• Mass Spectrometry Letters
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• v.6 no.2
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• pp.31-37
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• 2015

Phosphorylation upon protein is well known to a key regulator that implicates in modulating many cellular processes like growth, migration, and differentiation. Up to date, grafting of multidimensional separation techniques onto advanced mass spectrometry (MS) has emerged as a promising tool for figuring out the biological functions of phosphorylation in a cell. However, advanced MS-based phosphoproteomics is still challenging, due to its intrinsic issues, i.e., low stoichiometry, less susceptibility in positive ion mode, and low abundance in biological sample. To overcome these bottlenecks, diverse techniques (e.g., SCX, HILIC, ERLIC, IMAC, TiO₂, etc.) are continuously developed for on-/off-line enrichment of phosphorylated protein (or peptide) from biological samples, thereby helping qualitative/quantitative determination of phosphorylated protein and its phosphorylated sites. In this review, we introduce to the overall views of enrichment tools that are universally used to selectively isolate targeted phosphorylated protein (or peptide) from ordinary ones before MS-based phospoproteomic analysis.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.9
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• pp.1741-1747
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• 2011

Though various techniques have been studied as a way of adjusting parameters of PID controllers, no perfect method of determining parameters is available to date. This paper proposes a new method for enhancing performance of PID controllers by using the characteristics of dual-input describing function (DIDF). In other words, if nonlinear elements with two inputs (DIDF) are connected in series to the plant, the critical point (-1+j0) for Nyquist stability theory can be moved to a position arbitrarily selected on the complex plane by determining necessary coefficients of the DIDF appropriately. This makes the application of the existing conventional PID parameter tuning methods a lot easier, and stability and robustness of the system are improved simultaneously due to the DIDF inserted.

• Journal of the Korean Operations Research and Management Science Society
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• v.26 no.4
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• pp.143-153
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• 2001

In this study we develop a computer simulation model to evaluate the effects of various production and order processing policies measured in terms of on-time delivery rate and average waiting time of job orders. Policies considered include : eliminating inflated due date, lot splitting, loss time reduction, attaining full flexibility in production lines, and selective order promising scheme. Actual order-production data from a chemical company were used in the simulation model. Based on the simulation results, we make several suggestions that can significantly reduce the production lead time and increase the on-time delivery rate.

• Journal of Multimedia Information System
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• v.3 no.3
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• pp.77-84
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• 2016

The sailors on seagoing ships experience much difficulty in communicating with their families, friends or associates ashore due to communication cost or technical difficulties so that they are sometimes unable to adapt to the rapid social changes promptly. This is mainly the result of an insufficient Information and Communication Technology (ICT)-environment on their ships. To surmount such a problem, an electronic shipboard voting system that guarantees the publicness and absolute secrecy in voting process has been proposed in this paper. The system not only helps crews to catch up with up-to-date news and provides them a feeling that they are being connected to the everyday lives of the outside world, but also allows them to cast their votes based on the newly acquired information (e.g., current political or economic situations in their respective regions and etc.).

• Korean Management Science Review
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• v.13 no.1
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• pp.57-70
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• 1996

This paper develops an adaptive scheduling policy for flexible manufacturing systems. The inductive learning methodology used for constructing this state-dependent scheduling policy provides and understanding of the relative importance of the various system parameters in determining the appropriate scheduling rule. Experimental studies indicated the superiority of the suggested approach over the alternative approach involving the repeated application of a single scheduling rule for randomly generated test problems as well as a real system, and under both stationary and nonstationary conditions. In particular, its relative performance improves further when there are frequent disruptions, and when disruptions are caused by the introduction of tiiight due date jobs, one of the most common surces of disruptions in most manufacturing systems.

• Journal of the Korean Operations Research and Management Science Society
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• v.33 no.1
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• pp.117-129
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• 2008

Make-to-order manufacturers with multiple plants at multiple sites need to have the ability to quickly determine which plant will produce which customer order to meet the due date and minimize the transportation cost from the plants to the customer. Balancing the work loads and minimizing setups and make-span are also of great concern. Solving such scheduling problems usually takes a long time. We propose a new approach, which we call 'preprocessing', for resolving such complex problems. In preprocessing scheme, a 'good' a priori schedule is prepared and maintained using unconfirmed order information. Upon the confirmation of orders. the preprocessed schedule is quickly modified to obtain the final schedule. We present a preprocessing solution algorithm for multi-site constraint scheduling problem (MSCSP) using genetic algorithm; and conduct computational experiments to evaluate the performance of the algorithm.

• Journal of Korean Library and Information Science Society
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• v.9
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• pp.213-240
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• 1982

Today, one of the major pressures that libraries have been facing is the rapid growth of publications. Due to the rapid growth of publications, libraries have been faced the shortage of stack as well as quality deterioration of library collections. Naturally, these disa n.0, ppointed the users and made the present library activities weak and inadequate. One of the desirable actions in remedying these problems is to weed library collections properly and regularly. Weeding methods used in libraries are derived from the judgement by subject specialists, from the examining the imprint date and the past use patterns of a volume. Among these methods, the past use patterns are highly predictive of the future use, and can be used to create meaningful weeding criteria. Since the libraries in Korea have emphasized on numbers of library collection in the past, the libraries have neglected weeding library collections. Now, we must turn our concern toward the weeding library collections, and the attitude of the library services to the users must change from passive to active.

• The Journal of Information Systems
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• v.13 no.2
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• pp.135-153
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• 2004

The formation of a supply chain should be approached with distributive viewpoint considering the dynamic nature of ordering environments. The purpose of this paper is to design a semantic web to support agent negotiation forming supply chains. With the view of a supply chain as composed of competitive agents which represent each member of supply chains with a local goal, a supply chain is formed through negotiation of price, due date choosing partners to contract. In the development of a negotiation method, we employ ontology and rules which are the basic techniques of the semantic web for supporting automated negotiations. Especially, a framework for a negotiation process is suggested and domain, processes and rules ontology are designed interrelatedly. With this modeling, a possibility of the semantic web based agent negotiation is suggested.

• Journal of Industrial Technology
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• v.31 no.B
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• pp.51-58
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• 2011

Simulation plays a pivotal role in the analysis of complex systems. In this study, a job shop manufacturing system has been analyzed through DBR (Drum-buffer-rope) simulation. Specific attention has been put to examine the rate of due-date achievement. We first derived key factors affecting the system performance. We then developed ARENA simulation program based on DBR of TOC (Theory of Constraints) concepts. Based on the performance measure, factors, and experimental design, we obtained the results. We have drawn meaningful results through examination of the results. The results obtained from this study may provide a good base for practical applications.

• Proceedings of the Korean Geotechical Society Conference
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• 1993.03a
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• pp.41-48
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• 1993

The 2nd phase of Seoul Subway, Lines 5,6,7 and 8, is in progress. To reduce the surface traffic congestion during construction the greater part of the system has been engineered by bored tunnelling. The current tunnelling methodology is based on the New Austrian Tunnelling Method. Serveral collapses have been reported to date. Most of the collapses took place in the area forwed with soft ground. The modes and causes of the collapses were progressive failures in the unsupported surface and sliding failures due to the unfavourable joint direction. The major causes turned out to be the weakness of ground and the sudden influx of ground water from the surface. Some measures to prevent the failures are also presented. To ensure the safe tunnelling ghrough the soft ground the unsupported excavation area has to be minimized and closed as early as possible. Additional support measures such as supporting core, sealing shotcrete, forepoling, spread footing, face rock bolting and grouting should be employed as well depend on ground conditions.