• 한국응용곤충학회지
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• 제9권2호
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• pp.91-94
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• 1970

1. 담배 야화병은 비교적 기온과 습도가 낮은 $(18-20^{\circ}C,\; 65-75\%)$, 6월 상순부터 중순에 걸쳐 발생하기 시작했으며 기온과 습도가 점차 높아지는 $(22-26^{\circ}C,\;65-68\%)$ 6월 하순에서 7월 상순 사이에 더욱 빠른속도로 발달했고 7월 중순 이후 8월에 걸친 계절적인 폭풍우가 답배의 잎에 기계적 상해를 줌으로써 야화병의 감염을은 최대로 증가됨을 볼 수 있었다. 2. 약제처리로서는 히도마이신 300-350 배액을 발병기에 2-3회 살포한 것이 가장 효과적이어서 결과적으로 감염율을 $28.3\%$까지 감소시켰다. 3. 크로르피크린에 의한 이식전 토양 처리 (10l/10a)는 기타 병해의 방제를 겸해서 본 병의 피해를 월등히 감소시켰으며 본 포에서의 e담배 생육 상태에도 무처리구에 비해 왕성하였다. 4. 이상의 실험예서 담배 야화병의 효과적인 방제는 조기재배에 의한 수확기의 단축과 6월 상순에서 중순까지의 발병기에 적절한 약제의 살포 그리고 이식전의 토양처리 등을 함으로써 이룩될 수 있다고 본다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.54-54
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• 2023

Nypa fruticans Wurmb (N. fruticans) is a plant that belongs to Araceae and N. fruticans is mainly found in tropical mangrove systems. The parts (leaves, stems, and roots) of N. fruticans are traditionally used for asthma, sore throat, and liver disease. N. fruticans contains flavonoids and polyphenols, which are substances that have inhibitory effects on cancer and oxidant. In previous studies, some pharmaceutical effects of N. fruticans on melanogenesis and inflammation have been reported. The present study is conducted to investigate the effect of the ethyl acetate fraction of N. fruticans (ENF) on oxidative DNA damage and UVB-induced DNA damage. DNA damage response (DDR) pathway is important in research on cancer, apoptosis, and so on. DDR pathways are considered a crucial factor affecting the alleviation of cellular damage. ENF could reduce oxidative DNA damage derived from reactive oxygen species by the Fenton reaction. Also, ENF reduced the intensity of intracellular ROS in the live cell image by DCFDA assay. UVB is known to cause skin and cellular damage, then finally contribute to causing the formation of tumors. As for the strategies of reducing DNA damage by UVB, inhibition of p53, H2AX, and Chk2 can be important indexes to protect the human body from DNA damage. As a result of confirming the protective effect of ENF for UVB damage, MMPs significantly decreased, and the expression of apoptosis-related factors tended to decrease. In conclusion, ENF can provide protective effects against double-stranded DNA break (DSB) caused by oxidative DNA damage and UVB-induced DNA damage. These results are considered to be closely related to the protective effect against radicals based on catechin, epicatechin, and isoquercitrin contained in ENF. Based on these results, it is thought that additional mechanism studies for inhibiting cell damage are needed.

• Tuberculosis and Respiratory Diseases
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• 제42권3호
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• pp.400-406
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• 1995

저자들은 개흉폐조직검사상 확진된 DAD가 병발된 다발성근염환자 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한한의학원전학회지
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• 제31권4호
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• pp.1-16
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• 2018

Objectives : The paper studies the epistemology of Wind Herbs, its origin, its drug category and medicinal property, attempted to understand Lidongyuan's framework of mechanism of internal damage and treatment principle, and why he used it from his viewpoint. Methods : His suggestion was based on this treatment of internal damage suing wind herbs. Therefore, it cannot be viewed as a simple herbological concept. It rather displays the characteristics of medication based on clinical pathology. Therefore, wind herb should be comprehensively understood from the understanding of the mechanism of internal damage. That is why the paper studied around Piweilun, where Lidongyuan's concept on internal damage is established with finality. Additionally, the paper also referred to Wanghaogu's Tangyenbencao, a text that comprehensibly assembles the authors of Zhangyuans, Yixuqiyan's and Yishuixuepi's knowledge o herbology. Results : The origin of wind herb is 'herbs that uses the unique nature of wind in treatment of disease.' Medication unfolds yang qi, and this signifies the Shengyang function. This means that it starts from the lower energizer yin aspect, which is the beginning point of yang qi, and unfolds to the whole body through upbearing and effusion. Instead of producing yang qi directly similar to pungent, sweet and warm formula, however, it contributes to the achievement of the final purpose of the way of Shengyang through forming a ascending mechanism in the whole body via yin aspect's yang qi upbearing and effusion. Conclusions : Wind herb is within the scope of clinical herbology selected by Lidongyuan, for the purpose of achieving comprehensive clinical purposes, in order to treat internal damage. In this way, wind herb is distinguished from the application of other medicines that are limited in usage depending on Qiwei.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2004년도 International Meeting of the Microbiological Society of Korea
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• pp.132-136
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• 2004

Understanding the molecular pathogenesis of the multifaceted host-pathogen interaction is critical in the development of improved treatment and prevention, as well as elucidating how certain bacteria can circumvent host defenses, multiply in the host, and cause such extensive damage. Disease caused by infection with V. vulnificus is remarkable for the invasive nature of the infection, ensuing severe tissue damage, and rapidly fulminating course. The characterization of somatic as well as secreted products of V. vulnificus has yielded a large list of putative virulence attributes, whose known functions are easily imagined to explain the pathology of disease. These putative virulence factors include a carbohydrate capsule, lipopolysaccharide, a cytolysin/hemolysin, elastolytic metalloprotease, iron sequestering systems, lipase, and pili. However, only few among the putative virulence factors has been confirmed to be essential for virulence by the use of molecular Koch's postulates. This presentation describes molecular biological characterization of the virulence factors contributing to survival as well as to toxigenesis of V. vulnificus.

