• Title/Summary/Keyword: eIF5B

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ENDOMORPHISMS OF PROJECTIVE BUNDLES OVER A CERTAIN CLASS OF VARIETIES

  • Amerik, Ekaterina;Kuznetsova, Alexandra
    • Bulletin of the Korean Mathematical Society
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    • v.54 no.5
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    • pp.1743-1755
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    • 2017
  • Let B be a simply-connected projective variety such that the first cohomology groups of all line bundles on B are zero. Let E be a vector bundle over B and $X={\mathbb{P}}(E)$. It is easily seen that a power of any endomorphism of X takes fibers to fibers. We prove that if X admits an endomorphism which is of degree greater than one on the fibers, then E splits into a direct sum of line bundles.

Extracellular Production of Alpha-Interferon by Recombinant Escherichia coli: Part II. The Growth Behavior of the Recombinant Cells (유전자 재조합 대장균을 사용한 Alpha-interferon의 생산과 분비: 제2부. 재조합 균주의 생장특성)

  • 노갑수;최차용
    • KSBB Journal
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    • v.5 no.3
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    • pp.195-200
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    • 1990
  • The growth behavior of recombinant Escherichia coli cells having plasmid pIF-III-B, which carries human alpha-interferon gene under the control of lpp promoter, lac promoter and lac operator, was studied by using of various E. coli host strains. Expression of the alpha-IFN gene is controllable by using inducer IPTG because the plasmid also contains lacI gene which produces lac regressors. The repressors block the transcription of alpha-IFN gene. There were considerable differences in cell growth according to the host strains used. Cell growth was inhibited not only by plasmid pIF-III-B itself but also by the induction of alph-a-IFN gene expression. Growth inhibition caused by the plasmid itself was more serious than that caused by the induction of alpha-IFN gene expression.

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Some properties of equivalent fuzzy norms

  • Rhie, Gil-Seob;Hwang, In-Ah
    • International Journal of Fuzzy Logic and Intelligent Systems
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    • v.5 no.2
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    • pp.175-178
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    • 2005
  • In the present paper, we observe a relation between fuzzy norms and induced crisp norms on a linear space. We first prove that if $\rho_1,\;\rho_2$ are equivalent fuzzy norms on a linear space, then for every $\varepsilon\in(0.1)$, the induced crisp norms $P_\varepsilon^1,\;and\;P_\varepsilon^2$, respectively are equivalent. Since the converse does not hold, we prove it under some strict conditions. And consider the following theorem proved in [8]: Let $\rho$ be a lower semicontinuous fuzzy norm on a normed linear space X, and have the bounded support. Then $\rho$ is equivalent to the fuzzy norm $\chi_B$ where B is the closed unit ball of X. The lower semi-continuity of $\rho$ is an essential condition which guarantees the continuity of $P_\varepsilon$, where 0 < e < 1. As the last result, we prove that : if $\rho$ is a fuzzy norm on a finite dimensional vector space, then $\rho$ is equivalent to $\chi_B$ if and only if the support of $\rho$ is bounded.

신규베타락탐계 항생제 합성과 항균성

  • 고옥현;김경수;하재천;고봉석
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.171-171
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    • 1994
  • Cephem ring의 C-7위치에 aminothiazoly lmethoxyimino기를 가진 화합물들이 항균활성을 증가시키고, G(-)균의 외막투과성을 촉진시킬뿐 아니라 광범위항균 spectrum을 갖게 하고 $\beta$-lactamase에 안정하며 PBP(penicillin binding protein)에 대한 결합친화성을 증가시킨다는 보고에 따라 본 저자는 C-7위치에 cefotaxime구조와 같이 aminothiazolylmethoxyimino acetamido moiety를 고정시키고 항균활성을 증가시키기 위하여 약리활성이 기대되는 5-(substituted)-2H-tetrazole유도체들을 합성하여 C-3 위치에 도입시킨 새로운 화합물 7$\beta$-〔(z)-2-(2-aminothiazol-4-yl)-2_(methoxyimino)acetamido〕-3-〔5-(substituted)tetrazol-2-yl〕 methyl-3-cephem-4-carboxylic acid 유도체를 합성하여 B. subtilis ATCC 6633, M. luteus ATCC 1004, E. coli KCTC 1039, E. coli ESS, K. pncumonia KCTC 1560, P. aeruginosa IF0 13130, S. typhimurium KCTC 1925, S. typhimurium SL 1102, 및 C. albicans ATCC 10231 등의 균과 fungus에 대하여 기존의 cefotaxime과 cefazoline을 대조물질로 사용하여 항균력을 비교하였다. 이들 화합물들은 대체적으로 M. luteus ATCC 6633, E. coli ESS, S. typhimurium SL 1102 균에 대해서는 cefotaxime보다 항균력이 우수하였으나 P. aeruginosa IF0 13130에 대해서는 항균력이 저하되었고 cefazolin보다는 대체적으로 항균력이 우수하였다.

