Journal of Pharmaceutical Investigation
- Volume 10 Issue 1
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- Pages.24-33
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- 1980
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Study on Drug Product Design of Phenylbutazone Tablets by Direct Compressing
직타법(直打法)에 의(依)한 Phenylbutazone 정제(錠劑)의 제조설계(製造設計)에 관(關)한 연구(硏究)
- Kim, Ock-Nam (College of Pharmacy, Sookmyung Women's University) ;
- Young, Jae-Ick (College of Pharmacy, Sookmyung Women's University)
- Published : 1980.03.20
Abstract
Drug product design of phenylbutazone tablets by direct compressing was investigated. Weight variation, hardness, friability, disintegration time, apparent volume and dissolution rate for experimental tablets of nine formulations which were considered to be the effect of the additive concentration were measured. It was found out that direct compressing by the formulation No. 5 was the most suitable condition (phenylbutazone 16.7%, lactose 25%, calcium phosphate dibasic 15%,
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