• Nutritional Sciences
• /
• 제9권2호
• /
• pp.82-91
• /
• 2006

This study was performed to investigate the effect of normal diet with or without naringin supplement on the lipid and antioxidant metabolism in ethanol-treated rats for a short tenn. Male Sprague-Dawley rats were divided into three groups (n=10), which were assigned to one of three dietary categories : $E_8$ : ethanol diet for 8 wks, $E_4N_4$ : ethanol diet for the first 4 wks and normal diet for the last 4 wks, $E_4Nna_4$ : ethanol diet for the first 4 wks and normal diet with naringin supplement for the last 4 wks. Plasma total cholesterol concentrations were significantly higher in ethanol fed rats for 8 weeks. The HDL-C/total-C ratios of the $E_4N_4$ and the $E_4Nna_4$ groups were significantly higher than that of the $E_8$ group, while the atherogenic index was lower in the $E_4N_4$ and the $E_4Nna_4$ groups than in the $E_8$ group. The $E_4N_4$ and $E_4Nna_4$ diets significantly lowered both the hepatic cholesterol and triglyceride levels compared to the $E_8$ group. Accumulation of hepatic lipid droplets was observed to be the highest in the $E_8$ group. In the current study, the naringin supplement to normal diet significantly lowered both the hepatic HMG-CoA reductase and ACAT activities in ethanol pre-treated rats for 4 weeks. Antioxidant enzyme activities were also upregulated when ethanol feeding was ceased. Naringin supplement given for 4 weeks after ethanol cessation resulted in a significant decrease in the plasma cholesterol and hepatic lipids and plasma TBARS as well as the hepatic HMG-CoA reductase and ACAT activities compared to the rats given ethanol diet for the entire 8 weeks. Replacement of normal diet following a short tenn ethanol feeding was effective for the recovery of ethanol-induced fatty liver and for normalizing plasma and hepatic lipid profiles and antioxidant enzyme activities, regardless of an additional phytochemical supplement, naringin. The effect of naringin could seemingly be more evident if its supplementation period had been extended longer than 4 weeks after ethanol cessation.

• 한국인터넷방송통신학회논문지
• /
• 제17권4호
• /
• pp.173-179
• /
• 2017

오토바이는 자동차에 비해 차량주행정보가 부족하고 사고 위험성이 높아 충돌감지센서, 후방카메라, 블루투스 통신모듈, 마이크로콘트롤러, HUD로 구성되는 스마트헬멧을 제작하여 오토바이 주행정보와 e-call 기능을 제공하는 시스템을 개발한다면 사용자에게 매우 유용하고 교통사고 시에 인명피해 감소 및 신속한 교통사고 처리가 가능하다. 본 논문에서는 이와 같은 "스마트헬멧을 이용한 오토바이 운전자 주행정보 및 e-call 기능 제공 시스템"의 소프트웨어를 개발하는데 있어 객체지향 분석 방법인 UML을 이용한 소프트웨어 개발 분석 방법, 하드웨어 블록다이어 그램 구조, 플로우차트 및 UI 설계를 보여줌으로써 실무 개발에 적합한 분석/설계 방법을 제시하고자 한다.

• Journal of Microbiology and Biotechnology
• /
• 제17권7호
• /
• pp.1169-1176
• /
• 2007

Genes encoding proteins responsible for limonene catabolism were cloned from a limonene-degrading microorganism, Enterobacter cowanii 6L, which was isolated from citron (Citrus junos) peel. The 8.6, 4.7, and 7.7 kb fragments (CD3, CD4, and CD6) of E. cowanii 6L chromosomal DNA that confer to E. coli the ability to grow on limonene have been cloned and their corresponding DNA sequences were determined. Nine open reading frames (ORFs) were identified, and the four ORFs (921 bp of CD3-2; 1,515 bp of CD4-1; 1,776 bp of CD6-1; and 1,356 bp of CD6-2) that encode limonene hydroxylase were confirmed by independently expressing these genes in E. coli. FAD and NADH were found to stimulate the hydroxylation reaction if added to cell extracts from E. coli recombinants, and multiple compounds (linalool, dihydrolinalool, perillyl alcohol, (${\alpha}-terpineol$, and ${\gamma}-terpineol$) were the principal products observed. Our results suggest that the isolate E. cowanii 6L has a broad metabolic capability including utilization of limonene. This broad metabolic ability was confirmed by identifying four novel limonene hydroxylase functional ORFs in E. cowanii 6L.

