• Journal of Life Science
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• v.19 no.10
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• pp.1389-1395
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• 2009

Generally, it takes a long time to purify wood vinegar, and it contains toxic compounds such as tar, methanol, phenol and benzopyrene. To reduce the toxicity of wood vinegar itself, we have developed a new purification method of wood vinegar using an oxidation-cohesion reaction and distillation with an active carbon. We have investigated the physico-chemical change (pH, specific gravity, refractive index and dissolved tar), the change of amount of toxic compounds (carbonyl group, phenol, benzopyrene and residual solvents) and organic acids (formic acid (FA), acetic acid (AA), propionic acid (PA)) of the purified wood vinegar under the long term and accelerated storage conditions. Also, we have evaluated the effect of the purified wood vinegar on hair growth using an alopecia model of C57BL/6 mice. As a result, we could find out that the purified wood vinegar was stable and remained without decay under the storage conditions and benzopyrene, a carcinogenic agent, was not detected in the purified wood vinegar. After topical treatment of the purified wood vinegar solution or minoxidil (MXD) for 2 weeks to dorsal skin, the hair regrowth of the mice accelerated faster than that of the control, with no clinical signs. In conclusion, we could suggest a guideline for quality control of process to reduce the toxic compounds in wood vinegar and it might be a useful hair growth promoter in the treatment of baldness or alopecia.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.4 no.1
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• pp.33-42
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• 1994

This study was carried out to assess worker exposure to vinyl chloride monomer (VCM) and to present control measures in the factories processing and producing polyvinyl chloride (PVC) resin. The conclusion remarks are as follows. Only two personal samples in the factory ("E") processing polyvinyl chloride resin were analysed to be 27.6 ppm and 12.6 ppm, respectively. But, these concentration exceed 1 ppm, Permissible Exposure Limits (PEL) of OSHA. So, worker's exposure to VCM at "E" factory should be reevaluated. In "A", "B" and "C" factory producing polyvinyl chloride resin, the average worker's exposures to VCM were 0.12 ppm, 0.86 ppm and 1.23 ppm, respectivery. Worker exposure to VCM at distillation and dry process was higer than other processes at "A" factory. The average exposure concentration of worker at polymerization process of "B" and "C" factory was 1.23 ppm, and 1.46 ppm respcetively. These concentration exceed 1 ppm, Permissible Exposure Limits of OSHA. Control room of "B" and "C" factory had 0.91 ppm and 0.65 ppm of worker's exposure concentration respectively. "A" factory was evaluated to be "acceptable", but "B" and "C" factories were evaluated to be "not acceptable", by the workplace exposure assessment program of AIHA. Process other than bagging and control room of "A" factory was evaluated to "not acceptable". Immediate correction measures for preventing workers from exposure to VCM should be performed in the factories or process that were evaluated to be "not acceptable". After these control measures are taken, worker exposure to VCM must be reevaluated through personal air monitoring. Control measures presented by this study are complete sealing of connecting pipe lines, flanging, packing, bolting and nutting. Periodic leak test for leak parts is also required. And positive pressure facility should be constructed at control room of "B" and "C" factory. Fresh air through cleaner such as HEPA filter should be supplied to control room. In addition to these control measures, periodic personal monitoring for evaluating worker exposure to VCM should be performed.

• Membrane Journal
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• v.18 no.1
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• pp.103-107
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• 2008

Membrane process has been focused as an alternative separation process because not only it exhibits a high selectivity compared with a traditional distillation process, but also it is known to be an energy saving separation process. Inorganic membrane, especially zeolite membrane, has been studied since it can be operated in severe conditions compared to the organic membranes. Recently, new zeolite materials are tested as an inorganic membrane material to overcome disadvantages of existing zeolite membranes. Kalsilite can be used as an inorganic membrane material for gas separation and selective water separation from water/organic mixtures because it is expected to be hydrophilic resulted from Si/Al ratio of 1 like zeolite 4A and has a narrow pore size of 0.36 nm. In this study, kalsilite was synthesized by a new economical hydrothermal process using Si : Al : K : $H_2O$ mole ratio of 1 : 1 : 8 : 60. The synthesized kalsilite powder was confirmed by XRD and has a mean diameter of $2.73{\mu}m$. The vapor adsorption test showed the synthesized kalsilite is hydrophilic.

• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1121-1126
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• 2009

This paper describes a pattern recognition method of Magnoliae flos based on a gas chromatographic/mass spectrometric (GC/MS) analysis of the essential oil components. The botanical drug is mainly comprised of the four magnolia species (M. denudata, M. biondii, M. kobus, and M. liliflora) in Korea, although some other species are also being dealt with the drug. The GC/MS separation of the volatile components, which was extracted by the simultaneous distillation and extraction (SDE), was performed on a carbowax column (supelcowax 10; 30 m{\time}0.25 mm{\time}0.25{\mu}m$) using temperature programming. Variance in the retention times for all peaks of interests was within RSD 2% for repeated analyses (n = 9). Of the 74 essential oil components identified from the magnolia species, approximately 10 major components, which is $\alpha$-pinene, $\beta$-pinene, sabinene, myrcene, d-limonene, eucarlyptol (1,8-cineol), $\gamma$-terpinene, p-cymene, linalool, $\alpha$-terpineol, were commonly present in the four species. For statistical analysis, the original dataset was reduced to the 13 variables by Fisher criterion and factor analysis (FA). The essential oil patterns were processed by means of the multivariate statistical analysis including hierarchical cluster analysis (HCA), principal component analysis (PCA) and discriminant analysis (DA). All samples were divided into four groups with three principal components by PCA and according to the plant origins by HCA. Thirty-three samples (23 training sets and 10 test samples to be assessed) were correctly classified into the four groups predicted by PCA. This method would provide a practical strategy for assessing the authenticity or quality of the well-known herbal drug, Magnoliae flos.

• Journal of the Korean Applied Science and Technology
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• v.34 no.4
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• pp.874-882
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• 2017

As the interest on the air-pollution is gradually rising up at home and abroad, automotiv e and fuel researchers have been working on the exhaust emission reduction from vehicles through a lot of approaches, which consist of new engine design, innovative after-treatment systems, using clean (eco-friendly alternative) fuels and fuel quality improvement. This research has brought forward three main issues : evaporative, performance, air pollution. In addition, researcher studied the environment problems of the bio-ethanol, bio-butanol, bio-ETBE (Ethyl Tertiary Butyl Ether), MTBE (Methyl Tert iary Butyl Ether) fuel contained in the fuel as octane number improver. The researchers have many dat a about the health effects of ingestion of octane number improver. However, the data support the con clusion that octane number improver is a potential human carcinogen at high doses. Based on the bio-fuel and octane number improver types (bio-ethanol, bio-butanol, bio-ETBE, MTBE), this paper dis cussed the influence of gasoline fuel properties on the evaporative emission characteristics. Also, this p aper assessed the acceleration and power performance of gasoline vehicle for the bio-fuel property. As a result of the experiment, it was found that all the test fuels meet the domestic exhaust gas standards, and as a result of measurement of the vapor pressure of the test fuels, the bio - ethanol : 15 kPa and the biobutanol : 1.6 kPa. thus when manufacturing E3 fuel, Increasing the biobutanol content reduces evaporation gas and vapor pressure. In addition, Similar accelerating and powering performance was shown for the type of biofuel and when bio-butanol and bio-ethanol were compared accelerated perf ormance was improved by about 3.9% and vehicle power by 0.8%.

• Korean Journal of Oriental Medicine
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• v.3 no.1
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• pp.183-197
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• 1997

In order to detect the safety and effect of various aqua-acupunctures from Scutellariae Radix, the modifications of boiling, filtration and dilution were employed for the manufacture of aqua-acupunctures. We injected 0.2cc of aqua-acupunctures into Joksamri (足三里) of rat, repeatedly. We compared subacute toxicity of them with saline group, distilled water(D.W.) group, acupuncture group and control group. The results were summarized as follows: 1. The groups were all healthy and alive, and there was no special abnormality in physical condition and autopsy. And there were not any toxic symptoms in repeating application of aqua-acupunctures to the rat, including changes of body weight, organ weight, haematological examination and serum biochemical test. 2. There was slight change of body weight in acupuncture group : We could see significance after 3 days(p<0.05) and after 7 days(p<0.001) in body weight loss. After 9 days, all tested groups were suppressed in body weight increment. 3. Result of organ weight : In Palkang aqua-acupuncture(D-2 group), saline group and acupuncture group there were some statistical significance. Especially, acupuncture group revealed significant result in liver and spleen than aqua-acupunctures. From this result, we could suggest that the efficacy of acupuncture was preceded herbal medicine. 4. In serum biochemical test, we examined glucose(GLU), triglyceride(TG) and cholesterol(CHOL). In comparison with control group, the diluted 10 times of Hwanggum aqua-aqupuncture$({\times}10\;group)$ was recognized significant decrease of glucose, but the diluted 100 times of Hwanggum aqua-acupuncture$({\times}100\;group)$, D-2 group, saline group were confirmed significant increment. There was not any meaningful change of CHOL in all of tested group, excepting the acupuncture group was exhibited statistically significant decrease(p<0.05). In TG level all tested group except complex injection of standard compound(CPA group) and HG, there were significant value iii statistically. The diluted solution was more significant decrease than Hwanggum aqua-acupuncture(HG). The mutual relationship of components of aqua-acupunture tended to decrease level of TG, regardless of its concentration. In acupunture guoup, we gained some interesting result In meaningful decrease in 7G. 5. Haematological examination showed significant increment of granulocytes(GR) in all tested groups except Hwanggum aqua-acupuncture. And the diluted solutions of HG expressed very high increment of them(p<0.001). The GR and Mean Corpuscular Volume(MCV) of acupuncture group showed statistical significance.