• 한국정보과학회:학술대회논문집
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• 한국정보과학회 1998년도 가을 학술발표논문집 Vol.25 No.2 (2)
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• pp.51-53
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• 1998

3개 이상의 DNA 혹은 단백질의 염기서열을 정렬하는 복수 염기서열 정렬(multiple sequence alignment)방법은 염기서열들 사이의 진화관계, gene regulation, 단백질의 구조와 기능에 관한 연구에 필수적인 도구이다. 복수 염기서열 정렬문제는 NP-complete 문제군에 속하며, 이 문제를 해결하기 위하여 가장 유용하게 사용되는 알고리즘으로는 dynamic programming이 있다. Dynamic programming은 주어진 입력 염기서열 군들에 대한 최적의 정렬을 생산할 수 있다. 그러나 dynamic programming의 단점은 오랜 실행시간이 요구되며, 때로는 dynamic programming의 속성 때문에 이 알고리즘을 사용하여도 주어진 입력 염기서열 군들에 대한 최적의 정렬을 얻어내지 못하는 경우가 있다. 본 연구에서는 이러한 dynamic programming의 문제를 해결하기 위하여 genetic algorithm을 복수 염기서열 정렬문제에 적용하였다. 본 논문에서는 genetic algorithm의 design과 적용방법을 기술하였다. 본 연구에서 제안된 genetic algorithm을 사용하여 dynamic programming의 단점이었던 오랜 실행시간을 줄일 수 있었으며, dynamic programming이 제공하지 못하는 최적의 염기서열 정렬을 제공할 수 있었다.

• 한국의류학회지
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• 제24권7호
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• pp.1073-1080
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• 2000

Moisture transfer property of fabrics has known as one of the most important factors deciding wearer's subjective comfort not only thermally but also of sensorial. As a decisive property of fabric materials in determining human sensorial comfort, moisture vapor management property of heat resistant workwear material was examined in terms of increasing and decreasing rate and maximum value of relative humidity in the microclimate under the sweat pulse situation. An unique moisture regulation index, B$_{d}$, was calculated from the measurements using a novel dynamic sweating hot plate apparatus and was used to assess the buffering capacity of fabrics against a moisture vapor sweat pulse.e.

• KIEE International Transactions on Power Engineering
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• 제4A권2호
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• pp.51-57
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• 2004

This paper describes the dynamic performance of a variable speed wind turbine system responding to a wide variety of wind variations. Modeling of the wind generation using power electronics interface is proposed for dynamic simulation analysis. Component models and equations are addressed and their incorporations into a transient analysis program, PSCAD/EMTDC are provided. A wind model of four components is described, which enables observing dynamic behaviors of the wind turbine resulting from wind variations. Controllable power inverter strategies are intended for capturing the maximum power under variable speed operation and maintaining reactive power generation at a pre-determined level for constant power factor control or voltage regulation control. The components and control schemes are modeled by user-defined functions. Simulation case studies provide variable speed wind generator dynamic performance for changes in wind speed

• 한국정밀공학회지
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• 제29권6호
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• pp.626-631
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• 2012

In this study, fatigue life of the motor block bracket units for KTX-Sancheon trains was assessed. Design evaluation for railway structures was performed based on the UIC 566 regulation, and test and evaluation of fatigue life in welded parts was performed in accordance with standard ERRI B 12/RP17 and ERRI B 12/RP60. The actual vehicle dynamic stress testing was executed in KTX-Sancheon service line with the service operating speed. The dynamic stress was measured with commercial data acquisition system (MGC plus). The cumulative damage was evaluated by applying standard BS 7608 - Class F and cycle counting was used rain-flow counting method. As a result, the motor block bracket units for KTX-Sancheon trains was designed to fit the regulation and the safety of fatigue life for 30 years, assuming that KTX-Sancheon trains travels 600,000km annually, were confirmed under current operating conditions.

• 미생물학회지
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• 제35권2호
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• pp.115-120
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• 1999

3개 이상의 DNA 혹은 단백질의 염기서열을 정렬하는 복수 염기서열 정렬은 염기서열들 사이의 진화관계, gene regulation, 단백질의 구조와 기능에 관한 연구에 필수적인 도구이다. 복수 염기서열 정렬을 얻기 위한 기존의 방법은 progressive pairwise alignment 와같이 빠른 실행시간 내에 만족할 만한 복수 염기서열 정렬을 제공하는 방법과, 최적의 복수 여기서열 정렬을 제공하나 실행시간이 상대적으로 긴 dynamic programming 과 같은 방법 등이 있다. 본 논문에서는 진화 알고리즘을 사용하여 기존의 방법에서 제공하는 복수 염기서열 정렬을 짧은 시간내에보다 개선된 복수 염기서열 정렬을 획득하게 하는 방법을 제시하였으며, 진화 알고리즘의 구성내용을 설명하였으며, 실제의 염기서열을 사용하여 이 방법의 장점을 보였다.

