Multiple Roles of Phospholipase D in Growth Factor Signaling

  • Ryu, Sung-Ho (Division of Molecular and Life Sciences, Pohang University of Science & Technology)
  • Published : 2003.04.01

Abstract

The epidermal growth factor (EGF) is an important signaling ligand for the mitogenesis of many cells. The EGF receptors use signaling molecule multicomplexes and dynamic protein networks for the transmission and amplification of the signals as well as for the regulation of the cellular responses. EGF signaling has been reported to be enhanced in various tumors by the overexpressed EGF receptor and/or the mediators such as phospholipase C-$\gamma$1(PLC$\gamma$1). (omitted)

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