• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1997년도 춘계학술대회
• /
• pp.136-140
• /
• 1997

In this paper, we proposed a implantable middle ear system using FM transmission and receiving method which has higher detection efficiency than that of AM method. And a new shape of vibrating transducer which is more efficiently vibrate than the conventional type is designed. This tranducer consist of coil and small T-type cylindrical permanent magnet. We investigated and compared the differences between conventional methods and proposed methods by quantitive analysis. We proved them by experiment.

• 한방안이비인후피부과학회지
• /
• 제12권1호
• /
• pp.1-17
• /
• 1999

Shinisan has been used for treatment of allergic disease in Oriental Medicine. However, its effect in experimental models remains unknown. The mast cell plays a pivotal role in initiating allergic response by secreting intracytoplasmic granular mediators such as histamine. The present report describes an inhibitory effect of Shinisan on mast cell-mediated immediate type allergic reactions. Topical application of compound 48/80 can induce an ear swelling response in normal ($WBB6F_1-+/+$) mice but not in the congenic mast cell-deficient $WBB6F_1-W/W^v$ mice. Shinisan inhibited concentration-dependently mast cell-dependent ear swelling response induced by compound 48/80. Shinisan inhibited concentration-dependently passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by topical application. Shinisan also inhibited concentration-dependently the histamine release from the rat peritoneal mast cells by compound 48/80 or anti-DNP IgE. Moreover, Shinisan had a significant inhibitory effect on compound 48/80-induced systemic anaphylactic reaction. These results indicate that Shinisan inhibits immediate-type allergic reactions by inhibition of mast cell degranulation in vivo and in vitro.

• 대한두개안면성형외과학회지
• /
• 제16권2호
• /
• pp.84-87
• /
• 2015

Polyotia is an extremely rare type of the auricular malformation that is characterized by a large accessory ear. A 3-year-old girl presented to us with bilateral auricular abnormalities and underwent two-stage corrective operation for polyotia. In this report, we present the surgical details and postoperative outcomes of polyotia correction in the patient. Relevant literature is reviewed.

• 대한의용생체공학회:의공학회지
• /
• 제25권5호
• /
• pp.369-376
• /
• 2004

이명 재훈련 치료법은 백색 잡음을 이용하여 이명 환자를 치료하는 효과적인 방법이다. 이 치료법은 광대역의 청각 세포를 자극하기 위하여 백색 잡음을 이용한다. 본 논문에서는 열 잡음을 이용한 소형의 백색 잡음 발생기와 인간의 외이와 중이 시스템에 의해 변형된 주파수 응답을 보상할 수 있는 주파수 응답 조절부를 제안하였다. 실험 결과, 제안된 시스템이 기존의 백색 잡음 발생기에 비하여 이명 재훈련 치료의 목적에 보다 적합한 형태임을 알 수 있었다.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2003년도 춘계학술대회논문집
• /
• pp.1044-1047
• /
• 2003

An acoustic testing device composed of 2 probe microphones was developed for the electro-acoustic specification testing of the ITE (In-The-Ear) hearing aid (HA). The amplitude ratio and the phase difference between the incident pressure onto the HA microphone and the outward pressure of the HA receiver were measured by the present acoustic system. The microphones were particularly used because of small acoustic cavities where input and output pressures were present. The acoustic wall composed of clay completely blocks the propagation of the sound pressure between the small acoustic cavities. The system has an advantage of structural flexibility for the acoustic testing of different sizes and shapes of ITE-type HAs.

• 대한전기학회논문지:전기물성ㆍ응용부문C
• /
• 제49권10호
• /
• pp.583-588
• /
• 2000

This paper presents the design and fabrication of micro electromagnetic vibration silicon elastic body characterized with small size, high efficiency and selective frequency bandwidth for Bio-MENS applications, such as implantable middle ear hearing aid. The presented electromagnetic vibration transducer that composed of wounded coil, permanent magnet and 4-beam cross type elastic body is fabricated by using of micromachining technology. The fabricated transducer has experimental characteristics, that is 5 nm/mA of an energy trasfer rate at the frequency range of 100∼2800 Hz. It has a size of $2{\times}2{\times}2.5\;mm^3$.

