• 산업공학
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• 제13권2호
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• pp.147-156
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• 2000

It is known that the human stature and its related dimensions generally increase until the late teens or early twenties, remain relatively constant throughout early adulthood, and decline from early-to-middle adulthood into old age. However, there is exception that the length of the human ears, which continue to grow throughout life. In this study, 600 Korean male and female subjects aging from 17 to 89 were selected. Four different points of external ears including Pinna length, ear connection point length, Concha length, and Lobule thickness were measured along with other relative subjects' demographic data(e.g., age, stature, weight) to determine the relationship among these obtained data. The results showed that the age, sex, and different ethnic populations were functions of ear dimensions similar to the human stature. For example, the Pinna length increases as the age increases(r= 0.689, p<0.00l). The primary objective of this study was thus to provide anthropometric dimensions of Korean ear for the product designers and recommend the appropriate product design solutions in relation to human ear. Based on the results of this study, it is suggested that the continuing growth of the human body parts should be considered in the application of anthropometric data to the design of the things especially for human use.

• 한국식품영양과학회지
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• 제38권2호
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• pp.160-165
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• 2009

본 연구는 황금추출물인 baicalein의 피부알레르기 예방 효과를 알아본 연구로서 baicalein을 투여할 농도에 따라 0 mg/kg(대조군), 50 mg/kg(저용량군), 100 mg/kg(고용량군) 3개의 그룹으로 나누고, ear swelling을 측정하는 1군과 IgE 농도와 histamine 농도의 측정 및 조직병리학적 관찰을 위한 2군으로 나눠 실험을 하였다. Baicalein을 8일에 걸쳐 8회 경구투여를 실시한 후 접촉성 피부알레르기 유발 물질인 PCL을 귀에 감작시켜 알레르기를 유발시키고, 1군에서 ear swelling 변화를 확인하고 2군에서는 1군의 ear swelling의 결과에서 귀의 두께가 최고치를 이루는 시간대에 부검을 실시하여 적출한 조직으로는 HE염색과 TB염색을 실시하여 병변의 유무와 비만세포를 확인하였다. 채취한 혈청으로는 IgE 농도와 histamine 농도를 측정하였다. Ear swelling의 경우 0 mg/kg 농도의 baicalein을 투여한 대조군에 비해 50 mg/kg, 100 mg/kg 농도의 baicalein을 투여한 저용량군과 고용량군 그룹의 귀의 두께 증가폭이 낮게 나타났고, 저용량군보다 고용량군에서 그 증가폭이 낮게 나타났다. IgE 농도와 histamine 농도 측정결과에서도 0 mg/kg 농도의 baicalein을 투여한 대조군에 비해 50 mg/kg, 100 mg/kg 농도의 baicalein을 투여한 저용량군과 고용량군에서 낮은 수치가 나왔다. 조직병리학적 검사결과에서는 육안적으로 모든 그룹의 간과 신장에서는 별다른 병변은 관찰되지 않았고, HE염색을 한 귀 조직에서는 대조군에서 고용량군에 비해 귀의 두께가 두껍게 관찰되었고, TB염색을 한 귀 조직에서는 대조군에 비해 고용량군에서 적은 수의 비만세포들이 관찰되었다. 즉, ear swelling, IgE 농도, histamine 농도 및 조직병리학적 결과를 종합해봤을 때 황금추출물인 baicalein이 접촉성 피부알레르기 예방효과가 있다고 판단되어지고, 향후 baicalein은 항알레르기 치료제로 사용되는 생약제의 주요 성분으로 유용할 것이라 사료된다.

• 농업과학연구
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• 제38권1호
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• pp.1-6
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• 2011

Daeduckchal 1 waxy corn hybrid including check was planted and compared with domestic leading vatiety on agronomic characteristics, traits related to table gualities and crude income. Stem and ear height of Daeduckchal 1 among used hybrids were intermediate and stem diameter was also similar to other hybrids. Days to tasseling of this hybrid needed 56 days which was slightly shorter than check hybrid, Yeonnong. Ear length of CNU-H2 was longer than Yeonnongchal as 21.7 cm, while Chalok 2 was 14.1 cm. Number of tillers per plant of this hybrid were higher than Chalok 2 but lower than Yeonnong. Pericarp thickness of CNU-H2 and CNU-H3 were similar to Yeonnon. In sugar content, Daeduckchal 1 was intermediate level as 11.7 brix(%). Marketability of Daeduckchal 1 was the highest among used hybrids and crude incomes was also high.

• 대한융합한의학회지
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• 제5권2호
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• pp.17-22
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• 2023

Objectives: This study aimed to investigate the anti-atopic properties of Glechoma hederacea var. longituba extracts (GHE) in murine atopic dermatitis model. Methods: BALB/c mouse ear stimulated with oxazolone (OX) for 4 weeks, then 1% GHE was topically applied every two days for 3 weeks to mouse. Ear thickness was measured by a digital thickness gauge. The ears tissues were collected and subjected to hematoxylin-eosin (H&E) and toluidine blue (TB) staining. Results: Treatment with GHE successfully alleviated the symptoms of atopic dermatitis, such as erythema, horny substance, and swelling. The infiltration of lymphocytes and mast cells were significantly reduced following GHE treatment. Conclusion: Taken together, our results showed that GHE possessed the potential to be a novel immunomodulatory drug against atopic dermatitis.

