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Anti-allergic Effect sof Bee Venom on IgE-mediated Type I hypersensitivity Response in vivo  

Kim, Kyung-Jong (Department of Biochemistry, College of Natural Sciences, Kangwon National University)
Jeoung, Doo-Il (Department of Biochemistry, College of Natural Sciences, Kangwon National University)
Han, Chung-Sub (R&D Center, Dong Sung Bio Pharm Co. Ltd.)
Chun, Sung-Nam (R&D Center, Dong Sung Bio Pharm Co. Ltd.)
Kwon, Chung-Moo (R&D Center, Dong Sung Bio Pharm Co. Ltd.)
Publication Information
Korean Journal of Pharmacognosy / v.43, no.3, 2012 , pp. 243-249 More about this Journal
Abstract
Bee venom (BV), well known as a traditional Oriental medicine, has been widely used in the treatment of some immune-related diseases. However, the anti-allergic effect of BV have not been reported. In this study, we investigated the antiallergic effect of BV on triphasic cutaneous reaction (TpCR) and passive cutaneous anaphylaxis (PCA). Our results indicated that BV suppress ear swelling and vascular permeability on IgE mediated type I hypersensitivity response. Increase in ear thickness was significantly inhibited by BV in this model. BV also blocked the infiltration of immune cells into the ear. Moreover, BV suppressed expression of HDAC3, Tryptase, MCP-1 in ear tissue. These results demonstrated that BV has a suppressive effect on allergic reaction.
Keywords
PCA; Bee venom; Type I hypersensitivity response;
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