• Biomolecules & Therapeutics
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• v.30 no.5
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• pp.427-434
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• 2022

The drug repurposing strategy has been applied to the development of emergency COVID-19 therapeutic medicines. Current drug repurposing approaches have been directed against RNA polymerases and viral proteases. Recently, we found that the inhibition of the interaction between the SARS-CoV-2 structural nucleocapsid (N) and spike (S) proteins decreased viral replication. In this study, drug repurposing candidates were screened by in silico molecular docking simulation with the SARS-CoV-2 structural N protein. In the ChEMBL database, 1994 FDA-approved drugs were selected for the in silico virtual screening against the N terminal domain (NTD) of the SARS-CoV-2 N protein. The tyrosine 109 residue in the NTD of the N protein was used as the center of the ligand binding grid for the docking simulation. In plaque forming assays performed with SARS-CoV-2 infected Vero E6 cells, atovaquone, abiraterone acetate, and digoxin exhibited a tendency to reduce the size of the viral plagues without affecting the plaque numbers. Abiraterone acetate significantly decreased the accumulation of viral particles in the cell culture supernatants in a concentration-dependent manner. In addition, abiraterone acetate significantly decreased the production of N protein and S protein in the SARS-CoV-2-infected Vero E6 cells. In conclusion, abiraterone acetate has therapeutic potential to inhibit the viral replication of SARS-CoV-2.

• Journal of the Society of Naval Architects of Korea
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• v.60 no.2
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• pp.135-145
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• 2023

Developing high-fidelity Computational Fluid Dynamics (CFD) simulation methods used to evaluate the airwake characteristics along a flight deck of a large ship, the various kind of data such as actual ship measurement and wind tunnel results are required to verify the accuracy of CFD simulation. Inflow velocity profile at the bow, local unsteady flow field data around the flight deck, and highly reliable wind tunnel data which were measured after reviewing Atmospheric Boundary Layer (ABL) simulation and Reynolds Number effects were also used to determine the key parameters such as turbulence model, time resolution and accuracy, grid resolution and type, inflow condition, domain size, simulation length, and so on in STAR CCM⁺. Velocity ratio and turbulent intensity difference between Full-scale CFD and actual ship measurement at the measurement points show less than 2% and 1.7% respectively. And differences in velocity ratio and turbulence intensity between wind tunnel test and small-scale CFD are both less than 2.2%. Based upon this fact, the selected parameters in CFD simulation are highly reliable for a specific wind condition.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.4A
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• pp.605-609
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• 2006

In this study, two kinds of smart accelerometers are investigated for the application of smart sensors to the structural health monitoring of infrastructures. Smart optical Fiber Bragg Grating (FBG) type and Micro-Electo-Mechanical System (MEMS) type accelerometers are selected for this study and the high sensitive ICP type accelerometer is used for the reference sensor. Small size shaking table tests were performed with 3-story shear building model using random input ground motions. The output only modal identification was carried out using stochastic subspace identification and the performances of sensors are compared in modal domain indirectly. The modal sensitivity method was applied to update the story stiffness of numerical model and the updated results were verified using the additional experiments for the same structure with additional mass.

• Journal of The Geomorphological Association of Korea
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• v.28 no.1
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• pp.101-114
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• 2021

Junior Ranger is a self-directed interpretation program for young visitors at national parks in the United States. The success of this program can be largely attributed to the role of an activity book which is given an applicant free of charge at a visitor center. This study aims to analyze the main characteristics of activity books for 14 national parks' Junior Ranger and to draw some implications for Korean geomorphological education. Although the activity books are varied in size, volume and printing, all of them offer diverse activities which are composed of different contents related to park resources in four fields and are performed in different ways such as Q&A, picture and word game, and creative activity. The time-consuming activities including attendance at a ranger-led program prevent the participant from making a superficial visit to be a junior ranger. The implications of the study are as follows: Firstly, the geomorphological education for children is needed to be strongly based on field experience learning and to be more carried out using a way of game rather than conventional Q&A, suggesting that it encourages students not to lose their interest for learning. Secondly, it is also necessary for the learning contents to be focused on various resources related to landform as well as landform itself. In addition, a creative activity such as writing verse or drawing feeling should be more applied to the geomorphological education in order to enhance their effects on affective domain beyond cognitive one. It is likely to be an alternative approach to understand landform by internalizing a sense of landform.

