• Journal of Pharmaceutical Investigation
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• v.10 no.1
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• pp.24-33
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• 1980

Drug product design of phenylbutazone tablets by direct compressing was investigated. Weight variation, hardness, friability, disintegration time, apparent volume and dissolution rate for experimental tablets of nine formulations which were considered to be the effect of the additive concentration were measured. It was found out that direct compressing by the formulation No. 5 was the most suitable condition (phenylbutazone 16.7%, lactose 25%, calcium phosphate dibasic 15%, $Avicel^{\circledR}$ 41.83% and magnesium stearate 1.5%). The coefficient of correlation between disintegration time and dissolution rate, r, was = -0.97 (P<0.01).

• Journal of Pharmaceutical Investigation
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• v.39 no.6
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• pp.445-449
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• 2009

According to the statistical data, stroke is about 13.9% of leading causes of death. Some herbal medicines including Paeonia lactiflora, Angelica gigas nakai and Prunus persica, etc., had been reported to be effective in preventing stroke and mBHT (Modified BoyangHwanoTang) was an advanced prescription used in Korean clinics. Orally disintegrating tablets (ODT) is useful for patients suffering from dysphagia, motion sickness, repeated emesis and mental disorders. Further, drugs exhibiting satisfactory absorption through the mucosa intended for immediate pharmacological action could be advantageously formulated in ODT. The aim of this study was to develop the most efficient ODT formulation of mBHT. Corresponding herbal medicines comprising mBHT were extracted with water for 3 hr at 95~$100{^{\circ}C}$ and then dried. mBHT extract was obtained with about 30% of yield. Subsequently, some pharmaceutical excipients such as spray-dried lactose, crospovidone, glyceryl behenate and/or cogrinded-treated arabia gum were used to achieve an immediate disintegration of mBHT ODT in oral cavity. The requirements of ODT with mechanical strength sufficient to stand the rigors of handling and capability of disintegrating within a few seconds in contact with saliva are indispensable. mBHT ODT prepared by the wet granulation method showed a disintegration time of below 30 sec.

• Journal of Pharmaceutical Investigation
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• v.6 no.2
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• pp.69-82
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• 1976

Tablet product design problem was structured as constrained optimization problem and subsequently solved by multiple regression analysis and Lagrangian method of optimization. We used Lagrangian method for the purpose of finding the reason of the previous results. Biodiastase and cellulase were the enzymes, chosen, $Avicel{\circledR}$ and corn starch or calcium carboxy methyl cellulose were the binder and disintegrant, respectively. The effect of the dry binder and disintegrant concentration on tablet hardness, friability, volume, disintegration time was recorded. Optimization of this parameter was studied by using the constrained optimization method. In addition to finding a optimal condition of the enzyme tablets, the application of sensitivity analysis studies to such problems was also illustrated. In order to get a stable preparations of the enzyme tablets, accelerated test of coating tablets was carried out in this study. the results are as follows. 1) The minimum disintegration time, such that the average tablet volume did not exceed 0.0154 cubic inch and the average friability value did not exceed 0.62%, was 6.6 minutes and then $Avicel{\circledR}$ and corn starch were 15.4% and 17.2%, respectively. 2) The multiple-correlation coefficients for the regression models of tablet hardness, friability, disintegration time and volume were with in the 95% confidence range. 3) According to the test results, calcium carboxymethyl cellulose can be used as a disintegrant instead of corn starch.

• The Korean Journal of Pharmacology
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• v.13 no.1 s.21
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• pp.1-6
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• 1977

The physicochemical equivalencies of drugs are not usually correlate to the generic equivalencies of drugs and the generic equivalencies of drugs produced by different manufacturers or different formulations are being called in question frequently. The bioabailability of two formulations of oxytetracycline and erythromycin stearate were performed in healthy human volunteers. At the same time, the disintegration testes were performed with randomly sampled materials in question. For the biological evaluation of new oxytetracycline formulation; tablet(250mg), two-way cross over study in 10 healthy young volunteers was performed using oxytetracycline capsule (250mg) as reference, Erythromycin stearate (250mg) tablets and capsules produced by different manufacturers were compared in a two-way cross over study in 12 subjects with same manner of oxytetracyclines. oxytetracycline tablets showed somewhat slow disintegration rate, but appeared not statistical differences in serum concentrations from the reference, up to six hours after ingestion. Erythromycin stearate capsules disintegrated more rapidly than enteric coated tablets. Serum concentrations of capsules were more variable and markedly lower (P<.005 after 2hrs) than the enteric coated tablets. Rapid disintegration of capsules may result in destruction of active chemicals owing to the interaction with gastric acid and the above factor may contribute mainly to the low serum level after ingestion of capsules.

• Journal of the Korea Organic Resources Recycling Association
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• v.12 no.4
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• pp.121-129
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• 2004

Anaerobic digestion is the most common process for sewage sludge stabilization and has benefits of VS reduction and biogas production. Many pretreatment methods have been studied to improve hydrolysis rate because the rate of sewage sludge degradation is slow in anaerobic digestion. This study mainly focused upon the effects on disintegration of sewage sludge by ultrasonic pretreatment according to the variation of acoustic density and duration of sonication time. In this study, acoustic density has been changed as follows : 33W/L, 70W/L, 88W/L, 139W/L in case of 40 kHz with the test time changes of 10min, 20min, 25min, 30min and 40min. In the comparison of $SCOD_{Cr}/TCOD_{Cr}$ variation for excess sludge and mixed sludge disintegration, the rates of $SCOD_{Cr}/TCOD_{Cr}$ have been increased in the condition of denser acoustic density and longer sonication time with acoustic frequency of 40kHz. The pH of the excess sewage sludge and mixed sewage sludge has been decreased in the condition of denser acoustic density and longer sonication time with acoustic frequency of 40kHz.

