauterine and postnatal growth patterns of preterm infants. Growth in the earlier periods of life can contribute to later outcomes, and the refinement of postnatal growth failure is needed to optimize outcomes. Catch-up growth occurs mainly before discharge and until 24 months of age, and very low birth weight infants in Korea achieve retarded growth later in life. Knowing an infant's perinatal history, reducing morbidity rates during admission, and performing regular monitoring after discharge are required. Preterm infants with a lower birth weight or who were small for gestational age are at increased risk of poor neurodevelopmental outcomes. Furthermore, poor postnatal growth is predictive of adverse neurodevelopmental outcomes. Careful monitoring and early intervention will contribute to better development outcomes and national public health improvements.

• The Korean Journal of Community Living Science
• /
• v.23 no.2
• /
• pp.177-187
• /
• 2012

The research aimed at analyzing how the differences between teachers' personal backgrounds (age, teaching experience, educational background, position) and experiences with the mentee and the mentor affect their awareness on the mentor qualifications for the mentoring program conducted by infants' educational organizations. By fulfilling the purpose of the research, proper qualifications for a mentor of outstanding abilities, which would be desired by teachers in infant educational organizations, should be established while preliminary data on the mentor teacher training to improve the professionalism of a mentor is expected to be provided. The research was carried out targeting 319 teachers in infants' educational organizations located in Busan and Gyeongsangnam-do. The measuring instrument used was a recognized survey on how the mentor qualifications for the mentoring conducted by infants' educational organizations. The survey consisted of 22 questions. The researcher personally designed the survey based on results generated from preliminary research. SPSS 14.0 was used to analyze selected data as average, standard deviation and one-way layout dispersion. In addition, a post-analysis on the one-way layout dispersion was conducted via the Scheffe posteriori test. The results demonstrated that the mentor qualifications for the mentoring were differently recognized by teachers in infants' educational organizations according to both teacher's personal backgrounds (age, teaching experience, educational background and position) and experiences with the mentee and the mentor.

• Journal of the East Asian Society of Dietary Life
• /
• v.14 no.1
• /
• pp.27-33
• /
• 2004

The objectives of the present study were to measure the content of iron, copper and zinc in human milk and to estimate the intake of iron, copper and zinc of breast-fed infants during the early period of lactation. Twenty-five lactating women who delivered in a hospital in Seoul volunteered for the study. Milk samples were collected at day 2, 3, 4, 5, 6, 7, 15 and 30 postpartum. The contents of iron, copper and zinc were determined using the atomic absorption spectrophotometer after wet digestion. The intakes of iron, copper and zinc of infants were estimated by multiplization with the infant milk intake reported in our laboratory. The content of iron was 0.58 $\mu\textrm{g}$/g in colostrum, 0.48 $\mu\textrm{g}$/g in transitional milk and 0.39 $\mu\textrm{g}$/g in mature milk while the estimated iron intake of infants was 271, 255 and 259 $\mu\textrm{g}$/day, respectively. The content of copper in the milk was 0.45 $\mu\textrm{g}$/g in colostrum, 0.43 $\mu\textrm{g}$/g in transitional milk and 0.33 $\mu\textrm{g}$/g in mature milk while the estimated copper intake of infants was 210, 229 and 220 $\mu\textrm{g}$/day, respectively. The content of zinc in the milk was 5.24 $\mu\textrm{g}$/g in colostrum, 3.70 $\mu\textrm{g}$/g in transitional milk, 2.93 $\mu\textrm{g}$/g in mature milk while the estimated zinc intake of infants was 2452, 1968, and 1949 $\mu\textrm{g}$/day, respectively. These results suggest that copper and zinc intake of infants are met to RDA but iron is not.

• The Korean Journal of Community Living Science
• /
• v.22 no.3
• /
• pp.455-469
• /
• 2011

The purpose of this study was to find out how follow-up activities of reading picture books influenced infants' language and socio-emotional development. Subjects of this study were 27 2-year-old infants at public day care centers in Busan. After implementing follow-up activities of reading picture books for 8 weeks, this study tried to investigate changes in infants' language and socio-emotional development. Results of this study are as follows. First, follow-up activities of reading pictures have brought positive impacts on infants' language ability. Results indicate a positive influence on infants' expressive and acceptive language ability. Second, follow up activities have also enhanced infants' socio-emotional development. Sepcifically, they have been effective in improving infants' low-level socio-emotional development such as 'internal control', 'peer interaction', and 'achievement motivation'. It is expected that the follow-up activities developed by this research would help to enhance infants' language development and socio-emotional development.

• Korean Journal of Child Studies
• /
• v.30 no.4
• /
• pp.47-56
• /
• 2009

This longitudinal study examined picture book reading practices with very young children and its influence on early intellectual development. The home picture book reading activities of 322 infants and their mothers were assessed by questionnaire every 6 months from 18 months till 42 months of age. Infants' IQ was measured with Korean-Wechsler Preschool and Primary Scale of Intelligence(Park et al., 1996) at 42 months. Results showed that monthly book expense (r=.28, p<.01) and infants' asking for reading (r=.14, p<.05) at 18 months were positively correlated with IQ at 42 months. Reading time between 24 and 42 months correlated positively with IQ(r=.17~.34, p<.01). These results reveal the importance of early book environment and actual reading time in the intellectual development of very young children.

• Journal of the Korean Home Economics Association
• /
• v.49 no.3
• /
• pp.55-66
• /
• 2011

The purpose of this study was to examine the effects of We Start home visiting intervention program on the positive changes of infants and their low-income families. The subjects were 171 18~36-month olds and their mothers living in We Start and non We Start areas. The instruments used were Developmental Profile, Cleminshaw-Guidubaldi Parent Satisfaction Scale(CGPSS) and Home Observation for Measurement of the Environment(HOME). The results were as follows: First, the result of Developmental Profile showed positive changes in all domains(physical development, self-help skills, social development, cognitive development, and communication ability). Second, the result of CGPSS showed positive effects on parent-child relationships. Third, the result of HOME showed positive effects on mothers' emotional and language responses. In conclusion, We Start home visiting program for infants from low-income families is an effective early intervention program to end intergenerational transition of poverty in Korea.

• Korean Journal of Child Studies
• /
• v.27 no.6
• /
• pp.263-276
• /
• 2006

This study examined the relationship between children's temperament and their early vocabulary acquisition. Mothers of 317 toddlers (18 months of age) completed the Toddler Temperament Scale(Bak, 1996) and a vocabulary checklist(Pae, 2002). Results showed that mood, adaptability, and activity were associated with vocabulary acquisition. Specifically, infants rated as having a positive mood and low activity level acquired more expressive words. On the other hands, infants rated as easily adaptive and low activity level acquired more receptive words. These results suggest that different components of temperament may influence the way in which toddlers acquire vocabulary.