• Kyungpook Mathematical Journal
• /
• 제55권4호
• /
• pp.885-892
• /
• 2015

In this paper, we mainly obtain the following assertions: (1) If T is a quasi-*-n-paranormal operator, then T is finite and simply polaroid. (2) If T or $T^*$ is a quasi-*-n-paranormal operator, then Weyl's theorem holds for f(T), where f is an analytic function on ${\sigma}(T)$ and is not constant on each connected component of the open set U containing ${\sigma}(T)$. (3) If E is the Riesz idempotent for a nonzero isolated point ${\lambda}$ of the spectrum of a quasi-*-n-paranormal operator, then E is self-adjoint and $EH=N(T-{\lambda})=N(T-{\lambda})^*$.

• 생태와환경
• /
• 제53권1호
• /
• pp.63-72
• /
• 2020

본 연구에서는 멸종위기종이 서식하는 4개 하천(금강, 지천, 황지천, 섬진강)에서 환경유전자(environmental DNA, eDNA)와 보편적 어구를 이용한 조사 방법을 적용하여 지점별 종 다양성을 확인하고, 이를 통해 eDNA의 활용을 고찰하였다. eDNA 조사를 통해서 확인된 종 수는 지점 평균(±표준편차) 19종(±4.4)이며, 이는 어구를 이용한 정량 조사의 10종(±4.8)과 비교하여 높게 나타났다. 대부분의 지점에서 eDNA 조사가 어구를 이용한 조사보다 효율이 높게 나타났다. 반면 eDNA 조사 결과 고유종 및 근연종에 대해서 동정의 오류가 확인되어, universal primer (MiFish primer set)에 대한 국내 적용의 한계를 확인하였다. 또한 멸종위기종의 서식 여부도 일부 종에 대해서 eDNA 조사 결과가 현장 조사 및 문헌과의 차이를 보였다. 현재 개발된 universal primer는 국내에서 서식하는 모든 담수종의 서식을 확인하는 데 있어서 결과의 신뢰성을 담보할 수 없기 때문에 universal primer의 보완 및 개발이 필요하며, 멸종위기종과 같은 특정종의 서식 확인을 위해서는 종특이적 마커 개발을 통한 적용이 고려되어야 한다. 마지막으로 eDNA의 현장 조사 방법에 대한 매뉴얼이 개발될 경우, 수생태계 조사에 대한 활용성이 증대될 수 있을 것이다.

• 충청수학회지
• /
• 제19권4호
• /
• pp.375-381
• /
• 2006

This paper presents characterizations based on the identical distribution and the finite moments of the exponential distribution by record values. We prove that $X{\in}EXP({\sigma})$, ${\sigma}$>0, if and only if $X_{U(n+k)}-X_{U(n)}$ and $X_{U(n)}-X_{U(n-k)}$ for n > 1 and $k{\geq}1$ are identically distributed. Also, we show that $X{\in}EXP({\sigma})$, ${\sigma}$>0, if and only if $E(X_{U(n+k)}-X_{U(n)})=E(X_{U(n)}-X_{U(n-k)})$ for n>1 and $k{\geq}1$.

• 대한기계학회논문집A
• /
• 제36권4호
• /
• pp.373-378
• /
• 2012

본 논문에서는 공통원인고장을 고려하여 증기터빈 비산확률을 평가하였다. 이 과정에서 저속 및 고속에서 터빈 비산물 발생 경로를 제시하고, 고장수목을 활용하여 비산물 발생빈도를 구하였다. 공통원인고 장을 고려하기 위해서 Alpha Factor 방법론을 사용하였다. 순차 및 비순차 시험에 대해서 각각의 빈도를 비교분석 하였으며, 불확실성을 평가하였다. (1) 고속회전에 의한 연성파괴로 발생하는 터빈비산물 방출빈도는 8.005E-7/year로 평가되었다. (2) 만약, 공통원인고장이 고려되면, 시험방식에 따라 11% 및 33%의 방출빈도 증가를 확인하였다. (3) 사용된 CCF 변수의 불확실성을 고려하면, 터빈방출빈도는 90%의 신뢰도 기준 9.35E-7에서 1.13E-6 사이에 존재함을 알 수 있었다.