• 한방안이비인후피부과학회지
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• 제30권1호
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• pp.87-105
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• 2017

Objectives : Atopic Dermatitis (AD) is chronic skin disease characterized by allergic hypersensitivity reactions. Saeng-ryo-Samul-tang (SRSM) can treat skin disease by cooling down blood heat, cealering away congenital fever and detoxicating. This study was conducted to investigate the effects of SRSM on AD induced by 2,4-dinitrochlorobenzene (DNCB) in mice Methods : In this study, the effects of SRSM on changes in body weights, thicknesses of dorsum skin, thicknesses and weights of ear, changes of symptoms on the dorsum skin, histopathological degree of ear and dorsum skin, IL-10 and $TNF-{\alpha}$ in serum were observed. And the effects on the proliferation rates of splenocytes were also investigated in vivo and in vitro study. Results : In SRSM topical application (Topical) group, SRSM oral application (Oral) group and SRSM Combination (Combi) group thickness of dorsum skin decreased significantly. But in TPC, ORL and CBN group, weight of ear didn't show any changes, but thickness of ear decreased significantly. And TPC, ORL and CBN group showed meaningful effectiveness symptoms like desquamation and erythema on AD's clinical espect. In histopathological observation, spongiosis, edema and inflammatory cell infiltration of epidermal were remarkably diminished in TPC, ORL and CBN group. And SRSM diminished the proliferation rates of splenocytes in vivo and vitro study. Conclusions : The present study suggests that SRSM can significantly reduced symptoms of AD, therefore SRSM is effective to treatment of AD.

• 농업과학연구
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• 제4권2호
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• pp.215-228
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• 1977

양질 옥수수 육성을 위한 우량한 유전자원을 공급하기 위하여 전국적으로 수집한 총 948개의 재래종 옥수수 이삭에 대하여 주요 형태적 특성을 조사하였던바, 다음과 같은 몇가지 결과를 얻었다. 1) 이삭형태 : 한국 재래종 옥수수의 이삭형태는 IV형 II형 III형 I형의 순으로 구성되었으며, 옥수수의 주산지인 북동부 산악지대에서는 원통형 내지는 원통형에 가까운 형태의 이삭이 많았고, 옥수수가 소규모로 재배되고 있는 남부 평야지대에서는 원추형 내지는 원추형에 가까운 형태의 이삭이 많았다. 2) 입색 : 전국 10개 지역에서 수집된 모든 재래종 옥수수 이삭 가운데서 단색립을 가진 이삭이 54.4%, 가지 색갈의 입색이 혼합된 이삭이 39.0%이없고 세가지 이상의 입색을 가진 이삭이 6.6%이었다. 북부산간지대에서는 이삭의 색갈은 백색혹은 백색과 다른 색갈이 혼합된 것이 많았고, 그 밖의 다른 지역에서는 이삭이 색갈이 노란색 혹은 노란색과 다른 색갈이 혼합된 것이 많았다. 3) 마치성 : 수집된 재래종 옥수수 가운데 불과 4.3%만이 마치종 이었고 나머지는 경립종이었다. 마치종은 외국 옥수수 품종이 도입된 북부 지방에서 수집되었다. 4) 이삭열수 : 수집된 재래종 옥수수의 이삭열수는 12열 내지 16열이 대부분이었고, 수집된 지역에 따라 분류된 이삭열수 사이에는 큰 차이가 없었다. 여하튼, 이삭열수는 입의 크기에 밀접한 관계가 있는 것으로 나타났다. 예를 들면, 이삭열수가 24개나 되는 이삭의 입은 그 크기가 매우 작았다. 5) 입질 : 수집된 재래종 옥수수의 70.9%가 경질립이었고, 연질립은 26.0% 그리고 중간형이 3.1%이었다. 옥수수의 주산지인 A지역과 I지역에서 경질 옥수수가 더 많이 수집 되었다. 6) 폭열종과 찰옥수수 : 수집된 재래종 옥수수를 보면 폭열종 옥수수는 I지역(울릉도)를 제외하고는 고르게 분포되어 있었고, 찰옥수수는 북부 산간지방에서 많았다. 7) 이삭길이 : 수집된 재래종 옥수수의 평균 이삭길이는 13cm이었고, A지역과 I지역에서 수집된 옥수수의 길이가 다른 지방의 것보다 길었다. 8) 이삭직경 : 수집된 재래종 옥수수의 평균 이삭직경은 3.3cm이었고, A지역과 I지역에서 수집된 옥수수의 이삭직경이 다른 지방의 것보다 컸다. 9) 입길이, 입폭, 입깊이 : 수집된 재래종 옥수수의 평균 입길이, 입폭, 입깊이는 각각 0.82cm, 0.42cm 그리고 0.78cm 이었다. A 지역과 I 지역에서 수집된 옥수수의 입의 다른 지역에서 수집된 옥수수의 입보다 컷다. 10) 이삭 무게 : 수집된 재래종 옥수수의 평균 이삭무게는 평균 58.04gr 이었으며 A 지역과 I 지역에서 수집된 것이 현저히 무거웠다. 가장 무거운 이삭의 무게는 330gr 이었고 가장 가벼운 이삭의 무게는 5gr 이었다. 11) 이삭당 입중 및 100입중 : 수집된 재래종 옥수수의 이삭당 입중은 평균 47.07gr 이었고 100입중은 평균 15.07gr 이었다. 이삭당 입중 및 100입중은 A 지역과 I 지역에서 수집된 것이 더 무거웠다.

