• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.107-108
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• 2003

The epidermal growth factor (EGF) is an important signaling ligand for the mitogenesis of many cells. The EGF receptors use signaling molecule multicomplexes and dynamic protein networks for the transmission and amplification of the signals as well as for the regulation of the cellular responses. EGF signaling has been reported to be enhanced in various tumors by the overexpressed EGF receptor and/or the mediators such as phospholipase C-$\gamma$1(PLC$\gamma$1). (omitted)

• International Journal of Concrete Structures and Materials
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• 제5권1호
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• pp.19-28
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• 2011

This paper documents an experimental study of dynamic response of reinforced concrete beams following instantaneous removal of a bearing column. Four half-scale specimens representing two-span beam bridging across the removed column were tested. The test boundary conditions simulated rotational and longitudinal restraints imposed on a frame beam by the neighboring structural components. The gravity loads were simulated by attaching mass blocks on the beams at three locations. Dynamic loading effects due to sudden removal of a column were simulated by quickly releasing the supporting force at the middle of the specimens. The experimental study investigated the load-carrying capacity of beams restrained longitudinally at the boundaries and dynamic impact on forces. The tests confirmed the extra flexural strength provided by compressive arch action under dynamic loading. The tests also indicated that the dynamic amplification effects on forces were much lower than that assumed in the current design guideline for progressive collapse.

• Structural Engineering and Mechanics
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• 제69권3호
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• pp.347-359
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• 2019

This paper aims to evaluate the behavior of Dorim-Goh bridge in Seoul, Korea, under static and dynamic loads effects by ambient trucks. The prestressed concrete (PSC) girders and reinforcement concrete (RC) slab of the bridge are evaluated and assessed. A short period monitoring system is designed which comprises displacement, strain and accelerometer sensors to measure the bridge performance under static and dynamic trucks loads. The statistical analysis is used to assess the static behavior of the bridge and the wavelet analysis and probabilistic using Weibull distribution are used to evaluate the frequency and reliability of the dynamic behavior of the bridge. The results show that the bridge is safe under static and dynamic loading cases. In the static evaluation, the measured neutral axis position of the girders is deviated within 5% from its theoretical position. The dynamic amplification factor of the bridge girder and slab are lower than the design value of that factor. The Weibull shape parameters are decreased, it which means that the bridge performance decreases under dynamic loads effect. The bridge girder and slab's frequencies are higher than the design values and constant under different truck speeds.

• Advances in materials Research
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• 제6권2호
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• pp.155-168
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• 2017

The terrorist attacks and dangers by bomb blast have turned into an emerging issue throughout the world and the protection of the people and structures against terrorist acts depends on the prediction of the response of structures under blast and shock load. In this paper, behavior of aluminum and unidirectionally reinforced E-Glass Epoxy composite plates with and without focal circular holes subjected to shock loading has been identified. For isotropic and orthotropic plates (with and without holes) the classical normal mode approach has been utilized as a part of the processing of theoretical results. To obtain the accurate results, convergence of the results was considered and a number of modes were selected for plate with and without hole individually. Using a shock tube as a loading device, tests have been conducted to composite plates to verify the theoretical results. Moreover, peak dynamic strains, investigated by experiments are also compared with the theoretical values and deviation of the results are discussed accordingly. The strain-time histories are likewise indicated for a specific gauge area for aluminum and composite plates. Comparison of dynamic-amplification factors between the isotropic and the orthotropic plates with and without hole has been discussed.

• 한국지진공학회논문집
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• 제26권3호
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• pp.105-116
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• 2022

Seismic demand on nonstructural components (NSCs) is highly dependent on the coupled behavior of a combined supporting structure-NSC system. Because of the inherent complexities of the problem, many of the affecting factors are inevitably neglected or simplified based on engineering judgments in current seismic design codes. However, a systematic analysis of the key affecting factors should establish reasonable seismic design provisions for NSCs. In this study, an idealized 2-DOF model simulating the coupled structure-NSC system was constructed to analyze the parameters that affect the response of NSCs comprehensively. The analyses were conducted to evaluate the effects of structure-NSC mass ratio, structure, and NSC nonlinearities on the peak component acceleration. Also, the appropriateness of component ductility factor (R_p) given by current codes was discussed based on the required ductility capacity of NSCs. It was observed that the responses of NSCs on the coupled system were significantly affected by the mass ratio, resulting in lower accelerations than the floor spectrum-based response, which neglected the interaction effects. Also, the component amplification factor (a_p) in current provisions tended to underestimate the dynamic amplification of NSCs with a mass ratio of less than 15%. The nonlinearity of NSCs decreased the component responses. In some cases, the code-specified R_p caused nonlinear deformation far beyond the ductility capacity of NSCs, and a practically unacceptable level of ductility was required for short-period NSCs to achieve the assigned amount of response reduction.

