• Title/Summary/Keyword: dispersion method

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Effect of Manufacturing Method and Acidifier on the Dissolution Rate of Carvedilol from Solid Dispersion Formulations

  • Lim, Dong-Kyun;Bae, Jeong-Woo;Song, Byung-Joo;Jo, Han-Su;Kim, Hyoung-Eun;Lee, Dong-Won;Khang, Gil-Son
    • Journal of Pharmaceutical Investigation
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    • v.41 no.6
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    • pp.363-369
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    • 2011
  • In this study, we demonstrated the release behavior of carvedilol with the content of polyvinylpyrrolidone K-30 (PVP K-30) and the effect of citric acid and fumaric acid as acidifiers on the release behavior of drug. In addition, it tries to inquire into the release behavior difference of the carvedilol according to the manufacturing method. The release behavior of the tablets was compared with Dilatrand$^{(R)}$ in the simulated gastric fluid (pH1.2). Differential scanning calorimeter (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR) were characterized for the physicochemical properties of the tablets. In case of mixing the carvedilol and PVP K-30, in case the ratio of the carvedilol and PVP K-30 was 1:5, the release behavior was the highest among. As well as the dissolution rate of tablets manufactured by lyophilization and rotary evaporator was higher than physical mixture. The dissolution rate of containing acidifiers was more improved. But, rather the excessive amount of the acidifier addition reduced the dissolution rate.

Dispersion Characteristics of Odorous Elements from Nambu Wastewater Treatment Plant and a Nearby Streams in Busan (부산시 남부하수처리시설과 인근 하천에서 발생하는 악취물질 확산 특성)

  • Mun, Seong-Man;Lee, Hyung-Don;Cho, Sang-Won;Kang, Dong-Hyo;Park, Hae-Sik;Oh, Kwang-Joong
    • Journal of Environmental Science International
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    • v.20 no.8
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    • pp.953-962
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    • 2011
  • The covered stream of cities are considered an odor source. Also, the public do not want a wastewater treatment plant(WWTP) near their properties due to the emission of odor emanating from such sources, although they play an important role in urban development. The purpose of this study is to analyze the pattern distribution of the odorous compounds from the Nambu WWTP and Youngho stream in Busan. odor sampled four times were analyzed by instrumental analysis method and indirect olfactory method. The kinds of offensive odorous compounds examined are acetaldehyde, propion aldehyde, hydrogen sulfide, methyl mercaptan, dimethyl sulfide and ammonia. Also, Concentration of air pollutants has been calculated by ISCST3 models. At the result of this study, The Nambu WWTP releases sulfur compounds. And the major odorous were hydrogen sulfide (1,475 ppb) and acetaldehyde (95 ppb) at Youngho stream. The stink which residents feel will point out the Nambu WWTP mainly if the odor is removed with the improvement of a Youngho stream. Accordingly, we should pay more attention to appropriate components to processes in odor reducing plan at Nambu WWTP.

A manufacturing process and characteristic observation of alloy blocks for dental CAD/CAM system (치과 CAD/CAM 가공용 합금블럭 제조 및 특성 관찰)

  • Kim, Chi-young
    • Journal of Technologic Dentistry
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    • v.40 no.3
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    • pp.125-131
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    • 2018
  • Purpose: Automatic dental prosthesis manufacturing process was accelerated by the spread of dental CAD / CAM system. The CAD / CAM system with milling alloys were needed supplement. So, sintered alloy blocks were introduced. In this study, we want to study sintered alloy block. And to evaluate the alloy block manufacture and alloy properties. Methods: The alloy powders were prepared by high pressure water dispersion method. The sintered alloy blocks were prepared by low temperature pressing method. Their components observation were EDX, and the alloy structure was observed by XRD. Results: Co-Cr alloy powders were observed to have a circle shape with an average diameter of about $100{\mu}m$ and a Ni-Cr alloy powder had a circle shape with an average diameter of about $50{\mu}m$. The Co-Cr alloy block is composed of Co (34.62 wt%), Cr (17.33 wt%), Mo (2.98 wt%), Si (0.36 wt%) and C (44.17 wt%). The Ni-Cr alloy powder was composed of Ni (40.29 wt%), Cr (19.37 wt%), Mo (3.53 wt%), Si (0.52 wt%) and C (33.18 wt%). The peak of the Co and CoCr peaks were observed in the CoCr alloy body by the means of XRD study. Cr2Ni3 of the peak was observed in the Ni-Cr alloy material. Conclusion : As a result, the following conclusions were obtained. 1. Prepared by high-pressure water-law Co-Cr alloy powder has an average diameter $100{\mu}m$, Ni-Cr alloy powder was found to have the form of sphere having an average diameter $50{\mu}m$. 2. Co-Cr alloy and Ni-Cr alloy block produced by low-temperature processing showed a certain ratio. 3. In the XRD study, Co phase appeared in Co-Cr alloy block after sintering. and Cr2Ni3 phase appeared in Ni-Cr alloy block after sintering.