• Biomolecules & Therapeutics
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• v.32 no.2
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• pp.214-223
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• 2024

Metabolic abnormalities in the liver are closely associated with diverse metabolic diseases such as non-alcoholic fatty liver disease, type 2 diabetes, and obesity. The aim of this study was to evaluate the ameliorating effect of robinetin (RBN) on the significant pathogenic features of metabolic failure in the liver and to identify the underlying molecular mechanism. RBN significantly decreased triglyceride (TG) accumulation by downregulating lipogenesis-related transcription factors in AML-12 murine hepatocyte cell line. In addition, mice fed with Western diet (WD) containing 0.025% or 0.05% RBN showed reduced liver mass and lipid droplet size, as well as improved plasma insulin levels and homeostatic model assessment of insulin resistance (HOMA-IR) values. CD38 was identified as a target of RBN using the BioAssay database, and its expression was increased in OPA-treated AML-12 cells and liver tissues of WD-fed mice. Furthermore, RBN elicited these effects through its anti-histone acetyltransferase (HAT) activity. Computational simulation revealed that RBN can dock into the HAT domain pocket of p300, a histone acetyltransferase, which leads to the abrogation of its catalytic activity. Additionally, knock-down of p300 using siRNA reduced CD38 expression. The chromatin immunoprecipitation (ChIP) assay showed that p300 occupancy on the promoter region of CD38 was significantly decreased, and H3K9 acetylation levels were diminished in lipid-accumulated AML-12 cells treated with RBN. RBN improves the pathogenic features of metabolic failure by suppressing the p300-CD38 axis through its anti-HAT activity, which suggests that RBN can be used as a new phytoceutical candidate for preventing or improving this condition.

• Archives of Craniofacial Surgery
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• v.25 no.2
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• pp.71-76
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• 2024

Background: The rising incidence of dialysis-dependent end-stage renal disease (ESRD) has underscored the need for collaboration between plastic surgeons and nephrologists, particularly concerning preoperative and postoperative management for facial reconstruction. This collaboration is essential due to a scarcity of comprehensive information in this domain. Methods: A study initiated in January 2015 involved 10 ESRD cases on dialysis undergoing Mohs micrographic surgery for facial skin cancer, followed by reconstructive surgery under general anesthesia. To ensure surgical safety, rigorous measures were enacted, encompassing laboratory testing, nephrology consultations, and preoperative dialysis admission. Throughout surgery, meticulous control was exercised over vital signs, electrolytes, bleeding risk, and pain management (excluding nonsteroidal anti-inflammatory drugs). Postoperative assessments included monitoring flap integrity, hematoma formation, infection, and cardiovascular risk through plasma creatinine levels. Results: Adherence to the proposed guidelines yielded a notable absence of postoperative wound complications. Postoperative plasma creatinine levels exhibited an average decrease of 1.10 mg/dL compared to preoperative levels, indicating improved renal function. Importantly, no cardiopulmonary complications or 30-day mortality were observed. In ESRD patients, creatinine levels decreased significantly postoperatively compared to the preoperative levels (p< 0.05), indicating favorable outcomes. Conclusion: The consistent application of guidelines for admission, anesthesia, and surgery yielded robust and stable outcomes across all patients. In particular, the findings support the importance of adjusting dialysis schedules. Despite the limited sample size in this study, these findings underscore the effectiveness of a collaborative and meticulous approach for plastic surgeons performing surgery on dialysis-dependent patients, ensuring successful outcomes.