• Resources Recycling
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• v.21 no.5
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• pp.44-49
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• 2012

In this study, the sonication method was applied to remove ink from old newspaper(ONP) using flotation. Results indicated increased whiteness and effective residual ink concentration (ERIC) with longer disintegration. Therefore 58% of whiteness and 182.9 ppm ERIC were obtained for 30 minutes of disintegration time without the change in yield. Longer disintegration than 30 minutes had no effects on whiteness without the application of ultra-sonication. On the other hand, higher than 58% of whiteness was achieved in 2 minutes of disintegration when the ultra-sonication was applied. The highest whiteness (59.32 %) was obtained by applying sonication for 20 minutes and froth flotation with kerosene as a collector under the alkaline condition (pH 11).

• Journal of English Language & Literature
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• v.58 no.1
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• pp.117-142
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• 2012

The education of children is one of the most important parts in children's literature. Children's literature, whose implied readers are both children and parents, is a good means to teach how they should behave and interact. Therefore, literary conventions of children's literature tend to be conservative with happy endings or fairy tale elements. Most of the children's literature of the 18th century were read as a conduct book which teaches children good manners and proper behavior, and at the same time served as a guidebook which tells parents how to discipline children. It emphasized the need of discipline to ascertain the hierarchy and order of the family, and cherished the close relationship between parents and children. In the 19th century, the ideal of family becomes more internalized. In the early 20th century, the ideology of family still remained, even though the world wars and economic depressions caused the cracks and collapses of the family. In the later 20th century, the disintegration of the traditional family was accelerated. The ideal of family based on the close relationship between parents and children, has had problems from the start. The attachment and over-closeness became stressful and sometimes could be poisonous. Recent children's literature shows the process of disintegration of the traditional nuclear family, children suffering in the fractured family, children's mental trauma, and nostalgia for the lost family. However, modern children's literature manages to find the lost or ideal surrogate family, and often shows fairy-tale elements such as mystical and heroic child protagonists or helpers who might solve all the difficult problems at once, despite the collapse of the family in reality.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.48 no.2
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• pp.5-12
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• 2016

White waste papers are very important resources in the paper industry, but their use is limited because of the residual of fluorescent whitening agent (FWA). So the removal of FWAs from waste paper is an important task in the recycling process to improve the use of recycled resources. In this study, we focused on the FWAs used for surface treatments and carried out physical and chemical treatments to remove them from white waste papers. The white waste papers were disintegrated with a surfactant in different pH and temperature conditions, and then handsheets were made for the measurement of the fluorescence index, which is proportional to the amount of FWAs on papers. The effect of the flotation process on the removal of FWAs after disintegration was also investigated. The fluorescence index decreased as the disintegration time increased, but over a relatively long time, the fluorescence index increased again, which indicated the readsorption of the FWAs detached from the cellulosic fibers of the white waste papers. The lowest fluorescence index was shown when the waste papers were disintegrated with a 0.3% surfactant addition at pH 10 and at $45^{\circ}C$. However, the flotation treatment was not effective, because the flotation induced contact between the detached FWAs and the cellulosic fibers, and re-adsorption occurred.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.329-334
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• 2017

In this study, a new granular type mouthwash with equivalent antibacterial activity to marketed liquid type mouthwash was developed using a material called magnesium aluminometasilicate (Neusilin). This material adsorbs the surface of granules to improve the flowability of granules due to the formation of a eutectic mixture of the main constituents, which have improved flow properties and rapid disintegration time and little residue in the oral cavity. The characteristics of the granules were improved when the amount of Neusilin was 10% or more according to measurements of the granule properties, such as flowability. In addition, a disintegration test in artificial saliva and a sensory test in the human oral cavity were carried out to confirm the improved disintegration characteristics and sensory test results. The antimicrobial test confirmed similar antibacterial activity to that of the liquid oral cleanser already sold in the market. The granular oral cleanser composition prepared in this study can be used for the development of pharmaceuticals containing different drugs with similar characteristics as eutectic mixtures at the same time, which is considered to be useful in the development of medicines in the pharmaceutical industry.

• Proceedings of the KSME Conference
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• 2001.06d
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• pp.133-138
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• 2001

In this paper, we have investigated the drying characteristics of waste sludge in a rotary dryer equipped with disintegration device. The sludge samples($moisture\;contents\;:\;70{\sim}85%\;W.B.$) used in the experiment were mainly a soybean and an alcohol fermentation sludges in food industry, or sewage sludge. It was studied by measuring the change of moisture contents that the shaft speed($operating\;range\;:\;100{\sim}250rpm$) affected on the drying rate and the particle size distribution of the dried solid. The dried granular products of the diameter of 1 to 5mm are obtained from sludge materials. In the results, as the increased of shaft speed, the particle size and the moisture contents of dried solid was decreased, and the retention time was increased.