• 보건교육건강증진학회지
• /
• 제30권4호
• /
• pp.57-67
• /
• 2013

Objectives: The purpose of this study was to explore coordination strategy through reviewing policies, action plans and acts related to diet, nutrition and obesity from many sectors in Korea, and to develop a possible multi-sectoral approach. Methods: Literature reviews and empirical findings for ongoing international and domestic policies/programs on diet, nutrition and obesity in Korea. Results: Central and local governments have various policies/programs and related acts to improve nutrition and to reduce obesity. Meanwhile, those governments' activities are frequently criticized to be more coordinated in order to achieve their aims. Activities on nutrition and obesity prevention have interdepartmental characteristics but are scattered through six Ministries (including the Ministry of Health and Welfare, Ministry of Education, Ministry of Agriculture, Ministry of Employment and Labor, Ministry of Culture and Sports, and Ministry of Food/Drug Safety) and 27 Acts such as 'Nutrition Management Act', 'Health Promotion Act', 'Diet Education Support Act'. As a result, a number of areas, especially dietary guidance, nationwide surveys, education programs seem to overlap. Conclusions: Inter-ministerial coordination mechanism should be established to enforce multi-sectoral engagement and cooperation in implementing policies/programs on nutrition and obesity prevention. Furthermore, functions of the Ministries should be reorganized and coordinated in reference to other countries' experiences.

• 한국임상약학회지
• /
• 제28권1호
• /
• pp.40-50
• /
• 2018

Objective: This study presented the analysis period, the complexity of combined therapy and comparator choice as the key limitations in the economic evaluation of new drugs, and discussed programs for coping with these limitations. Methods: This study evaluated the post-evaluation, risk-sharing agreement, extra funding program, and flexible incremental cost-effectiveness ratio (ICER) threshold as actions or programs that would increase accessibility to costly new drugs. The study also presented the cases of other countries. The application of the post-evaluation was considered to deal with high uncertainty regarding new drugs. Results: The risk-sharing agreement was introduced in European countries as well as South Korea and has been responsible for the shift from using the financial schemes to outcome-based schemes. The drug funding program has had troubled in securing stable extra funds. The application of higher ICER in the economic evaluation of expensive and innovative oncology drugs was criticized because of the inequity between oncology patients and patients with other diseases. Conclusion: Therefore, introducing and applying actions that would increase the accessibility to costly new drugs in South Korea have been deemed necessary after careful reviews and discussions with various stakeholders (insurer, policy makers, pharmaceutical companies and patients).

• 대한의용생체공학회:의공학회지
• /
• 제29권3호
• /
• pp.173-178
• /
• 2008

Recent advancements in the electrospinning method enable the production of ultrafine solid and continuous fibers with diameters ranging from a few nanometers to a few hundred nanometers with controlled surface and morphological features. A wide range of biopolymers can be electrospun into mats with a specific fiber arrangement and structural integrity. These features of nanofiber mats are morphologically similar to the extracellular matrix of natural tissues, which are characterized by a wide pore diameter distribution, a high porosity, effective mechanical properties, and specific biochemical properties. This has resulted in various kinds of applications for polymer nanofibers in the field of biomedicine and biotechnology. The current emphasis of research is on exploiting these properties and focusing on determining the appropriate conditions for electrospinning various biopolymers for biomedical applications, including scaffolds used in tissue engineering, wound dressing, drug delivery, artificial organs, and vascular grafts, and for protective shields in specialty fabrics. This paper reviews the research on biomedical applications of electrospun nanofibers.

• 한국축산식품학회지
• /
• 제41권6호
• /
• pp.905-922
• /
• 2021

Novel bioactive metabolites have been developed through a bioconversion of dairy products or other foods using probiotics isolated from dairy products or other fermented foods. These probiotics-mediated bioconversion (PMB) metabolites show antioxidant, anti-inflammatory, antimicrobial, epithelial barrier, and anticancer activities. In addition, the effect of PMB metabolites in periodontitis is recently reported in several studies. Periodontitis is a chronic inflammatory disease caused by infections, and the tooth support tissue is destroyed. Common treatments for periodontitis include scaling and root planning with systemic antibiotics. However, the overuse of antibiotics has led to the emergence of drug-resistant microorganisms and disturbs the beneficial bacteria, including lactobacilli in the oral cavity. For this reason, PMB metabolites, such as fermented milk, have been suggested as substitutes for antibiotics to reduce periodontitis. This paper reviews the recent studies on the correlation between periodontitis and PMB metabolites and classifies the efficacy of major PMB metabolites for periodontitis. The review suggests that PMB is effective for periodontitis, and further studies are needed to confirm the therapeutic effect of PMB metabolites on periodontitis.

