• 대한가정학회지
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• 제39권5호
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• pp.107-121
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• 2001

The purpose of this study was to develop a sexuality education program for early adolescents. The overall goals of the program were to not only increase knowledge and skirts, but also to improve the awareness of healthy sex in order to promote premarital abstinence, parent-teen communication and parental awareness of the importance of parental roles and responsibilities in prevention of sexual problems of the early adolescent. The program consisted of six sessions: puberty changes during adolescence, the meaning of sexuality, sexual drives in dating relationships, understanding of the risks associated with early sexual involvement and support for postponing sexual activities, managing and avoiding sexually risky situations, the importance of communications with parents about issues related to sexuality. The program evaluation had three steps: pre-test, immediate post-test and two month follow-up post test. The results showed that the program had a significantly positive effect on the improvement of adolescent's knowledge about sex, and attitudes and behaviors toward sex, particularly in the immediate post-test. At the two month follow-up assessment, the effect of the program still remained strong, though there was a sight and partial reduction which was not statistically significant. Most of the program participants expressed a high level of satisfaction with the program. Parental involvement appeared to be effective as well. Recommendations for further study include: to re-evaluate the curriculum for various other participants. In addition, further study which would compare post-test results of these participants with a comparison group of peers who did not receive the program would be valuable. The author believes that the program can be used in implementing specific subjects (sessions) in new settings, as well as implementing the entire package of the program.

• Journal of mucopolysaccharidosis and rare diseases
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• 제2권1호
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• pp.5-7
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• 2016

Mucolipidoses II and III alpha/beta (ML II and ML III) are lysosomal disorders in which the essential mannose-6-phosphate recognition marker is not synthesized onto lysosomal hydrolases and other glycoproteins. The disorders are caused by mutations in GNPTAB, which encodes two of three subunits of the heterohexameric enzyme, N-acetylglucosamine-1-phosphotransferase ML II, recognizable at birth, often causes intrauterine growth impairment and sometimes the prenatal "Pacman" dysplasia. The main postnatal manifestations of ML II include gradual coarsening of neonatally evident craniofacial features, early cessation of statural growth and neuromotor development, dysostosis multiplex and major morbidity by hardening of soft connective tissue about the joints and in the cardiac valves. Fatal outcome occurs often before or in early childhood. ML III with clinical onset rarely detectable before three years of age, progresses slowly with gradual coarsening of the facial features, growth deficiency, dysostosis multiplex, restriction of movement in all joints before or from adolescence, painful gait impairment by prominent hip disease. Cognitive handicap remains minor or absent even in the adult, often wheelchair-bound patient with variable though significantly reduced life expectancy. As yet, there is no cure for individuals affected by these diseases. So, clinical manifestations and conservative treatment is important. This review aimed to highlight the extra-skeletal clinical problems in ML II and III.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제31권5호
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• pp.440-443
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• 2009

Cleidocranial dysplasia(CCD) is a rare syndrome usually caused by an autosomal dominant gene or no apparent genetic cause. The skull is large and short with marked bossing of the frontal bone. Closure on the fontanelles and sutures is delayed. The clavicle may be unilaterally or bilaterally aplastic. Oral manifestations include multiple impacted permanent teeth, prolonged retention of primary teeth and multiple supernumerary teeth. There are many difficulties in the early diagnosis of CCD because a majority of the craniofacial abnormalities becomes obvious only during adolescence. Late diagnosis produce occlusional & psychological problem. Therefore early detection and treatment of CCD can reduce the period and the extent of orthodontic and surgical interventions. We experienced CCD patient with multiple supernumerary teeth and will report it with the literature review.

• The Korean Journal of Physiology and Pharmacology
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• 제13권2호
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• pp.79-83
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• 2009

Exposure to early stressful adverse life events such as maternal and social separation plays an essential role in the development of the nervous system. Adolescent Sprague-Dawley rats that were separated on postnatal day 14 from their dam and litters (maternal social separation, MSS) showed hyperactivity and anxiolytic behavior in the open field test, elevated plus-maze test, and forced-swim test. Biologically, the number of astrocytes was significantly increased in the prefrontal cortex of MSS adolescent rats. The hyperactive and anxiolytic phenotype and biological alteration produced by this MSS protocol may provide a useful animal model for investigating the neurobiology of psychiatric disorders of childhood-onset diseases, such as attention deficient hyperactive disorder.

• 한국콘텐츠학회논문지
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• 제13권10호
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• pp.347-355
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• 2013

본 연구는 청소년의 자아탄력성과 또래애착이 삶의 만족도를 매개로 자기조절학습능력에 미치는 영향에 대해 살펴보고자 하였다. 자기조절학습능력은 학습자가 주도적으로 학습목표를 성취하기 위한 전략적인 접근방법으로 학습에 있어 자기조절을 의미한다. 이러한 자기조절학습능력의 변인에 청소년의 내적 힘인 자아탄력성과 외적지지체계 중 하나인 또래애착의 영향력이 청소년의 삶의 만족도를 매개하여 어떠한 영향을 미치고 있는가를 살펴보았다. 조사 대상자는 총 2,351명의 중학생을 대상으로 분석한 결과 첫째, 자아탄력성과 삶의 만족, 또래애착(의사소통, 신뢰, 소외) 그리고 자기조절학습능력(성취가치, 숙달목적지향, 행동통제, 학업시간관리)의 잠재변수와 하위변수 모두 서로 유의미한 상관관계를 보이고 있었다. 둘째, 자아탄력성과 또래애착은 삶의 만족도를 매개하지 않고 직접적으로 자기조절학습능력에 영향을 주고 있었다. 셋째, 삶의 만족도도 직접적으로 자기조절학습능력에 영향을 주고 있었다. 넷째, 자아탄력성과 또래애착은 삶의 만족도를 매개하여 자기조절학습능력에 영향을 주는 것으로 나타났다.

