Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.158-158
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- 2001
DIFFERENT EFFECTS OF QUERCETIN ON MATRIX METALLOPROTEINASES EXPRESSION IN EARLY AND LATE PASSAGE HUMAN FIBROBLASTS
- Eum, Sung-Yong (Department of Biological Science, Korea Advanced Institution of Science and Technology) ;
- Oh, Jang-Hee (Department of Biological Science, Korea Advanced Institution of Science and Technolog) ;
- Park, Jong-Min (Department of Biological Science, Korea Advanced Institution of Science and Technolog) ;
- Chung, An-Sik (Department of Biological Science, Korea Advanced Institution of Science and Technology)
- Published : 2001.10.01
Abstract
Bioflavonoids have been regarded as therapeutic agents for a wide range of disease including cancer. The increase of matrix metalloproteinases expression is a key event in several pathological conditions, e.g., dermal photocarcinogenesis, tumor initiation, invasion and metastasis. In this study, we investigated effects of quercetin, a major bioflavonoid in human diet, on matrix metalloproteinase (MMR)-1, MMP-2, MMP-3, MMP-9 mRNA expression during cellular aging in cultured human foreskin fibroblast. (omitted)
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