• Clinical and Experimental Reproductive Medicine
• /
• 제48권3호
• /
• pp.194-197
• /
• 2021

Polycystic ovary syndrome (PCOS) is a common disorder in reproductive-age women. In 2018, an international evidence-based guideline announced recommendations spanning a wide range of issues on the assessment and management of PCOS. From the 166 recommendations, the present study reviews those that are of particular clinical relevance for daily practice and introduces other relevant studies that have been published since the global guideline. The 2018 guideline increased the antral follicle count cutoff for the diagnosis of PCOS from 12 to 20 when using a high-frequency probe. Hirsutism was defined as having a score of ≥4-6 based on a lower percentile of 85%-90% or cluster analysis, which was lower than the traditionally used 95th percentile-based cutoff. The diagnosis of PCOS in adolescents is challenging, and irregular menstruation was defined carefully according to years from menarche. The use of ultrasonography for the diagnosis of PCOS was restricted to those 8 years after menarche. As medication for non-fertility indications, combined oral contraceptives are the first-line drug. Metformin, in addition to lifestyle modifications, should be considered for adult patients with a body mass index ≥25 kg/m² for the management of weight and metabolic outcomes. An aromatase inhibitor is the recommended first-line medication for ovulation induction, a subsequent individual patient data meta-analysis also reported the same conclusion. Whether the new global guideline will be fully adopted by many specialists and change clinical practice is open to question. Further studies are needed to better understand and manage PCOS patients well.

• Journal of Gastric Cancer
• /
• 제19권2호
• /
• pp.148-156
• /
• 2019

Esophagogastric junction (EGJ) cancer is a solid tumor entity with rapidly increasing incidence in the Western countries. Given the high proportion of advanced cancers in the West, treatment strategies routinely employed include surgery and chemotherapy perioperatively, and chemoradiation in neoadjuvant settings. Neoadjuvant chemoradiation and perioperative chemotherapy are mostly performed in esophageal cancer that extends to the EGJ and gastric as well as EGJ cancers, respectively. Recent trials have tried to combine both strategies in a perioperative context, which might have beneficial outcomes, especially in patients with EGJ cancer. However, it is difficult to recruit patients for trials, exclusively for EGJ cancers; therefore, the results have to be carefully reviewed before establishing a standard protocol. Trastuzumab was the first drug for targeted therapy that was positively evaluated for this tumor entity, and there are several ongoing trials investigating more targeted drugs in order to customize effective therapies based on tissue characteristics. The current study reviews the multimodal treatment concept for EGJ cancers in the West and summarizes the latest reports.

• 센서학회지
• /
• 제32권6호
• /
• pp.357-369
• /
• 2023

Wound healing is a complex and dynamic process, making the accurate and timely assessment of skin wounds a crucial aspect of effective wound care management, especially for chronic wounds. Unlike conventional wound dressings that simply cover the wound area once some form of medicine is administered onto the wound, recent studies have introduced versatile approaches to smart wound dressings capable of interacting with wound fluids to monitor physicochemical and pathological parameters to determine the wound healing status. Such electrochemical wound dressings can be integrated with on-demand, closed-loop drug delivery or stimulation systems and ultimately expanded into an ideal technological platform for the prevention, treatment, and management of skin wounds or illnesses. This article briefly reviews the wound healing mechanism and recent strategies for effective wound care management. Specifically, this review discusses the following aspects of smart wound dressings: sensor-integrated smart bandages to detect wound biomarkers, smart bandages developed to accelerate wound healing, and wireless, closed-loop automatic (on-demand) wound healing systems. This review concludes by providing future perspectives on effective wound care management.

