• Title/Summary/Keyword: dl-α-tocopherol

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Histopathological Observation and Effect of DL-α-Tocopherol on Hyperbaric Oxygen Toxicity (고압산소(高壓酸素)가 폐조직(肺組織)에 미치는 영향(影響)과 DL-α-Tocopherol의 내성효과(耐性效果)에 관(關)한 연구(硏究))

  • Lee, Won Chang;Yoon, Wha Joong
    • Korean Journal of Veterinary Research
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    • v.15 no.1
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    • pp.47-50
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    • 1975
  • Experimental studies were performed to observe the effect of exposure to 100% oxygen in 2 atmospheres on the lung tissue of rats, and to examine the resistant effect of DL-${\alpha}$-tocopherol. The following results were made through this experiment: 1. Half-lethal time by oxygen poisoning was longer in tocopherol treated group than not treated group. 2. Ratio of lung weight to body weight was significantly higher in fatal group within half-lethal time than survival group (p<0.01). 3. Histopathological changes of the lung by oxygen toxicity were vascular congestion, pulmonary edema, hemorrhage and emphysematous change. The degree of changes were rather marked in experimental group than tocopherol untreated group. Those were regard as the changes being occurred during tolerance process by prolonging half-lethal time.

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Serum selenium and α-tocopherol concentration in Cheju mares (제주도 암말의 혈청 selenium과 α-tocopherol 농도에 관하여)

  • Han, Bang-keun;Han, Ho-jae;Kim, Johng-bo;Ko, Min-soo;Matsumoto, Hiroshi
    • Korean Journal of Veterinary Research
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    • v.36 no.1
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    • pp.51-56
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    • 1996
  • Clinical findings of white muscle disease or dystrophia were reported in Hokkaido horses from 1960. This disease was caused by selenium and $\alpha$-tocopherol deficiency. Therefore, this study were conducted to measure serum selenium and $\alpha$-tocopherol levels in Cheju island horses using feedstuffs containing volcanic ashes. The results were as follows : 1. The mean values of serum total selenium and $\alpha$-tocophcrol were $91.90{\pm}49.18ppb$(13.20ppb-193.80ppb) and $0.345{\pm}0.253mg/dl$(0.056mg/dl-1.159mg/dl) in female respectively. There were no significant relation between serum total selenium and $\alpha$-tocopherol levels. 2. 22%(15 of 68) of the horse examined showed selenium levels below 50ppb. 11.8%(8 of 68) showed $\alpha$-tocopherol levels lower than 0.10mg/dl. These results could be useful to diagnose of white muscle disease of Cheju island foals and quality control of feedstuffs of pregnant mares.

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A Comparison of Natural (D-α-tocopherol) and Synthetic (DL-α-tocopherol Acetate) Vitamin E Supplementation on the Growth Performance, Meat Quality and Oxidative Status of Broilers

  • Cheng, K.;Niu, Y.;Zheng, X.C.;Zhang, H.;Chen, Y.P.;Zhang, M.;Huang, X.X.;Zhang, L.L.;Zhou, Y.M.;Wang, T.
    • Asian-Australasian Journal of Animal Sciences
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    • v.29 no.5
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    • pp.681-688
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    • 2016
  • The present study was conducted to compare the supplementation of natural (D-${\alpha}$-tocopherol) and synthetic (DL-${\alpha}$-tocopherol acetate) vitamin E on the growth performance, meat quality, muscular antioxidant capacity and genes expression related to oxidative status of broilers. A total of 144 1 day-old Arbor Acres broiler chicks were randomly allocated into 3 groups with 6 replicates of 8 birds each. Birds were given a basal diet (control group), and basal diet supplemented with either 20 IU D-${\alpha}$-tocopherol or DL-${\alpha}$-tocopherol acetate for 42 days, respectively. The results indicated that treatments did not alter growth performance of broilers (p>0.05). Compared with the control group, concentration of ${\alpha}$-tocopherol in the breast muscle was increased by the supplementation of vitamin E (p<0.05). In the thigh, ${\alpha}$-tocopherol content was also enhanced by vitamin E inclusion, and this effect was more pronounced in the natural vitamin E group (p<0.05). Vitamin E supplementation increased the redness of breast (p<0.05). In the contrast, the inclusion of synthetic vitamin E decreased lightness of thigh (p<0.05). Dietary vitamin E inclusion reduced drip loss at 24 h of thigh muscle (p<0.05), and this effect was maintained for drip loss at 48 h in the natural vitamin E group (p<0.05). Broilers given diet supplemented with vitamin E showed decreased malondialdehyde (MDA) content in the breast (p<0.05). Additionally, natural rather than synthetic vitamin E reduced MDA accumulation in the thigh (p<0.05). Neither natural nor synthetic vitamin E supplementation altered muscular mRNA abundance of genes related to oxidative stress (p>0.05). It was concluded that vitamin E supplementation, especially the natural vitamin E, can enhance the retention of muscular ${\alpha}$-tocopherol, improve meat quality and muscular antioxidant capacity of broilers.