• BMB Reports
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• 제44권5호
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• pp.312-316
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• 2011

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolite 1-methyl-4-phenylpyridium ion (MPP$^+$) have been shown to induce Parkinson's disease-like symptoms as well as neurotoxicity in humans and animal species. Recently, we reported that maintenance of redox balance and cellular defense against oxidative damage are primary functions of the novel antioxidant enzyme cytosolic NADP$^+$-dependent isocitrate dehydrogenase (IDPc). In this study, we examined the role of IDPc in cellular defense against MPP$^+$-induced oxidative injury using PC12 cells transfected with IDPc small interfering RNA (siRNA). Our results demonstrate that MPP$^+$-mediated disruption of cellular redox status, oxidative damage to cells, and apoptotic cell death were significantly enhanced by knockdown of IDPc.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2002년도 추계학술대회
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• pp.56-58
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• 2002

Understanding the molecular pathogenesis of the multifaceted host-pathogen interaction is critical in the development of improved treatment and prevention, as well as elucidating how certain bacteria can circumvent host defenses, multiply in the host, and cause such extensive damage. Disease caused by infection with V. vulnificus is remarkable for the invasive nature of the infection, ensuing severe tissue damage, and rapidly fulminating course. The characterization of somatic as well as secreted products of V. vulnificus has yielded a large list of putative virulence attributes, whose known functions are easily imagined to explain the pathology of disease. These putative virulence factors include a carbohydrate capsule, lipopolysaccharide, a cytolysin/hemolysin, elastolytic metalloprotease, iron sequestering systems, lipase, and pili. However, only few among the putative virulence factors has been confirmed to be essential for virulence by the use of molecular Koch's postulates. This presentation describes molecular biological characterization of the virulence factors contributing to survival as well as to toxigenesis of V. vulnificus.

• Environmental Engineering Research
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• 제20권1호
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• pp.59-63
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• 2015

About 4,500 mass burial sites of carcasses from the 2010/2011 outbreak of Foot-and-Mouth (FMD) disease in Korea show very slow stabilization speed, although more than 3 years have passed. Therefore, a plan is being considered to boost the speed of stabilization or removal. This is a study on the social value of the removal plan for 4,500 mass burial sites from the 2010/2011 outbreak of FMD in Korea. This valuation is based on the survey of 1,000 people living all over Korea. Korean people have a willingness to pay 101.2 billion Korean Won (about US $100 million). This value is a large amount, but it is small compared to the cost of a FMD outbreak. The cost for the Korean government from 5 outbreaks since 2000 ranged from 28.8 billion Won to 3.2 trillion Won. These were the costs only paid by the Korean government. One estimate reported that there would be a total damage of 1.4 trillion Won, if FMD outbreak occurs in Jeju Islands, a small part of Korea. If burial sites have very slow stabilization speed and some hazardous contents, the social damage will exceed the removal cost.

• 한국환경과학회지
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• 제32권10호
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• pp.723-729
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• 2023

Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by dopaminergic neuronal loss in the substantia nigra, resulting in reduced dopamine levels and consequent motor dysfunction. Genetic and environmental factors contribute to oxidative stress in PD. Cicadidae Periostracum (CP), a traditional Korean medicine, has shown neuroprotective effects against MPTP-induced neurotoxicity in PD. However, its effects on the 6-hydroxydopamine (6-OHDA) model have not been established. This study examined CP's effects on a 6-OHDA-induced PD model. CP protected against 6-OHDA damage in both in vitro and in vivo studies. Furthermore, CP reduced the production of reactive oxygen species, inhibited apoptosis, preserved dopamine levels, protected tyrosine hydroxylase in the substantia nigra, and improved motor function. These findings suggest that CP may delay PD progression by maintaining the redox balance.

• 한국작물학회지
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• 제27권4호
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• pp.411-434
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• 1982

Yield loss of wheat and barley due to meteorological constraints has been analyzed in order to get the basic information, which will lead to the counter-measures for dissemination of agricultural technology and administration. These meteorological damages were analyzed on the results of percentage yield loss and mechanism of damage and the aspects of constraints were explained. The annual yield loss of wheat and barley were 21.7% by meteorological stress: Cold damage, 5.9% ; excessive soil moisture, 5.6% ; lodging, 2.9% ; drought, 3.0% ; disease, 4.3% etc. Those damages by the stresses mentioned above and rain damage were analyzed in relation to the growth stages and the degrees of damage. The predispositions and the growth of wheat and barley to those meteorological stress are also discussed. Varietal resistances of wheat and barley to those stresses were indexed and the physiological and morphological characteristics of these resistant cultivars are described. Cultural practices to minimize the damages were also reviewed.