• 천문학회지
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• 제29권2호
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• pp.223-243
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• 1996

We have constructed a line-by-line model of the A-X system of CO in order to analyze the CO bands appearing in the UV spectra of comets. The model includes electronic, rotational, vibrational transitions, excitations by solar UV radiation, and effects of neutral and electron collisions. The major bands of the A-X system occur in the $1200 - 1800{\AA}$ range where the temporal variation of solar irradiation is significant. The solar spectrum in this spectral range shows many emission lines, which cause a significant Swings effect. We derived fluorescence efficiencies of the bands as functions of heliocentric velocity and cometocentric distance using a high resolution spectrum of the sun. We compared our model with a spectrum of comet P/Halley obtained with the IUE, and estimated that the UV Swings effects are less than 20 fluorescence efficiencies for the most bands of the A-X system. We discuss the temporal variation of solar UV irradiation and its effects on the fluorescence efficiencies. The study of the A-X system also requites knowledge of vibrational and rotational fluorescent processes in the infrared and radio regions because the majority of CO molecules in the coma is in the ground rotational states. The solar infrared spectrum near 5 microns, where the fundamental band of CO occurs, contains strong absorption lines of the fundamental band and hot bands of CO and its isotopes. We derived fluorescence efficiencies of the infrared band as functions of heliocentric velocity and cometrocentric distance. The solar absorption lines near 5 microns cause a 20 reduction of the g-factor of the fundamental band at heliocentric velocities close to 0 km/sec. We discuss the effects of neutral and electron collisions on the fluorescence efficiencies of the infrared and UV bands.

• Archives of Pharmacal Research
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• 제29권1호
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• pp.50-58
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• 2006

Translationally controlled tumor protein (TCTP), also known as histamine releasing factor (HRF), is found abundantly in different eukaryotic cell types. The sequence homology of TCTP between different species is very high, belonging to the MSS4/DSS4 superfamily of proteins. TCTP is involved in both cell growth and human late allergy reaction, as well as having a calcium binding property; however, its primary biological functions remain to be clearly elucidated. In regard to many possible functions, the TCTP of Plasmodium falciparum (Pf) is known to bind with an antimalarial agent, artemisinin, which is activated by heme. It is assumed that the endoperoxide-bridge of artemisinin is opened up by heme to form a free radical, which then eventually alkylates, probably to the Cys14 of PfTCTP. Study of the docking of artemisinin with heme, and subsequently with PfTCTP, was carried out to verify the above hypothesis on the basis of structural interactions. The three dimensional (3D) structure of PfTCTP was built by homology modeling, using the NMR structure of the TCTP of Schizosaccharomyces pombe as a template. The quality of the model was examined based on its secondary structure and biological function, as well as with the use of structure evaluating programs. The interactions between artemisinin, heme and PfTCTP were then studied using the docking program, FlexiDock. The center of the peroxide bond of artemisinin and the Fe of heme were docked within a short distance of $2.6{\AA}$, implying the strong possibility of an interaction between the two molecules, as proposed. When the activated form of artemisinin was docked on the PfTCTP, the C4-radical of the drug faced towards the sulfur of Cys14 within a distance of $2.48{\AA}$, again suggesting the possibility of alkylation having occurred. These results confirm the proposed mechanism of the antimalarial effect of artemisinin, which will provide a reliable method for establishing the mechanism of its biological activity using a molecular modeling study.

• Genomics & Informatics
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• 제6권3호
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• pp.142-146
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• 2008

In order to understand the protein functions that are related to disease, it is important to detect the correlation between amino acid mutations and disease. Many mutation studies about disease-related proteins have been carried out through molecular biology techniques, such as vector design, protein engineering, and protein crystallization. However, experimental protein mutation studies are time-consuming, be it in vivo or in vitro. We therefore performed a bioinformatic analysis of known disease-related mutations and their protein structure changes in order to analyze the correlation between mutation and disease. For this study, we selected 111 diseases that were related to 175 proteins from the PDB database and 710 mutations that were found in the protein structures. The mutations were acquired from the Human Gene Mutation Database (HGMD). We selected point mutations, excluding only insertions or deletions, for detecting structural changes. To detect a structural change by mutation, we analyzed not only the structural properties (distance of pocket and mutation, pocket size, surface size, and stability), but also the physico-chemical properties (weight, instability, isoelectric point (IEP), and GRAVY score) for the 710 mutations. We detected that the distance between the pocket and disease-related mutation lay within $20\;{\AA}$ (98.5%, 700 proteins). We found that there was no significant correlation between structural stability and disease-causing mutations or between hydrophobicity changes and critical mutations. For large-scale mutational analysis of disease-causing mutations, our bioinformatics approach, using 710 structural mutations, called "Structural Mutatomics," can help researchers to detect disease-specific mutations and to understand the biological functions of disease-related proteins.

