• Journal of the Optical Society of Korea
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• 제19권3호
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• pp.228-236
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• 2015

Fluorescence recovery after photobleaching (FRAP) is a well-established method commonly used to measure the diffusion of fluorescent solutes and biomolecules in living cells or tissues. Here a fiber-optic-based FRAP (f-FRAP) system was developed, and validated using macromolecules in water and agarose gels of different concentrations. We applied f-FRAP to measure the site-specific diffusion of fluorescein (NaFluo) in peritoneal membranes (PMs) on the liver, cecum, and kidney of a living rat during peritoneal dialysis. Diffusion of fluorescein in PM varied in a time-dependent manner according to the type of organ ($D_{PM\;on\;Liver}/D_{NaFluo}=0.199{\pm}0.085$, $D_{PM\;on\;Cecum}/D_{NaFluo}=0.292{\pm}0.151$, $D_{PM\;on\;Kidney}/D_{NaFluo}=0.218{\pm}0.110$). The proposed method allows direct quantitative measurement of the three-dimensional diffusion in local PM in vivo, which was previously inaccessible by peritoneal function test methods such as peritoneal equilibration test (PET) and standardized PM assessment (SPA). f-FRAP is promising for local and dynamic assessments of peritoneal pathophysiology and the mass transport properties of PMs, presumed to be affected by variation of tissue structures over different organs and functional changes of the PM with years of peritoneal dialysis.

• 융합정보논문지
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• 제9권8호
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• pp.155-163
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• 2019

수평원형관에서 나노입자인 산화알미늄과 기본유체인 물의 혼합인 나노유체에 대한 층류 혼합대류열전달현상을 유한체적법의 수치적 방법으로 규명하였다. 나노유체에 대하여 2상 혼합모델을 적용하였으며, 나노입자의 물성은 온도와 체적농도의 함수를 사용하였다. 수치해석에 적용한 모든 모델의 타당성 검증을 위하여 Kim등의 실험결과와 비교하였으며 좋은 결과를 얻었다. 벽면을 일정한 열유속으로 가열하므로 나노유체는 벽면부근에서 형성된 부력에 의하여 2차유동이 생성된다. Richardson수와 나노입자의 농도가 증가할수록 강한 2차유동이 형성되어 열전달을 향상시키게 된다. 또한 Richardson수와 나노입자의 농도가 증가하면 대류열전달계수와 전단응력도 증가한다. 이런 연구들은 열교환기의 성능향상을 위하여 나노유체를 적용하는데 기본자료로 활용이 가능하다. 이번 연구를 기반으로 향후 2중관형열교환기등 다양한 열교환기에 적용할 예정이다.

• Steel and Composite Structures
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• 제38권5호
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• pp.477-496
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• 2021

The main objective of this paper is to study vibration of sandwich open cylindrical panel with damaged core and FG face sheets based on three-dimensional theory of elasticity. The structures are made of a damaged isotropic core and two external face sheets. These skins are strengthened at the nanoscale level by randomly oriented Carbon nanotubes (CNTs) and are reinforced at the microscale stage by oriented straight fibers. These reinforcing phases are included in a polymer matrix and a three-phase approach based on the Eshelby-Mori-Tanaka scheme and on the Halpin-Tsai approach, which is developed to compute the overall mechanical properties of the composite material. Three complicated equations of motion for the panel under consideration are semi-analytically solved by using 2-D differential quadrature method. Several parametric analyses are carried out to investigate the mechanical behavior of these multi-layered structures depending on the damage features, through-the-thickness distribution and boundary conditions. It is seen that for the large amount of power-law index "P", increasing this parameter does not have significant effect on the non-dimensional natural frequency parameters of the FG sandwich curved panel. Results indicate that by increasing the value of isotropic damage parameter "D" up to the unity (fully damaged core) the frequency would tend to become zero. One can dictate the fiber variation profile through the radial direction of the sandwich panel via the amount of "P", "b" and "c" parameters. It should be noticed that with increase of volume fraction of fibers, the frequency parameter of the panels does not increase necessarily, so by considering suitable amounts of power-law index "P" and the parameters "b" and "c", one can get dynamic characteristics similar or better than the isotropic limit case for laminated FG curved panels.