Preparation of Antioxidative Polyethylene Film and Its Effects on the Lipid Oxidation of Semi-dried Squid during Storage (항산화 성분을 함유한 PE 필름이 반건오징어 저장 중 지질산화에 미치는 영향)

  • Kim Young-Myung;Park Hyung-Woo;Byun Jee-Young;Kim Kwang-Ho
    • The Korean Journal of Food And Nutrition
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    • v.18 no.1
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    • pp.19-27
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    • 2005
  • Antioxidative polyethylene films for food packaging were experimentally prepared by fortification of TBHQ(tertiary butylhydroquinone) and dl-a-tocopherol at the weight ratio of 0.05, 0.2 and 0.5%, respectively and laminated with nylon. TBHQ and tocopherol contents in the PE/nylon film were analyzed and the antioxidative effects of film were investigated on the lipid oxidation of semi-dried squid during storage at 5℃ and l5℃. TBHQ contents of TAP 1(TBHQ 0.05%), TAP 2(TBHQ 0.2%) and TAP 3(0.5%) were 38, 146 and 365 mg/100g, respectively. Tocopherol contents of DAP l(tocopherol 0.05%), DAP 2(tocopherol 0.2%) and DAP 3(tocopherol 0.5%) were 33, 139 and 356 mg/l00g, respectively. TBA value and POV during storage of semi-drid squid were affected both by storage temperatures and packaging films. Lipid oxidation during storage was retarded by anti-oxidative films, as TBA value of TAP 3 and DAP 3 revealed about 50% of control after storage at 5℃ for 20 days and similer effects in POV were also observed.

The antioxidative effects of α-tocopherol on the lipid peroxidation and protein oxidation by free radicals (Free radical에 의한 지질과산화와 단백질산화에 대한 α-tocopherol의 항산화효과)

  • Chung, Chung-won;Huh, Rhin-sou
    • Korean Journal of Veterinary Research
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    • v.34 no.2
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    • pp.249-258
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    • 1994
  • This study was carried out to investigate the inhibitory effects of vitamin E on the oxidative damage of cellular lipids and proteins in free radical reaction induced by $FeCl_3$, and ascorbic acid. In this experiment, a vitamin E treated rat group was administered with 100mg/kg body weight of $dl-{\alpha}-tocophery$ 1 acetate and an untreated rat group was administered with the same volume of corn oil. And then assays of malondialdehyde and carbonyl group in total homogenate, mitochondrial and microsomal fraction of rat liver were carried out at the scheduled time. The results obtained from this study were summarized as follows; 1. Lipid peroxidation levels in vitamin E administered rat liver cells were significantly (p<0.05) decreased at the intervals between 1 hour and 4 hours in liver homogenate, at all times except for 1 hour point in mitochondrial fraction, and also at the intervals between 0.5 hour and 3 hours in microsomal fraction compared with those of the control rat liver cell. 2. Protein oxidation levels in vitamin E administered rat liver cell were also significantly (p<0.05) decreased at the intervals between 1.5 hours and 4 hours in liver homogenate, at over 4 hours in liver mitochondrial fraction, and at the intervals between 0.5 hour and 3 hours in liver microsomal fraction compared with those of the control rat liver cells.