• 동남아시아연구
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• 제22권2호
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• pp.133-170
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• 2012

This thesis aims to analyze the political, social, and cultural activities of the Acehnese ethnic group living in Jakarta, Indonesia. Based on analysis, this thesis examines how their ethnicity and national identity have been formed and expressed. For this purpose, this study deals with Taman Iskandar Muda (hereinafter referred to as TIM), a group of Acehnese transmigrants living in Jakarta. The immigration of the Acehnese to Jakarta started in the 1950s and the number of Acehnese people living in Jakarta persently amounts to 100,000. TIM, which was organized by the first generational of immigrants, functions to group Acehnese immigrants of various generations and class. Forum Keprihatinan Untuk Aceh(hereinafter referred to as Forka), an organization designed to solve the political problems of TIM, undertook various activities to maintain the peace of Aceh as the representative of TIM. Through those activities, TIM and Forka were able to confirm the feeling of homogeneity among the Acehnese who were living in their hometown and also strengthen their identity within the organizations. However, the fact that TIM and Forka put their focus on humanitarian activities paradoxically shows the political limitations that they sustain. TIM and Forka take care not to make their humanitarian activities seem as if they intend to openly strengthen their Acehnese identity and deny their Indonesian one. These political characteristics of Forka's identity are commonly found in groups that practice long-distance nationalism, as transmigrants in diaspora circumstances do. In the organization of TIM, there exists the menasah, which is a space where discussions of the ethnicity and the nation are practiced. As it is the space for local exchange, menasah reveals the identity of TIM through educational/social activities and public services. Menasah functions as the public arena where people practice ethnic identity on the basis of national integration. As a minority ethnic group living in Jakarta and its neighborhood, they are accustomed to double and selective political activities, social activities, and cultural practices. In order to adapt themselves to the double circumstance that they are faced with, they should live extemporaneously, and this life may be the fate that minority ethnic and transmigrants should endure.

• 한국항행학회논문지
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• 제24권3호
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• pp.192-197
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• 2020

최근 운송수단의 안전운행 및 사고방지를 목표로 하는 자율운행 관련 기술이 적극적으로 연구되고 있다. 현재 자율운행에서 장애물 탐지를 위하여 레이다 및 카메라 기술이 사용되고 있으나, 근접한 물체의 탐지 및 이격거리의 정밀계측에는 LiDAR (light detection and ranging) 센서를 사용하는 방법이 가장 적합하다. LiDAR 센서는 레이저 펄스빔을 발사하고 물체로부터 반사되어 온 반사빔과의 시간차를 취득하여 이것으로 정밀한 거리를 계산하는 측정기로, 광을 이용하기 때문에 대기환경에서 물체의 인식률이 감소할 수 있는 단점이 있다. 본 논문은 LiDAR 센서의 raw 데이타에 대한 신뢰성 향상과 이를 기반으로 실시간 주변물체에 대한 탐지 및 이격거리 계측에서 오차를 개선하기 위하여 삼각함수에 의한 포인트 cloud를 추출하고, 선형회귀 모델을 이용하여 계측알고리즘을 구현하였으며, Python 라이브러리를 활용하여 물체탐지의 오차범위를 개선할 수 있음을 검증하였다.

• 한국지능시스템학회논문지
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• 제22권4호
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• pp.414-424
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• 2012

문제 인스턴스 탐색 혹은 자동 생성은 알고리즘 분석 및 테스트에 적용될 수 있으며, 하드웨어, 소프트웨어 프로그램, 계산 이론 등 다양한 수준에서 연구되어온 주제이다. 본 연구에서는 해(解) 공간에 사용된 목적값-거리 상관관계 분석을 문제 인스턴스 공간에 적용하였다. 문제 인스턴스의 목적값은 문제에 따라 알고리즘의 수행 시간과 최적해를 잘 구하는 정도로 정의하였다. 이러한 정의는 문제 인스턴스의 난이도로 해석할 수 있다. 상관관계는 3가지 측면에서 분석하였다: 첫째, 알고리즘과 거리 함수에 따른 상관관계 차이, 둘째, 알고리즘의 개선 전/후의 상관관계 변화, 셋째, 문제 인스턴스 공간과 해당 문제의 해 공간 사이의 연관성. 본 논문은 문제 인스턴스 공간에 상관계수 분석이 어떻게 적용될 수 있는지 보여주며, 문제 인스턴스 공간 분석을 본격적으로 다루는 첫번째 시도이다.