• 대한토목학회논문집
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• 제30권3A호
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• pp.211-219
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• 2010

고속철도교량의 설계개념은 정적하중에 따른 충격계수를 고려하여 기존 교량 구조물의 강성을 증가시키기 위한 방안을 적용하고 있으며, 전반적인 구조설계 과정은 선진 외국기술에 의존하고 있는 실정이다. 그러나 고속철도(Korea Train eXpress: KTX)의 긴 연장(380 m)과 고속(300 km/h) 주행은 공진현상에 상당한 영향을 미치기 때문에 고속철도교량의 동적증폭계수(DAF) 및 동적성능 평가는 상세한 검토가 필수적으로 수행되어야 할 것이다. 따라서 이 연구에서는 전형적인 PSC 박스 거더 고속철도교량을 대상으로 동적성능을 효율적으로 검토하고자 하며, 합리적인 구조설계를 위한 기초자료를 제시하고자 한다. 이를 위해, 기존문헌을 토대로 KTX의 하중선도를 고려하여 정적해석을 수행하였다. 또한 다양한 해석변수를 고려하여 KTX의 이동하중을 시계열하중으로 변환하였으며, 변환된 시계열하중을 이용하여 시간이력해석을 합리적으로 평가하였다. 이때, 시계열하중을 산정하기 위한 변수는 KTX의 하중재하 절점간격, 시간증분 및 속도변화를 고려하였다. FE해석 결과를 바탕으로 PSC 박스 거더 고속철도교량의 동적성능을 체계적으로 검토하였으며, 국내외 관련규정에 따라 구조안전성을 정량적으로 평가하였다.

• Structural Engineering and Mechanics
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• 제64권5호
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• pp.661-670
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• 2017

The dynamic model test of dam-reservoir coupling system for a 203m high gravity dam is performed to investigate effects of reservoir water on dynamic responses of dam during earthquake. The hydrodynamic pressure under condition of full reservoir, natural frequencies and acceleration amplification factors along the dam height under conditions of full and empty reservoir are obtained from the test. The results indicate that the reservoir water have a stronger influence on the dynamic responses of dam. The measured natural frequency of the dam model under full reservoir is 21.7% lower than that of empty reservoir, and the acceleration amplification factor at dam crest under full reservoir is 18% larger than that under empty reservoir. Seismic dynamic analysis of the gravity dams with five different heights is performed with the Fluid-Structure Coupling Model (FSCM). The hydrodynamic pressures from Westergaard formula are overestimated in the lower part of the dam body and underestimated in its upper part to compare with those from the FSCM. The underestimation and overestimation are more significance with the increase of the dam height. The position of the maximum hydrodynamic pressure from the FSCM is raised with the increase of dam height. In view of the above, the Westergaard formula is modified with consideration in the influence of the height of dam, the elasticity of dam on the hydrodynamic pressure. The solutions of modified Westergaard formula are quite coincident with the hydrodynamic pressures in the model test and the previous report.

• Earthquakes and Structures
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• 제23권3호
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• pp.283-295
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• 2022

Seismic design codes permit the use of Equivalent Static Analysis of buildings considering torsional eccentricity e with dynamic amplification factors on structural eccentricity and some accidental eccentricity. Estimation of e in buildings is not addressed in codes. This paper presents a simple approximate method to estimate e in RC Moment Frame and RC Structural Wall buildings, which required no detailed structural analysis. The method is validated by 3D analysis (using commercial structural analysis software) of a spectrum of building. Results show that dynamic amplification factor should be applied on torsional eccentricity when performing Response Spectrum Analysis also. Also, irregular or mixed modes of oscillation arise in torsionally unsymmetrical buildings owing to poor geometric distribution of mass and stiffness in plan, which is captured by the mass participation ratio. These irregular modes can be avoided in buildings of any plan geometry by limiting the two critical parameters (normalised torsional eccentricity e/B and Natural Period Ratio 𝜏 =T_𝜃/T, where B is building lateral dimension, T_𝜃 uncoupled torsional natural period and T uncoupled translational natural period). Suggestions are made for new building code provisions.

• 한국철도학회논문집
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• 제19권1호
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• pp.67-76
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• 2016

아스팔트콘크리트 궤도는 궤도구조에서 유지관리와 경제적 측면에서 많은 장점들을 가지고 있어 최근 많은 관심을 받고 있다. 이와 더불어 개발에 따른 실용성을 효과적으로 검증할 수 있는 방법 또한 제시되어야 한다. 본 연구에서는 기 개발된 아스팔트콘크리트 궤도에서 사용된 아스팔트콘크리트 재료의 탄성 및 점탄성 특성과 주어진 설계 두께를 고려한 수치해석을 통하여 아스팔트콘크리트 궤도에서 발생 가능한 동적특성을 분석하였다. 해석의 불확실성을 줄이기 위하여 3차원 동적해석을 수행하여 실제적인 거동분석이 가능하도록 하였으며, 궤도노반의 영향거리 분석을 통한 최적 모델링 도출과 무한요소 경계조건을 이용하여 반무한지반을 고려하였다. 아스팔트콘크리트 도상을 등방 탄성체로 간주한 기본설계 조건에서의 거동을 점탄성재료 조건과 비교하였으며 동적증폭계수 산정을 통하여 아스팔트 콘크리트 궤도의 향후 설계방향을 제시하고자 하였다.

• Earthquakes and Structures
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• 제17권1호
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• pp.75-89
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• 2019

The paper presents experimental and numerical studies carried out on low-rise RC frames, typically found in developing countries. Shake table tests were conducted on 1:3 reduced scaled two-story RC frames that included a code conforming SMRF model and another non-compliant model. The later was similar to the code conforming model, except, it was prepared in concrete having strength 33% lower than the design specified, which is commonly found in the region. The models were tested on shake table, through multiple excitations, using acceleration time history of 1994 Northridge earthquake, which was linearly scaled for multi-levels excitations in order to study the structures' damage mechanism and measure the structural response. A representative numerical model was prepared in finite element based program SeismoStruct, simulating the observed local damage mechanisms (bar-slip and joint shear hinging), for seismic analysis of RC frames having weaker beam-column joints. A suite of spectrum compatible acceleration records was obtained from PEER for incremental dynamic analysis of considered RC frames. The seismic performance of considered RC frames was quantified in terms of seismic response parameters (seismic response modification, overstrength and displacement amplification factors), for critical comparison.