• Journal of Microbiology and Biotechnology
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• 제15권3호
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• pp.551-559
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• 2005

The recent rapid increase in genomic data related to many microorganisms and the development of computational tools to accurately analyze large amounts of data have enabled us to design several kinds of simulation approaches for the complex behaviors of cells. Among these approaches, dFBA (dynamic flux balance analysis), which utilizes FBA, differential equations, and regulatory events, has correctly predicted cellular behaviors under given environmental conditions. However, until now, dFBA has centered on substrate concentration, cell growth, and gene on/off, but a detailed hierarchical structure of a regulatory network has not been taken into account. The use of Boolean rules for regulatory events in dFBA has limited the representation of interactions between specific regulatory proteins and genes and the whole transcriptional regulation mechanism with environmental change. In this paper, we adopted the operon as the basic structure, constructed a hierarchical structure for a regulatory network with defined fundamental symbols, and introduced a weight between symbols in order to solve the above problems. Finally, the total control mechanism of regulatory elements (operons, genes, effectors, etc.) with time was simulated through the linkage of dFBA with regulatory network modeling. The lac operon, trp operon, and tna operon in the central metabolic network of E. coli were chosen as the basic models for control patterns. The suggested modeling method in this study can be adopted as a basic framework to describe other transcriptional regulations, and provide biologists and engineers with useful information on transcriptional regulation mechanisms under extracellular environmental change.

• 자원ㆍ환경경제연구
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• 제30권2호
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• pp.269-297
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• 2021

바이오플라스틱은 탄소중립적이며 생분해가 가능하다는 점에서 기존 플라스틱의 대체재로 주목받고 있다. 이 연구는 일국 축차동태 연산가능일반균형 모형을 사용하여 석유 기반 플라스틱산업 규제와 바이오플라스틱산업 육성에 따른 경제적 환경적 파급효과를 추정하였다. 분석결과, 플라스틱산업 규제 시 온실가스 감축과 폐기물 감소 효과가 나타나 긍정적인 환경적 파급효과가 발생한 반면, GDP는 감소하여 경제적으로는 부정적인 파급효과를 확인할 수 있었다. 한편 플라스틱산업 규제와 바이오플라스틱산업 육성이 동시에 이루어지는 경우, 플라스틱 산업 규제만 시행하는 시나리오와 비교하여 유사한 수준의 온실가스 감축과 폐기물 감소효과가 발생했으나 바이오플라스틱산업 생산 확대가 기존의 경제적 손실을 상쇄시켜 GDP를 증가시키는 것으로 나타났다. 따라서 바이오플라스틱 생산 확대를 통해 석유 기반 플라스틱을 대체해 나간다면 온실가스 배출 및 플라스틱 폐기물 발생과 같은 환경문제를 개선하면서 경제성장을 가능하게 하는 탈동조화(decoupling)에 기여할 수 있을 것으로 판단한다.

• BMB Reports
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• 제48권3호
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• pp.131-138
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• 2015

Cardiac hypertrophy is a form of global remodeling, although the initial step seems to be an adaptation to increased hemodynamic demands. The characteristics of cardiac hypertrophy include the functional reactivation of the arrested fetal gene program, where histone deacetylases (HDACs) are closely linked in the development of the process. To date, mammalian HDACs are divided into four classes: I, II, III, and IV. By structural similarities, class II HDACs are then subdivided into IIa and IIb. Among class I and II HDACs, HDAC2, 4, 5, and 9 have been reported to be involved in hypertrophic responses; HDAC4, 5, and 9 are negative regulators, whereas HDAC2 is a pro-hypertrophic mediator. The molecular function and regulation of class IIa HDACs depend largely on the phosphorylation-mediated cytosolic redistribution, whereas those of HDAC2 take place primarily in the nucleus. In response to stresses, posttranslational modification (PTM) processes, dynamic modifications after the translation of proteins, are involved in the regulation of the activities of those hypertrophy-related HDACs. In this article, we briefly review 1) the activation of HDAC2 in the development of cardiac hypertrophy and 2) the PTM of HDAC2 and its implications in the regulation of HDAC2 activity.

• 수산경영론집
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• 제41권2호
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• pp.107-133
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• 2010

As policy makers are often concerned about dynamic effects of demand behavior and its welfare analysis by quantity changes, the paper shows how dynamic price formation systems can be built up to analyze the effect of policy options to the markets dynamically. The paper develops dynamic model of price formation for fish from the intertemporal optimization of the consumer choice problem. While the resulting model has a similar form of the error correction types of dynamic price formation system, it provides the rational demand behavior contrary to the myopic behavior of error correction demand models. The paper also develops appropriate tools of dynamic welfare analysis in quantity space using only short-run demand estimates both theoretically and empirically as a first attempt in the literature of price formation and fisheries. The empirical results of Korean fish markets show that the dynamic model and the welfare measures are reasonably plausible. The methodology and theory of this research can be applied and extended to the commodity aggregation, dynamic demand estimation, and dynamic welfare effects of regulation in the similar framework. Thus, it is hoped that this will enhance its applications to the demand-side economics.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 Proceedings of the Korea Automatic Control Conference, 11th (KACC); Pohang, Korea; 24-26 Oct. 1996
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• pp.231-234
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• 1996

This paper considers the output regulation problems on uncertain systems. Using NR-estimator(on-line), a family of equilibrium points for the uncertain system is computed. The state variables of the closed loop system track the average value of the obtained equilibrium manifold by dynamic state feedback control.