• 제목/요약/키워드: eIF2

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INJECTIVE PROPERTY OF LAURENT POWER SERIES MODULE

  • Park, Sang-Won
    • East Asian mathematical journal
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    • 제17권2호
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    • pp.367-374
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    • 2001
  • Northcott and McKerrow proved that if R is a left noetherian ring and E is an injective left R-module, then $E[x^{-1}]$ is an injective left R[x]-module. Park generalized Northcott and McKerrow's result so that if R is a left noetherian ring and E is an injective left R-module, then $E[x^{-S}]$ is an injective left $R[x^S]$-module, where S is a submonoid of $\mathbb{N}$($\mathbb{N}$ is the set of all natural numbers). In this paper we extend the injective property to the Laurent power series module so that if R is a ring and E is an injective left R-module, then $E[[x^{-1},x]]$ is an injective left $R[x^S]$-module.

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An Australian Retrospective Study to Evaluate the Prognostic Role of p53 and eIF4E Cancer Markers in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC): Study Protocol

  • Singh, Jagtar;Jayaraj, Rama;Baxi, Siddhartha;Mileva, Mariana;Curtin, Justin;Thomas, Mahiban
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권8호
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    • pp.4717-4721
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    • 2013
  • Complete surgical resection of the primary tumour is a crucial predictive step for head and neck squamous cell carcinoma (HNSCC), because incomplete resection may lead to increase in the recurrence rate. Molecular cancer markers have been investigated as potential predictors of prognosis marker, to identify patients who are at high risk of local recurrence. This retrospective study aimed to determine the prognostic correlation between p53 and eIF4E expression and clinical characteristics, recurrence and overall survival. Forty eight HNSCC patients were selected between 2006 and 2009 diagnosed at the Royal Darwin Hospital, Darwin, Northern Territory, Australia. Out of 48, only those 24 with negative surgical margins with hematoxylin and eosin (HandE) were chosedn for further analysis. A total of 77 surgical margins were obtained and subsequently analysed by immunohistochemical (IHC) staining with monoclonal p53 and polyclonal eIF4E antibodies. Contingency table and ${\chi}^2$-test were used to investigate the correlation between p53 and eIF4E expression and clinical characteristics, recurrence and overall survival of the HNSCC patients. The follow up period was 74 months (range 1-74 months). The Kaplan-Meier method was used to generate recurrence and survival curves. This is a first retrospective study of Northern Territory patients, including Indigenous and non-Indigenous Australians. Molecular study of surgical margins could help to identify patients with and without clear margins after surgery and help in choice of the most appropriate adjuvant treatment for HNSCC patients.

MULTIPLICATIVE SET OF IDEMPOTENTS IN A SEMIPERFECT RING

  • Park, Sang-Won;Han, Jun-Cheol
    • 대한수학회보
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    • 제48권5호
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    • pp.1033-1039
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    • 2011
  • Let R be a ring with identity 1, I(R) be the set of all idempotents in R and G be the group of all units of R. In this paper, we show that for any semiperfect ring R in which 2 = 1+1 is a unit, I(R) is closed under multiplication if and only if R is a direct sum of local rings if and only if the set of all minimal idempotents in R is closed under multiplication and eGe is contained in the group of units of eRe. In particular, for a left Artinian ring in which 2 is a unit, R is a direct sum of local rings if and only if the set of all minimal idempotents in R is closed under multiplication.

Depletion of PDCD4 Accelerates Stress Granule Assembly Through Sensitization of Stress Response Pathways

  • Kim, Jeeho;Chang, In Youb;Lee, Wooje;Ohn, Takbum
    • 통합자연과학논문집
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    • 제12권4호
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    • pp.127-132
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    • 2019
  • Programmed cell death 4 (PDCD4) is a novel tumor suppressor that function in the nucleus and the cytoplasm and appears to be involved in the regulation of transcription and translation. Stress granules (SGs) are cytoplasmic foci at which untranslated mRNAs accumulate when cells exposed to environmental stresses. Since PDCD4 has implicated in translation repression through direct interaction with eukaryotic translation initiation factor 4A (eIF4A), we here investigated if PDCD4 has a functional role in the process of SG assembly under oxidative stresses. Using immunofluorescence microscopy, we found that PDCD4 is localized to SGs under oxidative stresses. Next, we tested if knockdown of PDCD4 has an effect on the assembly of SG using PDCD4-specific siRNA. Interestingly, SG assembly was accelerated and this effect was caused by sensitization of phosphorylation of eIF2α and dephosphorylation of eIF4E binding protein (4E-BP). These results suggest that PDCD4 has an effect on SG dynamics and possibly involved in cap-dependent translation repression under stress conditions.