• The Journal of the Acoustical Society of Korea
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• v.28 no.2
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• pp.85-95
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• 2009

In the binaural synthesis environments, wide varieties of the head-related transfer functions (HRTFs) that have measured with a various direction would be desirable to obtain the accurate and various spatial sound images. To reduce the size' of HRTFs, interpolation has been often employed, where the HRTF for any direction is obtained by a limited number of the representative HRTFs. In this paper, we study on the distortion measures for interpolation, which has an important role in interpolation. With lhe various objective distortion metrics, the differences between the interpolated and the measured HRTFs were computed. These were then compared and analyzed with the results from the listening tests. From the results, the objective distortion measures were selected, that reflected the perceptual differences in spatial sound image. This measure was employed in a practical interpolation technique. We applied the proposed method to four kinds of an HRTF set, measured from three human heads and one mannequin. As a result, the Mel-frequency cepstral distortion was shown to be a good predictor for the differences in spatial sound location, when three HRTF measured from human, and the time-domain signal to distortion ratio revealed good prediction results for the entire four HRTF sets.

• The Journal of the Acoustical Society of Korea
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• v.28 no.1
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• pp.1-9
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• 2009

This paper deals with the realization of multi-channel live karaoke. In this study, 6-channel MP3 decoding and tempo/key scaling was operated in real time by using the TMS320C6713 DSP, which is 32 bit floating-point DSP made by TI Co. The 6 channel consists of front L/R instrument, rear L/R instrument, melody, and woofer. In case of the 4 channel, rear L/R instrument can be replaced with drum L/R channel. And the final output data is generated as adjusted to a 5.1 channel speaker. The SOLA algorithm was applied for tempo scaling, and key scaling was done with interpolation and decimation in the time domain. Drum channel was excluded in key scaling by separating instruments into drums and non-drums, and in processing SOLA, high-quality tempo scaling was made possible by differentiating SOLA frame size, which was optimized for real-time process. The use of 6 channels allows the composition of various channels, and the multi-channel audio system of this study can be effectively applied at any place where live music is needed.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.37 no.3
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• pp.187-195
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• 2024

This paper presents two-dimensional boundary value problems of the stress-based gradient elasticity within the smoothed finite element method (S-FEM) framework. Gradient elasticity is introduced to address the limitations of classical elasticity, particularly its struggle to capture size-dependent mechanical behavior at the micro/nano scale. The Ru-Aifantis theorem is employed to overcome the challenges of high-order differential equations in gradient elasticity. This theorem effectively splits the original equation into two solvable second-order differential equations, enabling its incorporation into the S-FEM framework. The present method utilizes a staggered scheme to solve the boundary value problems. This approach efficiently separates the calculation of the local displacement field (obtained over each smoothing domain) from the non-local stress field (computed element-wise). A series of numerical tests are conducted to investigate the influence of the internal length scale, a key parameter in gradient elasticity. The results demonstrate the effectiveness of the proposed approach in smoothing stress concentrations typically observed at crack tips and dislocation lines.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.12A
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• pp.1153-1160
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• 2005

OFDM/OQAM(Offset QAM)-IOTA system requires the IOTA(Isotropic Orthogonal Transform Algorithm) function that has superior localization property in time and frequency domain instead of guard interval used for conventional OFDM/QAM system to be robust to multipath channel. Therefore, OFDM/OQAM-IOTA system has more spectral efficiency than conventional OFDM/QAM system. But, when channel estimation scheme for conventional OFDM/QAM system is applied straightforwardly to OFDM/OQAM-IOTA system, an intrinsic Inter- symbol-Interference is observed. So suitable preamble structure for the channel estimation scheme of OFDM/OQAM-IOTA system is required. In this paper, we propose a new preamble structure that is appropriate to OPDM/OQAM-IOTA system and then perform ideal channel estimation and practical channel estimation in low-to-medium mobile speed and compare them with conventional OFDM/QAM system. Simulation results show that OFDM/OQAM-IOTA system with proposed preamble structure has 1.5 dB Eb/NO gain on Target BER $10^{-3}$ and about $25\%$ transmission rate gain against the conventional OFDM/QAM system considering quarter of FFT size as guard interval size.