• 한국포장학회지
• /
• 제28권1호
• /
• pp.31-38
• /
• 2022

안전한 식품, 긴 보관 수명과 좋은 품질을 보유한 식품에 대한 소비자의 요구가 증가하고 있으며, 이에 대응하여 활성포장의 상용화와 개발이 증가하고 있다. 본 총설에서는 산소제거제, 수분제거제, 이산화탄소제거제 및 에틸렌제거제의 정의, 사용되고 있는 활성포장의 구조, 활성물질과 구동 메커니즘, 적용 식품 분야와 잠재적 효과 및 활성포장 관리 규정 등에 대하여 조사하였다. 국내 상용화 현황을 보면 활성물질을 다공성 또는 타공 구조를 가진 파우치에 넣은 다음, 식품포장에 적용하는 사쉐형 활성포장이 주로 적용되고 있음을 확인하였다. 이러한 다양한 종류의 활성포장이 식품포장에 널리 사용되고 있음에도 불구하고, 유럽에 비해 국내에서는 소비자의 건강과 식품의 안전에 영향을 줄 수 있는 활성포장과 활성물질에 대한 정의, 관리, 안전성 평가 및 사용 등에 대한 구체적인 관리 규정과 안전성 평가방법에 대한 구축은 미비함을 확인하였다. 식품은 건조식품, 액상식품, 고 수분함유 식품 등 종류가 다양하고 각 식품의 품질에 영향을 미치는 화학적, 물리적, 생물학적 요인 및 보관조건 등도 다양하다. 활성포장에 사용되는 활성물질이 식품으로 전이되면, 식품 성분과 화학적/물리적으로 상호작용하여 품질과 안전에 부정적인 영향을 야기할 가능성이 있다. 따라서, 활성포장의 최적 성능을 구현하기 위해서는 식품 맞춤형으로 설계하는 것이 필요하며 활성포장과 활성물질에 대한 관리 규정 및 안전성 평가방법도 식품 종류와 활성포장의 종류에 따라 세분화하여 정립하는 것 또한 필요하다고 사료된다.

• Nutrition Research and Practice
• /
• 제11권5호
• /
• pp.402-411
• /
• 2017

BACKGROUND/OBJECTIVES: The role of a school's nutrition environment in explaining students' eating behaviors and weight status has not been examined in an Asian setting. The purpose of this study was to create a school nutrition environment index and to pilot test the index in elementary and middle schools in urban South Korea. SUBJECTS/METHODS: This study used a mixed-methods approach. Environment assessment tools were developed based on formative research, which comprised literature reviews, in-depth interviews, and focus group discussions. Key elements from the formative research were included in the assessment tool, which consisted of a structured survey questionnaire for school dietitians. Fifteen school dietitians from 7 elementary and 8 middle schools in Seoul completed the questionnaire. RESULTS: The formative research revealed four main sections that guided a summary index to assess a school's nutrition environment: resource availability, education and programs, dietitians' perceptions and characteristics, and school lunch menu. Based on the literature reviews and interviews, an index scoring system was developed. The total possible score from the combined four index sections was 40 points. From the 15 schools participating in the pilot survey, the mean school nutrition-environment index was 22.5 (standard deviation ${\pm}3.2$; range 17-28). The majority of the schools did not offer classroom-based nutrition education or nutrition counseling for students and parents. The popular modes of nutrition education were school websites, posters, and newsletters. CONCLUSIONS: This paper illustrates the process used to develop an instrument to assess a school's nutrition environment. Moreover, it presents the steps used to develop a scoring system for creation of a school nutrition environment index. As pilot testing indicated the total index score has some variation across schools, we suggest applying this instrument in future studies involving a larger number of schools. Future studies with larger samples will allow investigation of the validity and reliability of this newly developed tool.

• 한국산학기술학회논문지
• /
• 제20권11호
• /
• pp.121-129
• /
• 2019

본 연구의 목적은 비디오 흉강경을 이용한 폐기포 절제술을 받은 기흉 환자에게 계획된 퇴원 간호 중재 지침을 개발하여 적용한 후 약물복용 이행도, 치료 지시 이행도, 질병에 대한 지식과 간호 만족도에 미치는 효과를 확인하기 위한 것이다. 서울 소재 K 종합병원에서 비디오 흉강경을 이용한 폐기포 절제술을 받은 기흉 환자를 대상으로 자료수집 기간은 2010년 3월 16일부터 12월 31일까지이며, 실험군 29명, 대조군 30명이 연구 대상자로 참여하였다. 계획된 퇴원 간호 중재 지침은 포괄적인 문헌 고찰과 임상 경험을 바탕으로 개발되었다. 계획된 퇴원 간호 중재는 흉부외과 간호사가 3회 실시하였으며 1회 교육시간은 약 30~40분 정도가 소요되었다. 연구결과 계획된 퇴원 간호 중재 제공 후 치료 지시 이행도는 유의한 차이가 없었다. 그러나 복약순응도(t=-2.05, p=.044), 약알 세기 약물 이행도(t=-2.61, p=.011), 질병에 대한 지식(t=-4.39, p=.001), 간호 만족도(t=-4.13, p=.001)는 유의한 차이가 있었다. 본 연구에서 계획된 퇴원 간호 중재의 제공은 기흉 진단으로 수술을 시행 받은 환자를 위한 임상에서 적용 가능한 효과적인 간호 중재임을 확인하였다. 합병증이나 재발과 같은 장기적 영향을 평가하기 위한 종단적 연구가 필요하다.