• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2319-2321
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• 2014

Our aim was to determine GSTT1 expression levels in left colon tumors and paired normal tissue in order to identify specific alterations in GSTT1 mRNA levels. Alterations in GSTT1 expression in twenty-four left-sided colon tumors and paired cancer free tissue were determined by qRT-PCR. Significant fold changes were determined with t-test. When compared with cancer free tissue, left colon cancers showed a significant decrease in GSTT1 expression. However, GSTT1 mRNA levels among different grades increased gradually in correlation with tumor grade. Our results suggest that downregulation of GSTT1 in left-sided colon cancers is an early event and is reversed with cancer progression, probably due to cellular defense mechanisms as a response to changes in the microenvironment.

• BMB Reports
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• v.50 no.4
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• pp.201-207
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• 2017

Alternations in usage of polyadenylation sites during transcription termination yield transcript isoforms from a gene. Recent findings of transcriptome-wide alternative polyadenylation (APA) as a molecular response to changes in biology position APA not only as a molecular event of early transcriptional termination but also as a cellular regulatory step affecting various biological pathways. With the development of high-throughput profiling technologies at a single nucleotide level and their applications targeted to the 3'-end of mRNAs, dynamics in the landscape of mRNA 3'-end is measureable at a global scale. In this review, methods and technologies that have been adopted to study APA events are discussed. In addition, various bioinformatics algorithms for APA isoform analysis using publicly available RNA-seq datasets are introduced.

• The korean journal of orthodontics
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• v.1 no.1
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• pp.33-37
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• 1970

Class III malocclusions are difficult to treat and take more time than any other types. But if such problems are detected at the earliest opportunity, we may gain the best possible correction consistent with the limitations imposed by morphogenetic pattern. The question of whether a patient has false or real Class III malocclusion is not important. Therapy wilt eleminate the malrelationship, in any event. Graber said, 'It has been my experience that many so-called 'pseudo' Class III's are full-blown Class III's later on during the prolific growth period.' The authors have attempted early treatment of a Class III malocclusion of 8-year old girl, who has the familial history of Class III malocclusion.

• Fisheries and Aquatic Sciences
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• v.11 no.3
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• pp.177-181
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• 2008

Glyceraldehyde 3-phosphate dehydrogenase(GAPDH) is a key enzyme for carbohydrate metabolism in most living organisms. Recent reports and our own searches of teleost species in publicly available genomic databases have identified at least two distinct GAPDH genes in a given species. The two GAPDH genes are located on the same chromosome in teleosts, whereas they are located on the different chromosomes in mammals. Thus, we reconstructed a phylogenetic tree to better understand the evolutionary history of the GAPDH genes in the vertebrate lineage. Our phylogenetic analysis revealed unambiguously that the two GAPDH genes of teleosts are phylogenetically closely affiliated to one of the cytosolic GAPDH and spermatogenic GAPDH-S of mammals. This indicates that the two paralogous GAPDH genes shared a common ancestor and subsequently underwent a gene duplication event during early vertebrate evolution. However, GAPDH-S of teleosts showed significant differences in the polypeptide residues and tissue distribution of its mRNA transcripts from that of mammals, implying they have undergone a different history of functionalization.

• Reproductive and Developmental Biology
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• v.41 no.2
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• pp.33-40
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• 2017

X-chromosome inactivation is one of the most complex events observed in early embryo developments. The epigenetic changes occurred in female X-chromosome is essential to compensate dosages of X-linked genes between males and females. Because of the relevance of the epigenetic process to the normal embryo developments and stem cell studies, X-chromosome inactivation has been focused intensively for last 10 years. Initiation and regulation of the process is managed by diverse factors. Especially, proteins and non-coding RNAs encoded in X-chromosome inactivation center, and a couple of transcription factors have been reported to regulate the event. In this review, we introduce the reported factors, and how they regulate epigenetic inactivation of X-chromosomes.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.158-158
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• 2001

Bioflavonoids have been regarded as therapeutic agents for a wide range of disease including cancer. The increase of matrix metalloproteinases expression is a key event in several pathological conditions, e.g., dermal photocarcinogenesis, tumor initiation, invasion and metastasis. In this study, we investigated effects of quercetin, a major bioflavonoid in human diet, on matrix metalloproteinase (MMR)-1, MMP-2, MMP-3, MMP-9 mRNA expression during cellular aging in cultured human foreskin fibroblast. (omitted)

• Clinics in Shoulder and Elbow
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• v.19 no.2
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• pp.96-100
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• 2016

We encountered a rare condition of rice body in subacromial and subdeltoid spaces in a patient with unremarkable medical history. Although it is uncommon, there have been continued reports on its formation in certain type of infective and inflammatory arthritis. However, except for a traumatic event, evaluation yielded no known and conceivable cause for his chronic inflammatory bursitis. Relatively typical findings for rice body on magnetic resonance imaging have been described, and in our case the imaging prompted us to schedule early removal, which is generally accepted as the management of choice to prevent further progression of symptoms. The symptoms of the shoulder showed significant improvement, and a close follow-up schedule has been recommended for observation of recurrence and development of any foreseeable underlying cause.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.55.2-55.2
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• 2011

We present the current research activities of the Center for the Exploration of the Origin of the Universe, a center established at Seoul National University with the Creative Research Initiative program. Our activities focus on observational studies of distant objects such as gamma-ray bursts, quasars, and proto-cluster of galaxies, but we also carry out other observational and theoretical studies in related topics. We also developed a new instrument, Camera for Quasars at Early Universe (CQUEAN) in collaboration with Kyunghee University group, and have secured observing facilities such as UKIRT and McDonald 2.1m observatory. Our research highlights include results such as the discovery of high redshift quasars and gamma ray bursts, the discovery of tidal disruption event at z=0.38 and peculiar gamma ray burst events, analysis of proto-clusters of galaxies, the discovery of brown dwarfs, and development of CQUEAN and its usage at the McDonald observatory.

• Korean Journal of Bronchoesophagology
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• v.13 no.1
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• pp.51-54
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• 2007

Laryngeal trauma is an uncommon injury but can be life-threatening event. So, early diagnosis is important for appropriate surgical management and better outcome. Because there have been some controversies about Initial airway management, appropriate diagnostic evaluation, operative indication and timing, operative technique, it is difficult to make a common management pathway in laryngeal trauma. A case of laryngeal trauma with thyroid cartilage and hyoid bone fracture is presented with a brief review of literature.

• Journal of Korea Society of Digital Industry and Information Management
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• v.6 no.2
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• pp.29-38
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• 2010

It often occur to nature disaster that like earthquake, typhoon, etc. around KOREA. A Haiti and Chile also metropolitan area of KOREA occur earthquake. in result, People think of nature disaster. Structures of present age are easily affected by nature disaster. So we are important that warn of dangerous situation as soon as possible. On this study, I introduce Integrated monitoring system that administrator check a event as early. I develop Monitoring System using SMS(Short Message Service). Administrator always monitor structure on real-time using mobile web-page. As Administrator using mobile device like PDA, Administrator always monitor structure. As using this system, Damage of nature disaster is minimized and is prevented post damage.