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Polyadenylation Is Dispensable for Encapsidation and Reverse Transcription of Hepatitis B viral Pregenomic RNA

  • Lee, Hye-Jin;Lee, Jehan;Shin, Myeong-Kyun;Ryu, Wang-Shick
    • Molecules and Cells
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    • v.25 no.4
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    • pp.545-552
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    • 2008
  • A hepadnaviruses replicates its DNA genome via reverse transcription of an RNA template (pregenomic RNA or pgRNA), which has a cap structure at the 5' end and a poly(A) tail at the 3' end. We have previously shown that the 5' cap is indispensable for encapsidation of the pgRNA. A speculative extension of the above finding is that the cap contributes to encapsidation via its interaction with the poly(A) tail, possibly involving eIF4E-eIF4G-PABP interaction. To test this hypothesis, poly(A)-less pgRNAs were generated via cleavage by a cis-acting hepatitis delta virus ribozyme sequence. We found that accumulation of the poly(A)-less pgRNA was markedly diminished, mostly likely due to its reduced stability. Importantly, however, the remaining poly(A)-less pgRNAs were nonetheless encapsidated and reverse transcribed normally when the reduced stability was taken account. Our finding clearly contradicts the notion that the poly(A) tail has any function in encapsidation and viral reverse transcription.

A NOTE ON GORENSTEIN PRÜFER DOMAINS

  • Hu, Kui;Wang, Fanggui;Xu, Longyu
    • Bulletin of the Korean Mathematical Society
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    • v.53 no.5
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    • pp.1447-1455
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    • 2016
  • In this note, we mainly discuss the Gorenstein $Pr{\ddot{u}}fer$ domains. It is shown that a domain is a Gorenstein $Pr{\ddot{u}}fer$ domain if and only if every finitely generated ideal is Gorenstein projective. It is also shown that a domain is a PID (resp., Dedekind domain, $B{\acute{e}}zout$ domain) if and only if it is a Gorenstein $Pr{\ddot{u}}fer$ UFD (resp., Krull domain, GCD domain).

Erlang Capacity and Cell Coverage Based on Handoff Techniques in the Reverse Link of a CDMA System of 14.4 kbps/1.9 GHz Band (1.9 GHz 대역/14.4 kbps CDMA 시스템의 역방향 링크에서 핸드오프 유형별 얼랑용량과 셀커버리지)

  • Kwon, Young-Soo;Kim, Nam
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.28 no.1A
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    • pp.25-33
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    • 2003
  • We derive the outage probabilities for the Erlang capacity and link margin based on handoffs in the reverse link of a CDMA system of 14.4 kbps/1.9 GHz band, calculate them with the same parameters, and then with the maximum realizable Erlang capacity analyze newly the cell coverage in different areas by the COST-231 model If it decreases from 5 % to 2 % in case of $E_b/N_0$=5 dB under a soft handoff, the result shows a very reliable link with additional increment of 0.88 dB in the margin and a high quality of service within the coverage decrease of 0.12 km, 0.25 km, and 1 km in a city, suburban, and open areas respectively on the decrease of 2 Erlang in the capacity. When the $E_b/N_0$ decreases from 7 dB to 5 dB within the outage probability of 5 %, it shows the increase of 9 Erlang and of 0.2 km in a city on the same margin of 2.8 dB. Then, comparing it with a single cell, it shows the decrease of more than 10 Erlang in the capacity, but the enlargement of 0.17 km, 0.3 km, and 1 km in them on the margin decrease of 1.31 dB, also, with a hard handoff, the soft handoff gain of the increase of 10 Erlang and of 0.22 km, 0.5 km, and 2 km on the decrease of 2.16 dB.