• 대한두개안면성형외과학회지
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• 제21권4호
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• pp.225-228
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• 2020

Background: The aim of this study is to develop a two-stage training module using radish and swine scapular cartilage for carving ear cartilage. Methods: In the first stage, white radish was cut in 3-6 mm thick slices. The ear cartilage framework was carved using a graver and the helix and antihelix were fixed with pins. In the second stage, swine scapular cartilage was obtained. The thickness varied 3-6 mm. The ear cartilage framework was made. And triangular fossa and scaphoid fossa were carved with graver. A curvilinear cartilage for helix was assembled to the framework by pin fixing. Six participants were recruited for an ear reconstruction training workshop and figures of the cartilage framework were provided. Participants were asked answer the pre-workshop questionnaire and post-workshop questionnaire on a Likert scale to rate their satisfaction with the outcome. Results: On the pre-workshop questionnaire, participants indicated that they did not have sufficient knowledge and skill for fabricating the ear cartilage framework (1.5±0.5 using white radish; 1.3±0.5 using swine scapular cartilage). On the post-workshop questionnaire, participants responded that they had learned useful knowledge from this workshop, reflecting a significant improvement (3.8±1.0 using white radish; 4.0±1.1 using swine scapular cartilage). They also indicated that they had become somewhat confident in this skill (4.2±0.8 using white radish; 4.3±0.5 using swine scapular cartilage. The participants generally found the workshop satisfactory (practically helpful, 4.7±0.5; knowledge improved, 4.8±0.4; satisfied with course, 4.5±0.5; would recommend to others, 4.8±0.4). Conclusion: This model can be useful for ear reconstruction training for medical personnel.

• Biomolecules & Therapeutics
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• 제16권3호
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• pp.237-242
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• 2008

The effect of Picrorrhiza Rhizoma (PR) aqueous extracts were evaluated on 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis, type I allergic model. Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. Three different concentrations of PR extracts (300,150 and 75mg/kg) were orally administered to DNP-OVA sensitization mice once a day for 7 days with reference materials; dexamethasone (15mg/kg, intraperitoneal treatment). End of 7 days oral administration of PR extracts or intraperitoneal treatment of dexamethasone, the changes on the edematous changes and scratching behavior were measured. Immediate after DNFB challenge on ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected with anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these DNFB-induced increases on ear and paw thicknesses, weights and scratching behaviors were decreased by treatment of all three different dosages of PR extracts and dexamethasone, respectively. In addition, the increases of anterior skin thicknesses were also dramatically inhibited by treatment of all three different dosages of PR extracts and dexamethasone at histopathological observations. The results obtained in this study suggest that oral treatment of PR extracts also has relatively favorable effects on allergic dermatitis.

• 대한한의학방제학회지
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• 제13권2호
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• pp.59-69
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• 2005

Samyoyongantang (SMY), a herbal medicine, has been used as cure for gangrene. To evaluate anti-inflammatory effect of samyoyongantang, we treated samyoyongantang extract in animal model system induced contact hypersensitivity. Contact hypersensitivity, a local inflammatory response of the skin, was induced by 1% DNCB on the right ear of BALB/c mouse. Samyoyongantang was prepared as water extract and administrated everyday for 2 weeks per oral. A right ear of mouse was potently swelled by 1% of DNCB treatm ent, but a mouse ear thickness was significantly reduced by samyoyongantang after 2 we eks treatment. Samyoyongantang reduced IgG in serum obtained from blood of 1 % DNCB-treated mouse. IgE in serum was not changed by samyoyongantang treatment. From these results, anti-inflammatory effect of samyoyongantang, especially reduction of ear swell ing, might be partly due to reduction of IgG in serum.

• 생약학회지
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• 제43권3호
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• pp.243-249
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• 2012

Bee venom (BV), well known as a traditional Oriental medicine, has been widely used in the treatment of some immune-related diseases. However, the anti-allergic effect of BV have not been reported. In this study, we investigated the antiallergic effect of BV on triphasic cutaneous reaction (TpCR) and passive cutaneous anaphylaxis (PCA). Our results indicated that BV suppress ear swelling and vascular permeability on IgE mediated type I hypersensitivity response. Increase in ear thickness was significantly inhibited by BV in this model. BV also blocked the infiltration of immune cells into the ear. Moreover, BV suppressed expression of HDAC3, Tryptase, MCP-1 in ear tissue. These results demonstrated that BV has a suppressive effect on allergic reaction.