• Journal of Periodontal and Implant Science
• /
• 제29권3호
• /
• pp.553-560
• /
• 1999

The aim of the present study was to evaluate the effect of the expanded polytetrafluoroethylene (e-PTFE) membrane exposure on the initial healing of the periodontal tissue in guided tissue regeneration (GTR) procedure. 90 sites selected from 90 patients were treated with gingival flap surgery supported by an e-PTFE membrane. The material included angular bony defects with probing attachment loss of > 5mm or degree II furcation involvement. Treated sites were classified with membrane exposure group and non-exposure group at membrane removal and evaluated healing type. The results were obtained as follows. 1. e-PTFE membrane was exposed at 61 sites (67.8%) among 90 sites. 2. Thirteen sites (14.4%) depicted rapid healing type, 65 sites (72.2%) depicted typical healing type, 9 sites (10%) showed delayed healing type and 3 sites (3.3%) were categorized as adversed healing type. 3. In e-PTFE membrane exposure group, 1 site (1.6%), 51 sites (83.6%), 6 sites (9.8%) and 3 sites (4.9%) showed rapid healing type, typical healing type, delayed healing type and adverse healing type respectively. 4. In e-PTFE membrane non-exposure group, 12 sites (41.3%), 14 sites (48.3%) and 3 sites (10.3%) showed rapid healing type, typical healing type and delayed healing type respectively. Adverse healing type was not observed. 5. The rate of favourable healing between e-PTFE membrane exposure group and non-exposure group was not statistically significant(p=0.56). These results suggest that the prevention of membrane exposure may be important to obtain rapid healing type. However favourable healing could be obtained with stringent infection control program even if membrane was exposed.

• 천문학회지
• /
• 제8권1호
• /
• pp.29-34
• /
• 1975

Solar electrical conductivity has been calculated, making use of Yun and Wyller's formulation. The computed results arc presented in a tabulated form as functions of temperature and pressure for given magnetic field strengths. The results of the calculation show that the magnetic field does not play any important role in characterizing the electrical conductivity of the ionized gas when the gas pressure is relatively high (e.g., $P{\geq}10^4\;dynes/cm^2$). However, when the gas pressure is low (e.g., $P{\leq}10\;dynes/cm^2$), the magnetic field becomes very effective even if its field strength is quite small (e.g., $B{\leq}0.01$ gauss). It is also found that, except for lower temperature region (e.g., $T{\leq}10^{4^{\circ}}K$), there is a certain linear relationship in a log- log graph between the pressure and the critical magnetic field strength, which is defined as a field strength capable of reducing the non-magnetic component of the electrical conductivity by 20%.

• Biomolecules & Therapeutics
• /
• 제26권5호
• /
• pp.503-511
• /
• 2018

Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3'-diindolylmethane (DIM) are phytoestrogens that play chemopreventive roles in the inhibition of carcinogenesis and cancer progression. In this study, the influence of TCS, BPA, Kaem, and DIM on proliferation and apoptotic abilities of VM7Luc4E2 breast cancer cells were examined. MTT assay revealed that TCS ($0.1-10{\mu}M$), BPA ($0.1-10{\mu}M$) and E2 ($0.01-0.0001{\mu}M$) induced significant cell proliferation of VM7Luc4E2 cells, which was restored to the control (0.1% DMSO) by co-treatment with Kaem ($30{\mu}M$) or DIM ($15{\mu}M$). Reactive oxygen species (ROS) production assays showed that TCS and BPA inhibited ROS production of VM7Luc4E2 cells similar to E2, but that co-treatment with Kaem or DIM on VM7Luc4E2 cells induced increased ROS production. Based on these results, the effects of TCS, BPA, Kaem, and DIM on protein expression of apoptosis and ROS production-related markers such as Bax and Bcl-xl, as well as endoplasmic reticulum (ER) stress-related markers such as $eIF2{\alpha}$ and CHOP were investigated by Western blot assay. The results revealed that TCS, and BPA induced anti-apoptosis by reducing ROS production and ER stress. However, Kaem and DIM effectively inhibited TCS and BPA-induced anti-apoptotic processes in VM7Luc4E2 cells. Overall, TCS and BPA were revealed to be distinct xenoestrogens that enhanced proliferation and anti-apoptosis, while Kaem and DIM were identified as natural chemopreventive compounds that effectively inhibited breast cancer cell proliferation and increased anti-apoptosis induced by TCS and BPA.