Electrochemical Behavior of Pt-Ru Catalysts on Zeolite-templated Carbon Supports for Direct Methanol Fuel Cells

  • Lim, Tae-Jin;Lee, Seul-Yi;Yoo, Yoon-Jong;Park, Soo-Jin
    • Bulletin of the Korean Chemical Society
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    • v.35 no.12
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    • pp.3576-3582
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    • 2014
  • Zeolite-templated carbons (ZTCs), which have high specific surface area, were prepared by a conventional templating method using microporous zeolite-Y for catalyst supports in direct methanol fuel cells. The ZTCs were synthesized at different temperatures to investigate the characteristics of the surface produced and their electrochemical properties. Thereafter, Pt-Ru was deposited at different carbonization temperatures by a chemical reduction method. The crystalline and structural features were investigated using X-ray diffraction and scanning electron microscopy. The textural properties of the ZTCs were investigated by analyzing $N_2$/77 K adsorption isotherms using the Brunauer-Emmett-Teller equation, while the micro- and meso-pore size distributions were analyzed using the Barrett-Joyner-Halenda and Harvarth-Kawazoe methods, respectively. The surface morphology was characterized using transmission electron microscopy and inductively coupled plasma-mass spectrometry. The electrochemical properties of the Pt-Ru/ZTCs catalysts were also analyzed by cyclic voltammetry measurements. From the results, the ZTCs carbonized at $900^{\circ}C$ show the highest specific surface areas. In addition, ZTC900-PR led to uniform dispersion of Pt-Ru on the ZTCs, which enhanced the electro-catalytic activity of the Pt-Ru catalysts. The particle size of ZTC900-PR catalyst is about 3.4 nm, also peak current density from the CV plot is $12.5mA/cm^2$. Therefore, electro-catalytic activity of the ZTC900-PR catalyst is higher than those of ZTC1000-PR catalyst.

The characteristics of farmer's dermal exposure during pesticide spraying and dilution in cut rose greenhouse (절화장미 시설하우스에서 방제 작업시 농약의 피부노출 특성)

  • Kim, Hyo-Cher;Kim, Kyung-Ran;Lee, Kyung-Suk;Kim, Kyung-Su;Cho, Kyun-Ah
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.17 no.3
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    • pp.203-211
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    • 2007
  • This study was conducted in cut rose cultivation field in Goyang to evaluate pesticide exposure of farmers and the relationship between the exposure and work environment/method for cut rose farmers. Dermal exposure was assessed with patch (thin chromatography layer paper), cotton glove by body parts during mixing and spraying works in which pyrethroid, organophosphate, carbamate pesticide were used in 4 cut rose greenhouses located in Goyang province, checking characteristics of environment/working method at the same time. Body parts assessed were as follows ; glove : hand, patch : head, neck(front/back), chest, back, shoulder(right/left), upperarm(right/left), forearm(right/left), thigh(right/left), shin(right/left). Pesticides were analyzed using gas chromatography(NPD/FID) after extracting with ethyl acetate. Exposure amount differed according to pesticide type. But after standardizing with total net weight of pesticide sprayed, there were no significant difference among pesticides. There were significant difference in exposure amount among body parts(especially exposure amount of thigh, shin were more than the others), which means exposure happen not by pesticide dispersion in air but by contact with cut rose(leaf, branch) indirectly. Walking forward during spraying made farmers more exposed than waling backward, these results means contacts with leaves/branches made exposure happen in cut rose greenhouse also. As a result, pesticide exposure in cut rose greenhouse was related with contact of leaf/branch which pesticide remained in, which made exposure pattern (especially exposure amount) differ by body parts

Fabrication of 3Y-TZP/SUS316 Functionally Graded Material by Slip Casting Method Using Alumina Mold (알루미나몰드를 사용한 슬립캐스팅법에 의한 3Y-TZP/SUS316계 경사기능재료의 제조)

  • 여정구;정연길;이세훈;최성철
    • Journal of the Korean Ceramic Society
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    • v.34 no.1
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    • pp.70-78
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    • 1997
  • 3Y-TZP/SUS316 Functionally Graded Material (FGM) was fabricated by slip casting method. Alumina mold was used to overcome problems of gypsum mold in slip casting process, and the optimal dispersion con-ditions of 3Y-TZP/SUS316 binary slurries was determined using electrokinetic sonic amplitude and a viscometer, and observing sedimentation behavior. The properties of the specimens casted by gypsum mold and alumina mold were compared in terms of changes in shrinkage rate, drying and sintering conditions, and microstructure. It was found that the specimens obtaine from the alumina mold showed a clean surface, easier thickness control of each layer, and higher productivity. Especially, no degradation was observed in the SUS316 prepared using alumina mold. Thus it is desirable to use porous alumina mold rather than gyp-sum mold for the slip casting of 3Y-TZP/SUS316-FGM.