Capacity and Coverage according to Calculations of the Erlang Capacity in the Reverse Link of a DS/CDMA System (DS/CDMA 시스템의 역방향 링크에서 얼랑용량 계산에 따른 사용자 수와 셀 커버리지)

  • Kwon, Young-Soo;Kim, Hang-Rae;Kim, Nam
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.13 no.9
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    • pp.947-955
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    • 2002
  • In this paper, we derive an outage probability for the Erlang capacity and the link margin respectively, calculate them with the same parameters and outage probability, and then analyze a capacity and cell coverage in city, suburban, and open area. So, the Erlang capacity is more real than in a cell, and the cell coverage can be calculated with high reliability by the margin. When the $E_b/N_o$ decreases from 7 dB to 5 dB within the outage probability of 5 %, it is observed that the capacity is increased from 18 Erlang to 31 Erlang with the same margin of 2.8 dB, then the coverage is increased to 0.4 km, 1 km, and 2.5 km in city, suburban, and open area respectively. Also if the outage probability is decreased from 5 % to 2 % in case of $E_b/N_o$ of 5 dB, the result shows a very reliable link with additional increment of 0.88 dB in the margin and a high QoS (quality of service) within decrement of 0.15 km, 0.5 km, and 1.5 km for the same areas with decrement of 3 Erlang from 31 Erlang.

Post-transcriptional and post-translational regulation during mouse oocyte maturation

  • Kang, Min-Kook;Han, Seung-Jin
    • BMB Reports
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    • v.44 no.3
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    • pp.147-157
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    • 2011
  • The meiotic process from the primordial stage to zygote in female germ cells is mainly adjusted by post-transcriptional regulation of pre-existing maternal mRNA and post-translational modification of proteins. Several key proteins such as the cell cycle regulator, Cdk1/cyclin B, are post-translationally modified for precise control of meiotic progression. The second messenger (cAMP), kinases (PKA, Akt, MAPK, Aurora A, CaMK II, etc), phosphatases (Cdc25, Cdc14), and other proteins (G-protein coupled receptor, phosphodiesterase) are directly or indirectly involved in this process. Many proteins, such as CPEB, maskin, eIF4E, eIF4G, 4E-BP, and 4E-T, post-transcriptionally regulate mRNA via binding to the cap structure at the 5' end of mRNA or its 3' untranslated region (UTR) to generate a closed-loop structure. The 3' UTR of the transcript is also implicated in post-transcriptional regulation through an association with proteins such as CPEB, CPSF, GLD-2, PARN, and Dazl to modulate poly(A) tail length. RNA interfering is a new regulatory mechanism of the amount of mRNA in the mouse oocyte. This review summarizes information about post-transcriptional and post-translational regulation during mouse oocyte meiotic maturation.

ON INJECTIVITY AND P-INJECTIVITY, IV

  • Chi Ming, Roger Yue
    • Bulletin of the Korean Mathematical Society
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    • v.40 no.2
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    • pp.223-234
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    • 2003
  • This note contains the following results for a ring A : (1) A is simple Artinian if and only if A is a prime right YJ-injective, right and left V-ring with a maximal right annihilator ; (2) if A is a left quasi-duo ring with Jacobson radical J such that $_{A}$A/J is p-injective, then the ring A/J is strongly regular ; (3) A is von Neumann regular with non-zero socle if and only if A is a left p.p.ring containing a finitely generated p-injective maximal left ideal satisfying the following condition : if e is an idempotent in A, then eA is a minimal right ideal if and only if Ae is a minimal left ideal ; (4) If A is left non-singular, left YJ-injective such that each maximal left ideal of A is either injective or a two-sided ideal of A, then A is either left self-injective regular or strongly regular : (5) A is left continuous regular if and only if A is right p-injective such that for every cyclic left A-module M, $_{A}$M/Z(M) is projective. ((5) remains valid if 《continuous》 is replaced by 《self-injective》 and 《cyclic》 is replaced by 《finitely generated》. Finally, we have the following two equivalent properties for A to be von Neumann regula. : (a) A is left non-singular such that every finitely generated left ideal is the left annihilator of an element of A and every principal right ideal of A is the right annihilator of an element of A ; (b) Change 《left non-singular》 into 《right non-singular》in (a).(a).