UNITARY INTERPOLATION ON AX = Y IN ALG$\mathcal{L}$

  • Kang, Joo-Ho
    • 호남수학학술지
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    • 제31권3호
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    • pp.421-428
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    • 2009
  • Given operators X and Y acting on a Hilbert space $\mathcal{H}$, an interpolating operator is a bounded operator A such that AX = Y. In this paper, we showed the following : Let $\mathcal{L}$ be a subspace lattice acting on a Hilbert space $\mathcal{H}$ and let $X_i$ and $Y_i$ be operators in B($\mathcal{H}$) for i = 1, 2, ${\cdots}$. Let $P_i$ be the projection onto $\overline{rangeX_i}$ for all i = 1, 2, ${\cdots}$. If $P_kE$ = $EP_k$ for some k in $\mathbb{N}$ and all E in $\mathcal{L}$, then the following are equivalent: (1) $sup\;\{{\frac{{\parallel}E^{\perp}({\sum}^n_{i=1}Y_if_i){\parallel}}{{\parallel}E^{\perp}({\sum}^n_{i=1}Y_if_i){\parallel}}:f{\in}H,n{\in}{\mathbb{N}},E{\in}\mathcal{L}}\}$ < ${\infty}$ range $\overline{rangeY_k}\;=\;\overline{rangeX_k}\;=\;\mathcal{H}$, and < $X_kf,\;X_kg$ >=< $Y_kf,\;Y_kg$ > for some k in $\mathbb{N}$ and for all f and g in $\mathcal{H}$. (2) There exists an operator A in Alg$\mathcal{L}$ such that $AX_i$ = $Y_i$ for i = 1, 2, ${\cdots}$ and AA$^*$ = I = A$^*$A.

Injective Property Of Generalized Inverse Polynomial Module

  • Park, Sang-Won
    • 대한수학회논문집
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    • 제15권2호
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    • pp.257-261
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    • 2000
  • Northcott and Mckerrow proved that if R is a left noe-therian ring and E is an injective left R-module, then E[x-1] is an injective left R[x]-module. In this paper we generalize Northcott and McKerrow's result so that if R is a left noetherian ring and E is an in-jective left R-module, then E[x-S] is an injective left R[xS]-module, where S is a submonoid of N (N is the set of all natural numbers).

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JORDAN DERIVATIONS IN NONCOMMUTATIVE BANACH ALGEBRAS

  • Chang, Ick-Soon
    • 대한수학회보
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    • 제37권3호
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    • pp.429-435
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    • 2000
  • Our main goal is to show that if there exist Jordan derivations D, E and G on a noncommutative 2-torsion free prime ring R such that$(G^2(x)+E(x))D(x)=0\ or\ D(x)(G^2(x)+E(x))=0\ for\ all\ x\inR$, then we have D=o or E=0, G=0.

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Notes on correct modules

  • Lee, Dong-Soo;Park, Chul-Hwan
    • 대한수학회논문집
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    • 제11권2호
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    • pp.295-301
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    • 1996
  • In this paper we will define correct module and strongly correct module. We can have some basic results about those modules. And we will show that M is a graded correct R-module if and only if $M_e$ is a correct $R_e$-module.

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RING WHOSE MAXIMAL ONE-SIDED IDEALS ARE TWO-SIDED

  • Huh, Chan;Jang, Sung-Hee;Kim, Chol-On;Lee, Yang
    • 대한수학회보
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    • 제39권3호
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    • pp.411-422
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    • 2002
  • In this note we are concerned with relationships between one-sided ideals and two-sided ideals, and study the properties of polynomial rings whose maximal one-sided ideals are two-sided, in the viewpoint of the Nullstellensatz on noncommutative rings. Let R be a ring and R[x] be the polynomial ring over R with x the indeterminate. We show that eRe is right quasi-duo for $0{\neq}e^2=e{\in}R$ if R is right quasi-duo; R/J(R) is commutative with J(R) the Jacobson radical of R if R[$\chi$] is right quasi-duo, from which we may characterize polynomial rings whose maximal one-sided ideals are two-sided; if R[x] is right quasi-duo then the Jacobson radical of R[x] is N(R)[x] and so the $K\ddot{o}the's$ conjecture (i.e., the upper nilradical contains every nil left ideal) holds, where N(R) is the set of all nilpotent elements in R. Next we prove that if the polynomial rins R[x], over a reduced ring R with $\mid$X$\mid$ $\geq$ 2, is right quasi-duo, then R is commutative. Several counterexamples are included for the situations that occur naturally in the process of this note.