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Electromagnetic Wave Shielding Effect of Nano-powder Dispersed Epoxy Resin Composite (나노분말이 분산된 에폭시 섬유수지의 전자파차폐 효과)

  • Han, Jun-Young;Lee, Chul-Hee;Choi, Min-Gyu;Hong, Soon-Jik;Park, Joong-Hark;Lee, Dong-Jin
    • Journal of Powder Materials
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    • v.22 no.4
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    • pp.234-239
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    • 2015
  • Electronic products are a major part of evolving industry and human life style; however most of them are known to emit electromagnetic waves that have severe health hazards. Therefore, different materials and fabrication techniques are understudy to control or limit transfer of such waves to human body. In this study, nanocomposite powder is dispersed into epoxy resin and shielding effects such as absorption, reflection, penetration and multiple reflections are investigated. In addition, nano size powder (Ni, $Fe_2O_3$, Fe-85Ni, C-Ni) is fabricated by pulsed wire evaporation method and dispersed manually into epoxy. Characterization techniques such as X-ray diffraction, Scanning electron microscopy and Transmission electron microscopy are used to investigate the phase analysis, size and shape as well as dispersion trend of a nano powder on epoxy matrix. Shielding effect is measured by standard test method to investigate the electromagnetic shielding effectiveness of planar materials, ASTM D4935. At lower frequency, sample consisting nano-powder of Fe-85%Wt Ni shows better electromagnetic shielding effect compared to only epoxy, only Ni, $Fe_2O_3$ and C-Ni samples.

Analysis of Hydrodynamic Change around the Saemangeum Area Using a Particle Tracking Method (입자추적방법을 이용한 새만금 해역의 수리특성 변화 분석)

  • Suh, Seung-Won;Lee, Hwa-Young
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.23 no.6
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    • pp.442-450
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    • 2011
  • A three dimensional random walk particle tracking method is applied to the Saemangeum area in order to find stepwise environmental changes according to long term construction. Flow regime around Mangyeong, Dongjin and Geum river estuary changed greatly due to dike construction. It is distinctive that reduction of Byeonsan area's flow field and stagnant change in the northern part of the inner reservoir. Similar characteristics are found through the tidal excursion analysis. By analysis of the vertical mixing structures according to density stratification based on temperature and salinity variation, a salt wedge and very strong stratification arises in the inner part of the reservoir after final closure, while it has been well mixed or partially mixed estuary during construction. Shrinking of horizontal dispersion and vertical mixing capability may cause adverse effect on water quality not only inner part but also outer region of the Saemangeum reservoir.

Analysis Method for Air Quality Improvement Effect of Transport and Environment Policy (교통환경정책의 대기질 개선효과 분석 방법론 연구)

  • LEE, Gunwoo;HAHN, Jin-Seok
    • Journal of Korean Society of Transportation
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    • v.35 no.1
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    • pp.37-49
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    • 2017
  • This study proposes an analysis methodology for air quality improvement effect of transport and environment policy that are used for mobile pollution sources. The methodology considers the changes of traffic of road transport sources and air pollutant emission, the changes of atmospheric dispersion of air pollutants and the effects on the health of local residents in response to policy implementation. Especially, the changes to traffic flow must be considered in evaluating the effects on atmospheric environment as it has a direct connection to the effects of the policy in this study. We used bottom-up approach (BUA) based on the travel demand model to reflect the changes of travel behavior in detail in response to the policy implementation compared to the top-down approach (TDA) when calculating the changes of emission level of road transport. We showed the applicability of the proposed analysis methodology through a policy scenario analysis, and the analysis method can be effectively applied to the cases in which travelers' behavior changes are expected.

Preparation of WO3-TiO2 Photocatalyst and Evaluation of Its Photo-activity in the Visible Light Range (가시광 활성 WO3-TiO2 복합체 광촉매의 제조 및 이의 특성 평가)

  • Yeo, In-Chul;Kang, In-Cheol
    • Journal of Powder Materials
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    • v.20 no.6
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    • pp.474-478
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    • 2013
  • The most general photocatalyst, $TiO_2$ and $WO_3$, are acknowledged to be ineffective in range of visible light. Therefore, many efforts have been directed at improving their activity such as: band-gap narrowing with non-metal element doping and making composites with high specific surface area to effectively separate electrons and holes. In this paper, the method was introduced to prepare a photo-active catalyst to visible irradiation by making a mixture with $TiO_2$ and $WO_3$. In the $TiO_2-WO_3$ composite, $WO_3$ absorbs visible light creating excited electrons and holes while some of the excited electrons move to $TiO_2$ and the holes remain in $WO_3$. This charge separation reduces electron-hole recombination resulting in an enhancement of photocatalytic activity. Added Ag plays the role of electron acceptor, retarding the recombination rate of excited electrons and holes. In making a mixture of $TiO_2-WO_3$ composite, the mixing route affects the photocatalytic activity. The planetary ball-mill method is more effective than magnetic stirring route, owing to a more effective dispersion of aggregated powders. The volume ratio of $TiO_2(4)$ and $WO_3(6)$ shows the most effective photocatalytic activity in the range of visible light in the view point of effective separation of electrons and holes.