• 한국음향학회지
• /
• 제24권7호
• /
• pp.379-386
• /
• 2005

최근까지 개발되었던 청각 보조기 중에서 공기 전도형 보청기의 하울링 (howling) 현상과 수술 후 이소골 등 기존 음향계의 재생이 불가능한 인공 와우 (cochlear implant system)의 단점을 해결하고, 동시에 청음 명료도가 높은 음성 신호를 전달하기 위한 수단으로 연구된 것이 인공중이 (implantable middle ear hearing device) 이다. 본 연구에서는 인공중이의 음성 신호 재현을 위한 진동 장치인 차동전자 트랜스듀서 (differential electromagnetic transducer, DET)에 대한 수학적 모형화와 계의 진동을 기술하는 운동방정식을 유도하고 그 해를 구하였다. 제한된 크기와 인가 전류 $1\;mA_{rms}$ 정현파에서 최대 구동력을 얻기 위해서 전자기력에 대한 유한요소해석을 수행하였고, 결과에 의해서 자석과 코일에 대한 최적 크기를 결정하였다. 사람의 중이 내 등자뼈 (stapes)의 진동 특성과 유사한 진동을 갖는 DET를 설계하기 위해서, 진동막의 강성계수를 변화하면서 진동해석을 시뮬레이션 하였다. 설계된 DET는 마이크로 머시닝 기술에 의해서 제작하였고, 그 진동 특성을 측정 하였다. 최종적으로 측정된 진동 특성에 대한 분석을 통하여 인공중이를 위한 진동 장치로서의 적용 가능함을 확인하였다.

• 한국작물학회지
• /
• 제37권5호
• /
• pp.476-485
• /
• 1992

1. 옥수수의 자식계 9계통에 화학적 돌연변이 유기제를 처리하여 얻어진 M$_1$, 식물들은 형태적으로 왜성화, 백색화등 다양한 변이체로 나타났고 생식기관의 변이는 자성개체, 웅성개체, 자웅동화, 다수성들을 보였고 부임개체들이 증가하였다. 2. mutagen의 종자침지처리후 이삭에 수분방지대를 씌웠을때는 3.9-11.2%의 이삭착립율이 나타났으나 이삭당 성숙립수는 3.8-4.3게에 불과하였다. 한편 mutagen의 이삭주입처리에서는 5.1-10%의 착립이삭율과 이삭당 성숙립수는 1.7-6.3이었고 자연수분후 4시간만에 웅사를 절단하였던 이삭들은 착립이삭수가 27%로 증가하였다. 3. Mutagen처리와 수분방지처리에서 형성된 종자들의 조직학적 관찰은 aposporous apomictic reproduction이나 adventitious embryony의 가능성을 보여주었고 M2식물의 근단염색체를 조사하였을때 모두 2배체로서 확인되었다. 4. 무배합생식성 종자에서 출현된 식물들은 초장의 변이계수가 4-6%로 비교적 낮았고 외부형태상의 균일성을 보여주었다. 그러나 이들 무배합생식성과 결부된 표식형질을 발견할수는 없었다.

• 대한의용생체공학회:의공학회지
• /
• 제30권2호
• /
• pp.162-168
• /
• 2009

Implantable middle ear hearing devices (IMEHDs) have been widely studied as an alternative hearing aids to solve the problems of conventional hearing aids. Vibration transducer of middle ear hearing aids is a key component because vibration characteristics of transducer is directly involved performance of hearing aids. So, the study about middle ear hearing aids concentrate on the transducers. A floating mass type transducer is most efficient. In this paper, we suggest a lumped mechanical model of electromagnetic floating mass transducer implanted on human middle ear. The proposed model enables analysis of the vibration characteristics of a floating mass transducer and prediction of the variation after implant on ossicle that offers a simple and easy to analyze. The parameters was drawn based on the components and the structures of transducer. The Lumped mechanical model was converted by the electrical-mechanical equivalent model, and simulated using PSpice. So, we investigated vibration characteristics of transducer influenced it's components. And we predict vibration characteristics of stapes footplate due to implanted transducer's vibration using combining model of transducer and human ear. To prove the feasibility of the suggested model, we fabricated a differential floating mass transducer (DFMT) as one of floating mass transducers and performed experiments using the human temporal bones.

• Archives of Plastic Surgery
• /
• 제33권6호
• /
• pp.723-731
• /
• 2006

Purpose: Collagen is the principal structural biomolecule in cartilage extracellular matrix, which makes it a logical target for cartilage engineering. In this study, porous type I collagen scaffolds were cross-linked using dehydrothermal(DHT) treatment and/or 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide(EDC), in the presence and absence of chondroitin-6-sulfate(CS) for cartilage regeneration. Methods: Cartilage defects were created in the proximal part of the ear of New Zealand rabbits. Four types of scaffolds(n=4) were inserted. The types included DHT cross-linked(Group 1), DHT and EDC cross- linked(Group 2), CS added DHT cross-linked(Group 3), and CS added DHT and EDC cross-linked(Group 4). Histomorphometric analysis and cartilage-specific gene expression of the reconstructed tissues were evaluated respectively 4, 8, and 12 weeks after implantation. Results: The largest quantity of regenerated cartilage was found in DHT cross-linked groups 1 and 3 in the 8th week and then decreased in the 12th week, while calcification increased. Calcification was observed from the 8th week and the area increased in the 12th week. Group 4 was treated with EDC cross-linking and CS, and the matrix did not degrade in the 12th week. Cartilage-specific type II collagen mRNA expression increased with time in all groups. Conclusion: CS did not increase chondrogenesis in all groups. EDC cross-linking may prevent chondrocyte infiltration from the perichondrium into the collagen scaffold.