• Composites Research
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• 제36권3호
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• pp.141-153
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• 2023

본 리뷰 논문에서는 일반 접촉 역학 이론과 더불어 유기탄성체 마찰에 관한 이론 및 배경을 소개한다. 특히 Greenwood & Williamson 접촉 역학 이론을 확장하여 거친 표면을 자기-아핀(self-affine) 특성으로 고려한 접촉 역학 및 마찰의 수학적 모델을 제시한 Klüppel & Heinrich 이론을 중심으로 유기탄성체 복합재료의 마찰 거동에 대해 살펴본다. 자기-아핀 특성에 의한 노면의 멀티스케일 거칠기로 인해 미끄러짐 마찰 시 유기탄성체 복합재료는 다양한 주파수에 따른 동적 변형이 가해지며 이때 재료가 나타내는 점탄성이 마찰 거동에 주요한 영향을 미친다. 따라서 유기탄성체 복합재료의 비선형 점탄성을 고려하여 광범위한 주파수 영역에서의 점탄성 거동인 마스터커브를 구축하는 원리 및 방법을 제시하였다. 마지막으로 유기탄성체 복합재료 마찰 이론을 타이어 트레드 컴파운드와 노면 간의 마찰에 응용한 실험적 결과와 그 물리적 의미를 이론과 접목하여 설명하였다.

• 대한기계학회논문집A
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• 제36권12호
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• pp.1683-1688
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• 2012

수직 다관절 로봇의 세 가지 주요 부품인 베이스프레임, 하부프레임, 상부프레임의 경량화를 위하여 위상최적화를 적용하였다. 위상최적화를 위한 설계 영역은 기존 모델을 포함시키는 단순 영역으로 설정하고 이를 삼차원 솔리드 요소로 이산화하였다. 설계 변수들은 SIMP 법을 사용하여 각각의 요소의 물성치를 파라미터화 시켰다. 로봇의 다물체 동역학 해석으로부터 얻어진 하중들을 로봇의 하중조건으로 부여하였으며 최적화의 목적 함수는 구조의 정적, 동적 강성의 조합으로 설정하고 제한조건은 질량제한조건을 부과하였다. 위상최적설계로 얻은 결과는 주조 제조에 용이한 설계로 후처리하였다. 최종 최적화 모델은 기존 모델과 비교하여 비슷하거나 큰 정적, 동적 강성을 가지면서 베이스프레임은 11.0%, 하부프레임은 12.0%, 상부프레임은 10.0% 경량화시킬 수 있었다.

• 펄프종이기술
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• 제46권4호
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• pp.28-36
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• 2014

We studied the green synthesis and antibacterial activity of paper coated with chitosan-silver (Ag) green nanocomposites for packaging applications. Green synthesis of Ag nanoparticles (AgNPs) was achieved by a chemical reaction involving a mixture of chitosan-silver nitrate ($AgNO_3$) in an autoclave at 15 psi, $121^{\circ}C$, for 30 min. AgNPs and their formation in chitosan was confirmed by UV-Vis spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS). As-prepared chitosan-AgNPs composite materials were coated on manila paper using Meyer rod. Surface morphology and Ag contents in coating layer were characterized by field emission scanning electron microscopy (FESEM) and energy dispersive spectroscopy (EDS). The mechanical properties such as tensile strength and elongation were significantly affected by coating with chitosan-AgNPs. The antibacterial test of coated paper was performed qualitatively and quantitatively against Escherichia coli (E. coli). It was shown to be effective in suppressing the growth of E. coli with increasing Ag contents on the surface of coated paper and more than 95 R (%) of antimicrobial rate was obtained at chitosan-AgNPs coated papers.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2003년도 제27회 추계학술대회
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• pp.64-64
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• 2003

Objectives: Patient dose verification is clinically the most important parts in the treatment delivery of radiation therapy. The three dimensional(3D) reconstruction of dose distribution delivered to target volume helps to verify patient dose and determine the physical characteristics of beams used in intensity modulated radiation therapy(IMRT). We present Beam Intensity Scanner(BInS) system for the pre treatment dosimetric verification of two dimensional photon intensity. The BInS is a radiation detector with a custom made software for relative dose conversion of fluorescence signals from scintillator. Methods: This scintillator is fabricated by phosphor Gadolinium Oxysulphide and is used to produce fluorescence from the irradiation of 6MV photons on a Varian Clinac 21EX. The digitized fluoroscopic signals obtained by digital video camera will be processed by our custom made software to reproduce 3D relative dose distribution. For the intensity modulated beam(IMB), the BInS calculates absorbed dose in absolute beam fluence, which are used for the patient dose distribution. Results: Using BInS, we performed various measurements related to IMRT and found the followings: (1) The 3D dose profiles of the IMBs measured by the BInS demonstrate good agreement with radiographic film, pin type ionization chamber and Monte Carlo simulation. (2) The delivered beam intensity is altered by the mechanical and dosimetric properties of the collimating of dynamic and/or static MLC system. This is mostly due to leaf transmission, leaf penumbra, scattered photons from the round edges of leaves, and geometry of leaf. (3) The delivered dose depends on the operational detail of how to make multileaf opening. Conclusions: These phenomena result in a fluence distribution that can be substantially different from the initial and calculative intensity modulation and therefore, should be taken into account by the treatment planing for accurate dose calculations delivered to the target volume in IMRT.

