• Journal of Biomedical Engineering Research
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• v.25 no.4
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• pp.295-300
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• 2004

Coil embolization technique has been used recently to treat cerebral aneurysms. When a giant or a multilobular aneurysm are treated by roils, filling an aneurysm sac completely with coils is difficult and partial blocking of an aneurysm sac is inevitable. Blood flow characteristics, which nay affect the embolization process of an aneurysm sac, are changed by the locations of coils for the Partially blocked aneurysms. Blood flow fields are also influenced by the geometry of a parent vessel. In order to suggest the coil locations effective for aneurysm embolization, the blood flow fields of lateral aneurysm models were analyzed for the different coil locations and parent vessel geometries. Three dimensional pulsatile flow fields are analyzed by numerical methods considering non-Newtonian viscosity characteristics of blood. Flow rate into the aneurysm sac (inflow rate) and wall shear stress, which are suspected as flow dynamic factors influencing aneurysm embolization, are also calculated. Inflow rates were smaller and the low wall shear stress zones were larger in the neck blocked models compared to the dome blocked models. Smaller inflow and larger low wall shear stress zones in the distal neck blocked model imply that the distal neck should be the effective coil locations for aneurysm embolization.

• Journal of Korean Medicine Rehabilitation
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• v.25 no.2
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• pp.15-35
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• 2015

Objectives This study was performed to investigate the effects of Bujasasim-tang ethanol extract (BST) on oxidative stress, inflammation and osteoarthritic rat model. Methods To ensure safety of BST, heavy metal levels were measured and cytotoxicity test was done. In vitro, To evaluate antioxidative effects of BST, total phenolic contents, 1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activity, reactive oxygen species (ROS) levels were measured. Also, to evaluate anti-inflammatory effects of BST treated group, total nitric oxide (NO) and pro-inflammatory cytokines (IL-$1{\beta}$, IL-6, TNF-${\alpha}$) levels were measured in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. In vivo, We injected MIA $50{\mu}l$ (60 mg/ml) into knee joints of rats to induce osteoarthritis. Rats were divided into total 3 groups (normal, control, BST treated group, each n=7). Normal group was not treated at all without inducing osteoarthritis and taken normal diet. Control group was induced osteoarthritis by MIA and taken with 2 ml of distilled water once a day for 4 weeks. BST treated group was induced osteoarthritis by MIA and taken BST 2 ml (200 mg/kg/mouse) once a day for 4 weeks. We evaluated dynamic weight bearing with the Incapacitance Test Meter. At the end of experiment, the rats were sacrificed to observe the functions of liver and kidney, changes of WBC, neutrophil, lymphocyte, monocyte levels in blood, to evaluate the levels of pro-inflammatory cytokines, tissue inhibitor of metallopreteinases-1 (TIMP-1), matrix metalloproteinase-9 (MMP-9), prostaglandin $E_2$ ($PGE_2$), leukotriene $B_4$ ($LTB_4$) within serum. We observed change of articular structures by Hematoxylin & Eosin (H&E), safranin-O staining method and measured amount of cartilage by micro CT-arthrography. Statistical analysis was done by unpaired student's t-test with significance level at p<0.05 in SPSS 11.0 for windows. Results 1. Safety of the BST was identified. 2. AST, ALT, BUN, creatinine levels of BST treated group were within normal limit. In vitro, 1. DPPH and ABTS free radical scavenging activities of BST showed dose-dependent increase. 2. ROS production were significantly decreased. 3. Total nitric oxide (NO) and IL-$1{\beta}$ production were decreased. 4. IL-6 and TNF-${\alpha}$ production were significantly decreased. In vivo, 1. Weight bearing ability was significantly increased. 2. WBC, neutrophil, lymphocyte, monocyte levels in blood were decreased. 3. IL-$1{\beta}$ and TNF-${\alpha}$ levels in serum were significantly decreased. and the IL-6 level was decreased. 4. TIMP-1, MMP-9, $LTB_4$, $PGE_2$ levels in serum were significantly decreased. 5. Cartilage volume of BST treated group was significantly increased. Also changes of cartilage, synovial membrane, fibrous tissue were suppressed. Conclusions The results obtained in this study Bujasasim-tang have effects of antioxidative, anti-inflammatory, relieve pain and protection of cartilage. Therefore we expect that Bujasasim-tang is effective treatment for osteoarthritis.