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Changes in Meat Color and α-Tocopherol Concentrations in Plasma and Tissues from Japanese Beef Cattle Fed by Two Methods of Vitamin E Supplementation

  • Irie, M.;Fujita, K.;Sudou, K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.12 no.5
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    • pp.810-814
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    • 1999
  • The influence of dietary vitamin E supplementation on meat color and ${\alpha}$-tocopherol concentrations in plasma, longissimus thoracis muscle and subcutaneous fat was investigated. Ten Japanese $Black{\times}Holstein$ crossbred steers were placed in three experimental groups receiving different supplements of vitamin E. Four steers (control) were fed no supplemental vitamin E. Two groups of three steers each, were supplemented with 500 mg dl-${\alpha}$-tocopherol acetate per animal daily for 175 days and 1,000 mg for 100 days, respectively, before slaughter. The ${\alpha}$-tocopherol concentration in plasma increased, as vitamin E were fed, and were related to the length of time and the amount of supplement. The ${\alpha}$-tocopherol concentrations in the muscle and the fat from the two supplemental groups did not differ significantly and were three or more times greater than those in the control group. Vitamin E supplementation did not affect the quantity of marbling of beef. Supplemental vitamin E stabilized the color of displayed beef around wavelengths of 500 nm and 640 nm. The two methods of vitamin E supplementation had similar effects on meat color. The effect of supplemental vitamin E on the color of beef with marbling was observed 2-3 days after slaughter and was followed for another two weeks.

Relative Effectiveness of Some Antioxidants on Palm Oil and Beef Tallow by AOM Tests (AOM 시험에 의한 팜유와 우지에 대한 몇가지 산화방지제 효과와 비교)

  • Yang, Joo-Hong;Jang, Young-Sang;Shin, Hyo-Sun
    • Korean Journal of Food Science and Technology
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    • v.20 no.4
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    • pp.563-568
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    • 1988
  • Relative effectiveness of antioxidants with their synergists was investigated by measuring AOM stability of palm oil and beef tallow during heating. TBHQ added at a concentration of 0.02% gave the highest AOM stability to palm oil among the antioxidants tested at the equivalent concentration. Beef tallow with added TBHQ showed a higher AOM stability than those with α-tocopherol$({\alpha}-toc)$ and a mixture of BHA and BHT, but showed a lower AOM stability than those with {$\delta}-rich$ tocopherol$({\delta}-toc)$ and mixed tocopherol(m-toc). Addition of ${\alpha}-toc$ to palm oil and beef tallow increased the AOM stability less than a mixture of BHA and BHT. Palm oil and beef tallow with added ${\delta}-toc$ and m-toc showed higher AOM stabilities than that with ${\alpha}-toc$, and there was no significant difference in AOM stability noted between ${\delta}-toc$ and m-toc. The synergistic effects of citric acid to ${\alpha}-toc\;and\;{\delta}-toc$ and of ascorbyl palmitate to ${\delta}-toc$ was noted higher in beef tallow than in palm oil, while that of ascorbyl palmitate to ${\alpha}-toc$ was higher in palm oil than in beef tallow.

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Effect of Dietary Vitamin E Supplementation on Serum α-Tocopherol and Immune Status of Crossbred Calves