• 한국농공학회논문집
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• 제55권1호
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• pp.1-8
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• 2013

This study will not only prove experimental dynamic properties which are classified to slump, compressive strength, tensile strength, flexure strength and toughness granite soil concrete with a fine aggregate of granite soil and blast-furnace cement and polypropylene fiber over 45 mm, but also establish a basic data in order to use environment-friendly pavement through prove useful pavement mixed with granite and polypropylene (PP) fiber which is a kind of material to prevent a dry shrinkage clack, a partial destruction and useful and light. The value of slump test was gradually increased by PP fiber volume 3 $kgf/m^3$, but compressive strength took a sudden turn for the worse from 5 $kgf/m^3$. The compressive strength indicated a range of 13.72~18.35 MPa. On the contrary to compressive strength, the tensile strength showed to decrease with rising PP fiber volume, and the tensile strength indicated a range of 1.43~1.64 MPa. The tensile strength was stronger about 2~15 % in case of mixing with PP fiber volume than normal concrete. The flexural strength indicated a range of 2.76~3.41 MPa. The flexural strength was stronger about 20 % in case of PP fiber volume 0 $kg/m^3$ than PP fiber volume 9 $kg/m^3$. The toughness indicated a range of 0~25.46 $N{\cdot}mm$ and increased proportionally with PP fiber volume. The toughness was stronger about 8.3 times in case of PP fiber volume 9 $kg/m^3$ than PP fiber volume 1 $kg/m^3$. The pavement with PP fiber volume over such a fixed quantity in the park roads and walkways can have a effect to prevent not only resistance against clack but also rip off failures.

• The Korean Journal of Physiology and Pharmacology
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• 제2권1호
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• pp.9-19
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• 1998

The present study was primarily carried out to characterize the properties of the spinomesencephalic tract (SMT) neurons that project from the upper cervical spinal segments to the midbrain. It was also investigated whether these neurons received convergent afferent inputs from other sources in addition to cervical inputs. Extracellular single unit recordings were made from neurons antidromically activated by stimulation of midbrain. Recording sites were located in lamina $I{\sim}VIII\;of\;C1{\sim}C3$ segments of spinal cord. Receptive field (RF) and response properties to mechanical stimulation were studied in 71 SMT neurons. Response profiles were classified into six groups: complex (Comp, n=9), wide dynamic range (WDR, n=16), low threshold (LT, n=5), high threshold (HT, n=6), deep/tap (Deep, n=10), and non- responsive (NR, n=25). Distributions of stimulation and recording sites were not significantly different between SMT groups classified upon their locations and/or response profiles. Mean conduction velocity of SMT neurons was $16.7{\pm}1.28\;m/sec$. Conduction velocities of SMTs recorded in superficial dorsal horn (SDH, n=15) were significantly slower than those of SMTs recorded in deep dorsal horn (DDH, n=18), lateral reticulated area (LRA, n=21), and intermediate zone and ventral horn (IZ/VH, n=15). Somatic RFs for SMTs in LRA and IZ/VH were significantly larger than those in SDH and DDH. Five SMT units (4 Comps and 1 HT) had inhibitory somatic RFs. About half (25/46) of SMT units have their RFs over trigeminal dermatome. Excitabilities of 5/12 cells and 9/13 cells were modulated by stimulation of ipsilateral phrenic nerve and vagus nerve, respectively. These results suggest that upper cervical SMT neurons are heterogenous in their function by showing a wide range of variety in location within the spinal gray matter, in response profile, and in convergent afferent input.

• Smart Structures and Systems
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• 제13권4호
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• pp.615-636
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• 2014

Aluminium Foam Sandwich (AFS) panels are becoming always more attractive in transportation applications thanks to the excellent combination of mechanical properties, high strength and stiffness, with functional ones, thermo-acoustic isolation and vibration damping. These properties strongly depend on the density of the foam, the morphology of the pores, the type (open or closed cells) and the size of the gas bubbles enclosed in the solid material. In this paper, the vibrational performances of two classes of sandwich panels with an Alulight(R) foam core are studied. Experimental tests, in terms of frequency response function and modal analysis, are performed in order to investigate the effect of different percentage of porosity in the foam, as well as the effect of the random distribution of the gas bubbles. Experimental results are used as a reference for developing numerical models using finite element approach. Firstly, a sensitivity analysis is performed in order to obtain a limit-but-bounded dynamic response, modelling the foam core as a homogeneous one. The experimental-numerical correlation is evaluated in terms of natural frequencies and mode shapes. Afterwards, an update of the previous numerical model is presented, in which the core is not longer modelled as homogeneous. Mass and stiffness are randomly distributed in the core volume, exploring the space of the eigenvectors.