• 대한통합의학회지
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• 제8권3호
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• pp.83-91
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• 2020

Purpose : To identify changes and relationships in the fat mass and obesity associated (FTO) gene polymorphism, body composition, and physical fitness from childhood to adolescence over a three-year period spanning elementary school to middle school (2015-2018) Methods : A total of 84 male student participants were divided into two groups based on FTO genotype: aa+at (group A) and tt (group T) and tracked down. Body composition, cardiovascular endurance, flexibility, muscle strength, power, and other characteristics were measured in the two groups in both 2015 and 2018, respectively, and the changes over the three-year period were analyzed and compared. Results : Increases in height and weight did not differ significantly between the two groups, but body mass index (BMI) was significantly higher in group A (p=.035). With regard to physical fitness, there was no significant difference in flexibility, but cardiovascular endurance, strength, and power were significantly higher in group T (p<.001, p=.063, and p=.040, respectively). Conclusion : Group A is more likely to become obese than group T because of their lower level of physical fitness and increased BMI relative to group T. This result supports previous studies showing that group A has a relatively low level of physical activity and a greater tendency to eat fatty foods as compared with group T. Therefore, we suggest that the FTO gene polymorphism should be identified early and that students educated on diet and physical activity to help prevent adult obesity.

• Clinical and Experimental Pediatrics
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• 제64권5호
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• pp.229-238
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• 2021

Background: Bronchial hyperresponsiveness (BHR), an important physiological feature of asthma, is a prognostic marker of childhood asthma. Purpose: We aimed to investigate the factors associated with BHR in adolescents with childhood asthma. Methods: Two hundred and fifteen adolescents (≥13 years of age; 149 males, 66 females) who were diagnosed with asthma during childhood were enrolled, underwent methacholine challenge tests, and were divided into the BHR group (<25 mg/mL of provocation concentration causing a 20% fall in forced expiratory volume in 1 second [FEV₁] [PC₂₀], n=113) or non-BHR group (≥25 mg/mL of PC₂₀, n=102). We examined longitudinal changes in BHR and the risk factors for its persistence in the 108 adolescents for whom baseline data, including methacholine PC₂₀ at age 6 years, were available. Multivariate logistic regression analyses were performed to assess the factors associated with BHR in adolescents. Results: Mold sensitization (adjusted odds ratio [aOR], 5.569; P=0.005) and increased blood eosinophil count (aOR, 1.002; P=0.026) were independently associated with BHR in boys but not girls. The odds of BHR decreased by 32% with each 1-year increase in age in boys (aOR, 0.683; P=0.010) but not girls. A reduced FEV₁/forced vital capacity ratio (<90%) was independently related with BHR in female patients only (aOR, 7.500; P=0.007). BHR decreased with age throughout childhood. A low methacholine PC₂₀ at age 6 years was independently associated with persistent BHR throughout childhood in male and female patients, whereas early mold sensitization was a risk factor for persistent BHR in male patients only (aOR, 7.718; P=0.028). Conclusion: Our study revealed sex-specific differences in the factors associated with BHR in adolescents with childhood asthma. Our findings suggest the risk factors that might affect asthma transition from childhood to adolescence and adulthood.

• 대한유전성대사질환학회지
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• 제4권1호
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• pp.13-17
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• 2004

저자들은 생후 28일된 발열, 간종대, 출혈성 경향, 구토, 잦은 보챔, 전신의 황달 증상을 보이던 환아를 MS-MS 이용한 신생아 대사 이상 검사와 혈중 아미노산 분석, 뇨중 유기산 분석을 통하여 hereditary tyrosinemia type I으로 진단하였다. 저 페닐알라닌/타이로신 식이와 NTBC 사용으로 국내 첫 타이로신혈증 I 치료 성공례를 경험하였다.

• 아동학회지
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• 제26권5호
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• pp.311-330
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• 2005

The purpose of this study was to examine the paternal involvement tendency and its effect on adolescent's self-esteem for boys and girls. Subjects were 607 1st and 2nd grade middle school students in Busan. The data were analyzed by t-test, one-way Anova, Pearson's correlation, and multiple regression analysis. The results were as follows. The scores on paternal involvement were influenced by the amount of time spent with parents, 5days work a week of father, flexibility of leaving work-time of mother, regularity of holiday work of mother as well as adolescents' and fathers' sociodemographic characteristic. For boys, self-esteem was influenced by all sub-scales of paternal involvement : the leisure-life, proffering information, academic support, eveηday life, material support, discipline, and tradition-inheritance. For girls, self-esteem was influenced by leisure-life, proffering information, academic support, everyday life, and material supports.

• Clinical and Experimental Pediatrics
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• 제52권2호
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• pp.142-151
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• 2009

The incidence of small for gestational age (SGA) births is frequent, accounting for 2.3% to 8% of all live births. Several childhood and adult diseases are related to early postnatal growth and birth size, and 10% of children born SGA may have a short stature throughout postnatal life. Additionally, they may have abnormal growth hormone (GH)-insulin like growth factor axis, HPA axis, and gonadal function. Permanent changes are detrimental in an environment of nutritional abundance, and predispose SGA children to an array of diseases in adolescence and adulthood. Such changes may also cause premature pubarche, adrenarche, and precocious puberty. The varying results from clinical studies necessitate more prospective case control studies. Reproductive tract abnormalities and reproductive dysfunction are related to SGA births. GH treatment is required for SGA infants who do not experience catch-up growth.