• Journal of the Korean Geotechnical Society
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• v.20 no.5
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• pp.145-159
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• 2004

The conventional method for assessment of liquefaction potential proposed by Seed and Idriss has been widely used in most countries because of simplicity of tests. Even though various data such as stress, strain, stress path, and excess pore water pressure can be obtained from the dynamic test, especially, two simple experimental data such as the maximum deviatoric stress and the number of cycles at liquefaction have been used in the conventional assessment. In this study, a new detailed assessment for liquefaction potential to reflect both characteristics of real earthquake motion and dynamic soil resistance is proposed and verified. In the assessment, the safety factor of the liquefaction potential at a given depth of a site can be obtained by the ratio of a resistible cumulative plastic shear strain determined through the performance of the conventional cyclic test and a driving cumulative plastic shear strain calculated from the shear strain time history through the ground response analysis. The last point to cumulate the driving plastic shear strain to initiate soil liquefaction is important for this assessment. From the result of cyclic triaxial test using real earthquake motions, it was concluded that liquefaction under the impact-type earthquake loads would initiate as soon as a peak loading signal was reached. The driving cumulative plastic shear strain, therefore, can be determined by adding all plastic shear strains obtained from the ground response analysis up to the peak point. Through the verification of the proposed assessment, it can be concluded that the proposed assessment for liquefaction potential can be a progressive method to reflect both characteristics of the unique soil resistance and earthquake parameters such as peak earthquake signal, significant duration time, earthquake loading type, and magnitude.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.31 no.10
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• pp.999-1008
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• 2007

The spacer grid set is a component in the nuclear fuel assembly. The set supports the fuel rods safely. Therefore, the spacer grid set should have sufficient strength for the external impact forces such as earthquake. The fretting wear occurs between the spring of the fuel rod and the spacer grid due to flow-induced vibration. Conceptual design of the spacer grid set is performed based on the Independence Axiom of axiomatic design. Two functional requirements are defined for the impact load and the fretting wear, and corresponding design parameters are selected. The overall flow of design is defined according to the application of axiomatic design. Design for the impact load is carried out by using nonlinear dynamic analysis to determine the length of the dimple. Topology optimization is carried out to determine a new configuration of the spring. The fretting wear is reduced by shape optimization using the homology theory. The deformation of a structure is called homologous if a given geometrical relationship holds before, during, and after the deformation. In the design to reduce the fretting wear, the deformed shape of the spring should be the same as that of the fuel rod. This condition is transformed to a function and considered as a constraint in the shape optimization process. The fretting wear is expected to be reduced due to the homology constraint. The objective function is minimizing the maximum stress to allow a slight plastic deformation. Shape optimization results are confirmed through nonlinear static analysis.

• Journal of the Earthquake Engineering Society of Korea
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• v.20 no.4
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• pp.201-209
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• 2016

Damages of large embankment dams by recent strong earthquakes in the world highlight the importance of seismic security of dams. Some of recent dam construction projects for water storage and hydropower are located in highly seismic zone, hence the seismic performance evaluation is an important issue. While state-of-the-art numerical analysis technology is generally utilized in practice for seismic performance evaluation of large dams, physical modeling is also carried out where new construction technology is involved or numerical analysis technology cannot simulate the behavior appropriately. Geotechnical centrifuge modeling is widely adopted in earthquake engineering to simulate the seismic behavior of large earth structures, but sometimes it can't be applied for large embankment dams due to various limitations. This study proposes a dynamic centrifuge testing method for large embankment dams and evaluated its applicability. Scaling relations for a case which model scale and g-level are different could be derived considering the stress conditions and predominant period of the structure, which is equivalent to previously suggested scaling relations. The scaling principles and testing method could be verified by modified modeling of models using a model at different acceleration levels. Finally, its applicability was examined by centrifuge tests for an embankment dam in Korea.