  • Samanta, A.K.;Dass, R.S.;Rawat, Mayank;Mishra, S.C.;Mehra, U.R.
    • Asian-Australasian Journal of Animal Sciences
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    • v.19 no.4
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    • pp.500-506
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    • 2006
  • An experiment was conducted with twenty crossbred male calves (7-15 days old) divided into 4 different experimental groups on the basis of body weights to study the effect of vitamin E supplementation on the serum ${\alpha}$-tocopherol concentration and immune response of the calves. All the calves were fed on milk and calf starter up to 13 weeks and afterwards, they were fed on concentrate mixture and oat hay up to 32 weeks of age. In addition, the calves in groups I, II, III and IV were supplemented with 0, 125, 250 and 500 IU feed grade DL-${\alpha}$-tocopheryl acetate, respectively. Blood samples were collected at 0 day and subsequently at 1, 2, 3, 4, 6 and 8 months of age to monitor the serum ${\alpha}$-tocopherol concentration in crossbred calves. After 24 weeks of experimental feeding, 4 animals from each group were intramuscularly inoculated with single dose (3 ml) of Haemorrhagic septiceaemia (Pasteurella multocida P52 strain) oil adjuvant vaccine. The cumulative group mean serum ${\alpha}$-tocopherol concentration (${\mu}g/100ml$) was 88.12, 210.11, 235.21 and 294.02 in-groups I, II, III and IV, respectively and differed significantly (p<0.001) among the four groups. Lymphocyte stimulation indices (LSI) did not differ among the groups significantly. The pooled mean ELISA antibody titer against Pasteurella multocida (P52 strain) was 788.02, 926.85, 1,214.00 and 1,109.51 for group I, II, III and IV, respectively, which indicated higher antibody titer in groups supplemented with vitamin E as compared to the control group. It may be concluded that vitamin E supplementation increased the ${\alpha}$-tocopherol concentration in serum and dietary supplementation of vitamin E at higher level has a humoral immune enhancing effect against killed bacterial antigen.

Effect of Dietary Vitamin E supplement and Kinds of Lipid on the Serum vitamin E Concentration and Lipid Composition (지질의 종류를 달리하였을 때 식이내 Vitamin E 첨가가 흰쥐의 혈청 Vitamin E 농도 및 지질성분에 미치는 영향)

  • 박귀선
    • Journal of Nutrition and Health
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    • v.20 no.1
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    • pp.38-45
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    • 1987
  • This study was performed to investigate the effect of dietary vitamin E supplement and kinds of lipid on the vitamin E concentration and lipid composition in serum of the rats fed fro seven weeks. Supplemented vitamin E was 300mg/kg diet as DL-α-tocopherol acetate, and 15% of corn oil or beef tallow was added to standard diet. The results were as follows ; 1) Body weight and feed efficiency ratio were significantly increased by supplement with vitamin E, corn oil and beef tallow. 2) Serum vitamin E concentration increased significantly by supplement of vitamin E and beef tallow on the diets, while one of corn oil fed group decreased significantly . 3) The contents of triglyceride, total cholesterol, phospholipid in serum were significantly increased in the beef tallow group, and the vitamin E only -supplemented group showed significantly lower serum cholesterol in serum increased significantly in the vitamin E only -fed group and vitamin E plus corn oil-fed group. 4) The content of HDL-cholesterol in serum increased significantly in the vitamin E only -fed group and vitmain e plus corn oil -fed group. 5) The ratio of VLDL, LDL-cholesterol content to HDL-cholesterol one in serum was significantly low in the vitamin E only-supplemented group and corn oil group, and was significantly higher in the beef tallow group than in the corn oil group.

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A Study on the Catechins Contents and Antioxidative Effect of Various Solvent Extracts of Green, Oolong and Black Tea (녹차, 우롱차 및 홍차의 용매별 추출물의 카테킨류 함량 및 항산화효과에 관한 연구)

  • 이영자;안명수;오원택
    • Journal of Food Hygiene and Safety
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    • v.13 no.4
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    • pp.370-376
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    • 1998
  • The extraction yield of MeOH extract of green teas, oolong tea and black tea were 3 to 5, 4 to 5, and 5 to 7 fold higher than those of EtOH and EtAC extract, respectively. The amount of total catechins of EtAC extract of the black tea, and of the green teas and oolong tea were three- and two-fold higher than that of EtOH or MeOH extract of the corresponding teas, respectively. The antioxidative activities of EtOH, MeOH and EtAc extract were considerably higher than that of BHT and $dl-{\alpha}-tocopherol$ at 200 ppm level. The antioxidative activities of EtOH and MeOH extract at 200 and 500 ppm level, and of EtAc extract at 200 ppm level varied depending on the type of tea as follows : green tea I > green tea II > green tea III > oo-long tea> black tea. The antioxidative activity increased as the content of EGC increased. But the antioxidative activity of MeOH extract at 1000 ppm level, and of EtAc extract at 500 and 1000 ppm level were not affected by the content of EGC and EGCG.

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