• 한국항해항만학회지
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• 제29권8호
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• pp.647-652
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• 2005

선박이 수로 측벽부근을 항해할 경우, 수로 측벽은 선박에 작용하는 유체력과 모멘트를 유발시킨다. 이와 마찬가지로 근접 항해중인 두 선박간에도 상호간섭력이 작용한다. 수로 측벽부근을 항해하는 경우와 근접 항해중인 두 선박의 경우의 주요 차이는 선박의 경우에 비하여 수로 측벽은 길고 일정한 형태를 갖추고 있다. 두 선박간의 상호간섭력은 종방향 거리 $\chi_0$, 횡방향 거리 $y_0$ 및 두선박의 속도의 함수로서 가정될 수 있다. 본 연구에서는 근접 항해중인 두 선박간의 간섭력을 계산하고, 두 선박간의 횡방향 및 종방항 거리와 속도에 따른 안전 항과 거리에 대해서 검토, 고찰하였다.

• International journal of advanced smart convergence
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• 제5권4호
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• pp.15-20
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• 2016

When a virtual sound source for 3D auditory system is reproduced by a linear loudspeaker array, listeners can perceive not only the direction of the source, but also its distance. Control over perceived distance has often been implemented via the adjustment of various acoustic parameters, such as loudness, spectrum change, and the direct-to-reverberant energy ratio; however, there is a neglected yet powerful cue to the distance of a nearby virtual sound source that can be manipulated for sources that are positioned away from the listener's median plane. This paper address the problem of generating binaural signals for moving sources in closed or in open environments. The proposed perceptual enhancement algorithm composed of three main parts is developed: propagation, reverberation and the effect of the head, torso and pinna. For propagation the effect of attenuation due to distance and molecular air-absorption is considered. Related to the interaction of sounds with the environment, especially in closed environments is reverberation. The effects of the head, torso and pinna on signals that arrive at the listener are also objectives of the consideration. The set of HRTF that have been used to simulate the virtual sound source environment for 3D auditory system. Special attention has been given to the modelling and interpolation of HRTFs for the generation of new transfer functions and definition of trajectories, definition of closed environment, etc. also be considered for their inclusion in the program to achieve realistic binaural renderings. The evaluation is implemented in MATLAB.

• 컴퓨터교육학회논문지
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• 제5권1호
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• pp.57-66
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• 2002

컴퓨터와 인터넷 기술의 비약적인 발전으로 인해 인터넷상에서의 실시간 멀티미디어 서비스가 가능해짐에 따라 주문형 비디오(Video on Demand ; VOD)서비스나 GVA기술을 이용한 원격 교육이 시도되고 있다. 그러나 현재 VOD나 GVA서비스는 양질의 비디오화면을 실시간으로 서비스하는 서버의 연구나 효율적인 교육내용에만 집중되어 있을 뿐 사용자를 위한 서비스 형태에 대한 개발은 거의 이루어지지 않고 있다. 따라서 본 논문에서는 VOD나 GVA 서비스를 이용하여 원격교육을 받고자 하는 사용자 측면의 정보 서비스를 위한 서비스 시스템을 설계하고 구현하였다. 본 논문에서 설계한 주문형 멀티미디어 서비스 시스템은 E-mail올 이용한 오프라인 검색 서비스, PUSH 기술을 이용한 주기적인 최신정보 서비스, SDI서비스를 이용한 고객 맞춤 예약정보서비스와 피드백 서비스를 제공함으로서 사용자가 원하는 교육 자료를 선별하고 검색하는데 있어 걸리는 노력과 시간을 최대한 단축시키고, 서버에 접속하는 횟수를 최대한 줄여서 보다 고차원적인 정보 서비스를 받을 수 있도록 하였다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2005년도 추계학술대회 논문집
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• pp.11-16
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• 2005

선박이 수로 측벽부근을 항해할 경우, 수로 측벽은 선박에 작용하는 유체력과 모멘트를 유발시킨다. 이와 마찬가지로 근접항해중인 두 선박간에도 상호간섭력이 작용한다 수로 측벽부근을 항해하는 경우와 근접 항해중인 두 선박의 경우의 주요 차이는 선박의 경우에 비하여 수로 측벽은 길고 일정한 형태를 갖추고 있다. 두 선박간의 상호간섭력은 종방향 거리 $x_0$, 횡방향 거리 $y_0$ 및 두선박의 속도의 함수로서 가정 될 수 있다. 저자는 근접 항해중인 두 선박간의 간섭력을 계산하고, 두 선박간의 횡방향 및 종방향 거리와 속도에 따른 안전 항과 거리에 대해서 검토, 고찰하였다.