• Wind and Structures
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• v.27 no.4
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• pp.269-282
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• 2018

In this paper, a new displacement field based on quasi-3D hybrid-type higher order shear deformation theory is developed to analyze the static and dynamic response of exponential (E), power-law (P) and sigmoïd (S) functionally graded beams. Novelty of this theory is that involve just three unknowns with including stretching effect, as opposed to four or even greater numbers in other shear and normal deformation theories. It also accounts for a parabolic distribution of the transverse shear stresses across the thickness, and satisfies the zero traction boundary conditions at beams surfaces without introducing a shear correction factor. The beam governing equations and boundary conditions are determined by employing the Hamilton's principle. Navier-type analytical solutions of bending and free vibration analysis are provided for simply supported beams subjected to uniform distribution loads. The effect of the sigmoid, exponent and power-law volume fraction, the thickness stretching and the material length scale parameter on the deflection, stresses and natural frequencies are discussed in tabular and graphical forms. The obtained results are compared with previously published results to verify the performance of this theory. It was clearly shown that this theory is not only accurate and efficient but almost comparable to other higher order shear deformation theories that contain more number of unknowns.

• Polymer(Korea)
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• v.27 no.3
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• pp.183-188
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• 2003

The dielectric constants of fluorine-containing epoxy resins, 2-diglycidylether of benzotrifluoride(FER)/4,4'-diamino-diphenyl methane (DDM) and diglycidylether of bisphenol-A (DGEBA)/DDM systems were evaluated by dielectric spectrometer. Glass transition temperature and thermal stability factors, including initial decomposed temperature, temperatures of maximum rate of degradation, and decomposition activation energy of the cured specimens were investigated by dynamic mechanical analysis and thermogravimetric analysis. For the mechanical properties of the casting specimens, the fracture toughness, flexural, and impact tests were performed, and their fractured surfaces were examined by scanning electron microscope. The dielectric constant of FER/DDM system was lower than that of commercial DGEBA/DDM system, and the mechanical properties of the cured specimens showed higher values than those of DGEBA/DDM system. This was probably due to the introduction of trifluoromethyl (CF$_3$) group into the side chain of the epoxy resins, resulting in improving the electric and mechanical properties of the epoxy cure system studied.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.10
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• pp.1437-1442
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• 2010

A slipper metal is used for power transmission in the aluminum hot rolling process. The slipper metal connects a spindle with a coupling. Therefore, if the slipper metal is seriously damaged, the spindle and the coupling will crash into each other. Therefore, preventing the destruction of the slipper metal is essential for ensuring a long mechanical life cycle. In this study, the structural analysis and optimal design of the slipper metal was carried out by finite element method for life extension of the slipper metal. To verify the interference of spindle assembly with modified slipper metal, a kinematics simulation was performed by applying various combinations of dynamic boundary conditions. As a result of structural analysis and optimal design of the slipper metal, the maximum stress of the modified slipper metal was lower than that of the initial model by 22%.

• Journal of the Korean Society for Railway
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• v.12 no.1
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• pp.16-24
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• 2009

In this study, fatigue crack growth rate of a cracked railway bogie frame under variable amplitude loading is predicted by applying linear elastic fracture mechanics. For this purpose, we find the critical points by reference surveying on cracked railway bogie frames. And we make an effective load history by synthesizing the dynamic load measured from the critical points of railway bogie frame during commercial line operation and the static load calculated from structural analysis. Crack growth analyses are performed at the 3 critical points under the commercial operation loading condition by assuming an initial crack size as 40 mm. and the results are compared with the experimental results from Japanese railway bogie frame crack growth case. From the analysis results, we find that around 500,000 km operating distance is necessary to bring crack growth from the initial crack to unstable crack. And it takes around 3.8 normal operating years. We conclude that it is enough time to detect the crack between normal maintenance period.

• Journal of the Korean Society of Marine Environment & Safety
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• v.11 no.2 s.23
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• pp.77-82
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• 2005

Previously sailing yachts or leisure yachts were mainly made from FRP(Fiber glass reinforced plastic) in the small shipbuilding, but recently there is a trend to replace it for steel or aluminum to substitute FRP for environmental friendly materials. Although It have to need a many checked item in case of hull girder strength and transverse strength normally evaluate base on calculation of class guideline so called direct calculation method. Otherwise. this method of initial structural design considered enough for safety margin on the structure. But, case of small craft must consider for evaluating local strength through rational method. In this paper, check the bow structure members for satisfying results base on allowable stress criterion of damaged bow structure by dynamic load due to slamming and bottom impact load due to pitching motion through finite element analysis. and investigate engine bed structure considering engine weight load and transverse wave load.